HSPB6 (heat shock protein family B (small) member 6)

Gene

• Entrez ID: 126393
• Gene name: Heat shock protein family B (small) member 6
• Gene symbol: HSPB6
• Synonyms (NCBI Gene): HEL55, Hsp20, PPP1R91
• Chromosome: 19
• Chromosome location: 19q13.12
• Summary: This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004508	hsa-miR-320a	Luciferase reporter assay	19380620
MIRT572330	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT572329	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT572328	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT572327	hsa-miR-6132	PAR-CLIP	20371350
MIRT572326	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572325	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572324	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572323	hsa-miR-4533	PAR-CLIP	20371350
MIRT572322	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT572320	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT572321	hsa-miR-4271	PAR-CLIP	20371350
MIRT572319	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT572318	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT572317	hsa-miR-656-5p	PAR-CLIP	20371350
MIRT572316	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572315	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT572314	hsa-miR-1231	PAR-CLIP	20371350
MIRT572330	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT572329	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT572328	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT572327	hsa-miR-6132	PAR-CLIP	20371350
MIRT572326	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572325	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572324	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572323	hsa-miR-4533	PAR-CLIP	20371350
MIRT572322	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT572320	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT572321	hsa-miR-4271	PAR-CLIP	20371350
MIRT572319	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT572318	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT572317	hsa-miR-656-5p	PAR-CLIP	20371350
MIRT572316	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572315	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT572314	hsa-miR-1231	PAR-CLIP	20371350
MIRT1056406	hsa-miR-1252	CLIP-seq
MIRT1056407	hsa-miR-1253	CLIP-seq
MIRT1056408	hsa-miR-1587	CLIP-seq
MIRT1056409	hsa-miR-3135b	CLIP-seq
MIRT1056410	hsa-miR-3652	CLIP-seq
MIRT1056411	hsa-miR-3689a-3p	CLIP-seq
MIRT1056412	hsa-miR-3689c	CLIP-seq
MIRT1056413	hsa-miR-3689d	CLIP-seq
MIRT1056414	hsa-miR-3940-5p	CLIP-seq
MIRT1056415	hsa-miR-4428	CLIP-seq
MIRT1056416	hsa-miR-4430	CLIP-seq
MIRT1056417	hsa-miR-4434	CLIP-seq
MIRT1056418	hsa-miR-4492	CLIP-seq
MIRT1056419	hsa-miR-4498	CLIP-seq
MIRT1056420	hsa-miR-4507	CLIP-seq
MIRT1056421	hsa-miR-4516	CLIP-seq
MIRT1056422	hsa-miR-4656	CLIP-seq
MIRT1056423	hsa-miR-4675	CLIP-seq
MIRT1056424	hsa-miR-4728-5p	CLIP-seq
MIRT1056425	hsa-miR-4741	CLIP-seq
MIRT1056426	hsa-miR-4779	CLIP-seq
MIRT1056427	hsa-miR-486-3p	CLIP-seq
MIRT1056428	hsa-miR-762	CLIP-seq
MIRT1056429	hsa-miR-765	CLIP-seq
MIRT1549651	hsa-miR-3126-3p	CLIP-seq
MIRT1056424	hsa-miR-4728-5p	CLIP-seq
MIRT2012966	hsa-miR-1909	CLIP-seq
MIRT2012967	hsa-miR-4481	CLIP-seq
MIRT2012968	hsa-miR-4745-5p	CLIP-seq
MIRT2012966	hsa-miR-1909	CLIP-seq
MIRT1056410	hsa-miR-3652	CLIP-seq
MIRT1056416	hsa-miR-4430	CLIP-seq
MIRT2451438	hsa-miR-1275	CLIP-seq
MIRT2451439	hsa-miR-193a-3p	CLIP-seq
MIRT2451440	hsa-miR-193b	CLIP-seq
MIRT2451441	hsa-miR-3170	CLIP-seq
MIRT2451442	hsa-miR-3176	CLIP-seq
MIRT2451443	hsa-miR-3922-3p	CLIP-seq
MIRT2451444	hsa-miR-4525	CLIP-seq
MIRT2451445	hsa-miR-4665-5p	CLIP-seq
MIRT2451446	hsa-miR-4723-5p	CLIP-seq
MIRT1056424	hsa-miR-4728-5p	CLIP-seq
MIRT2451447	hsa-miR-625	CLIP-seq
MIRT2451448	hsa-miR-661	CLIP-seq
MIRT2548406	hsa-miR-2467-5p	CLIP-seq
MIRT2548407	hsa-miR-3150b-3p	CLIP-seq
MIRT2548408	hsa-miR-342-5p	CLIP-seq
MIRT2548409	hsa-miR-4293	CLIP-seq
MIRT2548410	hsa-miR-4466	CLIP-seq
MIRT2548411	hsa-miR-4532	CLIP-seq
MIRT2548412	hsa-miR-4664-5p	CLIP-seq
MIRT2548413	hsa-miR-4689	CLIP-seq
MIRT2548414	hsa-miR-4695-5p	CLIP-seq
MIRT2548415	hsa-miR-4784	CLIP-seq
MIRT2548416	hsa-miR-544b	CLIP-seq
MIRT2548417	hsa-miR-675	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005212	Function	Structural constituent of eye lens	IEA
GO:0005515	Function	Protein binding	IPI	16225851
GO:0005576	Component	Extracellular region	IDA	22427880
GO:0005634	Component	Nucleus	IDA	19464326
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	19464326
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006937	Process	Regulation of muscle contraction	IEA
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0045766	Process	Positive regulation of angiogenesis	IDA	22427880
GO:0051082	Function	Unfolded protein binding	IDA	19845507
GO:0051087	Function	Chaperone binding	IPI	23948568
GO:0061077	Process	Chaperone-mediated protein folding	IDA	14717697

Other IDs

• MIM: 610695
• HGNC: 26511
• e!Ensembl: ENSG00000004776

Protein

• UniProt ID: O14558
• Protein name: Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) (Heat shock protein family B member 6)
• Protein function: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function
• PDB: 4JUS, 4JUT, 5LTW, 5LU1, 5LU2, 5LUM, 5OK9, 5OKF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00525	Crystallin	3 → 62	Alpha crystallin A chain, N terminal	Family
  PF00011	HSP20	66 → 158	Hsp20/alpha crystallin family	Family

• Sequence:

  MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSV
  ALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRR
  YRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK

• Sequence length: 160