ZNF648 (zinc finger protein 648)

Gene

• Entrez ID: 127665
• Gene name: Zinc finger protein 648
• Gene symbol: ZNF648
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1533401	hsa-miR-1324	CLIP-seq
MIRT1533402	hsa-miR-135a	CLIP-seq
MIRT1533403	hsa-miR-135b	CLIP-seq
MIRT1533404	hsa-miR-153	CLIP-seq
MIRT1533405	hsa-miR-298	CLIP-seq
MIRT1533406	hsa-miR-3119	CLIP-seq
MIRT1533407	hsa-miR-3192	CLIP-seq
MIRT1533408	hsa-miR-3678-3p	CLIP-seq
MIRT1533409	hsa-miR-3689a-3p	CLIP-seq
MIRT1533410	hsa-miR-3689c	CLIP-seq
MIRT1533411	hsa-miR-370	CLIP-seq
MIRT1533412	hsa-miR-3929	CLIP-seq
MIRT1533413	hsa-miR-4419b	CLIP-seq
MIRT1533414	hsa-miR-4478	CLIP-seq
MIRT1533415	hsa-miR-448	CLIP-seq
MIRT1533416	hsa-miR-4643	CLIP-seq
MIRT1533417	hsa-miR-466	CLIP-seq
MIRT1533418	hsa-miR-4728-5p	CLIP-seq
MIRT1533419	hsa-miR-4731-5p	CLIP-seq
MIRT1533420	hsa-miR-4789-3p	CLIP-seq
MIRT1533421	hsa-miR-485-5p	CLIP-seq
MIRT2161381	hsa-miR-1275	CLIP-seq
MIRT2161382	hsa-miR-376a	CLIP-seq
MIRT2161383	hsa-miR-376b	CLIP-seq
MIRT2161384	hsa-miR-3920	CLIP-seq
MIRT2161385	hsa-miR-4525	CLIP-seq
MIRT2161386	hsa-miR-4665-5p	CLIP-seq
MIRT2161387	hsa-miR-4723-5p	CLIP-seq
MIRT2161388	hsa-miR-4762-3p	CLIP-seq
MIRT2161389	hsa-miR-625	CLIP-seq
MIRT2380263	hsa-miR-34c-3p	CLIP-seq
MIRT2464481	hsa-miR-4509	CLIP-seq
MIRT2464482	hsa-miR-548m	CLIP-seq
MIRT2464483	hsa-miR-590-3p	CLIP-seq
MIRT2464484	hsa-miR-651	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5T619
• Protein name: Zinc finger protein 648
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	279 → 301	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	335 → 358	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	364 → 386	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	420 → 442	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	448 → 470	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	476 → 498	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	504 → 526	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	532 → 554	Zinc finger, C2H2 type	Domain

• Sequence:

  MAQVDSQDRWGEASPLSSLTEEAHDTQMLSMNLESDDEDGGEAEKEGTADPVACPRGSSP
  VTHENPDLPWPHPLGKEEEKFSDSSSAGGMGQKPVEMSGKASWSRDVTKINETQGSPGAS
  RALGSLPSGLAHKLLGQMQPLGDRLPAGDDGYSGANQDAVLDVPPSFPSNGKYLCAHKSV
  DTSAGNSSLLCFPRPGSNWDLPTQETHTPAQASATPASLAAAVLAKARNSRKVQNQAGRR
  EGGEAEARPYRCLRGGRAFQKPSKPLSPAETRGGAAKRYACELCGKAYSHRGTLQQHRRL
  HTGERPYQCSFCDKAYTWSSDHRKHIRTHTGEKPYPCPDCGKAFVRSSDLRKHQRNMHSN
  NKPFPCSECGLTFNKPLSLLRHQRTHLGAKPFRCPACDREFAVASRMVEHQRVHSGERPF
  PCPTCGKCFTKSSNLSEHQTLHTGQRPFKCADCGVAFAQPSRLVRHQRIHTGERPFPCTQ
  CGQAFARSSTLKRHQQIHSGEKGFLCAECGRAFRIASELAQHIRMHNGERPYQCEDCGQA
  FTRSNHLQRHRAKHGTCKKEPIPSSSDE

• Sequence length: 568

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC OSTEONECROSIS OF THE FEMORAL HEAD	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations