TMEM18 (transmembrane protein 18)

Gene

• Entrez ID: 129787
• Gene name: Transmembrane protein 18
• Gene symbol: TMEM18
• Synonyms (NCBI Gene): lncND
• Chromosome: 2
• Chromosome location: 2p25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT531415	hsa-miR-548ac	PAR-CLIP	22012620
MIRT531413	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT531412	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT531411	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT531410	hsa-miR-548z	PAR-CLIP	22012620
MIRT531409	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT531408	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT531407	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT531406	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT531405	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT531404	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT531403	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT531402	hsa-miR-5094	PAR-CLIP	22012620
MIRT531401	hsa-miR-936	PAR-CLIP	22012620
MIRT531400	hsa-miR-199a-3p	PAR-CLIP	22012620
MIRT531399	hsa-miR-199b-3p	PAR-CLIP	22012620
MIRT531398	hsa-miR-3129-5p	PAR-CLIP	22012620
MIRT531397	hsa-miR-361-5p	PAR-CLIP	22012620
MIRT531396	hsa-miR-222-5p	PAR-CLIP	22012620
MIRT531395	hsa-miR-374a-3p	PAR-CLIP	22012620
MIRT531415	hsa-miR-548ac	PAR-CLIP	22012620
MIRT531413	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT531412	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT531411	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT531410	hsa-miR-548z	PAR-CLIP	22012620
MIRT531409	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT531408	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT531407	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT531406	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT531405	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT531404	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT531403	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT531402	hsa-miR-5094	PAR-CLIP	22012620
MIRT531401	hsa-miR-936	PAR-CLIP	22012620
MIRT531400	hsa-miR-199a-3p	PAR-CLIP	22012620
MIRT531399	hsa-miR-199b-3p	PAR-CLIP	22012620
MIRT531398	hsa-miR-3129-5p	PAR-CLIP	22012620
MIRT531397	hsa-miR-361-5p	PAR-CLIP	22012620
MIRT531396	hsa-miR-222-5p	PAR-CLIP	22012620
MIRT531395	hsa-miR-374a-3p	PAR-CLIP	22012620
MIRT1433194	hsa-miR-106a	CLIP-seq
MIRT1433195	hsa-miR-106b	CLIP-seq
MIRT1433196	hsa-miR-1208	CLIP-seq
MIRT1433197	hsa-miR-1279	CLIP-seq
MIRT1433198	hsa-miR-1293	CLIP-seq
MIRT1433199	hsa-miR-142-5p	CLIP-seq
MIRT1433200	hsa-miR-17	CLIP-seq
MIRT1433201	hsa-miR-184	CLIP-seq
MIRT1433202	hsa-miR-1913	CLIP-seq
MIRT1433203	hsa-miR-20a	CLIP-seq
MIRT1433204	hsa-miR-20b	CLIP-seq
MIRT1433205	hsa-miR-223	CLIP-seq
MIRT1433206	hsa-miR-25	CLIP-seq
MIRT1433207	hsa-miR-3145-5p	CLIP-seq
MIRT1433208	hsa-miR-32	CLIP-seq
MIRT1433209	hsa-miR-3201	CLIP-seq
MIRT1433210	hsa-miR-324-3p	CLIP-seq
MIRT1433211	hsa-miR-340	CLIP-seq
MIRT1433212	hsa-miR-3609	CLIP-seq
MIRT1433213	hsa-miR-363	CLIP-seq
MIRT1433214	hsa-miR-367	CLIP-seq
MIRT1433215	hsa-miR-3671	CLIP-seq
MIRT1433216	hsa-miR-3681	CLIP-seq
MIRT1433217	hsa-miR-3692	CLIP-seq
MIRT1433218	hsa-miR-374a	CLIP-seq
MIRT1433219	hsa-miR-374b	CLIP-seq
MIRT1433220	hsa-miR-3973	CLIP-seq
MIRT1433221	hsa-miR-4276	CLIP-seq
MIRT1433222	hsa-miR-4277	CLIP-seq
MIRT1433223	hsa-miR-4461	CLIP-seq
