Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	132789
Gene name	Glucosamine-6-phosphate deaminase 2
Gene symbol	GNPDA2
Synonyms (NCBI Gene)	GNP2SB52
Chromosome	4
Chromosome location	4p12
Summary	The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing bod

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002816	hsa-miR-1-3p	Microarray	15685193
MIRT020422	hsa-miR-106b-5p	Microarray	17242205
MIRT023359	hsa-miR-122-5p	Microarray	17612493
MIRT002816	hsa-miR-1-3p	Microarray	18668037
MIRT002816	hsa-miR-1-3p	Microarray	15685193
MIRT440547	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT440547	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT1025175	hsa-miR-3162-5p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025177	hsa-miR-320a	CLIP-seq
MIRT1025178	hsa-miR-320b	CLIP-seq
MIRT1025179	hsa-miR-320c	CLIP-seq
MIRT1025180	hsa-miR-320d	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT1025186	hsa-miR-4429	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT1025189	hsa-miR-568	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025191	hsa-miR-656	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2004004	hsa-miR-3613-3p	CLIP-seq
MIRT2236780	hsa-miR-101	CLIP-seq
MIRT2236781	hsa-miR-144	CLIP-seq
MIRT2236782	hsa-miR-4703-3p	CLIP-seq
MIRT2236783	hsa-miR-582-5p	CLIP-seq
MIRT2540672	hsa-miR-106a	CLIP-seq
MIRT2540673	hsa-miR-106b	CLIP-seq
MIRT2540674	hsa-miR-1206	CLIP-seq
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT2540675	hsa-miR-124	CLIP-seq
MIRT2540676	hsa-miR-1265	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT2540677	hsa-miR-1298	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT2540678	hsa-miR-17	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT2540679	hsa-miR-20a	CLIP-seq
MIRT2540680	hsa-miR-20b	CLIP-seq
MIRT2540681	hsa-miR-2355-5p	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT2540682	hsa-miR-2964a-5p	CLIP-seq
MIRT2540683	hsa-miR-298	CLIP-seq
MIRT2540684	hsa-miR-302a	CLIP-seq
MIRT2540685	hsa-miR-302b	CLIP-seq
MIRT2540686	hsa-miR-302c	CLIP-seq
MIRT2540687	hsa-miR-302d	CLIP-seq
MIRT2540688	hsa-miR-302e	CLIP-seq
MIRT2540689	hsa-miR-30a	CLIP-seq
MIRT2540690	hsa-miR-30b	CLIP-seq
MIRT2540691	hsa-miR-30c	CLIP-seq
MIRT2540692	hsa-miR-30d	CLIP-seq
MIRT2540693	hsa-miR-30e	CLIP-seq
MIRT2540694	hsa-miR-3194-3p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT2540695	hsa-miR-3647-3p	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT2540696	hsa-miR-3714	CLIP-seq
MIRT2540697	hsa-miR-372	CLIP-seq
MIRT2540698	hsa-miR-373	CLIP-seq
MIRT2540699	hsa-miR-3907	CLIP-seq
MIRT2540700	hsa-miR-3910	CLIP-seq
MIRT2540701	hsa-miR-3941	CLIP-seq
MIRT2540702	hsa-miR-4307	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT2540703	hsa-miR-4476	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT2540704	hsa-miR-4495	CLIP-seq
MIRT2540705	hsa-miR-4643	CLIP-seq
MIRT2540706	hsa-miR-466	CLIP-seq
MIRT2540707	hsa-miR-4672	CLIP-seq
MIRT2540708	hsa-miR-4698	CLIP-seq
MIRT2540709	hsa-miR-4716-5p	CLIP-seq
MIRT2540710	hsa-miR-4718	CLIP-seq
MIRT2540711	hsa-miR-4760-3p	CLIP-seq
MIRT2540712	hsa-miR-4777-5p	CLIP-seq
MIRT2540713	hsa-miR-4789-3p	CLIP-seq
MIRT2540714	hsa-miR-506	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT2540715	hsa-miR-519d	CLIP-seq
MIRT2540716	hsa-miR-520a-3p	CLIP-seq
MIRT2540717	hsa-miR-520b	CLIP-seq
MIRT2540718	hsa-miR-520c-3p	CLIP-seq
MIRT2540719	hsa-miR-520d-3p	CLIP-seq
MIRT2540720	hsa-miR-520e	CLIP-seq
MIRT2540721	hsa-miR-548g	CLIP-seq
MIRT2540722	hsa-miR-548t	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2540723	hsa-miR-93	CLIP-seq
MIRT2540672	hsa-miR-106a	CLIP-seq
MIRT2540673	hsa-miR-106b	CLIP-seq
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT2540675	hsa-miR-124	CLIP-seq
