Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	130132
Gene name	Raftlin family member 2
Gene symbol	RFTN2
Synonyms (NCBI Gene)	C2orf11Raftlin-2
Chromosome	2
Chromosome location	2q33.1

134

Show/Hide all (134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017859	hsa-miR-335-5p	Microarray	18185580
MIRT648585	hsa-miR-4310	HITS-CLIP	23824327
MIRT648584	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT648583	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT648582	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT648581	hsa-miR-4673	HITS-CLIP	23824327
MIRT648580	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT620695	hsa-miR-4284	HITS-CLIP	23824327
MIRT620694	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT648579	hsa-miR-3122	HITS-CLIP	23824327
MIRT648578	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT648577	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT620697	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT620696	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT620695	hsa-miR-4284	HITS-CLIP	23824327
MIRT620694	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620693	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT620692	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT620691	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT620690	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT620689	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT620688	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT620687	hsa-miR-7977	HITS-CLIP	23824327
MIRT620686	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT620685	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT620684	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT620683	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT620682	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT620681	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT620680	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT620679	hsa-miR-3689c	HITS-CLIP	23824327
MIRT620678	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT620677	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT620676	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT545177	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT545175	hsa-miR-137	PAR-CLIP	21572407
MIRT545173	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT460073	hsa-miR-5186	PAR-CLIP	23592263
MIRT460072	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT460071	hsa-miR-6086	PAR-CLIP	23592263
MIRT460070	hsa-miR-658	PAR-CLIP	23592263
MIRT460069	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT460068	hsa-miR-7156-3p	PAR-CLIP	23592263
MIRT460067	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT460066	hsa-miR-5047	PAR-CLIP	23592263
MIRT460065	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT460064	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT460063	hsa-miR-4459	PAR-CLIP	23592263
MIRT648585	hsa-miR-4310	HITS-CLIP	23824327
MIRT648584	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT648583	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT648582	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT648581	hsa-miR-4673	HITS-CLIP	23824327
MIRT648580	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT620695	hsa-miR-4284	HITS-CLIP	23824327
MIRT620694	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT648579	hsa-miR-3122	HITS-CLIP	23824327
MIRT648578	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT648577	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT620697	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT620696	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT620695	hsa-miR-4284	HITS-CLIP	23824327
MIRT620694	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620693	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT620692	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT620691	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT620690	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT620689	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT620688	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT620687	hsa-miR-7977	HITS-CLIP	23824327
MIRT620686	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT620685	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT620684	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT620683	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT620682	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT620681	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT620680	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT620679	hsa-miR-3689c	HITS-CLIP	23824327
MIRT620678	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT620677	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT620676	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT545177	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT545175	hsa-miR-137	PAR-CLIP	21572407
MIRT545173	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT460073	hsa-miR-5186	PAR-CLIP	23592263
MIRT460072	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT460071	hsa-miR-6086	PAR-CLIP	23592263
MIRT460070	hsa-miR-658	PAR-CLIP	23592263
MIRT460069	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT460068	hsa-miR-7156-3p	PAR-CLIP	23592263
MIRT460067	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT460066	hsa-miR-5047	PAR-CLIP	23592263
MIRT460065	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT460064	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT460063	hsa-miR-4459	PAR-CLIP	23592263
MIRT1302080	hsa-miR-154	CLIP-seq
MIRT1302081	hsa-miR-2053	CLIP-seq
MIRT1302082	hsa-miR-4311	CLIP-seq
MIRT1302083	hsa-miR-4712-3p	CLIP-seq
MIRT1302084	hsa-miR-505	CLIP-seq
MIRT1302085	hsa-miR-569	CLIP-seq
MIRT1302080	hsa-miR-154	CLIP-seq
MIRT1302082	hsa-miR-4311	CLIP-seq
MIRT1302080	hsa-miR-154	CLIP-seq
MIRT1302082	hsa-miR-4311	CLIP-seq
MIRT2610950	hsa-miR-1305	CLIP-seq
MIRT2610951	hsa-miR-1976	CLIP-seq
MIRT2610952	hsa-miR-3647-3p	CLIP-seq
MIRT2610953	hsa-miR-421	CLIP-seq
MIRT2610954	hsa-miR-4464	CLIP-seq
MIRT2610955	hsa-miR-4698	CLIP-seq
MIRT2610956	hsa-miR-4722-3p	CLIP-seq
MIRT2610957	hsa-miR-4725-5p	CLIP-seq
MIRT2610958	hsa-miR-4748	CLIP-seq
MIRT2610959	hsa-miR-485-3p	CLIP-seq
MIRT2610960	hsa-miR-487a	CLIP-seq
MIRT2610961	hsa-miR-494	CLIP-seq
MIRT2610962	hsa-miR-504	CLIP-seq
MIRT2610963	hsa-miR-543	CLIP-seq
MIRT2610964	hsa-miR-556-5p	CLIP-seq
MIRT2610950	hsa-miR-1305	CLIP-seq
MIRT2610951	hsa-miR-1976	CLIP-seq
MIRT2610952	hsa-miR-3647-3p	CLIP-seq
MIRT2610953	hsa-miR-421	CLIP-seq
MIRT2610954	hsa-miR-4464	CLIP-seq
MIRT2610956	hsa-miR-4722-3p	CLIP-seq
MIRT2610957	hsa-miR-4725-5p	CLIP-seq
MIRT2610958	hsa-miR-4748	CLIP-seq
MIRT2610959	hsa-miR-485-3p	CLIP-seq
MIRT2610960	hsa-miR-487a	CLIP-seq
MIRT2610961	hsa-miR-494	CLIP-seq
MIRT2610962	hsa-miR-504	CLIP-seq
MIRT2610963	hsa-miR-543	CLIP-seq
MIRT2610964	hsa-miR-556-5p	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0033227	Process	DsRNA transport	IEA
GO:0043330	Process	Response to exogenous dsRNA	IEA

MIM	HGNC	e!Ensembl
618215	26402	ENSG00000162944

Q52LD8

Protein name

Raftlin-2 (Raft-linking protein 2)

Protein function

Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-med

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15250	Raftlin	1 → 440	Raftlin	Family

Sequence

MGCGLRKLEDPDDSSPGKIFSTLKRPQVETKTEFAYEYVLLDFTLQASSNPEVIKINSIL
DIVTKVENYYLKGYIVGAIHPVIQPVGQRKHLPASYLYRVVLLRLKLSPKNSAAPSGQRR
PRLVIEECPLTSEAQTNDAAKELIEKINVAAKRGMKFVGFISQHYSPSKFCNGTNHDGDI
ESMLHVRHGSDENCRSWNEGTLSGQSSESGIEEELHHESGQYQMEQNGSPTSSKSRKGEA
SDNKLYTVFNAFDDDSTSWAYQEGILSMKVTRKGSVISTLDADWLELTTFYYKQGLSLID
SFVFWETSKGEHLPKSLEGFFIYEEEGSGVPGSSRKGNDAIVVEQWTVIEGCEIKTDYGP
LLHTLAEFGWLLTSVLPTPVLRHDSEGNLATKQIVFLQRPVMWNSAAQTPDKKASRHIKG
EDKNKATSRSIGLDTTSSQPAESRHLPEECRLSPSRECWTKEGRLAQHNSFSGFSSSDNV
LRELDDGQFDQEDGVTQVTCM

Sequence length

501

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATOPIC ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DILATED CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSLEXIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC DILATED CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Non alcoholic Fatty Liver Disease	Associate	35188871	★★★★★ ★☆☆☆☆ Found in Text Mining only

RFTN2 (raftlin family member 2)