Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	128989
Gene name	Transport and golgi organization 2 homolog
Gene symbol	TANGO2
Synonyms (NCBI Gene)	C22orf25MECRCN
Chromosome	22
Chromosome location	22q11.21
Summary	This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In

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SNP ID	Visualize variation	Clinical significance	Consequence
rs199801224	C>A,T	Pathogenic	Stop gained, 5 prime UTR variant, synonymous variant, non coding transcript variant, coding sequence variant
rs367912276	C>G	Likely-pathogenic	Intron variant
rs372949028	G>A,C	Pathogenic, likely-pathogenic	Non coding transcript variant, intron variant, splice donor variant
rs752298579	G>A	Pathogenic	Intron variant, missense variant, coding sequence variant, non coding transcript variant
rs764883927	C>T	Pathogenic	Non coding transcript variant, coding sequence variant, intron variant, stop gained
rs869320693	T>-	Pathogenic	Non coding transcript variant, 5 prime UTR variant, frameshift variant, upstream transcript variant, coding sequence variant, genic upstream transcript variant
rs896249235	G>A,C	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant, 5 prime UTR variant
rs1057520382	G>A	Likely-pathogenic	5 prime UTR variant, coding sequence variant, non coding transcript variant, missense variant
rs1162037663	C>T	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant, missense variant
rs1328647913	T>C	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, non coding transcript variant, missense variant
rs1601975780	CT>-	Pathogenic	5 prime UTR variant, genic upstream transcript variant, non coding transcript variant, coding sequence variant, frameshift variant, upstream transcript variant
rs1602255030	G>A	Likely-pathogenic	Intron variant, splice donor variant

