Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
132660
Gene name Gene Name - the full gene name approved by the HGNC.
Lin-54 DREAM MuvB core complex component
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LIN54
Synonyms (NCBI Gene) Gene synonyms aliases
CXCDC1, JC8.6, MIP120, TCX1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.22
Summary Summary of gene provided in NCBI Entrez Gene.
LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028262 hsa-miR-32-5p Sequencing 20371350
MIRT094312 hsa-miR-4735-3p PAR-CLIP 21572407
MIRT094297 hsa-miR-18a-5p PAR-CLIP 21572407
MIRT094303 hsa-miR-18b-5p PAR-CLIP 21572407
MIRT506745 hsa-miR-499a-3p PAR-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
E2F4 Unknown 19725879
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001067 Function Regulatory region nucleic acid binding IDA 27465258
GO:0003680 Function Minor groove of adenine-thymine-rich DNA binding IDA 27465258
GO:0005515 Function Protein binding IPI 17531812, 19725879, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613367 25397 ENSG00000189308
Protein
UniProt ID Q6MZP7
Protein name Protein lin-54 homolog (CXC domain-containing protein 1)
Protein function Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is requ
PDB 5FD3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03638 TCR 522 558 Tesmin/TSO1-like CXC domain, cysteine-rich domain Domain
PF03638 TCR 596 633 Tesmin/TSO1-like CXC domain, cysteine-rich domain Domain
Sequence
MEVVPAEVNSLLPEEIMDTGITLVDDDSIEAVIVSSPIPMETELEEIVNINSTGDSTATP
ISTEPITVYSNHTNQVAVNTTITKADSNTTVKPAFPSGLQKLGAQTPVTISANQIILNKV
SQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQLPQAQKVTTQAQSGDAKLPP
QQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSVLQTQQLKTVQIAKKPRTPTSGP
VITKLIFAKPINSKAVTGQTTQVSPPVIAGRVLSQSTPGTPSKTITISESGVIGSTLNST
TQTPNKIAISPLKSPNKAVKSTVQTITVGGVSTSQFKTIIPLATAPNVQQIQVPGSKFHY
VRLVTATSASSSTQPVSQNPSTNTQPLQQAKPVVVNTTPVRMSVPIVSAQAVKQVVPKPI
NPTSQIVTTSQPQQRLIMPATPLPQIQPNLTNLPPGTVLAPAPGTGNVGYAVLPAQYVTQ
LQQSSYVSIASNSTFTGTSGIQTQARLPFNGIIPSESASRPRKPCNCTKSLCLKLYCDCF
ANGEFCNNCNCTNCYNNL
EHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCN
CKRSGCLKNYCECYEAKIMCSSICKCIGCKNFE
ESPERKTLMHLADAAEVRVQQQTAAKT
KLSSQISDLLTRPTPALNSGGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAER
MILEEFGRCLMSVINSAGKAKSDPCAMNC
Sequence length 749
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cellular senescence   Transcription of E2F targets under negative control by DREAM complex
G0 and Early G1
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A:Cdk2-associated events at S phase entry
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Atrial Fibrillation Atrial Fibrillation GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 25889361
Carcinoma Basal Cell Associate 29967001
Carcinoma Endometrioid Associate 29967001
Lymphoma Non Hodgkin Associate 29967001