Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	127294
Gene name	Myomesin 3
Gene symbol	MYOM3
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p36.11

115

Show/Hide all (115)

miRTarBase ID	miRNA	Experiments
MIRT1170306	hsa-miR-1207-3p	CLIP-seq
MIRT1170307	hsa-miR-125a-3p	CLIP-seq
MIRT1170308	hsa-miR-150	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT1170310	hsa-miR-22	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT1170312	hsa-miR-361-5p	CLIP-seq
MIRT1170313	hsa-miR-3689d	CLIP-seq
MIRT1170314	hsa-miR-3934	CLIP-seq
MIRT1170315	hsa-miR-409-5p	CLIP-seq
MIRT1170316	hsa-miR-4254	CLIP-seq
MIRT1170317	hsa-miR-4267	CLIP-seq
MIRT1170318	hsa-miR-4308	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT1170322	hsa-miR-495	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT1170324	hsa-miR-599	CLIP-seq
MIRT1170325	hsa-miR-634	CLIP-seq
MIRT1170326	hsa-miR-764	CLIP-seq
MIRT2049066	hsa-miR-1224-3p	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT2049068	hsa-miR-1260	CLIP-seq
MIRT2049069	hsa-miR-1260b	CLIP-seq
MIRT2049070	hsa-miR-1280	CLIP-seq
MIRT1170308	hsa-miR-150	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2049072	hsa-miR-3189-3p	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT2049073	hsa-miR-3619-3p	CLIP-seq
MIRT2049074	hsa-miR-4320	CLIP-seq
MIRT2049075	hsa-miR-4438	CLIP-seq
MIRT2049076	hsa-miR-4535	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT2049077	hsa-miR-4713-5p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT2049078	hsa-miR-4776-5p	CLIP-seq
MIRT2049079	hsa-miR-5095	CLIP-seq
MIRT2049080	hsa-miR-532-3p	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2278143	hsa-miR-3187-3p	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT2278144	hsa-miR-3663-5p	CLIP-seq
MIRT2278145	hsa-miR-4435	CLIP-seq
MIRT2278146	hsa-miR-4701-5p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT2278148	hsa-miR-4755-3p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2278149	hsa-miR-4781-3p	CLIP-seq
MIRT2278150	hsa-miR-548a-3p	CLIP-seq
MIRT2278151	hsa-miR-548e	CLIP-seq
MIRT2278152	hsa-miR-548f	CLIP-seq
MIRT2278153	hsa-miR-548s	CLIP-seq
MIRT2278154	hsa-miR-588	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2278155	hsa-miR-601	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT2391293	hsa-miR-1255a	CLIP-seq
MIRT2391294	hsa-miR-1255b	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2391295	hsa-miR-493	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2454740	hsa-miR-3149	CLIP-seq
MIRT2454741	hsa-miR-411	CLIP-seq
MIRT2454742	hsa-miR-4715-3p	CLIP-seq
MIRT2454743	hsa-miR-4722-3p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2454744	hsa-miR-4794	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2454745	hsa-miR-661	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT1170307	hsa-miR-125a-3p	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2454740	hsa-miR-3149	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT1170314	hsa-miR-3934	CLIP-seq
MIRT2454741	hsa-miR-411	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT2454742	hsa-miR-4715-3p	CLIP-seq
MIRT2454743	hsa-miR-4722-3p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2454744	hsa-miR-4794	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2454745	hsa-miR-661	CLIP-seq
MIRT1170326	hsa-miR-764	CLIP-seq
MIRT2049067	hsa-miR-1254	CLIP-seq
MIRT1170307	hsa-miR-125a-3p	CLIP-seq
MIRT1170309	hsa-miR-1913	CLIP-seq
MIRT2049071	hsa-miR-3116	CLIP-seq
MIRT2454740	hsa-miR-3149	CLIP-seq
MIRT1170311	hsa-miR-324-3p	CLIP-seq
MIRT1170314	hsa-miR-3934	CLIP-seq
MIRT2454741	hsa-miR-411	CLIP-seq
MIRT2685705	hsa-miR-4269	CLIP-seq
MIRT2049075	hsa-miR-4438	CLIP-seq
MIRT1170319	hsa-miR-4707-3p	CLIP-seq
MIRT2454742	hsa-miR-4715-3p	CLIP-seq
MIRT2454743	hsa-miR-4722-3p	CLIP-seq
MIRT2278147	hsa-miR-4735-5p	CLIP-seq
MIRT1170320	hsa-miR-4757-5p	CLIP-seq
MIRT1170321	hsa-miR-4775	CLIP-seq
MIRT2454744	hsa-miR-4794	CLIP-seq
MIRT2049079	hsa-miR-5095	CLIP-seq
MIRT1170323	hsa-miR-590-3p	CLIP-seq
MIRT2454745	hsa-miR-661	CLIP-seq
MIRT1170326	hsa-miR-764	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0031430	Component	M band	IBA
GO:0031430	Component	M band	IEA
GO:0031430	Component	M band	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0045214	Process	Sarcomere organization	IBA

