Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	127
Gene name	Alcohol dehydrogenase 4 (class II), pi polypeptide
Gene symbol	ADH4
Synonyms (NCBI Gene)	ADH-2HEL-S-4
Chromosome	4
Chromosome location	4q23
Summary	This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxystero

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT768628	hsa-miR-3907	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167643	hsa-miR-1236	CLIP-seq
MIRT2167644	hsa-miR-1298	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT2167646	hsa-miR-338-3p	CLIP-seq
MIRT2167647	hsa-miR-3675-3p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167648	hsa-miR-4286	CLIP-seq
MIRT2167649	hsa-miR-4786-3p	CLIP-seq
MIRT2167650	hsa-miR-885-5p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	15369820
GO:0003960	Function	Quinone reductase (NADPH) activity	IEA
GO:0003960	Function	Quinone reductase (NADPH) activity	ISS
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IBA
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IDA	3466164, 10407146, 16787387
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IEA
GO:0004032	Function	Aldose reductase (NADPH) activity	IEA
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IDA	10514444, 15369820, 16787387, 17279314
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IEA
GO:0005503	Function	All-trans retinal binding	IDA	15369820
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006066	Process	Alcohol metabolic process	IDA	3466164
GO:0006067	Process	Ethanol metabolic process	IEA
GO:0006081	Process	Aldehyde metabolic process	IDA	3466164
GO:0006081	Process	Aldehyde metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	10407146
GO:0008270	Function	Zinc ion binding	IEA
GO:0010430	Process	Fatty acid omega-oxidation	IDA	16081420
GO:0010430	Process	Fatty acid omega-oxidation	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0018479	Function	Benzaldehyde dehydrogenase (NAD+) activity	IDA	3466164
GO:0019841	Function	Retinol binding	IDA	10407146
GO:0042572	Process	Retinol metabolic process	IDA	16787387, 17279314
GO:0046164	Process	Alcohol catabolic process	IEA
GO:0046164	Process	Alcohol catabolic process	ISS
GO:0046294	Process	Formaldehyde catabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051287	Function	NAD binding	IDA	10407146
GO:0051903	Function	S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA
GO:1901661	Process	Quinone metabolic process	IEA
GO:1901661	Process	Quinone metabolic process	ISS

MIM	HGNC	e!Ensembl
103740	252	ENSG00000198099

P08319

Protein name

All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain)

Protein function

Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end p

PDB

3COS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08240	ADH_N	34 → 166	Alcohol dehydrogenase GroES-like domain	Domain
PF00107	ADH_zinc_N	208 → 340	Zinc-binding dehydrogenase	Family

Sequence

MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
LAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLK
SPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGC
GFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKA
LGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGV
AAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDK
ISEAFDLMNQGKSVRTILIF

Sequence length

380

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism Pyruvate metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Alcoholic liver disease		RA biosynthesis pathway Ethanol oxidation

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
CIC-rearranged sarcoma	not provided	rs1579406737	RCV000993829

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	29808834
Alcoholism	Associate	20363298, 24692236, 31933193
Calcinosis Cutis	Associate	27662660
Carcinogenesis	Associate	21480392
Carcinoma Hepatocellular	Associate	30628708, 30720105, 33287761, 33879119, 33988674, 34147074, 35892599, 36199423, 36341373, 36553522, 37248957, 37957550, 38025761, 40389832
Carcinoma Non Small Cell Lung	Associate	29808834
Cholangiocarcinoma	Associate	36199423
Cluster Headache	Associate	29318394
Diabetic Neuropathies	Associate	37033211
Esophageal Squamous Cell Carcinoma	Associate	26039424
Fatty Liver	Stimulate	26551085
Fatty Liver Alcoholic	Associate	20221393, 23300535
Fatty Liver Alcoholic	Stimulate	26551085
Inflammation	Associate	37248957
Non alcoholic Fatty Liver Disease	Inhibit	29718361
Ovarian Neoplasms	Associate	21480392
Stomach Neoplasms	Associate	34773716
Substance Related Disorders	Associate	17069770
Zinc Deficiency Neonatal due to Low Breast Milk Zinc	Associate	10978274

ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)