TMEM178A (transmembrane protein 178A)

Gene

• Entrez ID: 130733
• Gene name: Transmembrane protein 178A
• Gene symbol: TMEM178A
• Synonyms (NCBI Gene): TMEM178
• Chromosome: 2
• Chromosome location: 2p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019194	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0016020	Component	Membrane	IEA
GO:0045671	Process	Negative regulation of osteoclast differentiation	IBA
GO:0045671	Process	Negative regulation of osteoclast differentiation	IEA
GO:0045671	Process	Negative regulation of osteoclast differentiation	ISS
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IBA
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IEA
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	ISS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8NBL3
• Protein name: Transmembrane protein 178A
• Protein function: Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13903	Claudin_2	16 → 277	PMP-22/EMP/MP20/Claudin tight junction	Family

• Sequence:

  MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLM
  PLSHLPLRDSPPLGRRLLPGGPGRADPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYF
  LGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGF
  LGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASISYDLNRLP
  KLIYSLPADVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAQLKSGRDSTV

• Sequence length: 297