TMEM182 (transmembrane protein 182)

Gene

• Entrez ID: 130827
• Gene name: Transmembrane protein 182
• Gene symbol: TMEM182
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1433136	hsa-miR-106a	CLIP-seq
MIRT1433137	hsa-miR-106b	CLIP-seq
MIRT1433138	hsa-miR-1257	CLIP-seq
MIRT1433139	hsa-miR-1260	CLIP-seq
MIRT1433140	hsa-miR-1260b	CLIP-seq
MIRT1433141	hsa-miR-1264	CLIP-seq
MIRT1433142	hsa-miR-130a	CLIP-seq
MIRT1433143	hsa-miR-130b	CLIP-seq
MIRT1433144	hsa-miR-17	CLIP-seq
MIRT1433145	hsa-miR-188-3p	CLIP-seq
MIRT1433146	hsa-miR-19a	CLIP-seq
MIRT1433147	hsa-miR-19b	CLIP-seq
MIRT1433148	hsa-miR-20a	CLIP-seq
MIRT1433149	hsa-miR-20b	CLIP-seq
MIRT1433150	hsa-miR-297	CLIP-seq
MIRT1433151	hsa-miR-299-3p	CLIP-seq
MIRT1433152	hsa-miR-301a	CLIP-seq
MIRT1433153	hsa-miR-301b	CLIP-seq
MIRT1433154	hsa-miR-3121-5p	CLIP-seq
MIRT1433155	hsa-miR-3156-3p	CLIP-seq
MIRT1433156	hsa-miR-3163	CLIP-seq
MIRT1433157	hsa-miR-3201	CLIP-seq
MIRT1433158	hsa-miR-3666	CLIP-seq
MIRT1433159	hsa-miR-3667-3p	CLIP-seq
MIRT1433160	hsa-miR-3691-5p	CLIP-seq
MIRT1433161	hsa-miR-4264	CLIP-seq
MIRT1433162	hsa-miR-4266	CLIP-seq
MIRT1433163	hsa-miR-4295	CLIP-seq
MIRT1433164	hsa-miR-4301	CLIP-seq
MIRT1433165	hsa-miR-4491	CLIP-seq
MIRT1433166	hsa-miR-450b-5p	CLIP-seq
MIRT1433167	hsa-miR-454	CLIP-seq
MIRT1433168	hsa-miR-4643	CLIP-seq
MIRT1433169	hsa-miR-4657	CLIP-seq
MIRT1433170	hsa-miR-4659a-3p	CLIP-seq
MIRT1433171	hsa-miR-4659b-3p	CLIP-seq
MIRT1433172	hsa-miR-466	CLIP-seq
MIRT1433173	hsa-miR-4695-5p	CLIP-seq
MIRT1433174	hsa-miR-4752	CLIP-seq
MIRT1433175	hsa-miR-4762-5p	CLIP-seq
MIRT1433176	hsa-miR-4779	CLIP-seq
MIRT1433177	hsa-miR-4789-3p	CLIP-seq
MIRT1433178	hsa-miR-4791	CLIP-seq
MIRT1433179	hsa-miR-4797-3p	CLIP-seq
MIRT1433180	hsa-miR-485-3p	CLIP-seq
MIRT1433181	hsa-miR-519a	CLIP-seq
MIRT1433182	hsa-miR-519b-3p	CLIP-seq
MIRT1433183	hsa-miR-519c-3p	CLIP-seq
MIRT1433184	hsa-miR-519d	CLIP-seq
MIRT1433185	hsa-miR-520g	CLIP-seq
MIRT1433186	hsa-miR-520h	CLIP-seq
MIRT1433187	hsa-miR-548n	CLIP-seq
MIRT1433188	hsa-miR-548t	CLIP-seq
MIRT1433189	hsa-miR-567	CLIP-seq
MIRT1433190	hsa-miR-586	CLIP-seq
MIRT1433191	hsa-miR-622	CLIP-seq
MIRT1433192	hsa-miR-656	CLIP-seq
MIRT1433193	hsa-miR-93	CLIP-seq
MIRT1433138	hsa-miR-1257	CLIP-seq
MIRT2129851	hsa-miR-1298	CLIP-seq
MIRT2129852	hsa-miR-205	CLIP-seq
MIRT2129853	hsa-miR-23a	CLIP-seq
MIRT2129854	hsa-miR-23b	CLIP-seq
MIRT2129855	hsa-miR-23c	CLIP-seq
MIRT2129856	hsa-miR-298	CLIP-seq
MIRT2129857	hsa-miR-5096	CLIP-seq
MIRT2351281	hsa-miR-1253	CLIP-seq
MIRT1433139	hsa-miR-1260	CLIP-seq
MIRT1433140	hsa-miR-1260b	CLIP-seq
MIRT1433141	hsa-miR-1264	CLIP-seq
MIRT2351282	hsa-miR-140-3p	CLIP-seq
MIRT1433145	hsa-miR-188-3p	CLIP-seq
