KCNH8 (potassium voltage-gated channel subfamily H member 8)

Gene

• Entrez ID: 131096
• Gene name: Potassium voltage-gated channel subfamily H member 8
• Gene symbol: KCNH8
• Synonyms (NCBI Gene): ELK, ELK1, Kv12.1, elk3, hElk-1
• Chromosome: 3
• Chromosome location: 3p24.3
• Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019154	hsa-miR-335-5p	Microarray	18185580
MIRT1081119	hsa-miR-4760-5p	CLIP-seq
MIRT2020101	hsa-miR-221	CLIP-seq
MIRT2020102	hsa-miR-222	CLIP-seq
MIRT2020103	hsa-miR-3120-3p	CLIP-seq
MIRT2020104	hsa-miR-3689d	CLIP-seq
MIRT2020105	hsa-miR-4802-5p	CLIP-seq
MIRT2020106	hsa-miR-548v	CLIP-seq
MIRT2251916	hsa-miR-1302	CLIP-seq
MIRT2020101	hsa-miR-221	CLIP-seq
MIRT2020102	hsa-miR-222	CLIP-seq
MIRT2020103	hsa-miR-3120-3p	CLIP-seq
MIRT2020104	hsa-miR-3689d	CLIP-seq
MIRT2251917	hsa-miR-4298	CLIP-seq
MIRT2251918	hsa-miR-4717-3p	CLIP-seq
MIRT2251919	hsa-miR-4719	CLIP-seq
MIRT2020105	hsa-miR-4802-5p	CLIP-seq
MIRT2020106	hsa-miR-548v	CLIP-seq
MIRT2251920	hsa-miR-876-3p	CLIP-seq
MIRT2389629	hsa-miR-1264	CLIP-seq
MIRT2389630	hsa-miR-136	CLIP-seq
MIRT2389631	hsa-miR-2110	CLIP-seq
MIRT2389632	hsa-miR-3150a-3p	CLIP-seq
MIRT2389633	hsa-miR-4260	CLIP-seq
MIRT2389634	hsa-miR-4450	CLIP-seq
MIRT2452184	hsa-miR-1276	CLIP-seq
MIRT2452185	hsa-miR-129-5p	CLIP-seq
MIRT2452186	hsa-miR-146a	CLIP-seq
MIRT2452187	hsa-miR-146b-5p	CLIP-seq
MIRT2452188	hsa-miR-2113	CLIP-seq
MIRT2452189	hsa-miR-3148	CLIP-seq
MIRT2452190	hsa-miR-3165	CLIP-seq
MIRT2452191	hsa-miR-3925-5p	CLIP-seq
MIRT2452192	hsa-miR-4311	CLIP-seq
MIRT2452193	hsa-miR-583	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005249	Function	Voltage-gated potassium channel activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0034765	Process	Regulation of ion transmembrane transport	IEA
GO:0042391	Process	Regulation of membrane potential	IBA	21873635
GO:0071805	Process	Potassium ion transmembrane transport	IBA	21873635

Other IDs

• MIM: 608260
• HGNC: 18864
• e!Ensembl: ENSG00000183960

Protein

• UniProt ID: Q96L42
• Protein name: Voltage-gated delayed rectifier potassium channel KCNH8 (ELK1) (hElk-1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Potassium voltage-gated channel subfamily H member 8) (Voltage-gated potassium channel subunit Kv12.1)
• Protein function: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents (PubMed:11897058). Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium c
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13426	PAS_9	29 → 135	PAS domain	Domain
  PF00520	Ion_trans	221 → 481	Ion transport protein	Family
  PF00027	cNMP_binding	570 → 654	Cyclic nucleotide-binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Primarily expressed in the nervous system. {ECO:0000269|PubMed:12890647}.
• Sequence:

  MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV
  MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK
  GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR
  REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP
  YNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT
  TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM
  SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA
  YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW
  SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM
  HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK
  DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHK
  FVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGE
  EEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQE
  IDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP
  RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS
  PQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWS
  VDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTL
  TPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASA
  STKPLENLPLEVVTSTAEVKDNKAINV

• Sequence length: 1107

Pathways

Reactome:

Voltage gated Potassium channels

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Mental Depression	Mental Depression			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Non Small Cell Lung	Associate	19945765
Lymphoma T Cell Peripheral	Associate	26536348