Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	125150
Gene name	Zinc finger SWIM-type containing 7
Gene symbol	ZSWIM7
Synonyms (NCBI Gene)	ODG10SPGF71SWS1
Chromosome	17
Chromosome location	17p12

189

Show/Hide all (189)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025326	hsa-miR-34a-5p	Proteomics	21566225
MIRT690385	hsa-miR-433-5p	HITS-CLIP	23313552
MIRT690384	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT690383	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT690382	hsa-miR-370-5p	HITS-CLIP	23313552
MIRT690381	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT690380	hsa-miR-4459	HITS-CLIP	23313552
MIRT690379	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT690378	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT690377	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT690376	hsa-miR-8073	HITS-CLIP	23313552
MIRT690375	hsa-miR-4794	HITS-CLIP	23313552
MIRT690374	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT690373	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT690372	hsa-miR-1273f	HITS-CLIP	23313552
MIRT690371	hsa-miR-4534	HITS-CLIP	23313552
MIRT690370	hsa-miR-8082	HITS-CLIP	23313552
MIRT690369	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT690385	hsa-miR-433-5p	HITS-CLIP	23313552
MIRT690384	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT690383	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT690382	hsa-miR-370-5p	HITS-CLIP	23313552
MIRT690381	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT690380	hsa-miR-4459	HITS-CLIP	23313552
MIRT690379	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT690378	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT690377	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT690376	hsa-miR-8073	HITS-CLIP	23313552
MIRT690375	hsa-miR-4794	HITS-CLIP	23313552
MIRT690374	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT690373	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT690372	hsa-miR-1273f	HITS-CLIP	23313552
MIRT690371	hsa-miR-4534	HITS-CLIP	23313552
MIRT690370	hsa-miR-8082	HITS-CLIP	23313552
MIRT690369	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT1544218	hsa-miR-1827	CLIP-seq
MIRT1544219	hsa-miR-204	CLIP-seq
MIRT1544220	hsa-miR-211	CLIP-seq
MIRT1544221	hsa-miR-2117	CLIP-seq
MIRT1544222	hsa-miR-3130-3p	CLIP-seq
MIRT1544223	hsa-miR-3158-3p	CLIP-seq
MIRT1544224	hsa-miR-3160-3p	CLIP-seq
MIRT1544225	hsa-miR-3675-3p	CLIP-seq
MIRT1544226	hsa-miR-412	CLIP-seq
MIRT1544227	hsa-miR-4252	CLIP-seq
MIRT1544228	hsa-miR-4273	CLIP-seq
MIRT1544229	hsa-miR-4277	CLIP-seq
MIRT1544230	hsa-miR-4327	CLIP-seq
MIRT1544231	hsa-miR-4487	CLIP-seq
MIRT1544232	hsa-miR-4649-3p	CLIP-seq
MIRT1544233	hsa-miR-4677-5p	CLIP-seq
MIRT1544234	hsa-miR-4722-5p	CLIP-seq
MIRT1544235	hsa-miR-4731-3p	CLIP-seq
MIRT1544236	hsa-miR-4755-5p	CLIP-seq
MIRT1544237	hsa-miR-4780	CLIP-seq
MIRT1544238	hsa-miR-4801	CLIP-seq
MIRT1544239	hsa-miR-485-3p	CLIP-seq
MIRT1544240	hsa-miR-487a	CLIP-seq
MIRT1544241	hsa-miR-516a-5p	CLIP-seq
MIRT1544242	hsa-miR-558	CLIP-seq
MIRT1544243	hsa-miR-579	CLIP-seq
MIRT1544244	hsa-miR-623	CLIP-seq
