Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	131890
Gene name	G protein-coupled receptor kinase 7
Gene symbol	GRK7
Synonyms (NCBI Gene)	GPRK7
Chromosome	3
Chromosome location	3q23
Summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate con

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miRTarBase ID	miRNA	Experiments	Reference
MIRT518975	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT518974	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT518973	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT518972	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT518971	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT518970	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT518969	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT518968	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT518967	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT518966	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT518965	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT518964	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT518963	hsa-miR-302e	PAR-CLIP	23446348
MIRT518962	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT518961	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT518960	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT518959	hsa-miR-520b	PAR-CLIP	23446348
MIRT518958	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT518957	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT518956	hsa-miR-520e	PAR-CLIP	23446348
MIRT518955	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT518954	hsa-miR-6128	PAR-CLIP	23446348
MIRT518953	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT518952	hsa-miR-3135b	PAR-CLIP	23446348
MIRT518951	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT518950	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT518949	hsa-miR-6511b-5p	PAR-CLIP	23446348
MIRT518948	hsa-miR-6811-5p	PAR-CLIP	23446348
MIRT518975	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT518974	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT518973	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT518972	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT518971	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT518970	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT518969	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT518968	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT518967	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT518966	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT518965	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT518964	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT518963	hsa-miR-302e	PAR-CLIP	23446348
MIRT518962	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT518961	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT518960	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT518959	hsa-miR-520b	PAR-CLIP	23446348
MIRT518958	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT518957	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT518956	hsa-miR-520e	PAR-CLIP	23446348
MIRT518955	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT518954	hsa-miR-6128	PAR-CLIP	23446348
MIRT518953	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT518952	hsa-miR-3135b	PAR-CLIP	23446348
MIRT518951	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT518950	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT518949	hsa-miR-6511b-5p	PAR-CLIP	23446348
MIRT518948	hsa-miR-6811-5p	PAR-CLIP	23446348

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 32707033, 33961781, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007601	Process	Visual perception	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0022400	Process	Regulation of opsin-mediated signaling pathway	TAS
GO:0046777	Process	Protein autophosphorylation	IMP	15946941
GO:0050254	Function	Rhodopsin kinase activity	IBA
GO:0050254	Function	Rhodopsin kinase activity	IDA	15946941
GO:0050254	Function	Rhodopsin kinase activity	IEA
GO:0050254	Function	Rhodopsin kinase activity	TAS
GO:0097381	Component	Photoreceptor disc membrane	TAS

MIM	HGNC	e!Ensembl
606987	17031	ENSG00000114124

Q8WTQ7

Protein name

Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7)

Protein function

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	55 → 175	Regulator of G protein signaling domain	Domain
PF00069	Pkinase	191 → 454	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Retinal cones, outer and inner segments. {ECO:0000269|PubMed:11754336, ECO:0000269|PubMed:18803695}.

Sequence

MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC
EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG
NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL
FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK
EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI
ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE
ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT
EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA
KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE
EGNSSKSGVCLLL

Sequence length

553

Interactions

View interactions

	KEGG		Reactome
	Chemokine signaling pathway Endocytosis Phototransduction		Inactivation, recovery and regulation of the phototransduction cascade

GRK7 (G protein-coupled receptor kinase 7)