TYW3 (tRNA-yW synthesizing protein 3 homolog)

Gene

• Entrez ID: 127253
• Gene name: TRNA-yW synthesizing protein 3 homolog
• Gene symbol: TYW3
• Synonyms (NCBI Gene): C1orf171
• Chromosome: 1
• Chromosome location: 1p31.1
• Summary: Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW s

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016492	hsa-miR-193b-3p	Microarray	20304954
MIRT030497	hsa-miR-24-3p	Microarray	19748357
MIRT043795	hsa-miR-328-3p	CLASH	23622248
MIRT643218	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT643217	hsa-miR-4476	HITS-CLIP	19536157
MIRT643216	hsa-miR-6876-5p	HITS-CLIP	19536157
MIRT643212	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT716206	hsa-miR-3183	HITS-CLIP	19536157
MIRT716205	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT716204	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT643210	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT643209	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT716203	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT643208	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT643207	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT643219	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT643218	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT643217	hsa-miR-4476	HITS-CLIP	23824327
MIRT643216	hsa-miR-6876-5p	HITS-CLIP	23824327
MIRT643215	hsa-miR-6074	HITS-CLIP	23824327
MIRT643214	hsa-miR-892c-5p	HITS-CLIP	23824327
MIRT643213	hsa-miR-506-5p	HITS-CLIP	23824327
MIRT643212	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT643211	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT643210	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT643209	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT643208	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT643207	hsa-miR-6828-5p	HITS-CLIP	23824327
MIRT643206	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT497116	hsa-miR-6715b-3p	PAR-CLIP	22291592
MIRT643218	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT643217	hsa-miR-4476	HITS-CLIP	19536157
MIRT643216	hsa-miR-6876-5p	HITS-CLIP	19536157
MIRT643212	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT716206	hsa-miR-3183	HITS-CLIP	19536157
MIRT716205	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT716204	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT643210	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT643209	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT716203	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT643208	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT643207	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT643219	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT643218	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT643217	hsa-miR-4476	HITS-CLIP	23824327
MIRT643216	hsa-miR-6876-5p	HITS-CLIP	23824327
MIRT643215	hsa-miR-6074	HITS-CLIP	23824327
MIRT643214	hsa-miR-892c-5p	HITS-CLIP	23824327
MIRT643213	hsa-miR-506-5p	HITS-CLIP	23824327
MIRT643212	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT643211	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT643210	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT643209	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT643208	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT643207	hsa-miR-6828-5p	HITS-CLIP	23824327