MIRT1433224	hsa-miR-4483	CLIP-seq
MIRT1433225	hsa-miR-452	CLIP-seq
MIRT1433226	hsa-miR-4533	CLIP-seq
MIRT1433227	hsa-miR-4676-3p	CLIP-seq
MIRT1433228	hsa-miR-4681	CLIP-seq
MIRT1433229	hsa-miR-4697-3p	CLIP-seq
MIRT1433230	hsa-miR-4717-3p	CLIP-seq
MIRT1433231	hsa-miR-4731-3p	CLIP-seq
MIRT1433232	hsa-miR-4743	CLIP-seq
MIRT1433233	hsa-miR-4747-5p	CLIP-seq
MIRT1433234	hsa-miR-4791	CLIP-seq
MIRT1433235	hsa-miR-4795-3p	CLIP-seq
MIRT1433236	hsa-miR-4796-3p	CLIP-seq
MIRT1433237	hsa-miR-4801	CLIP-seq
MIRT1433238	hsa-miR-4804-5p	CLIP-seq
MIRT1433239	hsa-miR-518a-5p	CLIP-seq
MIRT1433240	hsa-miR-519d	CLIP-seq
MIRT1433241	hsa-miR-527	CLIP-seq
MIRT1433242	hsa-miR-548a-5p	CLIP-seq
MIRT1433243	hsa-miR-548ab	CLIP-seq
MIRT1433244	hsa-miR-548ah	CLIP-seq
MIRT1433245	hsa-miR-548ak	CLIP-seq
MIRT1433246	hsa-miR-548b-5p	CLIP-seq
MIRT1433247	hsa-miR-548c-5p	CLIP-seq
MIRT1433248	hsa-miR-548d-5p	CLIP-seq
MIRT1433249	hsa-miR-548h	CLIP-seq
MIRT1433250	hsa-miR-548i	CLIP-seq
MIRT1433251	hsa-miR-548j	CLIP-seq
MIRT1433252	hsa-miR-548w	CLIP-seq
MIRT1433253	hsa-miR-548y	CLIP-seq
MIRT1433254	hsa-miR-552	CLIP-seq
MIRT1433255	hsa-miR-559	CLIP-seq
MIRT1433256	hsa-miR-646	CLIP-seq
MIRT1433257	hsa-miR-802	CLIP-seq
MIRT1433258	hsa-miR-92a	CLIP-seq
MIRT1433259	hsa-miR-92b	CLIP-seq
MIRT1433260	hsa-miR-93	CLIP-seq
MIRT2129858	hsa-miR-1273f	CLIP-seq
MIRT2129859	hsa-miR-1283	CLIP-seq
MIRT2129860	hsa-miR-143	CLIP-seq
MIRT2129861	hsa-miR-148a	CLIP-seq
MIRT2129862	hsa-miR-148b	CLIP-seq
MIRT2129863	hsa-miR-152	CLIP-seq
MIRT2129864	hsa-miR-181a	CLIP-seq
MIRT2129865	hsa-miR-181b	CLIP-seq
MIRT2129866	hsa-miR-181c	CLIP-seq
MIRT2129867	hsa-miR-181d	CLIP-seq
MIRT1433205	hsa-miR-223	CLIP-seq
MIRT2129868	hsa-miR-3134	CLIP-seq
MIRT2129869	hsa-miR-3622a-3p	CLIP-seq
MIRT2129870	hsa-miR-3622b-3p	CLIP-seq
MIRT1433215	hsa-miR-3671	CLIP-seq
MIRT1433217	hsa-miR-3692	CLIP-seq
MIRT2129871	hsa-miR-425	CLIP-seq
MIRT2129872	hsa-miR-4262	CLIP-seq
MIRT2129873	hsa-miR-4269	CLIP-seq
MIRT1433221	hsa-miR-4276	CLIP-seq
MIRT1433222	hsa-miR-4277	CLIP-seq
MIRT2129874	hsa-miR-4292	CLIP-seq
MIRT2129875	hsa-miR-4293	CLIP-seq
MIRT2129876	hsa-miR-4308	CLIP-seq
MIRT2129877	hsa-miR-4450	CLIP-seq
MIRT2129878	hsa-miR-4514	CLIP-seq
MIRT2129879	hsa-miR-4534	CLIP-seq
MIRT2129880	hsa-miR-4643	CLIP-seq
MIRT2129881	hsa-miR-4652-3p	CLIP-seq
MIRT2129882	hsa-miR-4692	CLIP-seq
MIRT1433229	hsa-miR-4697-3p	CLIP-seq
MIRT2129883	hsa-miR-4708-5p	CLIP-seq
MIRT1433230	hsa-miR-4717-3p	CLIP-seq
MIRT2129884	hsa-miR-4742-5p	CLIP-seq
MIRT1433232	hsa-miR-4743	CLIP-seq
MIRT2129885	hsa-miR-4762-5p	CLIP-seq
MIRT2129886	hsa-miR-4770	CLIP-seq
MIRT2129887	hsa-miR-4772-5p	CLIP-seq
MIRT2129888	hsa-miR-4778-3p	CLIP-seq
MIRT2129889	hsa-miR-4802-3p	CLIP-seq
MIRT2129890	hsa-miR-512-3p	CLIP-seq
MIRT2129891	hsa-miR-520d-5p	CLIP-seq
MIRT2129892	hsa-miR-524-5p	CLIP-seq
MIRT2129893	hsa-miR-607	CLIP-seq
MIRT2129894	hsa-miR-642b	CLIP-seq
MIRT2351294	hsa-miR-1184	CLIP-seq
MIRT2351295	hsa-miR-1205	CLIP-seq
MIRT2351296	hsa-miR-1262	CLIP-seq
MIRT2351297	hsa-miR-127-5p	CLIP-seq
MIRT1433198	hsa-miR-1293	CLIP-seq
MIRT2351298	hsa-miR-1470	CLIP-seq
MIRT2351299	hsa-miR-2467-3p	CLIP-seq
MIRT2351300	hsa-miR-3144-5p	CLIP-seq
MIRT2351301	hsa-miR-3145-3p	CLIP-seq
MIRT2351302	hsa-miR-3157-3p	CLIP-seq
MIRT2351303	hsa-miR-3158-5p	CLIP-seq
MIRT2351304	hsa-miR-3162-3p	CLIP-seq
MIRT2351305	hsa-miR-3191	CLIP-seq
