Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	126205
Gene name	NLR family pyrin domain containing 8
Gene symbol	NLRP8
Synonyms (NCBI Gene)	CLR19.2NALP8NOD16PAN4
Chromosome	19
Chromosome location	19q13.43
Summary	This gene encodes a member of the nucleotide-binding oligomerization domain/ leucine rich repeat/ pyrin domain containing (NLRP) subfamily, which belongs to the Nod-like receptor family of proteins. NLRP genes play roles in the mammalian innate immune sys

161

Show/Hide all (161)

miRTarBase ID	miRNA	Experiments	Reference
MIRT540661	hsa-miR-8485	HITS-CLIP	23824327
MIRT540660	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT540659	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT540658	hsa-miR-603	HITS-CLIP	23824327
MIRT540657	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT540656	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT540654	hsa-miR-3941	HITS-CLIP	23824327
MIRT540655	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT540653	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT540652	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT540661	hsa-miR-8485	PAR-CLIP	21572407
MIRT540660	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT540659	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT540658	hsa-miR-603	PAR-CLIP	21572407
MIRT540657	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT540656	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT540654	hsa-miR-3941	PAR-CLIP	21572407
MIRT540655	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT540653	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT540652	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT540661	hsa-miR-8485	HITS-CLIP	23824327
MIRT540660	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT540659	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT540658	hsa-miR-603	HITS-CLIP	23824327
MIRT540657	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT540656	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT540654	hsa-miR-3941	HITS-CLIP	23824327
MIRT540655	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT540653	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT540652	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT540661	hsa-miR-8485	PAR-CLIP	21572407
MIRT540660	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT540659	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT540658	hsa-miR-603	PAR-CLIP	21572407
MIRT540657	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT540656	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT540654	hsa-miR-3941	PAR-CLIP	21572407
MIRT540655	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT540653	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT540652	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT1187290	hsa-miR-122	CLIP-seq
MIRT1187291	hsa-miR-130a	CLIP-seq
MIRT1187292	hsa-miR-130b	CLIP-seq
MIRT1187293	hsa-miR-301a	CLIP-seq
MIRT1187294	hsa-miR-301b	CLIP-seq
MIRT1187295	hsa-miR-3135b	CLIP-seq
MIRT1187296	hsa-miR-3160-3p	CLIP-seq
MIRT1187297	hsa-miR-3194-3p	CLIP-seq
MIRT1187298	hsa-miR-3652	CLIP-seq
MIRT1187299	hsa-miR-3666	CLIP-seq
MIRT1187300	hsa-miR-3672	CLIP-seq
MIRT1187301	hsa-miR-4251	CLIP-seq
MIRT1187302	hsa-miR-4295	CLIP-seq
MIRT1187303	hsa-miR-431	CLIP-seq
MIRT1187304	hsa-miR-4430	CLIP-seq
MIRT1187305	hsa-miR-451b	CLIP-seq
MIRT1187306	hsa-miR-454	CLIP-seq
MIRT1187307	hsa-miR-4659a-3p	CLIP-seq
MIRT1187308	hsa-miR-4659b-3p	CLIP-seq
MIRT1187309	hsa-miR-4685-5p	CLIP-seq
MIRT1187310	hsa-miR-4761-3p	CLIP-seq
MIRT1187311	hsa-miR-4778-3p	CLIP-seq
MIRT1187312	hsa-miR-4797-5p	CLIP-seq
MIRT1187313	hsa-miR-483-3p	CLIP-seq
MIRT1187314	hsa-miR-508-5p	CLIP-seq
MIRT1187315	hsa-miR-526b	CLIP-seq
MIRT1187316	hsa-miR-548m	CLIP-seq
MIRT1187317	hsa-miR-580	CLIP-seq
MIRT1187318	hsa-miR-924	CLIP-seq
MIRT2054266	hsa-miR-1976	CLIP-seq
MIRT2054267	hsa-miR-3663-5p	CLIP-seq
MIRT2054268	hsa-miR-4279	CLIP-seq
MIRT2054269	hsa-miR-4527	CLIP-seq
MIRT2054270	hsa-miR-4722-3p	CLIP-seq
MIRT2054271	hsa-miR-4740-3p	CLIP-seq
MIRT2283406	hsa-miR-1207-3p	CLIP-seq
MIRT1187290	hsa-miR-122	CLIP-seq
MIRT1187291	hsa-miR-130a	CLIP-seq
MIRT1187292	hsa-miR-130b	CLIP-seq
MIRT2283407	hsa-miR-1908	CLIP-seq
MIRT2283408	hsa-miR-197	CLIP-seq
MIRT2054266	hsa-miR-1976	CLIP-seq
MIRT1187293	hsa-miR-301a	CLIP-seq
MIRT1187294	hsa-miR-301b	CLIP-seq
MIRT1187295	hsa-miR-3135b	CLIP-seq
MIRT2283409	hsa-miR-3187-3p	CLIP-seq
MIRT1187297	hsa-miR-3194-3p	CLIP-seq
MIRT1187298	hsa-miR-3652	CLIP-seq
MIRT2054267	hsa-miR-3663-5p	CLIP-seq
MIRT1187299	hsa-miR-3666	CLIP-seq
MIRT2283410	hsa-miR-376c	CLIP-seq
MIRT2283411	hsa-miR-411	CLIP-seq
MIRT2054268	hsa-miR-4279	CLIP-seq
MIRT1187302	hsa-miR-4295	CLIP-seq
MIRT1187303	hsa-miR-431	CLIP-seq
MIRT1187304	hsa-miR-4430	CLIP-seq
MIRT2283412	hsa-miR-4435	CLIP-seq
MIRT2283413	hsa-miR-4438	CLIP-seq
MIRT2054269	hsa-miR-4527	CLIP-seq
MIRT1187306	hsa-miR-454	CLIP-seq
MIRT2283414	hsa-miR-4695-3p	CLIP-seq
MIRT2283415	hsa-miR-4700-3p	CLIP-seq
MIRT2283416	hsa-miR-4701-5p	CLIP-seq
MIRT2283417	hsa-miR-4716-5p	CLIP-seq
MIRT2054270	hsa-miR-4722-3p	CLIP-seq
MIRT2054271	hsa-miR-4740-3p	CLIP-seq
MIRT2283418	hsa-miR-4755-3p	CLIP-seq
MIRT2283419	hsa-miR-4781-3p	CLIP-seq
MIRT1187312	hsa-miR-4797-5p	CLIP-seq
MIRT2283420	hsa-miR-5095	CLIP-seq
MIRT2283421	hsa-miR-5096	CLIP-seq
MIRT2283422	hsa-miR-548s	CLIP-seq
MIRT2283423	hsa-miR-588	CLIP-seq
MIRT2283424	hsa-miR-646	CLIP-seq
MIRT2283425	hsa-miR-663	CLIP-seq
MIRT1187318	hsa-miR-924	CLIP-seq
MIRT1187290	hsa-miR-122	CLIP-seq
MIRT1187291	hsa-miR-130a	CLIP-seq
MIRT1187292	hsa-miR-130b	CLIP-seq
MIRT1187293	hsa-miR-301a	CLIP-seq
MIRT1187294	hsa-miR-301b	CLIP-seq
MIRT1187295	hsa-miR-3135b	CLIP-seq
MIRT1187297	hsa-miR-3194-3p	CLIP-seq
MIRT1187298	hsa-miR-3652	CLIP-seq
MIRT1187299	hsa-miR-3666	CLIP-seq
MIRT1187302	hsa-miR-4295	CLIP-seq
MIRT1187304	hsa-miR-4430	CLIP-seq
MIRT1187306	hsa-miR-454	CLIP-seq
MIRT2283414	hsa-miR-4695-3p	CLIP-seq
MIRT1187290	hsa-miR-122	CLIP-seq
MIRT1187291	hsa-miR-130a	CLIP-seq
MIRT1187292	hsa-miR-130b	CLIP-seq
MIRT1187293	hsa-miR-301a	CLIP-seq
MIRT1187294	hsa-miR-301b	CLIP-seq
MIRT1187295	hsa-miR-3135b	CLIP-seq
MIRT1187297	hsa-miR-3194-3p	CLIP-seq
MIRT1187298	hsa-miR-3652	CLIP-seq
MIRT1187299	hsa-miR-3666	CLIP-seq
MIRT1187302	hsa-miR-4295	CLIP-seq
MIRT1187303	hsa-miR-431	CLIP-seq
MIRT1187304	hsa-miR-4430	CLIP-seq
MIRT1187306	hsa-miR-454	CLIP-seq
MIRT2283414	hsa-miR-4695-3p	CLIP-seq
MIRT1187312	hsa-miR-4797-5p	CLIP-seq
MIRT1187318	hsa-miR-924	CLIP-seq
MIRT1187290	hsa-miR-122	CLIP-seq
MIRT1187291	hsa-miR-130a	CLIP-seq
MIRT1187292	hsa-miR-130b	CLIP-seq
MIRT1187293	hsa-miR-301a	CLIP-seq
MIRT1187294	hsa-miR-301b	CLIP-seq
MIRT1187295	hsa-miR-3135b	CLIP-seq
MIRT1187297	hsa-miR-3194-3p	CLIP-seq
MIRT1187298	hsa-miR-3652	CLIP-seq
MIRT1187299	hsa-miR-3666	CLIP-seq
MIRT1187302	hsa-miR-4295	CLIP-seq
MIRT1187303	hsa-miR-431	CLIP-seq
MIRT1187304	hsa-miR-4430	CLIP-seq
MIRT1187306	hsa-miR-454	CLIP-seq
MIRT2283414	hsa-miR-4695-3p	CLIP-seq
MIRT1187312	hsa-miR-4797-5p	CLIP-seq
MIRT1187318	hsa-miR-924	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0050727	Process	Regulation of inflammatory response	IBA

