Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	130271
Gene name Gene Name - the full gene name approved by the HGNC.	Pleckstrin homology, MyTH4 and FERM domain containing H2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLEKHH2
Synonyms (NCBI Gene) Gene synonyms aliases	PLEKHH1L
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p21

Show/Hide all(353)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018517	hsa-miR-335-5p	Microarray	18185580
MIRT023913	hsa-miR-1-3p	Microarray	18668037
MIRT045121	hsa-miR-186-5p	CLASH	23622248
MIRT719211	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719210	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT719209	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT719208	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT719211	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719210	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT719209	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT719208	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT1242265	hsa-miR-1	CLIP-seq
MIRT1242266	hsa-miR-1208	CLIP-seq
MIRT1242267	hsa-miR-1243	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242271	hsa-miR-1321	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT1242273	hsa-miR-2054	CLIP-seq
MIRT1242274	hsa-miR-206	CLIP-seq
MIRT1242275	hsa-miR-2114	CLIP-seq
MIRT1242276	hsa-miR-2277-3p	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT1242279	hsa-miR-3136-5p	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242281	hsa-miR-3162-5p	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242283	hsa-miR-335	CLIP-seq
MIRT1242284	hsa-miR-342-3p	CLIP-seq
MIRT1242285	hsa-miR-3616-5p	CLIP-seq
MIRT1242286	hsa-miR-3647-5p	CLIP-seq
MIRT1242287	hsa-miR-3654	CLIP-seq
MIRT1242288	hsa-miR-3658	CLIP-seq
MIRT1242289	hsa-miR-3660	CLIP-seq
MIRT1242290	hsa-miR-3662	CLIP-seq
MIRT1242291	hsa-miR-3673	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT1242294	hsa-miR-3714	CLIP-seq
MIRT1242295	hsa-miR-378g	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT1242298	hsa-miR-410	CLIP-seq
MIRT1242299	hsa-miR-4270	CLIP-seq
MIRT1242300	hsa-miR-4272	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242304	hsa-miR-4421	CLIP-seq
MIRT1242305	hsa-miR-4427	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242307	hsa-miR-4434	CLIP-seq
MIRT1242308	hsa-miR-4439	CLIP-seq
MIRT1242309	hsa-miR-4441	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT1242311	hsa-miR-4486	CLIP-seq
MIRT1242312	hsa-miR-4504	CLIP-seq
MIRT1242313	hsa-miR-4513	CLIP-seq
MIRT1242314	hsa-miR-4516	CLIP-seq
MIRT1242315	hsa-miR-4517	CLIP-seq
MIRT1242316	hsa-miR-4526	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242318	hsa-miR-4662a-3p	CLIP-seq
MIRT1242319	hsa-miR-4672	CLIP-seq
MIRT1242320	hsa-miR-4680-3p	CLIP-seq
MIRT1242321	hsa-miR-4683	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT1242323	hsa-miR-4725-5p	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT1242325	hsa-miR-4739	CLIP-seq
MIRT1242326	hsa-miR-4756-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242328	hsa-miR-4786-5p	CLIP-seq
MIRT1242329	hsa-miR-4789-3p	CLIP-seq
MIRT1242330	hsa-miR-4790-3p	CLIP-seq
MIRT1242331	hsa-miR-4795-5p	CLIP-seq
MIRT1242332	hsa-miR-4802-5p	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT1242334	hsa-miR-488	CLIP-seq
MIRT1242335	hsa-miR-504	CLIP-seq
MIRT1242336	hsa-miR-542-3p	CLIP-seq
MIRT1242337	hsa-miR-545	CLIP-seq
MIRT1242338	hsa-miR-548ag	CLIP-seq
MIRT1242339	hsa-miR-548ai	CLIP-seq
MIRT1242340	hsa-miR-554	CLIP-seq
MIRT1242341	hsa-miR-573	CLIP-seq
MIRT1242342	hsa-miR-593	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242344	hsa-miR-613	CLIP-seq
MIRT1242345	hsa-miR-642b	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242348	hsa-miR-758	CLIP-seq
MIRT1242349	hsa-miR-759	CLIP-seq
MIRT1242350	hsa-miR-765	CLIP-seq
MIRT1242351	hsa-miR-769-5p	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT2071388	hsa-miR-2467-5p	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242284	hsa-miR-342-3p	CLIP-seq