MIRT2351306	hsa-miR-3194-3p	CLIP-seq
MIRT1433209	hsa-miR-3201	CLIP-seq
MIRT2351307	hsa-miR-335	CLIP-seq
MIRT1433215	hsa-miR-3671	CLIP-seq
MIRT2351308	hsa-miR-3678-3p	CLIP-seq
MIRT2351309	hsa-miR-3691-5p	CLIP-seq
MIRT1433221	hsa-miR-4276	CLIP-seq
MIRT2351310	hsa-miR-4287	CLIP-seq
MIRT2351311	hsa-miR-4302	CLIP-seq
MIRT2351312	hsa-miR-4318	CLIP-seq
MIRT2351313	hsa-miR-4423-3p	CLIP-seq
MIRT2129877	hsa-miR-4450	CLIP-seq
MIRT1433224	hsa-miR-4483	CLIP-seq
MIRT2129880	hsa-miR-4643	CLIP-seq
MIRT2351314	hsa-miR-4652-5p	CLIP-seq
MIRT2351315	hsa-miR-4666-3p	CLIP-seq
MIRT2351316	hsa-miR-4667-3p	CLIP-seq
MIRT2351317	hsa-miR-4685-3p	CLIP-seq
MIRT2351318	hsa-miR-4701-3p	CLIP-seq
MIRT1433230	hsa-miR-4717-3p	CLIP-seq
MIRT2351319	hsa-miR-4722-5p	CLIP-seq
MIRT1433232	hsa-miR-4743	CLIP-seq
MIRT2351320	hsa-miR-4752	CLIP-seq
MIRT2129885	hsa-miR-4762-5p	CLIP-seq
MIRT2129888	hsa-miR-4778-3p	CLIP-seq
MIRT2351321	hsa-miR-4780	CLIP-seq
MIRT1433234	hsa-miR-4791	CLIP-seq
MIRT2351322	hsa-miR-4793-3p	CLIP-seq
MIRT2129889	hsa-miR-4802-3p	CLIP-seq
MIRT2351323	hsa-miR-491-5p	CLIP-seq
MIRT2351324	hsa-miR-514	CLIP-seq
MIRT2351325	hsa-miR-514b-3p	CLIP-seq
MIRT1433254	hsa-miR-552	CLIP-seq
MIRT2129893	hsa-miR-607	CLIP-seq
MIRT2351326	hsa-miR-623	CLIP-seq
MIRT2129894	hsa-miR-642b	CLIP-seq
MIRT2461737	hsa-miR-29a	CLIP-seq
MIRT2461738	hsa-miR-29b	CLIP-seq
MIRT2461739	hsa-miR-29c	CLIP-seq
MIRT2461740	hsa-miR-3663-3p	CLIP-seq
MIRT1433217	hsa-miR-3692	CLIP-seq
MIRT1433222	hsa-miR-4277	CLIP-seq
MIRT2461741	hsa-miR-4434	CLIP-seq
MIRT2461742	hsa-miR-4516	CLIP-seq
MIRT1433230	hsa-miR-4717-3p	CLIP-seq
MIRT1433232	hsa-miR-4743	CLIP-seq
MIRT2461743	hsa-miR-4768-3p	CLIP-seq
MIRT2461744	hsa-miR-4786-3p	CLIP-seq
MIRT2461745	hsa-miR-665	CLIP-seq
MIRT1433217	hsa-miR-3692	CLIP-seq
MIRT1433222	hsa-miR-4277	CLIP-seq
MIRT1433230	hsa-miR-4717-3p	CLIP-seq
MIRT1433232	hsa-miR-4743	CLIP-seq
MIRT2351296	hsa-miR-1262	CLIP-seq
MIRT2129858	hsa-miR-1273f	CLIP-seq
MIRT1433198	hsa-miR-1293	CLIP-seq
MIRT2129860	hsa-miR-143	CLIP-seq
MIRT2351300	hsa-miR-3144-5p	CLIP-seq
MIRT2351305	hsa-miR-3191	CLIP-seq
MIRT1433217	hsa-miR-3692	CLIP-seq
MIRT1433222	hsa-miR-4277	CLIP-seq
MIRT2129877	hsa-miR-4450	CLIP-seq
MIRT1433224	hsa-miR-4483	CLIP-seq
MIRT2129880	hsa-miR-4643	CLIP-seq
MIRT2351314	hsa-miR-4652-5p	CLIP-seq
MIRT2351318	hsa-miR-4701-3p	CLIP-seq
MIRT2129883	hsa-miR-4708-5p	CLIP-seq
MIRT1433230	hsa-miR-4717-3p	CLIP-seq
MIRT1433232	hsa-miR-4743	CLIP-seq
MIRT2129886	hsa-miR-4770	CLIP-seq
MIRT2351323	hsa-miR-491-5p	CLIP-seq
MIRT2129894	hsa-miR-642b	CLIP-seq
MIRT2351294	hsa-miR-1184	CLIP-seq
MIRT2351295	hsa-miR-1205	CLIP-seq
MIRT2351297	hsa-miR-127-5p	CLIP-seq
MIRT2351299	hsa-miR-2467-3p	CLIP-seq
MIRT2351303	hsa-miR-3158-5p	CLIP-seq
MIRT2351306	hsa-miR-3194-3p	CLIP-seq
MIRT1433215	hsa-miR-3671	CLIP-seq
MIRT2351308	hsa-miR-3678-3p	CLIP-seq
MIRT1433217	hsa-miR-3692	CLIP-seq
MIRT1433222	hsa-miR-4277	CLIP-seq
MIRT1433230	hsa-miR-4717-3p	CLIP-seq
MIRT1433232	hsa-miR-4743	CLIP-seq
MIRT2129885	hsa-miR-4762-5p	CLIP-seq
MIRT2129888	hsa-miR-4778-3p	CLIP-seq
MIRT2129889	hsa-miR-4802-3p	CLIP-seq
MIRT2129893	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IDA	18559506
GO:0031965	Component	Nuclear membrane	IBA
GO:0031965	Component	Nuclear membrane	IDA	18559506
GO:0031965	Component	Nuclear membrane	IEA
GO:0042755	Process	Eating behavior	IEA
GO:0097009	Process	Energy homeostasis	IEA