170

Show/Hide all (170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT686734	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT686733	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT686732	hsa-miR-940	HITS-CLIP	23313552
MIRT686731	hsa-miR-1827	HITS-CLIP	23313552
MIRT686730	hsa-miR-6089	HITS-CLIP	23313552
MIRT686729	hsa-miR-3665	HITS-CLIP	23313552
MIRT686728	hsa-miR-4736	HITS-CLIP	23313552
MIRT453056	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT453055	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT453054	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT453053	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT453052	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT453051	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT686727	hsa-miR-3165	HITS-CLIP	23313552
MIRT686726	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT453046	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT453045	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT453044	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT453043	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT453042	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT453041	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT453040	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT453039	hsa-miR-3689c	HITS-CLIP	23313552
MIRT453037	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT453038	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT686725	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT686724	hsa-miR-3122	HITS-CLIP	23313552
MIRT686723	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT453036	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT686722	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT607596	hsa-miR-4432	HITS-CLIP	24906430
MIRT607595	hsa-miR-508-5p	HITS-CLIP	24906430
MIRT607594	hsa-miR-451b	HITS-CLIP	24906430
MIRT607593	hsa-miR-3613-3p	HITS-CLIP	24906430
MIRT607592	hsa-miR-6501-3p	HITS-CLIP	24906430
MIRT607591	hsa-miR-1273g-3p	HITS-CLIP	24906430
MIRT607590	hsa-miR-6849-3p	HITS-CLIP	24906430
MIRT607589	hsa-miR-340-3p	HITS-CLIP	24906430
MIRT607588	hsa-miR-6827-3p	HITS-CLIP	24906430
MIRT607587	hsa-miR-6742-3p	HITS-CLIP	24906430
MIRT607586	hsa-miR-371b-5p	HITS-CLIP	24906430
MIRT607585	hsa-miR-373-5p	HITS-CLIP	24906430
MIRT607584	hsa-miR-616-5p	HITS-CLIP	24906430
MIRT607583	hsa-miR-371a-5p	HITS-CLIP	24906430
MIRT607582	hsa-miR-372-5p	HITS-CLIP	24906430
MIRT607581	hsa-miR-766-3p	HITS-CLIP	24906430
MIRT607580	hsa-miR-4793-3p	HITS-CLIP	24906430
MIRT607579	hsa-miR-6776-5p	HITS-CLIP	24906430
MIRT607578	hsa-miR-4696	HITS-CLIP	24906430
MIRT607577	hsa-miR-661	HITS-CLIP	24906430
MIRT607576	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT607575	hsa-miR-1227-3p	HITS-CLIP	24906430
MIRT607574	hsa-miR-6512-3p	HITS-CLIP	24906430
MIRT607573	hsa-miR-6720-5p	HITS-CLIP	24906430
MIRT607572	hsa-miR-7703	HITS-CLIP	24906430
MIRT607571	hsa-miR-1262	HITS-CLIP	24906430
MIRT607570	hsa-miR-4701-3p	HITS-CLIP	24906430
MIRT607569	hsa-miR-6736-5p	HITS-CLIP	24906430
MIRT526813	hsa-miR-652-5p	PAR-CLIP	22012620
MIRT526812	hsa-miR-548b-3p	PAR-CLIP	22012620
MIRT526811	hsa-miR-105-5p	PAR-CLIP	22012620
MIRT526809	hsa-miR-7853-5p	PAR-CLIP	22012620
MIRT526810	hsa-miR-454-5p	PAR-CLIP	22012620
MIRT526808	hsa-miR-519d-5p	PAR-CLIP	22012620
MIRT526806	hsa-miR-5695	PAR-CLIP	22012620
MIRT526807	hsa-miR-7-5p	PAR-CLIP	22012620
MIRT526804	hsa-miR-6077	PAR-CLIP	22012620
MIRT526805	hsa-miR-515-5p	PAR-CLIP	22012620
MIRT526803	hsa-miR-519e-5p	PAR-CLIP	22012620
MIRT526802	hsa-miR-455-3p	PAR-CLIP	22012620
MIRT453063	hsa-miR-302f	PAR-CLIP	23592263
MIRT453061	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT453062	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT453059	hsa-miR-6087	PAR-CLIP	23592263
MIRT453060	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT453058	hsa-miR-658	PAR-CLIP	23592263
MIRT453057	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT453056	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT453055	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453054	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453053	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453052	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453051	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT453050	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT453049	hsa-miR-7158-3p	PAR-CLIP	23592263
MIRT453048	hsa-miR-203b-3p	PAR-CLIP	23592263
MIRT453047	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453046	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT453045	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT453044	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT453043	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT453042	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT453041	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT453040	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT453039	hsa-miR-3689c	PAR-CLIP	23592263
MIRT453037	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT453038	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT453036	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT453035	hsa-miR-4459	PAR-CLIP	23592263
MIRT686734	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT686733	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT686732	hsa-miR-940	HITS-CLIP	23313552
MIRT686731	hsa-miR-1827	HITS-CLIP	23313552
MIRT686730	hsa-miR-6089	HITS-CLIP	23313552
MIRT686729	hsa-miR-3665	HITS-CLIP	23313552
MIRT686728	hsa-miR-4736	HITS-CLIP	23313552
MIRT453056	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT453055	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT453054	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT453053	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT453052	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT453051	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT686727	hsa-miR-3165	HITS-CLIP	23313552
MIRT686726	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT453046	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT453045	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT453044	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT453043	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT453042	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT453041	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT453040	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT453039	hsa-miR-3689c	HITS-CLIP	23313552
MIRT453037	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT453038	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT686725	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT686724	hsa-miR-3122	HITS-CLIP	23313552
MIRT686723	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT453036	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT686722	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT526813	hsa-miR-652-5p	PAR-CLIP	22012620
MIRT526812	hsa-miR-548b-3p	PAR-CLIP	22012620
MIRT526811	hsa-miR-105-5p	PAR-CLIP	22012620
MIRT526809	hsa-miR-7853-5p	PAR-CLIP	22012620
MIRT526810	hsa-miR-454-5p	PAR-CLIP	22012620
MIRT526808	hsa-miR-519d-5p	PAR-CLIP	22012620
MIRT526806	hsa-miR-5695	PAR-CLIP	22012620
MIRT526807	hsa-miR-7-5p	PAR-CLIP	22012620
MIRT526804	hsa-miR-6077	PAR-CLIP	22012620
MIRT526805	hsa-miR-515-5p	PAR-CLIP	22012620
MIRT526803	hsa-miR-519e-5p	PAR-CLIP	22012620
MIRT526802	hsa-miR-455-3p	PAR-CLIP	22012620
MIRT453063	hsa-miR-302f	PAR-CLIP	23592263
MIRT453061	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT453062	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT453059	hsa-miR-6087	PAR-CLIP	23592263
MIRT453060	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT453058	hsa-miR-658	PAR-CLIP	23592263
MIRT453057	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT453056	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT453055	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453054	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453053	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453052	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453051	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT453050	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT453049	hsa-miR-7158-3p	PAR-CLIP	23592263
MIRT453048	hsa-miR-203b-3p	PAR-CLIP	23592263
MIRT453047	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453046	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT453045	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT453044	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT453043	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT453042	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT453041	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT453040	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT453039	hsa-miR-3689c	PAR-CLIP	23592263
MIRT453037	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT453038	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT453036	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT453035	hsa-miR-4459	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005737	Component	Cytoplasm	IDA	31276219
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	32909282, 35197517, 36961129
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	26805781
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA	32909282
GO:0007030	Process	Golgi organization	IBA
GO:0009306	Process	Protein secretion	IBA

