Gene Gene information from NCBI Gene database.
Entrez ID 130026
Gene name Islet cell autoantigen 1 like
Gene symbol ICA1L
Synonyms (NCBI Gene)
ALS2CR14ALS2CR15
Chromosome 2
Chromosome location 2q33.2
miRNA miRNA information provided by mirtarbase database.
899
miRTarBase ID miRNA Experiments Reference
MIRT662382 hsa-miR-589-3p HITS-CLIP 19536157
MIRT662381 hsa-miR-452-3p HITS-CLIP 19536157
MIRT662380 hsa-miR-3149 HITS-CLIP 19536157
MIRT662414 hsa-miR-106a-5p HITS-CLIP 23313552
MIRT662413 hsa-miR-106b-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IEA
GO:0005515 Function Protein binding IPI 25416956, 32296183, 32814053
GO:0005737 Component Cytoplasm IEA
GO:0007286 Process Spermatid development IEA
GO:0012505 Component Endomembrane system IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
621083 14442 ENSG00000163596
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NDH6
Protein name Islet cell autoantigen 1-like protein (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06456 Arfaptin 15 242 Arfaptin-like domain Domain
PF04629 ICA69 254 482 Islet cell autoantigen ICA69, C-terminal domain Domain
Sequence
Sequence length 482
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
18
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC BRONCHITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Alzheimer Disease Associate 34937778, 38353984
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Alzheimer Disease Inhibit 36759259, 40141087
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Blood Coagulation Disorders Associate 31478943
★☆☆☆☆
Found in Text Mining only
Brain Diseases Associate 38353984
★☆☆☆☆
Found in Text Mining only
Carcinoma Associate 31478943
★☆☆☆☆
Found in Text Mining only
Cerebral Hemorrhage Associate 31430377, 35328582, 39298701
★☆☆☆☆
Found in Text Mining only
Cerebral Small Vessel Diseases Associate 31430377, 35328582, 35449099
★☆☆☆☆
Found in Text Mining only
Dementia Vascular Associate 40141087
★☆☆☆☆
Found in Text Mining only
Diffuse Cerebral Sclerosis of Schilder Inhibit 36475386
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 37592229
★☆☆☆☆
Found in Text Mining only