MIRT1544245	hsa-miR-940	CLIP-seq
MIRT2164233	hsa-miR-1908	CLIP-seq
MIRT2164234	hsa-miR-2114	CLIP-seq
MIRT2164235	hsa-miR-3929	CLIP-seq
MIRT2164236	hsa-miR-4419b	CLIP-seq
MIRT2164237	hsa-miR-4478	CLIP-seq
MIRT1544232	hsa-miR-4649-3p	CLIP-seq
MIRT2164238	hsa-miR-485-5p	CLIP-seq
MIRT2164239	hsa-miR-663	CLIP-seq
MIRT2383351	hsa-miR-1266	CLIP-seq
MIRT2383352	hsa-miR-1273	CLIP-seq
MIRT2383353	hsa-miR-1273c	CLIP-seq
MIRT2383354	hsa-miR-1275	CLIP-seq
MIRT2383355	hsa-miR-149	CLIP-seq
MIRT1544218	hsa-miR-1827	CLIP-seq
MIRT2164233	hsa-miR-1908	CLIP-seq
MIRT2383356	hsa-miR-2052	CLIP-seq
MIRT2164234	hsa-miR-2114	CLIP-seq
MIRT2383357	hsa-miR-24	CLIP-seq
MIRT2383358	hsa-miR-29a	CLIP-seq
MIRT2383359	hsa-miR-29b	CLIP-seq
MIRT2383360	hsa-miR-29c	CLIP-seq
MIRT1544222	hsa-miR-3130-3p	CLIP-seq
MIRT1544224	hsa-miR-3160-3p	CLIP-seq
MIRT2383361	hsa-miR-3609	CLIP-seq
MIRT2383362	hsa-miR-3919	CLIP-seq
MIRT2164235	hsa-miR-3929	CLIP-seq
MIRT1544227	hsa-miR-4252	CLIP-seq
MIRT2383363	hsa-miR-4260	CLIP-seq
MIRT2383364	hsa-miR-4284	CLIP-seq
MIRT2383365	hsa-miR-4307	CLIP-seq
MIRT1544230	hsa-miR-4327	CLIP-seq
MIRT2383366	hsa-miR-4330	CLIP-seq
MIRT2164236	hsa-miR-4419b	CLIP-seq
MIRT2383367	hsa-miR-4463	CLIP-seq
MIRT2164237	hsa-miR-4478	CLIP-seq
MIRT2383368	hsa-miR-4486	CLIP-seq
MIRT1544231	hsa-miR-4487	CLIP-seq
MIRT2383369	hsa-miR-4488	CLIP-seq
MIRT2383370	hsa-miR-4518	CLIP-seq
MIRT1544232	hsa-miR-4649-3p	CLIP-seq
MIRT2383371	hsa-miR-4649-5p	CLIP-seq
MIRT2383372	hsa-miR-4665-5p	CLIP-seq
MIRT2383373	hsa-miR-4697-5p	CLIP-seq
MIRT1544234	hsa-miR-4722-5p	CLIP-seq
MIRT2383374	hsa-miR-4756-3p	CLIP-seq
MIRT2164238	hsa-miR-485-5p	CLIP-seq
MIRT2383375	hsa-miR-520g	CLIP-seq
MIRT2383376	hsa-miR-520h	CLIP-seq
MIRT2383377	hsa-miR-548ah	CLIP-seq
MIRT1544242	hsa-miR-558	CLIP-seq
MIRT2383378	hsa-miR-578	CLIP-seq
MIRT2383379	hsa-miR-661	CLIP-seq
MIRT2164239	hsa-miR-663	CLIP-seq
MIRT2383380	hsa-miR-664	CLIP-seq
MIRT2383381	hsa-miR-892b	CLIP-seq
MIRT1544245	hsa-miR-940	CLIP-seq
MIRT2397772	hsa-miR-3122	CLIP-seq
MIRT2397773	hsa-miR-338-3p	CLIP-seq
MIRT2397774	hsa-miR-3689a-3p	CLIP-seq
MIRT2397775	hsa-miR-3689c	CLIP-seq
MIRT2397776	hsa-miR-3913-5p	CLIP-seq
MIRT2397777	hsa-miR-4530	CLIP-seq
MIRT2397778	hsa-miR-4728-5p	CLIP-seq
MIRT2164233	hsa-miR-1908	CLIP-seq
MIRT2164234	hsa-miR-2114	CLIP-seq
MIRT2164235	hsa-miR-3929	CLIP-seq
MIRT2164236	hsa-miR-4419b	CLIP-seq
MIRT2164237	hsa-miR-4478	CLIP-seq
MIRT2164238	hsa-miR-485-5p	CLIP-seq
MIRT2164239	hsa-miR-663	CLIP-seq
MIRT2383351	hsa-miR-1266	CLIP-seq
MIRT2383354	hsa-miR-1275	CLIP-seq
MIRT1544218	hsa-miR-1827	CLIP-seq
MIRT2164233	hsa-miR-1908	CLIP-seq
MIRT2383356	hsa-miR-2052	CLIP-seq
MIRT2164234	hsa-miR-2114	CLIP-seq
MIRT2383357	hsa-miR-24	CLIP-seq
MIRT2383358	hsa-miR-29a	CLIP-seq
MIRT2383359	hsa-miR-29b	CLIP-seq
MIRT2383360	hsa-miR-29c	CLIP-seq
MIRT1544223	hsa-miR-3158-3p	CLIP-seq
MIRT2673791	hsa-miR-3160-5p	CLIP-seq
MIRT2673792	hsa-miR-3607-3p	CLIP-seq
MIRT2673793	hsa-miR-3672	CLIP-seq
MIRT1544225	hsa-miR-3675-3p	CLIP-seq
MIRT2673794	hsa-miR-371-5p	CLIP-seq
MIRT2673795	hsa-miR-371b-5p	CLIP-seq
MIRT2164235	hsa-miR-3929	CLIP-seq