MIM	HGNC	e!Ensembl
609659	22940	ENSG00000179709

Q86W28

Protein name

NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4)

Protein function

Involved in inflammation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02758	PYRIN	40 → 115	PAAD/DAPIN/Pyrin domain	Domain
PF05729	NACHT	204 → 373	NACHT domain	Domain
PF17779	NOD2_WH	449 → 505	NOD2 winged helix domain	Domain
PF17776	NLRC4_HD2	508 → 624	NLRC4 helical domain HD2	Domain
PF13516	LRR_6	865 → 887	Leucine Rich repeat	Repeat
PF13516	LRR_6	922 → 945	Leucine Rich repeat	Repeat
PF13516	LRR_6	979 → 1002	Leucine Rich repeat	Repeat

Sequence

MSDVNPPSDTPIPFSSSSTHSSHIPPWTFSCYPGSPCENGVMLYMRNVSHEELQRFKQLL
LTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRRE
INAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQ
GVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCA
FYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLE
DLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTM
EKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSC
PNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLD
QTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQR
LIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPP
SPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVEL
TVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFL
KALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLC
RVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ
LERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQR
LVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL
ENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVIFCIPA
WTRITSFSPTPHPPDFTGKSDCLSQINP

Sequence length

1048

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cholangiocarcinoma	Benign	rs41391053	RCV005904988
Clear cell carcinoma of kidney	Benign	rs41391053	RCV005904987

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Multiple Sclerosis	Associate	36755464
Pulmonary Disease Chronic Obstructive	Associate	31601004

NLRP8 (NLR family pyrin domain containing 8)