MITD1 (microtubule interacting and trafficking domain containing 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
129531
Gene name Gene Name - the full gene name approved by the HGNC.
Microtubule interacting and trafficking domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MITD1
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT048421 hsa-miR-100-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0000281 Process Mitotic cytokinesis IMP 23045692
GO:0005515 Function Protein binding IPI 16730941, 22190034, 23045692, 25416956, 32296183
GO:0019898 Component Extrinsic component of membrane IDA 23045692
GO:0019904 Function Protein domain specific binding IPI 23015756
GO:0030496 Component Midbody IDA 23045692
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q8WV92
Protein name MIT domain-containing protein 1
Protein function Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.
PDB 2YMB , 4A5X , 4A5Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04212 MIT 13 → 77 MIT (microtubule interacting and transport) domain Domain
PF16565 MIT_C 100 → 242 Phospholipase D-like domain at C-terminus of MIT Domain
Sequence
Sequence length 249
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lipoyltransferase deficiency LIPOYLTRANSFERASE 1 DEFICIENCY rs786205156, rs767568897, rs863224892, rs137891647, rs1468529365 24341803
Show/Hide Text Mining Associations (7)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 36291174
Carcinoma Hepatocellular Associate 35293026, 36046690
Carcinoma Renal Cell Stimulate 34346239
Carcinoma Renal Cell Associate 36046690
Esophageal Neoplasms Associate 38159255
Neoplasms Associate 36046690, 36291174
Urinary Bladder Neoplasms Associate 33200223