MIRT643206	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT497116	hsa-miR-6715b-3p	PAR-CLIP	22291592
MIRT1465796	hsa-miR-1285	CLIP-seq
MIRT1465797	hsa-miR-2355-3p	CLIP-seq
MIRT1465798	hsa-miR-3065-5p	CLIP-seq
MIRT1465799	hsa-miR-3187-5p	CLIP-seq
MIRT1465800	hsa-miR-326	CLIP-seq
MIRT1465801	hsa-miR-330-5p	CLIP-seq
MIRT1465802	hsa-miR-3655	CLIP-seq
MIRT1465803	hsa-miR-378g	CLIP-seq
MIRT1465804	hsa-miR-4486	CLIP-seq
MIRT1465805	hsa-miR-4718	CLIP-seq
MIRT1465806	hsa-miR-4795-3p	CLIP-seq
MIRT1465807	hsa-miR-549	CLIP-seq
MIRT1465808	hsa-miR-612	CLIP-seq
MIRT1465809	hsa-miR-643	CLIP-seq
MIRT1465810	hsa-miR-676	CLIP-seq
MIRT1465811	hsa-miR-155	CLIP-seq
MIRT1465812	hsa-miR-21	CLIP-seq
MIRT1465813	hsa-miR-2278	CLIP-seq
MIRT1465814	hsa-miR-28-3p	CLIP-seq
MIRT1465815	hsa-miR-3163	CLIP-seq
MIRT1465816	hsa-miR-340	CLIP-seq
MIRT1465817	hsa-miR-362-5p	CLIP-seq
MIRT1465805	hsa-miR-4718	CLIP-seq
MIRT1465818	hsa-miR-500b	CLIP-seq
MIRT1465819	hsa-miR-501-5p	CLIP-seq
MIRT1465820	hsa-miR-548aa	CLIP-seq
MIRT1465821	hsa-miR-590-5p	CLIP-seq
MIRT1465822	hsa-miR-646	CLIP-seq
MIRT2140079	hsa-miR-1270	CLIP-seq
MIRT2140080	hsa-miR-3143	CLIP-seq
MIRT2140081	hsa-miR-376c	CLIP-seq
MIRT2140082	hsa-miR-432	CLIP-seq
MIRT2140083	hsa-miR-4531	CLIP-seq
MIRT2140084	hsa-miR-4683	CLIP-seq
MIRT2140085	hsa-miR-543	CLIP-seq
MIRT2140086	hsa-miR-578	CLIP-seq
MIRT2140087	hsa-miR-582-5p	CLIP-seq
MIRT2140088	hsa-miR-620	CLIP-seq
MIRT2140089	hsa-miR-764	CLIP-seq
MIRT2360701	hsa-miR-1248	CLIP-seq
MIRT2360702	hsa-miR-127-5p	CLIP-seq
MIRT2360703	hsa-miR-128	CLIP-seq
MIRT2360704	hsa-miR-1297	CLIP-seq
MIRT2360705	hsa-miR-1299	CLIP-seq
MIRT2360706	hsa-miR-193a-3p	CLIP-seq
MIRT2360707	hsa-miR-193b	CLIP-seq
MIRT2360708	hsa-miR-197	CLIP-seq
MIRT2360709	hsa-miR-217	CLIP-seq
MIRT2360710	hsa-miR-26a	CLIP-seq
MIRT2360711	hsa-miR-26b	CLIP-seq
MIRT2360712	hsa-miR-27a	CLIP-seq
MIRT2360713	hsa-miR-27b	CLIP-seq
MIRT2360714	hsa-miR-3130-3p	CLIP-seq
MIRT2360715	hsa-miR-3146	CLIP-seq
MIRT2360716	hsa-miR-3182	CLIP-seq
MIRT2360717	hsa-miR-3194-3p	CLIP-seq
MIRT2360718	hsa-miR-34c-3p	CLIP-seq
MIRT2360719	hsa-miR-3618	CLIP-seq
MIRT2360720	hsa-miR-374a	CLIP-seq
MIRT2360721	hsa-miR-374b	CLIP-seq
MIRT2360722	hsa-miR-3908	CLIP-seq
MIRT2360723	hsa-miR-3924	CLIP-seq
MIRT2360724	hsa-miR-3942-5p	CLIP-seq
MIRT2360725	hsa-miR-4325	CLIP-seq
MIRT2360726	hsa-miR-4418	CLIP-seq
MIRT2360727	hsa-miR-4465	CLIP-seq
MIRT2360728	hsa-miR-4485	CLIP-seq
MIRT2360729	hsa-miR-4528	CLIP-seq
MIRT2360730	hsa-miR-4637	CLIP-seq
MIRT2360731	hsa-miR-4659a-3p	CLIP-seq
MIRT2360732	hsa-miR-4659b-3p	CLIP-seq
MIRT2360733	hsa-miR-4699-3p	CLIP-seq
MIRT2360734	hsa-miR-4703-5p	CLIP-seq
MIRT2360735	hsa-miR-4755-3p	CLIP-seq
MIRT2360736	hsa-miR-4766-3p	CLIP-seq
MIRT2360737	hsa-miR-4772-3p	CLIP-seq
MIRT2360738	hsa-miR-4782-5p	CLIP-seq
MIRT2360739	hsa-miR-4793-3p	CLIP-seq
MIRT2360740	hsa-miR-4803	CLIP-seq
MIRT2360741	hsa-miR-499-3p	CLIP-seq
MIRT2360742	hsa-miR-499a-3p	CLIP-seq
MIRT2360743	hsa-miR-501-3p	CLIP-seq
MIRT2360744	hsa-miR-502-3p	CLIP-seq
MIRT2360745	hsa-miR-509-3-5p	CLIP-seq
MIRT2360746	hsa-miR-509-5p	CLIP-seq
MIRT2360747	hsa-miR-513a-5p	CLIP-seq
MIRT2360748	hsa-miR-516b	CLIP-seq
MIRT2360749	hsa-miR-616	CLIP-seq
MIRT2360750	hsa-miR-656	CLIP-seq
MIRT2360751	hsa-miR-802	CLIP-seq