MIRT2071389	hsa-miR-3613-3p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT2071392	hsa-miR-564	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT2298647	hsa-miR-183	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT2298648	hsa-miR-4793-3p	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT2298649	hsa-miR-508-5p	CLIP-seq
MIRT2071392	hsa-miR-564	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT2298650	hsa-miR-766	CLIP-seq
MIRT2392675	hsa-miR-4307	CLIP-seq
MIRT1242265	hsa-miR-1	CLIP-seq
MIRT2595569	hsa-miR-1251	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242271	hsa-miR-1321	CLIP-seq
MIRT2595570	hsa-miR-149	CLIP-seq
MIRT2595571	hsa-miR-1825	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT2595572	hsa-miR-194	CLIP-seq
MIRT2595573	hsa-miR-199a-5p	CLIP-seq
MIRT2595574	hsa-miR-199b-5p	CLIP-seq
MIRT1242273	hsa-miR-2054	CLIP-seq
MIRT1242274	hsa-miR-206	CLIP-seq
MIRT2595575	hsa-miR-214	CLIP-seq
MIRT1242276	hsa-miR-2277-3p	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT2595576	hsa-miR-3064-3p	CLIP-seq
MIRT2595577	hsa-miR-3064-5p	CLIP-seq
MIRT2595578	hsa-miR-3065-5p	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT2595579	hsa-miR-3129-3p	CLIP-seq
MIRT2595580	hsa-miR-3143	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242281	hsa-miR-3162-5p	CLIP-seq
MIRT2595581	hsa-miR-3163	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT2595582	hsa-miR-323-5p	CLIP-seq
MIRT2071389	hsa-miR-3613-3p	CLIP-seq
MIRT2595583	hsa-miR-3619-5p	CLIP-seq
MIRT2595584	hsa-miR-3622b-5p	CLIP-seq
MIRT2595585	hsa-miR-3652	CLIP-seq
MIRT2595586	hsa-miR-3667-5p	CLIP-seq
MIRT2595587	hsa-miR-3672	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT1242294	hsa-miR-3714	CLIP-seq
MIRT2595588	hsa-miR-371b-5p	CLIP-seq
MIRT2595589	hsa-miR-377	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT2595590	hsa-miR-3914	CLIP-seq
MIRT2595591	hsa-miR-3925-3p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT2595592	hsa-miR-3945	CLIP-seq
MIRT2595593	hsa-miR-409-5p	CLIP-seq
MIRT2595594	hsa-miR-4253	CLIP-seq
MIRT1242299	hsa-miR-4270	CLIP-seq
MIRT2595595	hsa-miR-4282	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT2595596	hsa-miR-4291	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242304	hsa-miR-4421	CLIP-seq
MIRT2595597	hsa-miR-4430	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242307	hsa-miR-4434	CLIP-seq
MIRT1242309	hsa-miR-4441	CLIP-seq
MIRT2595598	hsa-miR-4477a	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2595599	hsa-miR-4493	CLIP-seq
MIRT1242314	hsa-miR-4516	CLIP-seq
MIRT1242315	hsa-miR-4517	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT2595600	hsa-miR-4638-3p	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242321	hsa-miR-4683	CLIP-seq
MIRT2595601	hsa-miR-4684-5p	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT2595602	hsa-miR-4694-3p	CLIP-seq
MIRT2595603	hsa-miR-4696	CLIP-seq
MIRT1242323	hsa-miR-4725-5p	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT1242325	hsa-miR-4739	CLIP-seq
MIRT1242326	hsa-miR-4756-5p	CLIP-seq
MIRT2595604	hsa-miR-4760-3p	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242328	hsa-miR-4786-5p	CLIP-seq
MIRT1242329	hsa-miR-4789-3p	CLIP-seq
MIRT2595605	hsa-miR-4794	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT1242335	hsa-miR-504	CLIP-seq
MIRT2298649	hsa-miR-508-5p	CLIP-seq
MIRT2595606	hsa-miR-513a-3p	CLIP-seq
MIRT2595607	hsa-miR-522	CLIP-seq
MIRT2595608	hsa-miR-543	CLIP-seq
MIRT1242337	hsa-miR-545	CLIP-seq
MIRT2595609	hsa-miR-548c-3p	CLIP-seq
MIRT2595610	hsa-miR-590-3p	CLIP-seq
MIRT1242342	hsa-miR-593	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242344	hsa-miR-613	CLIP-seq
MIRT2595611	hsa-miR-645	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242349	hsa-miR-759	CLIP-seq
MIRT2595612	hsa-miR-760	CLIP-seq
MIRT2595613	hsa-miR-761	CLIP-seq
MIRT1242351	hsa-miR-769-5p	CLIP-seq
MIRT2595614	hsa-miR-802	CLIP-seq
