Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1317
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 31 member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC31A1
Synonyms (NCBI Gene) Gene synonyms aliases
COPT1, CTR1, NSCT
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NSCT
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q32
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030998 hsa-miR-21-5p Microarray 18591254
MIRT047052 hsa-miR-183-5p CLASH 23622248
MIRT666283 hsa-miR-3614-3p HITS-CLIP 23824327
MIRT666282 hsa-miR-8062 HITS-CLIP 23824327
MIRT666281 hsa-miR-6513-3p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
SP1 Unknown 20159940
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005375 Function Copper ion transmembrane transporter activity IBA 21873635
GO:0005375 Function Copper ion transmembrane transporter activity TAS
GO:0005770 Component Late endosome IEA
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603085 11016 ENSG00000136868
Protein
UniProt ID O15431
Protein name High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1) [Cleaved into: Truncated CTR1 form]
Protein function [High affinity copper uptake protein 1]: Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed:11734551, PubMed:16135512, PubMed:17525160, PubMed:19740744, PubMed:20
PDB 2LS2 , 2LS3 , 2LS4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04145 Ctr 45 175 Ctr copper transporter family Family
Sequence
Sequence length 190
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Platinum drug resistance
Mineral absorption
  Metal ion SLC transporters
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Mental retardation Profound Mental Retardation, Mental deficiency, Intellectual Disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
21937992
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 25320179
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 28640195
Adenocarcinoma of Lung Inhibit 37853210
Adrenocortical Carcinoma Associate 36973786
Alzheimer Disease Associate 39396083
Anemia Associate 27797249
Atherosclerosis Stimulate 37324184
Atrial Fibrillation Associate 37620966
Breast Neoplasms Associate 35996075, 37884650
Carcinoma Hepatocellular Associate 33146201
Carcinoma Hepatocellular Inhibit 37853210