Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1270
Gene name Gene Name - the full gene name approved by the HGNC.	Ciliary neurotrophic factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CNTF
Synonyms (NCBI Gene) Gene synonyms aliases	HCNTF
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival fact

Show/Hide all(132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT608879	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608878	hsa-miR-8068	HITS-CLIP	21572407
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608875	hsa-miR-147a	HITS-CLIP	21572407
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608873	hsa-miR-4455	HITS-CLIP	21572407
MIRT608872	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528927	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT608879	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608878	hsa-miR-8068	HITS-CLIP	23824327
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608875	hsa-miR-147a	HITS-CLIP	23824327
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT608873	hsa-miR-4455	HITS-CLIP	23824327
MIRT608872	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT608879	hsa-miR-511-3p	HITS-CLIP	24906430
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608878	hsa-miR-8068	HITS-CLIP	24906430
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608875	hsa-miR-147a	HITS-CLIP	24906430
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	24906430
MIRT608873	hsa-miR-4455	HITS-CLIP	24906430
MIRT608872	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT528928	hsa-miR-8485	HITS-CLIP	24906430
MIRT528928	hsa-miR-8485	HITS-CLIP	24906430
MIRT528928	hsa-miR-8485	PAR-CLIP	22012620
MIRT528927	hsa-miR-377-3p	PAR-CLIP	22012620
MIRT608875	hsa-miR-147a	HITS-CLIP	27418678
MIRT608875	hsa-miR-147a	HITS-CLIP	27418678
MIRT528927	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT528927	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT528927	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608873	hsa-miR-4455	HITS-CLIP	27418678
MIRT608873	hsa-miR-4455	HITS-CLIP	27418678
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608872	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608872	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608878	hsa-miR-8068	HITS-CLIP	27418678
MIRT608878	hsa-miR-8068	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT733687	hsa-let-7a-5p	ELISA, Luciferase reporter assay, qRT-PCR, Western blotting	31925656
MIRT608879	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608878	hsa-miR-8068	HITS-CLIP	21572407
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608875	hsa-miR-147a	HITS-CLIP	21572407
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608873	hsa-miR-4455	HITS-CLIP	21572407
MIRT608872	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528927	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT608879	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608878	hsa-miR-8068	HITS-CLIP	23824327
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608875	hsa-miR-147a	HITS-CLIP	23824327
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT608873	hsa-miR-4455	HITS-CLIP	23824327
MIRT608872	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	PAR-CLIP	22012620
MIRT528927	hsa-miR-377-3p	PAR-CLIP	22012620
MIRT901519	hsa-miR-216b	CLIP-seq
MIRT901520	hsa-miR-34c-3p	CLIP-seq
MIRT901521	hsa-miR-3609	CLIP-seq
MIRT901522	hsa-miR-4677-3p	CLIP-seq
MIRT901523	hsa-miR-4679	CLIP-seq
MIRT901524	hsa-miR-4711-5p	CLIP-seq
MIRT901525	hsa-miR-4762-5p	CLIP-seq
MIRT901526	hsa-miR-4763-5p	CLIP-seq
MIRT901527	hsa-miR-548ah	CLIP-seq
MIRT901528	hsa-miR-548n	CLIP-seq
MIRT901529	hsa-miR-548t	CLIP-seq
MIRT1967445	hsa-miR-2115	CLIP-seq
MIRT1967446	hsa-miR-4694-3p	CLIP-seq
MIRT1967447	hsa-miR-4698	CLIP-seq
MIRT2506140	hsa-miR-1178	CLIP-seq
MIRT2506141	hsa-miR-3200-3p	CLIP-seq
MIRT2506142	hsa-miR-3591-3p	CLIP-seq
MIRT2506143	hsa-miR-4457	CLIP-seq
MIRT2506144	hsa-miR-513b	CLIP-seq
MIRT2506145	hsa-miR-624	CLIP-seq
MIRT2506140	hsa-miR-1178	CLIP-seq
MIRT2506141	hsa-miR-3200-3p	CLIP-seq
MIRT2506142	hsa-miR-3591-3p	CLIP-seq
MIRT2506143	hsa-miR-4457	CLIP-seq
MIRT2506144	hsa-miR-513b	CLIP-seq
MIRT2506145	hsa-miR-624	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	IBA
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	IEA
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	TAS	1714745
GO:0005138	Function	Interleukin-6 receptor binding	IPI	12643274
GO:0005515	Function	Protein binding	IPI	16051226, 18775332, 20584990, 25416956, 32296183, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IC	12643274
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	NAS	1840538
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0008083	Function	Growth factor activity	IBA
GO:0008083	Function	Growth factor activity	IDA	12643274
GO:0008083	Function	Growth factor activity	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	24129709
GO:0030154	Process	Cell differentiation	IEA
GO:0030424	Component	Axon	IBA
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	21912637
GO:0043025	Component	Neuronal cell body	IBA
GO:0043067	Process	Regulation of programmed cell death	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IBA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IDA	10966616
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0044877	Function	Protein-containing complex binding	IPI	10966616
GO:0046533	Process	Negative regulation of photoreceptor cell differentiation	IEA
GO:0046668	Process	Regulation of retinal cell programmed cell death	IEA
GO:0048143	Process	Astrocyte activation	IBA
GO:0048644	Process	Muscle organ morphogenesis	IEA
GO:0048666	Process	Neuron development	IEA
GO:0048680	Process	Positive regulation of axon regeneration	IBA
GO:0060221	Process	Retinal rod cell differentiation	IEA
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IBA
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IDA	12643274
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IEA
GO:0097386	Component	Glial cell projection	IBA
GO:0097696	Process	Cell surface receptor signaling pathway via STAT	IDA	12643274

MIM	HGNC	e!Ensembl
118945	2169	ENSG00000242689

Protein

UniProt ID

P26441

Protein name

Ciliary neurotrophic factor (CNTF)

Protein function

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

PDB

1CNT , 8D74

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01110	CNTF	1 → 194	Ciliary neurotrophic factor	Domain

Tissue specificity

TISSUE SPECIFICITY: Nervous system.

Sequence

MAFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVAS
TDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFA
YQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFIS
SHQTGIPARGSHYIANNKKM

Sequence length

200

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway		IL-6-type cytokine receptor ligand interactions

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Hypertension	Hypertension (confirmatory factor analysis Factor 12), High blood pressure / hypertension	N/A	N/A	GWAS
Lymphoma	Lymphoma	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Brain Neoplasms	Associate	28765641
Breast Neoplasms	Associate	34477239
Colorectal Neoplasms	Associate	25117815
Diabetes Complications	Associate	25394427
Glioma	Associate	28765641
Inflammation	Associate	9459616
Inflammatory Bowel Diseases	Associate	33069917
Mandibular Nerve Injuries	Inhibit	7796798
Mental Disorders	Associate	9790747
Multiple Myeloma	Associate	8145045
Neoplasm Metastasis	Associate	34477239
Neoplasms	Associate	34477239
Neuroblastoma	Associate	10660304, 9459616, 9523557
Neurodegenerative Diseases	Associate	24802752, 25118897, 25394427, 7796798
Neuroma Acoustic	Associate	24030433
Obesity	Associate	16210701, 25394427
Pain	Stimulate	22337942
Posterior Tibial Tendon Dysfunction	Stimulate	22337942
Pre Eclampsia	Stimulate	23654315
Psychotic Disorders	Associate	9790747
Retinal Degeneration	Associate	16505355
Sleep Initiation and Maintenance Disorders	Associate	16210701
Stress Disorders Post Traumatic	Associate	32894097

CNTF (ciliary neurotrophic factor)