MIRT2360752	hsa-miR-885-5p	CLIP-seq
MIRT2360753	hsa-miR-892b	CLIP-seq
MIRT2360754	hsa-miR-934	CLIP-seq
MIRT1465811	hsa-miR-155	CLIP-seq
MIRT2360741	hsa-miR-499-3p	CLIP-seq
MIRT2360742	hsa-miR-499a-3p	CLIP-seq
MIRT2654341	hsa-miR-1	CLIP-seq
MIRT2360701	hsa-miR-1248	CLIP-seq
MIRT2360705	hsa-miR-1299	CLIP-seq
MIRT2654342	hsa-miR-1343	CLIP-seq
MIRT2654343	hsa-miR-1470	CLIP-seq
MIRT2654344	hsa-miR-150	CLIP-seq
MIRT2654345	hsa-miR-206	CLIP-seq
MIRT1465813	hsa-miR-2278	CLIP-seq
MIRT1465814	hsa-miR-28-3p	CLIP-seq
MIRT1465798	hsa-miR-3065-5p	CLIP-seq
MIRT2654346	hsa-miR-3074-5p	CLIP-seq
MIRT2654347	hsa-miR-3124-3p	CLIP-seq
MIRT2654348	hsa-miR-3157-5p	CLIP-seq
MIRT2654349	hsa-miR-3160-5p	CLIP-seq
MIRT1465815	hsa-miR-3163	CLIP-seq
MIRT2360716	hsa-miR-3182	CLIP-seq
MIRT1465816	hsa-miR-340	CLIP-seq
MIRT2654350	hsa-miR-3690	CLIP-seq
MIRT2140081	hsa-miR-376c	CLIP-seq
MIRT2654351	hsa-miR-4254	CLIP-seq
MIRT2654352	hsa-miR-4297	CLIP-seq
MIRT2360731	hsa-miR-4659a-3p	CLIP-seq
MIRT2654353	hsa-miR-4659a-5p	CLIP-seq
MIRT2360732	hsa-miR-4659b-3p	CLIP-seq
MIRT2654354	hsa-miR-4659b-5p	CLIP-seq
MIRT2654355	hsa-miR-4667-3p	CLIP-seq
MIRT2654356	hsa-miR-4709-3p	CLIP-seq
MIRT2654357	hsa-miR-4717-3p	CLIP-seq
MIRT2654358	hsa-miR-4776-3p	CLIP-seq
MIRT2360738	hsa-miR-4782-5p	CLIP-seq
MIRT2654359	hsa-miR-4797-5p	CLIP-seq
MIRT2654360	hsa-miR-495	CLIP-seq
MIRT2360748	hsa-miR-516b	CLIP-seq
MIRT2654361	hsa-miR-532-5p	CLIP-seq
MIRT1465820	hsa-miR-548aa	CLIP-seq
MIRT2654362	hsa-miR-613	CLIP-seq
MIRT2654363	hsa-miR-642a	CLIP-seq
MIRT1465822	hsa-miR-646	CLIP-seq
MIRT2360708	hsa-miR-197	CLIP-seq
MIRT2694558	hsa-miR-218	CLIP-seq
MIRT2694559	hsa-miR-221	CLIP-seq
MIRT2694560	hsa-miR-222	CLIP-seq
MIRT1465813	hsa-miR-2278	CLIP-seq
MIRT1465814	hsa-miR-28-3p	CLIP-seq
MIRT1465798	hsa-miR-3065-5p	CLIP-seq
MIRT1465815	hsa-miR-3163	CLIP-seq
MIRT2694561	hsa-miR-323-3p	CLIP-seq
MIRT1465816	hsa-miR-340	CLIP-seq
MIRT2654356	hsa-miR-4709-3p	CLIP-seq
MIRT2694562	hsa-miR-494	CLIP-seq
MIRT2654360	hsa-miR-495	CLIP-seq
MIRT1465820	hsa-miR-548aa	CLIP-seq
MIRT2694563	hsa-miR-548v	CLIP-seq
MIRT2694564	hsa-miR-555	CLIP-seq
MIRT1465822	hsa-miR-646	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008175	Function	TRNA methyltransferase activity	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0030488	Process	TRNA methylation	IBA
GO:0031591	Process	Wybutosine biosynthetic process	IBA
GO:0032259	Process	Methylation	IEA

Other IDs

• MIM: 611245
• HGNC: 24757
• e!Ensembl: ENSG00000162623

Protein

• UniProt ID: Q6IPR3
• Protein name: tRNA wybutosine-synthesizing protein 3 homolog (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase)
• Protein function: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02676	TYW3	9 → 194	Methyltransferase TYW3	Family

• Sequence:

  MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDRGI
  NGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHS
  MAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLNVANQKMEE
  NKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYIHKKKRNPEKTRAQCITKESDEEL
  ENDDDDDLGINVTIFPEDY

• Sequence length: 259

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROFACIAL CLEFT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Coronary Disease	Associate	22843503	★☆☆☆☆ Found in Text Mining only