KCNH8 (potassium voltage-gated channel subfamily H member 8)

Gene

• Entrez ID: 131096
• Gene name: Potassium voltage-gated channel subfamily H member 8
• Gene symbol: KCNH8
• Synonyms (NCBI Gene): ELK, ELK1, Kv12.1, elk3, hElk-1
• Chromosome: 3
• Chromosome location: 3p24.3
• Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019154	hsa-miR-335-5p	Microarray	18185580
MIRT1081119	hsa-miR-4760-5p	CLIP-seq
MIRT2020101	hsa-miR-221	CLIP-seq
MIRT2020102	hsa-miR-222	CLIP-seq
MIRT2020103	hsa-miR-3120-3p	CLIP-seq
MIRT2020104	hsa-miR-3689d	CLIP-seq
MIRT2020105	hsa-miR-4802-5p	CLIP-seq
MIRT2020106	hsa-miR-548v	CLIP-seq
MIRT2251916	hsa-miR-1302	CLIP-seq
MIRT2020101	hsa-miR-221	CLIP-seq
MIRT2020102	hsa-miR-222	CLIP-seq
MIRT2020103	hsa-miR-3120-3p	CLIP-seq
MIRT2020104	hsa-miR-3689d	CLIP-seq
MIRT2251917	hsa-miR-4298	CLIP-seq
MIRT2251918	hsa-miR-4717-3p	CLIP-seq
MIRT2251919	hsa-miR-4719	CLIP-seq
MIRT2020105	hsa-miR-4802-5p	CLIP-seq
MIRT2020106	hsa-miR-548v	CLIP-seq
MIRT2251920	hsa-miR-876-3p	CLIP-seq
MIRT2389629	hsa-miR-1264	CLIP-seq
MIRT2389630	hsa-miR-136	CLIP-seq
MIRT2389631	hsa-miR-2110	CLIP-seq
MIRT2389632	hsa-miR-3150a-3p	CLIP-seq
MIRT2389633	hsa-miR-4260	CLIP-seq
MIRT2389634	hsa-miR-4450	CLIP-seq
MIRT2452184	hsa-miR-1276	CLIP-seq
MIRT2452185	hsa-miR-129-5p	CLIP-seq
MIRT2452186	hsa-miR-146a	CLIP-seq
MIRT2452187	hsa-miR-146b-5p	CLIP-seq
MIRT2452188	hsa-miR-2113	CLIP-seq
MIRT2452189	hsa-miR-3148	CLIP-seq
MIRT2452190	hsa-miR-3165	CLIP-seq
MIRT2452191	hsa-miR-3925-5p	CLIP-seq
MIRT2452192	hsa-miR-4311	CLIP-seq
MIRT2452193	hsa-miR-583	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005249	Function	Voltage-gated potassium channel activity	IBA
GO:0005249	Function	Voltage-gated potassium channel activity	IEA
GO:0005251	Function	Delayed rectifier potassium channel activity	IDA	11897058
GO:0005251	Function	Delayed rectifier potassium channel activity	IEA
GO:0005267	Function	Potassium channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IDA	11897058
GO:0006813	Process	Potassium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0042391	Process	Regulation of membrane potential	IBA
GO:0055085	Process	Transmembrane transport	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IEA

Other IDs

• MIM: 608260
• HGNC: 18864
• e!Ensembl: ENSG00000183960

Protein

• UniProt ID: Q96L42
• Protein name: Voltage-gated delayed rectifier potassium channel KCNH8 (ELK1) (hElk-1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Potassium voltage-gated channel subfamily H member 8) (Voltage-gated potassium channel subunit Kv12.1)
• Protein function: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents (PubMed:11897058). Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium c
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13426	PAS_9	29 → 135	PAS domain	Domain
  PF00520	Ion_trans	221 → 481	Ion transport protein	Family
  PF00027	cNMP_binding	570 → 654	Cyclic nucleotide-binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Primarily expressed in the nervous system. {ECO:0000269|PubMed:12890647}.
• Sequence:

  MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV
  MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK
  GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR
  REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP
  YNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT
  TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM
  SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA
  YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW
  SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM
  HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK
  DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHK
  FVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGE
  EEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQE
  IDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP
  RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS
  PQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWS
  VDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTL
  TPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASA
  STKPLENLPLEVVTSTAEVKDNKAINV

• Sequence length: 1107

Pathways

Reactome:

Voltage gated Potassium channels

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Mental Depression	Major depressive disorder	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Non Small Cell Lung	Associate	19945765
Lymphoma T Cell Peripheral	Associate	26536348