GAB4 (GRB2 associated binding protein family member 4)

Gene

• Entrez ID: 128954
• Gene name: GRB2 associated binding protein family member 4
• Gene symbol: GAB4
• Synonyms (NCBI Gene): -
• Chromosome: 22
• Chromosome location: 22q11.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1009359	hsa-miR-1185	CLIP-seq
MIRT1009360	hsa-miR-1252	CLIP-seq
MIRT1009361	hsa-miR-3126-5p	CLIP-seq
MIRT1009362	hsa-miR-3154	CLIP-seq
MIRT1009363	hsa-miR-3184	CLIP-seq
MIRT1009364	hsa-miR-3605-5p	CLIP-seq
MIRT1009365	hsa-miR-3679-5p	CLIP-seq
MIRT1009366	hsa-miR-3975	CLIP-seq
MIRT1009367	hsa-miR-423-5p	CLIP-seq
MIRT1009368	hsa-miR-4261	CLIP-seq
MIRT1009369	hsa-miR-4419a	CLIP-seq
MIRT1009370	hsa-miR-4499	CLIP-seq
MIRT1009371	hsa-miR-4510	CLIP-seq
MIRT1009372	hsa-miR-4688	CLIP-seq
MIRT1009373	hsa-miR-4690-3p	CLIP-seq
MIRT1009374	hsa-miR-486-3p	CLIP-seq
MIRT1009375	hsa-miR-665	CLIP-seq
MIRT1999087	hsa-miR-1276	CLIP-seq
MIRT1009372	hsa-miR-4688	CLIP-seq
MIRT1999088	hsa-miR-4711-5p	CLIP-seq
MIRT1999089	hsa-miR-545	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q2WGN9
• Protein name: GRB2-associated-binding protein 4 (GRB2-associated binder 2-like) (GAB2-like) (GRB2-associated binder 4) (GRB2-associated-binding protein 2-like) (Growth factor receptor bound protein 2-associated protein 4)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	40 → 152	PH domain	Domain

• Sequence:

  MSLPSPSPSRELCPPDPAFAPLSSWPGSGPAGGSTRSGHVLYSGWLRKSPPEKKLRLFAW
  RKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLNLCEQLDVDVTLNFNKKEIQKGYM
  FDIKTSERTFYLVAETREDMNEWVQSICQICGFRQEESTGFLGNISSASHGLCSSPAEPS
  CSHQHLPQEQEPTSEPPVSHCVPPTWPIPAPPGCLRSHQHASQRAEHARSASFSQGSEAP
  FIMRRNTAMQNLAQHSGYSVDGVSGHIHGFHSLSKPSQHNAEFRGSTHRIPWSLASHGHT
  RGSLTGSEADNEASSGKYTQHGGGNASRPAESMHEGVCSFLPGRTLVGLSDSIASEGSCV
  PMNPGSPTLPAVKQAGDDSQGVCIPVGSCLVRFDLLGSPLTELSMHQDLSQGHEVQLPPV
  NRSLKPNQKANPTPPNLRNNRVINELSFKPPVTEPWSGTSHTFDSSSSQHPISTQSITNT
  DSEDSGERYLFPNPASAFPVSGGTSSSAPPRSTGNIHYAALDFQPSKPSIGSVTSGKKVD
  YVQVDLEKTQALQKTMHEQMCLRQSSEPPRGAKL

• Sequence length: 574

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
COVID 19	Associate	37990144	★☆☆☆☆ Found in Text Mining only