MIRT1433155	hsa-miR-3156-3p	CLIP-seq
MIRT2351283	hsa-miR-3200-3p	CLIP-seq
MIRT1433159	hsa-miR-3667-3p	CLIP-seq
MIRT2351284	hsa-miR-3919	CLIP-seq
MIRT1433164	hsa-miR-4301	CLIP-seq
MIRT2351285	hsa-miR-4463	CLIP-seq
MIRT2351286	hsa-miR-450b-3p	CLIP-seq
MIRT2351287	hsa-miR-4641	CLIP-seq
MIRT2351288	hsa-miR-4713-3p	CLIP-seq
MIRT2351289	hsa-miR-4797-5p	CLIP-seq
MIRT2351290	hsa-miR-549	CLIP-seq
MIRT2351291	hsa-miR-638	CLIP-seq
MIRT2351292	hsa-miR-769-3p	CLIP-seq
MIRT2351293	hsa-miR-944	CLIP-seq
MIRT2645078	hsa-miR-10a	CLIP-seq
MIRT2645079	hsa-miR-10b	CLIP-seq
MIRT2645080	hsa-miR-2115	CLIP-seq
MIRT2645081	hsa-miR-3065-5p	CLIP-seq
MIRT2645082	hsa-miR-3180-5p	CLIP-seq
MIRT2645083	hsa-miR-3188	CLIP-seq
MIRT2645084	hsa-miR-331-3p	CLIP-seq
MIRT2645085	hsa-miR-3612	CLIP-seq
MIRT2645086	hsa-miR-4443	CLIP-seq
MIRT2645087	hsa-miR-4534	CLIP-seq
MIRT2645088	hsa-miR-4802-5p	CLIP-seq
MIRT2645089	hsa-miR-494	CLIP-seq
MIRT2645090	hsa-miR-520a-5p	CLIP-seq
MIRT2645091	hsa-miR-525-5p	CLIP-seq
MIRT2645092	hsa-miR-650	CLIP-seq
MIRT2645078	hsa-miR-10a	CLIP-seq
MIRT2645079	hsa-miR-10b	CLIP-seq
MIRT2645080	hsa-miR-2115	CLIP-seq
MIRT2645081	hsa-miR-3065-5p	CLIP-seq
MIRT2645082	hsa-miR-3180-5p	CLIP-seq
MIRT2645083	hsa-miR-3188	CLIP-seq
MIRT2645084	hsa-miR-331-3p	CLIP-seq
MIRT2645085	hsa-miR-3612	CLIP-seq
MIRT2645086	hsa-miR-4443	CLIP-seq
MIRT2645087	hsa-miR-4534	CLIP-seq
MIRT2645088	hsa-miR-4802-5p	CLIP-seq
MIRT2645089	hsa-miR-494	CLIP-seq
MIRT2645090	hsa-miR-520a-5p	CLIP-seq
MIRT2645091	hsa-miR-525-5p	CLIP-seq
MIRT2645092	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6ZP80
• Protein name: Transmembrane protein 182
• Protein function: Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (By similarity). Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogen
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13903	Claudin_2	15 → 220	PMP-22/EMP/MP20/Claudin tight junction	Family

• Sequence:

  MRLNIAIFFGALFGALGVLLFLVAFGSDYWLLATEVGRCSGEKNIENVTFHHEGFFWRCW
  FNGIVEENDSNIWKFWYTNQPPSKNCTHAYLSPYPFMRGEHNSTSYDSAVIYRGFWAVLM
  LLGVVAVVIASFLIICAAPFASHFLYKAGGGSYIAAGILFSLVVMLYVIWVQAVADMESY
  RNMKMKDCLDFTPSVLYGWSFFLAPAGIFFSLLAGLLFLVVGWHIQIHH

• Sequence length: 229

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Schizophrenia	Schizophrenia			GWAS
Eosinophilia	Eosinophilia			GWAS
Cutaneous mastocytosis	Cutaneous mastocytosis			GWAS
Hypertrophic cardiomyopathy	Hypertrophic cardiomyopathy			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Dyslexia	Dyslexia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	35095769
Carcinogenesis	Associate	30893332
Colorectal Neoplasms	Associate	39596218
Squamous Cell Carcinoma of Head and Neck	Associate	30893332