Gene Gene information from NCBI Gene database.
Entrez ID 125919
Gene name Zinc finger protein 543
Gene symbol ZNF543
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19q13.43
miRNA miRNA information provided by mirtarbase database.
570
miRTarBase ID miRNA Experiments Reference
MIRT023415 hsa-miR-30b-5p Sequencing 20371350
MIRT607459 hsa-miR-508-5p HITS-CLIP 24906430
MIRT607458 hsa-miR-1273g-3p HITS-CLIP 24906430
MIRT607457 hsa-miR-6849-3p HITS-CLIP 24906430
MIRT607456 hsa-miR-4258 HITS-CLIP 24906430
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616847 25281 ENSG00000178229
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q08ER8
Protein name Zinc finger protein 543
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 8 49 KRAB box Family
PF00096 zf-C2H2 199 221 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 227 249 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 255 277 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 283 305 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 311 333 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 339 361 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 367 389 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 395 417 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 423 445 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 451 473 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 479 501 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 507 529 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 535 557 Zinc finger, C2H2 type Domain
Sequence
MAASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQ
LDHRQELWMATKDLSQSSYPGDNTKPKTTEPTFSHLALPEEVLLQEQLTQGASKNSQLGQ
SKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSDDGVCTKITQKQVSTEGDLYE
CDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKST
HLLQHLIIH
TGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSECGKAFTHRSTFVL
HHRSH
TGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRSYLTWHQQI
H
TGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIHTGE
KPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIHTGEKPYE
CVECGKAFNRSSHLTRHQQIH
TGEKPYECIQCGKAFCRSANLIRHSIIHTGEKPYECSEC
GKAFNRGSSLTHHQRIH
TGRNPTIVTDVGRPFMTAQTSVNIQELLLGKEFLNITTEENLW
Sequence length 600
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
OBSESSIVE-COMPULSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations