Gene Gene information from NCBI Gene database.
Entrez ID 132660
Gene name Lin-54 DREAM MuvB core complex component
Gene symbol LIN54
Synonyms (NCBI Gene)
CXCDC1JC8.6MIP120TCX1
Chromosome 4
Chromosome location 4q21.22
Summary LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
miRNA miRNA information provided by mirtarbase database.
412
miRTarBase ID miRNA Experiments Reference
MIRT028262 hsa-miR-32-5p Sequencing 20371350
MIRT094312 hsa-miR-4735-3p PAR-CLIP 21572407
MIRT094297 hsa-miR-18a-5p PAR-CLIP 21572407
MIRT094303 hsa-miR-18b-5p PAR-CLIP 21572407
MIRT506745 hsa-miR-499a-3p PAR-CLIP 21572407
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
E2F4 Unknown 19725879
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
GO ID Ontology Definition Evidence Reference
GO:0001067 Function Transcription regulatory region nucleic acid binding IDA 27465258
GO:0003677 Function DNA binding IEA
GO:0003680 Function Minor groove of adenine-thymine-rich DNA binding IDA 27465258
GO:0005515 Function Protein binding IPI 17531812, 19725879, 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613367 25397 ENSG00000189308
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6MZP7
Protein name Protein lin-54 homolog (CXC domain-containing protein 1)
Protein function Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is requ
PDB 5FD3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03638 TCR 522 558 Tesmin/TSO1-like CXC domain, cysteine-rich domain Domain
PF03638 TCR 596 633 Tesmin/TSO1-like CXC domain, cysteine-rich domain Domain
Sequence
MEVVPAEVNSLLPEEIMDTGITLVDDDSIEAVIVSSPIPMETELEEIVNINSTGDSTATP
ISTEPITVYSNHTNQVAVNTTITKADSNTTVKPAFPSGLQKLGAQTPVTISANQIILNKV
SQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQLPQAQKVTTQAQSGDAKLPP
QQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSVLQTQQLKTVQIAKKPRTPTSGP
VITKLIFAKPINSKAVTGQTTQVSPPVIAGRVLSQSTPGTPSKTITISESGVIGSTLNST
TQTPNKIAISPLKSPNKAVKSTVQTITVGGVSTSQFKTIIPLATAPNVQQIQVPGSKFHY
VRLVTATSASSSTQPVSQNPSTNTQPLQQAKPVVVNTTPVRMSVPIVSAQAVKQVVPKPI
NPTSQIVTTSQPQQRLIMPATPLPQIQPNLTNLPPGTVLAPAPGTGNVGYAVLPAQYVTQ
LQQSSYVSIASNSTFTGTSGIQTQARLPFNGIIPSESASRPRKPCNCTKSLCLKLYCDCF
ANGEFCNNCNCTNCYNNL
EHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCN
CKRSGCLKNYCECYEAKIMCSSICKCIGCKNFE
ESPERKTLMHLADAAEVRVQQQTAAKT
KLSSQISDLLTRPTPALNSGGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAER
MILEEFGRCLMSVINSAGKAKSDPCAMNC
Sequence length 749
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cellular senescence   Transcription of E2F targets under negative control by DREAM complex
G0 and Early G1
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A:Cdk2-associated events at S phase entry