MIRT2540676	hsa-miR-1265	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT2540678	hsa-miR-17	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT2540679	hsa-miR-20a	CLIP-seq
MIRT2540680	hsa-miR-20b	CLIP-seq
MIRT2540681	hsa-miR-2355-5p	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT2540682	hsa-miR-2964a-5p	CLIP-seq
MIRT2540683	hsa-miR-298	CLIP-seq
MIRT2540684	hsa-miR-302a	CLIP-seq
MIRT2540685	hsa-miR-302b	CLIP-seq
MIRT2540686	hsa-miR-302c	CLIP-seq
MIRT2540687	hsa-miR-302d	CLIP-seq
MIRT2540688	hsa-miR-302e	CLIP-seq
MIRT2540689	hsa-miR-30a	CLIP-seq
MIRT2540690	hsa-miR-30b	CLIP-seq
MIRT2540691	hsa-miR-30c	CLIP-seq
MIRT2540692	hsa-miR-30d	CLIP-seq
MIRT2540693	hsa-miR-30e	CLIP-seq
MIRT2540694	hsa-miR-3194-3p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT2540695	hsa-miR-3647-3p	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT2540696	hsa-miR-3714	CLIP-seq
MIRT2540697	hsa-miR-372	CLIP-seq
MIRT2540698	hsa-miR-373	CLIP-seq
MIRT2540699	hsa-miR-3907	CLIP-seq
MIRT2540700	hsa-miR-3910	CLIP-seq
MIRT2540701	hsa-miR-3941	CLIP-seq
MIRT2540702	hsa-miR-4307	CLIP-seq
MIRT2681756	hsa-miR-4422	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT2540703	hsa-miR-4476	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT2540704	hsa-miR-4495	CLIP-seq
MIRT2540705	hsa-miR-4643	CLIP-seq
MIRT2540706	hsa-miR-466	CLIP-seq
MIRT2540707	hsa-miR-4672	CLIP-seq
MIRT2540708	hsa-miR-4698	CLIP-seq
MIRT2540709	hsa-miR-4716-5p	CLIP-seq
MIRT2540710	hsa-miR-4718	CLIP-seq
MIRT2540711	hsa-miR-4760-3p	CLIP-seq
MIRT2540712	hsa-miR-4777-5p	CLIP-seq
MIRT2540713	hsa-miR-4789-3p	CLIP-seq
MIRT2540714	hsa-miR-506	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT2540715	hsa-miR-519d	CLIP-seq
MIRT2540716	hsa-miR-520a-3p	CLIP-seq
MIRT2540717	hsa-miR-520b	CLIP-seq
MIRT2540718	hsa-miR-520c-3p	CLIP-seq
MIRT2540719	hsa-miR-520d-3p	CLIP-seq
MIRT2540720	hsa-miR-520e	CLIP-seq
MIRT2540721	hsa-miR-548g	CLIP-seq
MIRT2540722	hsa-miR-548t	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2540723	hsa-miR-93	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004342	Function	Glucosamine-6-phosphate deaminase activity	IBA
GO:0004342	Function	Glucosamine-6-phosphate deaminase activity	IDA	12616532
GO:0004342	Function	Glucosamine-6-phosphate deaminase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 29892012, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006043	Process	Glucosamine catabolic process	IBA
GO:0006044	Process	N-acetylglucosamine metabolic process	IEA
GO:0006046	Process	N-acetylglucosamine catabolic process	IBA
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	IEA
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	IMP	26887390
GO:0016787	Function	Hydrolase activity	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0019262	Process	N-acetylneuraminate catabolic process	IBA
GO:0042802	Function	Identical protein binding	IBA

MIM	HGNC	e!Ensembl
613222	21526	ENSG00000163281

Q8TDQ7

Protein name

Glucosamine-6-phosphate deaminase 2 (GlcN6P deaminase 2) (EC 3.5.99.6) (Glucosamine-6-phosphate isomerase 2) (Glucosamine-6-phosphate isomerase SB52)

Protein function

Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) bios

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01182	Glucosamine_iso	7 → 237	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous, with highest expression detected in testis, ovary, placenta, and heart. {ECO:0000269|PubMed:12616532}.

Sequence

MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGH
LSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDA
FENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD
EDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN

Sequence length

276

Interactions

View interactions

	KEGG		Reactome
	Amino sugar and nucleotide sugar metabolism Metabolic pathways		Glycolysis

GNPDA2 (glucosamine-6-phosphate deaminase 2)