Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	126393
Gene name Gene Name - the full gene name approved by the HGNC.	Heat shock protein family B (small) member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HSPB6
Synonyms (NCBI Gene) Gene synonyms aliases	HEL55, Hsp20, PPP1R91
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.12
Summary Summary of gene provided in NCBI Entrez Gene.	This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]

Show/Hide all(91)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004508	hsa-miR-320a	Luciferase reporter assay	19380620
MIRT572330	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT572329	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT572328	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT572327	hsa-miR-6132	PAR-CLIP	20371350
MIRT572326	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572325	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572324	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572323	hsa-miR-4533	PAR-CLIP	20371350
MIRT572322	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT572320	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT572321	hsa-miR-4271	PAR-CLIP	20371350
MIRT572319	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT572318	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT572317	hsa-miR-656-5p	PAR-CLIP	20371350
MIRT572316	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572315	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT572314	hsa-miR-1231	PAR-CLIP	20371350
MIRT572330	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT572329	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT572328	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT572327	hsa-miR-6132	PAR-CLIP	20371350
MIRT572326	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572325	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572324	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572323	hsa-miR-4533	PAR-CLIP	20371350
MIRT572322	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT572320	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT572321	hsa-miR-4271	PAR-CLIP	20371350
MIRT572319	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT572318	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT572317	hsa-miR-656-5p	PAR-CLIP	20371350
MIRT572316	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572315	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT572314	hsa-miR-1231	PAR-CLIP	20371350
MIRT1056406	hsa-miR-1252	CLIP-seq
MIRT1056407	hsa-miR-1253	CLIP-seq
MIRT1056408	hsa-miR-1587	CLIP-seq
MIRT1056409	hsa-miR-3135b	CLIP-seq
MIRT1056410	hsa-miR-3652	CLIP-seq
MIRT1056411	hsa-miR-3689a-3p	CLIP-seq
MIRT1056412	hsa-miR-3689c	CLIP-seq
MIRT1056413	hsa-miR-3689d	CLIP-seq
MIRT1056414	hsa-miR-3940-5p	CLIP-seq
MIRT1056415	hsa-miR-4428	CLIP-seq
MIRT1056416	hsa-miR-4430	CLIP-seq
MIRT1056417	hsa-miR-4434	CLIP-seq
MIRT1056418	hsa-miR-4492	CLIP-seq
MIRT1056419	hsa-miR-4498	CLIP-seq
MIRT1056420	hsa-miR-4507	CLIP-seq
MIRT1056421	hsa-miR-4516	CLIP-seq
MIRT1056422	hsa-miR-4656	CLIP-seq
MIRT1056423	hsa-miR-4675	CLIP-seq
MIRT1056424	hsa-miR-4728-5p	CLIP-seq
MIRT1056425	hsa-miR-4741	CLIP-seq
MIRT1056426	hsa-miR-4779	CLIP-seq
MIRT1056427	hsa-miR-486-3p	CLIP-seq
MIRT1056428	hsa-miR-762	CLIP-seq
MIRT1056429	hsa-miR-765	CLIP-seq
MIRT1549651	hsa-miR-3126-3p	CLIP-seq
MIRT1056424	hsa-miR-4728-5p	CLIP-seq
MIRT2012966	hsa-miR-1909	CLIP-seq
MIRT2012967	hsa-miR-4481	CLIP-seq
MIRT2012968	hsa-miR-4745-5p	CLIP-seq
MIRT2012966	hsa-miR-1909	CLIP-seq
MIRT1056410	hsa-miR-3652	CLIP-seq
MIRT1056416	hsa-miR-4430	CLIP-seq
MIRT2451438	hsa-miR-1275	CLIP-seq
MIRT2451439	hsa-miR-193a-3p	CLIP-seq
MIRT2451440	hsa-miR-193b	CLIP-seq
MIRT2451441	hsa-miR-3170	CLIP-seq
MIRT2451442	hsa-miR-3176	CLIP-seq
MIRT2451443	hsa-miR-3922-3p	CLIP-seq
MIRT2451444	hsa-miR-4525	CLIP-seq
MIRT2451445	hsa-miR-4665-5p	CLIP-seq
MIRT2451446	hsa-miR-4723-5p	CLIP-seq
MIRT1056424	hsa-miR-4728-5p	CLIP-seq
MIRT2451447	hsa-miR-625	CLIP-seq
MIRT2451448	hsa-miR-661	CLIP-seq
MIRT2548406	hsa-miR-2467-5p	CLIP-seq
MIRT2548407	hsa-miR-3150b-3p	CLIP-seq
MIRT2548408	hsa-miR-342-5p	CLIP-seq
MIRT2548409	hsa-miR-4293	CLIP-seq
MIRT2548410	hsa-miR-4466	CLIP-seq
MIRT2548411	hsa-miR-4532	CLIP-seq
MIRT2548412	hsa-miR-4664-5p	CLIP-seq
MIRT2548413	hsa-miR-4689	CLIP-seq
MIRT2548414	hsa-miR-4695-5p	CLIP-seq
MIRT2548415	hsa-miR-4784	CLIP-seq
MIRT2548416	hsa-miR-544b	CLIP-seq
MIRT2548417	hsa-miR-675	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005212	Function	Structural constituent of eye lens	IEA
GO:0005576	Component	Extracellular region	IDA	22427880
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19464326
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	19464326
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006457	Process	Protein folding	IDA	14717697
GO:0009408	Process	Response to heat	IBA
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0019901	Function	Protein kinase binding	IEA
GO:0042026	Process	Protein refolding	IBA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0044183	Function	Protein folding chaperone	IDA	24382496
GO:0045766	Process	Positive regulation of angiogenesis	IDA	22427880
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IDA	19845507
GO:0051087	Function	Protein-folding chaperone binding	IPI	23948568

MIM	HGNC	e!Ensembl
610695	26511	ENSG00000004776

Protein

UniProt ID

O14558

Protein name

Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) (Heat shock protein family B member 6)

Protein function

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function

PDB

4JUS , 4JUT , 5LTW , 5LU1 , 5LU2 , 5LUM , 5OK9 , 5OKF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00525	Crystallin	3 → 62	Alpha crystallin A chain, N terminal	Family
PF00011	HSP20	66 → 158	Hsp20/alpha crystallin family	Family

Sequence

MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSV
ALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRR
YRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK

Sequence length

160

Interactions

View interactions

HSPB6 (heat shock protein family B (small) member 6)