Other IDs

• MIM: 613220
• HGNC: 25257
• e!Ensembl: ENSG00000151353

Protein

• UniProt ID: Q96B42
• Protein name: Transmembrane protein 18
• Protein function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor ce
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14770	TMEM18	16 → 133	Transmembrane protein 18	Family

• Sequence:

  MPSAFSVSSFPVSIPAVLTQTDWTEPWLMGLATFHALCVLLTCLSSRSYRLQIGHFLCLV
  ILVYCAEYINEAAAMNWRLFSKYQYFDSRGMFISIVFSAPLLVNAMIIVVMWVWKTLNVM
  TDLKNAQERRKEKKRRRKED

• Sequence length: 140

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Likely benign	rs149085075	RCV005926885
Colon adenocarcinoma	Likely benign	rs149085075	RCV005926884
Colorectal cancer	Likely benign	rs149085075	RCV005926886
Familial cancer of breast	Likely benign	rs149085075	RCV005926883
Melanoma	Likely benign	rs149085075	RCV005926888
Sarcoma	Likely benign	rs149085075	RCV005926887
Uterine corpus endometrial carcinoma	Likely benign	rs149085075	RCV005926889

Associations from Text Mining
Disease Name	Relationship Type	References
Abdominal Injuries	Associate	31167208
Breast Neoplasms	Associate	29073238
Diabetes Mellitus Type 2	Associate	31167208, 32228543
Glucocorticoid Receptor Deficiency	Associate	30026463
Kidney Neoplasms	Inhibit	33299884
Neoplasms	Stimulate	33299884
Neoplasms Adipose Tissue	Associate	33491310
Obesity	Associate	19164386, 19910938, 20628085, 20724581, 20725061, 21720444, 21779088, 21796137, 21976109, 21980424, 22051089, 22095114, 23347264, 23349760, 23408508, 23505181, 23820787, 24059907, 24129437, 24626232, 26365393, 27421018, 28025578, 31167208, 32228543, 33299884, 33801339, 33859285, 36678137, 37709841
Overweight	Associate	23347264
Thinness	Associate	23890480
Thyrotropin Biologically Inactive	Associate	36678137