Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	128239
Gene name Gene Name - the full gene name approved by the HGNC.	IQ motif containing GTPase activating protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IQGAP3
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q22

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1571320137	A>T	Likely-pathogenic	Intron variant

Show/Hide all(53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001363	hsa-miR-1-3p	pSILAC	18668040
MIRT001363	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT1070068	hsa-miR-128	CLIP-seq
MIRT1070069	hsa-miR-140-3p	CLIP-seq
MIRT1070070	hsa-miR-3591-5p	CLIP-seq
MIRT1070071	hsa-miR-4424	CLIP-seq
MIRT1070072	hsa-miR-4710	CLIP-seq
MIRT1070073	hsa-miR-4792	CLIP-seq
MIRT2017198	hsa-miR-3925-5p	CLIP-seq
MIRT2017199	hsa-miR-4632	CLIP-seq
MIRT2017200	hsa-miR-4641	CLIP-seq
MIRT2017201	hsa-miR-4709-5p	CLIP-seq
MIRT2017202	hsa-miR-520a-5p	CLIP-seq
MIRT2017203	hsa-miR-525-5p	CLIP-seq
MIRT2017204	hsa-miR-640	CLIP-seq
MIRT2017205	hsa-miR-759	CLIP-seq
MIRT2249140	hsa-miR-1225-5p	CLIP-seq
MIRT2249141	hsa-miR-127-5p	CLIP-seq
MIRT2249142	hsa-miR-186	CLIP-seq
MIRT2249143	hsa-miR-2392	CLIP-seq
MIRT2249144	hsa-miR-2467-3p	CLIP-seq
MIRT2249145	hsa-miR-29a	CLIP-seq
MIRT2249146	hsa-miR-29b	CLIP-seq
MIRT2249147	hsa-miR-29c	CLIP-seq
MIRT2249148	hsa-miR-3132	CLIP-seq
MIRT2249149	hsa-miR-3184	CLIP-seq
MIRT2249150	hsa-miR-34a	CLIP-seq
MIRT2249151	hsa-miR-34c-5p	CLIP-seq
MIRT2017198	hsa-miR-3925-5p	CLIP-seq
MIRT2249152	hsa-miR-423-5p	CLIP-seq
MIRT2249153	hsa-miR-4259	CLIP-seq
MIRT2249154	hsa-miR-4422	CLIP-seq
MIRT2249155	hsa-miR-449a	CLIP-seq
MIRT2249156	hsa-miR-449b	CLIP-seq
MIRT2249157	hsa-miR-4635	CLIP-seq
MIRT2249158	hsa-miR-4726-3p	CLIP-seq
MIRT2249159	hsa-miR-4731-5p	CLIP-seq
MIRT2249160	hsa-miR-486-3p	CLIP-seq
MIRT2017202	hsa-miR-520a-5p	CLIP-seq
MIRT2249161	hsa-miR-520f	CLIP-seq
MIRT2017203	hsa-miR-525-5p	CLIP-seq
MIRT2249162	hsa-miR-636	CLIP-seq
MIRT2017204	hsa-miR-640	CLIP-seq
MIRT2017205	hsa-miR-759	CLIP-seq
MIRT2249163	hsa-miR-940	CLIP-seq
MIRT2249149	hsa-miR-3184	CLIP-seq
MIRT2249152	hsa-miR-423-5p	CLIP-seq
MIRT2017202	hsa-miR-520a-5p	CLIP-seq
MIRT2017203	hsa-miR-525-5p	CLIP-seq
MIRT2249149	hsa-miR-3184	CLIP-seq
MIRT2249152	hsa-miR-423-5p	CLIP-seq
MIRT2017202	hsa-miR-520a-5p	CLIP-seq
MIRT2017203	hsa-miR-525-5p	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IEA
GO:0000187	Process	Activation of MAPK activity	IEA
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005516	Function	Calmodulin binding	IPI	21299499
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005911	Component	Cell-cell junction	IEA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0008361	Process	Regulation of cell size	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0033601	Process	Positive regulation of mammary gland epithelial cell proliferation	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051015	Function	Actin filament binding	IBA	21873635
GO:0070371	Process	ERK1 and ERK2 cascade	IEA
GO:0070856	Function	Myosin VI light chain binding	IPI	21299499
GO:0071310	Process	Cellular response to organic substance	IEA

MIM	HGNC	e!Ensembl
621092	20669	ENSG00000183856

Protein

UniProt ID

Q86VI3

Protein name

Ras GTPase-activating-like protein IQGAP3

PDB

3ISU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00307	CH	34 → 150	Calponin homology (CH) domain	Domain
PF00612	IQ	733 → 751	IQ calmodulin-binding motif	Motif
PF00612	IQ	761 → 781	IQ calmodulin-binding motif	Motif
PF00612	IQ	791 → 811	IQ calmodulin-binding motif	Motif
PF00612	IQ	821 → 841	IQ calmodulin-binding motif	Motif
PF00616	RasGAP	1009 → 1221	GTPase-activator protein for Ras-like GTPase	Family
PF03836	RasGAP_C	1433 → 1554	RasGAP C-terminus	Family

Sequence

MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEE
SLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPS
TFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELA
KYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENL
REPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVV
DDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEV
QAGVAAANTKGDQEQAMLHAVQRINKAIRRRVAADTVKELMCPEAQLPPVYPVASSMYQL
ELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGEN
AQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSP
EKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRAN
QDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAK
KQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAA
YDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY
LEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY
RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDI
KIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLF
YLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKS
KVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYK
NWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQI
PYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGA
LAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPE
ERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT
IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFH
PGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRV
LRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTF
YEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFR
NVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLL
IFLLNKKFLRK

Sequence length

1631

Interactions

View interactions

	KEGG		Reactome
	Regulation of actin cytoskeleton		RHO GTPases activate IQGAPs

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728 View all (51 more)	28191889

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	34872584
Adenocarcinoma of Lung	Associate	26647728
Adenoma Liver Cell	Associate	18277965
Breast Neoplasms	Associate	28281966, 31605603
Carcinogenesis	Associate	25848980, 30696738, 36275458
Carcinoma Hepatocellular	Associate	18277965, 35030478, 36524514
Carcinoma Hepatocellular	Stimulate	36320006
Carcinoma Pancreatic Ductal	Associate	35355828
Carcinoma Renal Cell	Associate	36275458
Colorectal Neoplasms	Stimulate	31544570
Fibrosarcoma	Associate	35993042
Lung Neoplasms	Associate	24849319
Lymphatic Metastasis	Stimulate	31544570
Microsatellite Instability	Associate	36164370
Neoplasm Metastasis	Associate	24849319, 28281966
Neoplasms	Stimulate	24849319
Neoplasms	Associate	25848980, 28281966, 29073199, 31544570, 34872584, 36164370, 36320006
Pancreatic Neoplasms	Associate	35355828, 36164370
Prostatitis	Stimulate	29073199
Stomach Neoplasms	Associate	37724892
Stomach Ulcer	Stimulate	29073199
Urinary Bladder Neoplasms	Associate	35993042
Uterine Cervical Neoplasms	Associate	37042849
Uterine Cervicitis	Associate	30696738

IQGAP3 (IQ motif containing GTPase activating protein 3)