MIM	HGNC	e!Ensembl
616830	25439	ENSG00000183597

Q6ICL3

Protein name

Transport and Golgi organization protein 2 homolog

Protein function

May be involved in lipid homeostasis.

PDB

8SV7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05742	TANGO2	1 → 259	Transport and Golgi organisation 2	Family

Sequence

MCIIFFKFDPRPVSKNAYRLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEEGKEGGT
WLGISTRGKLAALTNYLQPQLDWQARGRGELVTHFLTTDVDSLSYLKKVSMEGHLYNGFN
LIAADLSTAKGDVICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVER
SQALPKDVLIASLLDVLNNEEAQLPDPAIEDQGGEYVQPMLSKYAAVCVRCPGYGTRTNT
IILVDADGHVTFTERSMMDKDLSHWETRTYEFTLQS

Sequence length

276

Interactions

View interactions

Show/Hide Causal Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormality of metabolism/homeostasis	Likely pathogenic; Pathogenic	rs372949028	RCV001836751
Acute rhabdomyolysis	Likely pathogenic; Pathogenic	rs752298579, rs372949028, rs2048401628	RCV000210033 RCV000210035 RCV005865474
Cardiac arrhythmia	Likely pathogenic; Pathogenic	rs752298579, rs372949028	RCV000210033 RCV000210035
Episodic flaccid weakness	Likely pathogenic; Pathogenic	rs752298579, rs372949028	RCV000210033 RCV000210035
Intellectual disability	Likely pathogenic; Pathogenic	rs752298579, rs372949028	RCV000210033 RCV000210035
Metabolic crises with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration	Pathogenic	rs764883927	RCV001250177
Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome	Pathogenic; Likely pathogenic	rs140115503, rs2046773175, rs780264323, rs752298579, rs372949028, rs869320693, rs764883927, rs2519147386, rs199801224, rs367912276, rs1162037663, rs1602255030, rs2048401628	RCV001761402 RCV002290394 RCV004798945 RCV000210337 RCV000210343 RCV000210340 RCV000210334 RCV004764859 RCV000825574 RCV001764479 RCV000754642 RCV001004913 RCV001264750
Seizure	Likely pathogenic; Pathogenic	rs752298579, rs372949028	RCV000210033 RCV000210035
TANGO2-related disorder	Likely pathogenic; Pathogenic	rs372949028	RCV004734845

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
See cases	Benign; Uncertain significance	rs73389745, rs770262515	RCV002252697 RCV002252598
Thymoma	Likely benign	rs961902850	RCV005935029
Uterine corpus endometrial carcinoma	Benign	rs77399579	RCV005903923

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arrhythmias Cardiac	Associate	26805781, 26805782, 35691983
Brain Diseases	Associate	26805782
Brain Diseases Metabolic	Associate	35691983
Cognition Disorders	Associate	26805782
Heart Diseases	Associate	26805781
Hyperammonemia	Associate	26805781
Hypoglycemia	Associate	26805781, 26805782
Metabolic Diseases	Associate	37460236
Microphthalmia Syndromic 10	Associate	26805782
Muscle Weakness	Associate	26805781
Personality Disorders	Associate	27902461
Prostatic Neoplasms	Associate	27902461
Rhabdomyolysis	Associate	26805781, 26805782, 32978841
Spastic Paraplegia Hereditary	Associate	26805782
Status Asthmaticus	Associate	26805782

TANGO2 (transport and golgi organization 2 homolog)