Gene Gene information from NCBI Gene database.
Entrez ID 131965
Gene name Methyltransferase 6, tRNA N3-cytidine
Gene symbol METTL6
Synonyms (NCBI Gene)
hMETTL6
Chromosome 3
Chromosome location 3p25.1
miRNA miRNA information provided by mirtarbase database.
466
miRTarBase ID miRNA Experiments Reference
MIRT052628 hsa-let-7a-5p CLASH 23622248
MIRT486617 hsa-miR-6783-5p PAR-CLIP 23592263
MIRT486616 hsa-miR-637 PAR-CLIP 23592263
MIRT486615 hsa-miR-3150b-3p PAR-CLIP 23592263
MIRT486613 hsa-miR-4784 PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183, 34268557
GO:0005634 Component Nucleus IDA 34268557
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 34268557
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618903 28343 ENSG00000206562
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TCB7
Protein name tRNA N(3)-cytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6)
Protein function S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34268557, PubMed:34862
PDB 7EZG , 7F1E , 8OWX , 8OWY , 8P7B , 8P7C , 8P7D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08242 Methyltransf_12 84 183 Methyltransferase domain Domain
Sequence
MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK
QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK
PGK
SVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV
NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS
Sequence length 284
Interactions View interactions