MIRT2595615	hsa-miR-873	CLIP-seq
MIRT2595616	hsa-miR-876-3p	CLIP-seq
MIRT2595617	hsa-miR-922	CLIP-seq
MIRT2595618	hsa-miR-944	CLIP-seq
MIRT1242265	hsa-miR-1	CLIP-seq
MIRT2688090	hsa-miR-1229	CLIP-seq
MIRT2595569	hsa-miR-1251	CLIP-seq
MIRT2688091	hsa-miR-1273d	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242271	hsa-miR-1321	CLIP-seq
MIRT2688092	hsa-miR-140-3p	CLIP-seq
MIRT2595570	hsa-miR-149	CLIP-seq
MIRT2595571	hsa-miR-1825	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT2595572	hsa-miR-194	CLIP-seq
MIRT2595573	hsa-miR-199a-5p	CLIP-seq
MIRT2595574	hsa-miR-199b-5p	CLIP-seq
MIRT1242273	hsa-miR-2054	CLIP-seq
MIRT1242274	hsa-miR-206	CLIP-seq
MIRT1242276	hsa-miR-2277-3p	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT2071388	hsa-miR-2467-5p	CLIP-seq
MIRT2595577	hsa-miR-3064-5p	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT2595579	hsa-miR-3129-3p	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT2688093	hsa-miR-3160-5p	CLIP-seq
MIRT1242281	hsa-miR-3162-5p	CLIP-seq
MIRT2595581	hsa-miR-3163	CLIP-seq
MIRT2688094	hsa-miR-3182	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242284	hsa-miR-342-3p	CLIP-seq
MIRT2688095	hsa-miR-3607-3p	CLIP-seq
MIRT2071389	hsa-miR-3613-3p	CLIP-seq
MIRT2595585	hsa-miR-3652	CLIP-seq
MIRT2595586	hsa-miR-3667-5p	CLIP-seq
MIRT2595587	hsa-miR-3672	CLIP-seq
MIRT2688096	hsa-miR-3686	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT2688097	hsa-miR-370	CLIP-seq
MIRT2595588	hsa-miR-371b-5p	CLIP-seq
MIRT2595589	hsa-miR-377	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT2595590	hsa-miR-3914	CLIP-seq
MIRT2595591	hsa-miR-3925-3p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT2688098	hsa-miR-409-3p	CLIP-seq
MIRT2595593	hsa-miR-409-5p	CLIP-seq
MIRT2688099	hsa-miR-4263	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242304	hsa-miR-4421	CLIP-seq
MIRT2595597	hsa-miR-4430	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT2688100	hsa-miR-4459	CLIP-seq
MIRT2595598	hsa-miR-4477a	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT2595600	hsa-miR-4638-3p	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242321	hsa-miR-4683	CLIP-seq
MIRT2595601	hsa-miR-4684-5p	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT2595602	hsa-miR-4694-3p	CLIP-seq
MIRT2688101	hsa-miR-4695-5p	CLIP-seq
MIRT2595603	hsa-miR-4696	CLIP-seq
MIRT1242323	hsa-miR-4725-5p	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT1242325	hsa-miR-4739	CLIP-seq
MIRT1242326	hsa-miR-4756-5p	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242328	hsa-miR-4786-5p	CLIP-seq
MIRT1242329	hsa-miR-4789-3p	CLIP-seq
MIRT2595605	hsa-miR-4794	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT1242335	hsa-miR-504	CLIP-seq
MIRT2298649	hsa-miR-508-5p	CLIP-seq
MIRT2595606	hsa-miR-513a-3p	CLIP-seq
MIRT2595607	hsa-miR-522	CLIP-seq
MIRT2595609	hsa-miR-548c-3p	CLIP-seq
MIRT2688102	hsa-miR-576-5p	CLIP-seq
MIRT2595610	hsa-miR-590-3p	CLIP-seq
MIRT1242342	hsa-miR-593	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242344	hsa-miR-613	CLIP-seq
MIRT2595611	hsa-miR-645	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242349	hsa-miR-759	CLIP-seq
MIRT2595612	hsa-miR-760	CLIP-seq
MIRT1242351	hsa-miR-769-5p	CLIP-seq
MIRT2595614	hsa-miR-802	CLIP-seq
MIRT2595615	hsa-miR-873	CLIP-seq
MIRT2595618	hsa-miR-944	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22832517
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	22832517
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0030027	Component	Lamellipodium	IDA	22832517
GO:0030027	Component	Lamellipodium	IEA
GO:0030835	Process	Negative regulation of actin filament depolymerization	IBA
GO:0030835	Process	Negative regulation of actin filament depolymerization	IEA
GO:0030835	Process	Negative regulation of actin filament depolymerization	ISS
GO:0030864	Component	Cortical actin cytoskeleton	IEA
GO:0030864	Component	Cortical actin cytoskeleton	ISS
GO:0042995	Component	Cell projection	IEA
GO:0071944	Component	Cell periphery	IEA

