ZNF684 (zinc finger protein 684)

Gene

• Entrez ID: 127396
• Gene name: Zinc finger protein 684
• Gene symbol: ZNF684
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p34.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1535631	hsa-miR-1238	CLIP-seq
MIRT1535632	hsa-miR-1255a	CLIP-seq
MIRT1535633	hsa-miR-1255b	CLIP-seq
MIRT1535634	hsa-miR-1264	CLIP-seq
MIRT1535635	hsa-miR-34c-3p	CLIP-seq
MIRT1535636	hsa-miR-3647-3p	CLIP-seq
MIRT1535637	hsa-miR-3653	CLIP-seq
MIRT1535638	hsa-miR-4420	CLIP-seq
MIRT1535639	hsa-miR-4760-3p	CLIP-seq
MIRT1535640	hsa-miR-4775	CLIP-seq
MIRT1535641	hsa-miR-590-3p	CLIP-seq
MIRT1535642	hsa-miR-656	CLIP-seq
MIRT2161776	hsa-miR-3115	CLIP-seq
MIRT2161777	hsa-miR-3180-5p	CLIP-seq
MIRT1535635	hsa-miR-34c-3p	CLIP-seq
MIRT2161778	hsa-miR-509-3p	CLIP-seq
MIRT2161779	hsa-miR-520a-5p	CLIP-seq
MIRT2161780	hsa-miR-525-5p	CLIP-seq
MIRT2380675	hsa-miR-153	CLIP-seq
MIRT2380676	hsa-miR-342-3p	CLIP-seq
MIRT2380677	hsa-miR-448	CLIP-seq
MIRT2380678	hsa-miR-944	CLIP-seq
MIRT2464525	hsa-miR-106a	CLIP-seq
MIRT2464526	hsa-miR-106b	CLIP-seq
MIRT2464527	hsa-miR-1202	CLIP-seq
MIRT1535632	hsa-miR-1255a	CLIP-seq
MIRT1535633	hsa-miR-1255b	CLIP-seq
MIRT2464528	hsa-miR-17	CLIP-seq
MIRT2464529	hsa-miR-20a	CLIP-seq
MIRT2464530	hsa-miR-20b	CLIP-seq
MIRT2464531	hsa-miR-3194-5p	CLIP-seq
MIRT1535636	hsa-miR-3647-3p	CLIP-seq
MIRT2464532	hsa-miR-3972	CLIP-seq
MIRT2464533	hsa-miR-4694-3p	CLIP-seq
MIRT2464534	hsa-miR-519d	CLIP-seq
MIRT2464535	hsa-miR-545	CLIP-seq
MIRT2464536	hsa-miR-548n	CLIP-seq
MIRT2464537	hsa-miR-548t	CLIP-seq
MIRT2464538	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5T5D7
• Protein name: Zinc finger protein 684
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	7 → 48	KRAB box	Family
  PF00096	zf-C2H2	159 → 181	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	187 → 209	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	215 → 237	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	243 → 265	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	271 → 293	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	299 → 321	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	327 → 349	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	355 → 377	Zinc finger, C2H2 type	Domain

• Sequence:

  MISFQESVTFQDVAVDFTAEEWQLLDCAERTLYWDVMLENYRNLISVGCPITKTKVILKV
  EQGQEPWMVEGANPHESSPESDYPLVDEPGKHRESKDNFLKSVLLTFNKILTMERIHHYN
  MSTSLNPMRKKSYKSFEKCLPPNLDLLKYNRSYTVENAYECSECGKAFKKKFHFIRHEKN
  HTRKKPFECNDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGE
  KPYECSQCGKTFTWNSSFNQHVKSHTLEKSFECKECGKTFRYSSSLYKHSRFHTGEKPYQ
  CIICGKAFGNTSVLVTHQRIHTGEKPYSCIECGKAFIKKSHLLRHQITHTGEKPYECNRC
  GKAFSQKSNLIVHQKIHT

• Sequence length: 378

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Depressive Disorder	Associate	35017462	★☆☆☆☆ Found in Text Mining only