CPO (carboxypeptidase O)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
130749
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase O
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPO
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT019012 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity IEA
GO:0004181 Function Metallocarboxypeptidase activity IBA
GO:0004181 Function Metallocarboxypeptidase activity IDA 21921028
GO:0004181 Function Metallocarboxypeptidase activity IEA
GO:0005615 Component Extracellular space IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
609563 21011 ENSG00000144410
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q8IVL8
Protein name Carboxypeptidase O (CPO) (EC 3.4.17.-)
Protein function Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.
PDB 5MRV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00246 Peptidase_M14 56 → 336 Zinc carboxypeptidase Domain
Tissue specificity TISSUE SPECIFICITY: Detected in enterocytes of the ileum. {ECO:0000269|PubMed:21921028}.
Sequence
Sequence length 374
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Childhood asthma exacerbations in long-acting beta2-agonist treatment N/A N/A GWAS
Show/Hide Text Mining Associations (9)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Bipolar Disorder Associate 21876473
Coproporphyria Hereditary Associate 11309681
Diabetes Mellitus Associate 30869579
Harderoporphyria Associate 11309681
Infections Associate 30869579
Osteomyelitis Associate 30869579
Stenotrophomonas maltophilia bacteremia Associate 30869579
Surgical Wound Infection Associate 30869579
Urinary Tract Infections Associate 30869579