CD200R1 (CD200 receptor 1)

Gene

• Entrez ID: 131450
• Gene name: CD200 receptor 1
• Gene symbol: CD200R1
• Synonyms (NCBI Gene): CD200R, HCRTR2, MOX2R, OX2R
• Chromosome: 3
• Chromosome location: 3q13.2
• Summary: This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the recept

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT708788	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT708787	hsa-miR-1249-5p	HITS-CLIP	19536157
MIRT708786	hsa-miR-6797-5p	HITS-CLIP	19536157
MIRT708785	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT708784	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT708783	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT708782	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT708781	hsa-miR-6825-5p	HITS-CLIP	19536157
MIRT708780	hsa-miR-6515-5p	HITS-CLIP	19536157
MIRT444485	hsa-miR-1264	PAR-CLIP	22100165
MIRT444484	hsa-miR-4635	PAR-CLIP	22100165
MIRT444483	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444482	hsa-miR-573	PAR-CLIP	22100165
MIRT444485	hsa-miR-1264	PAR-CLIP	22100165
MIRT444484	hsa-miR-4635	PAR-CLIP	22100165
MIRT444483	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444482	hsa-miR-573	PAR-CLIP	22100165
MIRT708788	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT708787	hsa-miR-1249-5p	HITS-CLIP	19536157
MIRT708786	hsa-miR-6797-5p	HITS-CLIP	19536157
MIRT708785	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT708784	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT708783	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT708782	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT708781	hsa-miR-6825-5p	HITS-CLIP	19536157
MIRT708780	hsa-miR-6515-5p	HITS-CLIP	19536157
MIRT444485	hsa-miR-1264	PAR-CLIP	22100165
MIRT444484	hsa-miR-4635	PAR-CLIP	22100165
MIRT444483	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444482	hsa-miR-573	PAR-CLIP	22100165
MIRT444485	hsa-miR-1264	PAR-CLIP	22100165
MIRT444484	hsa-miR-4635	PAR-CLIP	22100165
MIRT444483	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444482	hsa-miR-573	PAR-CLIP	22100165
MIRT874048	hsa-miR-1260	CLIP-seq
MIRT874049	hsa-miR-1260b	CLIP-seq
MIRT874050	hsa-miR-133a	CLIP-seq
MIRT874051	hsa-miR-133b	CLIP-seq
MIRT874052	hsa-miR-188-3p	CLIP-seq
MIRT874053	hsa-miR-3156-3p	CLIP-seq
MIRT874054	hsa-miR-3945	CLIP-seq
MIRT874055	hsa-miR-4253	CLIP-seq
MIRT874056	hsa-miR-4301	CLIP-seq
MIRT874057	hsa-miR-4312	CLIP-seq
MIRT874058	hsa-miR-489	CLIP-seq
MIRT874059	hsa-miR-514	CLIP-seq
MIRT874060	hsa-miR-514b-3p	CLIP-seq
MIRT874061	hsa-miR-548q	CLIP-seq
MIRT874062	hsa-miR-642b	CLIP-seq
MIRT2196222	hsa-miR-23a	CLIP-seq
MIRT2196223	hsa-miR-23b	CLIP-seq
MIRT2196224	hsa-miR-23c	CLIP-seq
MIRT2196225	hsa-miR-4422	CLIP-seq
MIRT2196226	hsa-miR-5096	CLIP-seq
MIRT2677653	hsa-miR-192	CLIP-seq
MIRT2677654	hsa-miR-215	CLIP-seq
MIRT2677655	hsa-miR-3661	CLIP-seq
MIRT2677656	hsa-miR-3662	CLIP-seq
MIRT2677657	hsa-miR-631	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21982860, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	TAS	10981966
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009986	Component	Cell surface	IDA	19151626
GO:0009986	Component	Cell surface	IEA
GO:0009986	Component	Cell surface	ISS
GO:0016020	Component	Membrane	IEA
GO:0019763	Function	Immunoglobulin receptor activity	TAS	10981966
GO:0032715	Process	Negative regulation of interleukin-6 production	ISS
GO:0034113	Process	Heterotypic cell-cell adhesion	ISS	11260322
GO:0035556	Process	Intracellular signal transduction	TAS	12072366
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038093	Process	Fc receptor signaling pathway	IEA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0140081	Function	Glycosylated region protein binding	TAS	10981966
GO:0150077	Process	Regulation of neuroinflammatory response	IEA
GO:0150077	Process	Regulation of neuroinflammatory response	ISS
GO:0150079	Process	Negative regulation of neuroinflammatory response	ISS
GO:1905522	Process	Negative regulation of macrophage migration	ISS
GO:2000405	Process	Negative regulation of T cell migration	ISS