MIM	HGNC	e!Ensembl
612723	30506	ENSG00000152527

Protein

UniProt ID

Q8IVE3

Protein name

Pleckstrin homology domain-containing family H member 2

Protein function

In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyt

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	704 → 797	PH domain	Domain
PF00784	MyTH4	1000 → 1109	MyTH4 domain	Family
PF00373	FERM_M	1226 → 1354	FERM central domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Kidney. Reduced expression in patients with focal segmental glomerulosclerosis. {ECO:0000269|PubMed:22832517}.

Sequence

MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAF
QQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEA
KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTL
KLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDN
QVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKS
RCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQW
KALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHP
NSLSGKGTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIR
PLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPP
TPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTP
VYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLS
SVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSW
KRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTAD
SPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYY
FRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLL
IGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGI
ISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEI
CCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKY
AIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAS
TTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQ
QPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA
ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL
STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL
LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLI
ASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL

Sequence length

1493

Interactions

View interactions

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alopecia Areata	Alopecia areata	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes mellitus adjusted for BMI or coronary artery disease (pleiotropy)	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease (MTAG)	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Non Small Cell Lung	Stimulate	36209201
Diabetes Mellitus Insulin Dependent 19	Associate	27670767
Lung Neoplasms	Associate	36209201
Lymphatic Metastasis	Stimulate	36209201
Schizophrenia	Associate	31959813
Venous Thromboembolism	Associate	29117201

PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2)