MIM	HGNC	e!Ensembl
616832	26679	ENSG00000142661

Q5VTT5

Protein name

Myomesin-3 (Myomesin family member 3)

Protein function

May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	154 → 247	Immunoglobulin I-set domain	Domain
PF07679	I-set	271 → 362	Immunoglobulin I-set domain	Domain
PF00041	fn3	374 → 459	Fibronectin type III domain	Domain
PF00041	fn3	502 → 587	Fibronectin type III domain	Domain
PF00041	fn3	603 → 685	Fibronectin type III domain	Domain
PF00041	fn3	701 → 786	Fibronectin type III domain	Domain
PF00041	fn3	803 → 888	Fibronectin type III domain	Domain
PF00047	ig	1127 → 1200	Immunoglobulin domain	Domain
PF07679	I-set	1335 → 1424	Immunoglobulin I-set domain	Domain

Sequence

MTLPHSLGGAGDPRPPQAMEVHRLEHRQEEEQKEERQHSLRMGSSVRRRTFRSSEEEHEF
SAADYALAAALALTASSELSWEAQLRRQTSAVELEERGQKRVGFGNDWERTEIAFLQTHR
LLRQRRDWKTLRRRTEEKVQEAKELRELCYGRGPWFWIPLRSHAVWEHTTVLLTCTVQAS
PPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVRVKNAHGQAS
SFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLD
AESIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQSTYV
LVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWI
ACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASELVVMGDHDAARRKTEIP
FDLGNKITISTDAFEDTVTIPSPPTNVHASEIREAYVVLAWEEPSPRDRAPLTYSLEKSV
IGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPA
TLPPPAQVQAFRDTQTSVSLTWDPVKDPELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTV
PGLRTGKEYEFCVRSVSEAGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMVIGW
KPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWA
GVGELSAPSSLFECKEWTMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSF
QEEGSEQWKPVTPGPISGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLLEDKP
GAHEIEVGVDEEGFIYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKVNKSKVILKE
PGLEDLGTYSVIVTDADEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNIDILERG
EVRLWLEVEKLSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDKGSYTA
QLQDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERPLQWKVTEDCQVQLTC
KVTNTKKETRFQWFFQRAEMPDGQYDPETGTGLLCIEELSKKDKGIYRAMVSDDRGEDDT
ILDLTGDALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKR
LESGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEH
QRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDR
YRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKELKSM

Sequence length

1437

Interactions

View interactions

	KEGG
	Cytoskeleton in muscle cells

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Flexion contracture	Uncertain significance; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colorectal Neoplasms	Associate	37434131	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Associate	37130628	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Stimulate	37130628	★★★★★ ★☆☆☆☆ Found in Text Mining only

MYOM3 (myomesin 3)