Other IDs

• MIM: 607546
• HGNC: 24235
• e!Ensembl: ENSG00000163606

Protein

• UniProt ID: Q8TD46
• Protein name: Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1)
• Protein function: Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected
• PDB: 9GWT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08205	C2-set_2	149 → 226	CD80-like C2-set immunoglobulin domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-d
• Sequence:

  MLCPWRTANLGLLLILTIFLVAASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLC
  CPPIALRNLIIITWEIILRGQPSCTKAYRKETNETKETNCTDERITWVSRPDQNSDLQIR
  PVAITHDGYYRCIMVTPDGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAQISW
  IPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKS
  AKLYIPYIILTIIILTIVGFIWLLKVNGCRKYKLNKTESTPVVEEDEMQPYASYTEKNNP
  LYDTTNKVKASEALQSEVDTDLHTL

• Sequence length: 325

Pathways

KEGG:

Kaposi sarcoma-associated herpesvirus infection

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Alzheimer Disease	Associate	18938162, 32592865	★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Associate	23091555, 30033738	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Associate	28402258	★☆☆☆☆ Found in Text Mining only
Bone Diseases	Associate	23940819, 24333170	★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	32395395	★☆☆☆☆ Found in Text Mining only
Celiac Disease	Associate	38255930	★☆☆☆☆ Found in Text Mining only
Chanarin Dorfman Syndrome	Stimulate	39307292	★☆☆☆☆ Found in Text Mining only
Chronic Disease	Associate	18938162	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Associate	28164626	★☆☆☆☆ Found in Text Mining only
Communicable Diseases	Associate	32592865	★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	36012423	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Associate	28164626	★☆☆☆☆ Found in Text Mining only
Delirium	Associate	32592865	★☆☆☆☆ Found in Text Mining only
Drug Hypersensitivity	Associate	32603359	★☆☆☆☆ Found in Text Mining only
Hyperplasia	Associate	23595568	★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Associate	22621248	★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	18938162, 22334534, 32395395	★☆☆☆☆ Found in Text Mining only
Inflammation	Inhibit	32451434	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Associate	26690123, 28164626	★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Associate	23632869, 23690219	★☆☆☆☆ Found in Text Mining only
Leukemia Lymphocytic Chronic B Cell	Associate	16418292	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	23179394, 33054128, 35642341	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	32395395	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Associate	22621248	★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Associate	40049088	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	23632869, 32166404, 32395395, 32514618	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	39333342	★☆☆☆☆ Found in Text Mining only
Nerve Degeneration	Stimulate	28402258	★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Associate	32514618	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Associate	18938162	★☆☆☆☆ Found in Text Mining only
Osteoarthropathy Primary Hypertrophic	Associate	23595568	★☆☆☆☆ Found in Text Mining only
Pain	Associate	23595568	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	30179225	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Associate	38203236	★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Inhibit	27929051	★☆☆☆☆ Found in Text Mining only
Spinal Cord Injuries	Inhibit	32537668	★☆☆☆☆ Found in Text Mining only
Spondylarthritis	Associate	19333931	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	28052009	★☆☆☆☆ Found in Text Mining only