MIRT2383363	hsa-miR-4260	CLIP-seq
MIRT2383364	hsa-miR-4284	CLIP-seq
MIRT2383365	hsa-miR-4307	CLIP-seq
MIRT2164236	hsa-miR-4419b	CLIP-seq
MIRT2164237	hsa-miR-4478	CLIP-seq
MIRT2383369	hsa-miR-4488	CLIP-seq
MIRT2383370	hsa-miR-4518	CLIP-seq
MIRT1544232	hsa-miR-4649-3p	CLIP-seq
MIRT2383372	hsa-miR-4665-5p	CLIP-seq
MIRT2673796	hsa-miR-4668-3p	CLIP-seq
MIRT2673797	hsa-miR-4684-5p	CLIP-seq
MIRT2673798	hsa-miR-4690-3p	CLIP-seq
MIRT2383373	hsa-miR-4697-5p	CLIP-seq
MIRT1544235	hsa-miR-4731-3p	CLIP-seq
MIRT1544238	hsa-miR-4801	CLIP-seq
MIRT1544239	hsa-miR-485-3p	CLIP-seq
MIRT2164238	hsa-miR-485-5p	CLIP-seq
MIRT1544240	hsa-miR-487a	CLIP-seq
MIRT2673799	hsa-miR-526b	CLIP-seq
MIRT2383378	hsa-miR-578	CLIP-seq
MIRT2164239	hsa-miR-663	CLIP-seq
MIRT2383351	hsa-miR-1266	CLIP-seq
MIRT2383357	hsa-miR-24	CLIP-seq
MIRT1544223	hsa-miR-3158-3p	CLIP-seq
MIRT2673793	hsa-miR-3672	CLIP-seq
MIRT1544225	hsa-miR-3675-3p	CLIP-seq
MIRT2673794	hsa-miR-371-5p	CLIP-seq
MIRT2673795	hsa-miR-371b-5p	CLIP-seq
MIRT2383364	hsa-miR-4284	CLIP-seq
MIRT2383370	hsa-miR-4518	CLIP-seq
MIRT2673797	hsa-miR-4684-5p	CLIP-seq
MIRT2673798	hsa-miR-4690-3p	CLIP-seq
MIRT1544235	hsa-miR-4731-3p	CLIP-seq
MIRT1544238	hsa-miR-4801	CLIP-seq
MIRT1544239	hsa-miR-485-3p	CLIP-seq
MIRT1544240	hsa-miR-487a	CLIP-seq
MIRT2673799	hsa-miR-526b	CLIP-seq
MIRT2383378	hsa-miR-578	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000724	Process	Double-strand break repair via homologous recombination	IMP	21965664
GO:0005515	Function	Protein binding	IPI	21965664, 28514442, 31665741, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006310	Process	DNA recombination	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050821	Process	Protein stabilization	IMP	21965664
GO:0097196	Component	Shu complex	IBA
GO:0097196	Component	Shu complex	IDA	21965664

MIM	HGNC	e!Ensembl
614535	26993	ENSG00000214941

Q19AV6

Protein name

Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog) (SWIM-type zinc finger domain-containing protein 7)

Protein function

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Required for meiotic progression, hence for fertility (PubMed:32719396,

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04434	SWIM	65 → 113	SWIM zinc finger	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in ovary and testis. {ECO:0000269|PubMed:34402903}.

Sequence

MAVVLPAVVEELLSEMAAAVQESARIPDEYLLSLKFLFGSSATQALDLVDRQSITLISSP
SGRRVYQVLGSSSKTYTCLASCHYCSCPAFAFSVLRKSDSILCKHLLAVYLSQVMRTCQQ
LSVSDKQLTDILLMEKKQEA

Sequence length

140

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Infertility disorder	Likely pathogenic	rs764189883	RCV002273908	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Non-obstructive azoospermia	Likely pathogenic	rs368517882	RCV001544513	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ovarian dysgenesis 10	Likely pathogenic; Pathogenic	rs368517882, rs1970424535	RCV003135958 RCV002221961	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Spermatogenic failure 71	Likely pathogenic; Pathogenic	rs368517882, rs2151625014	RCV002221273 RCV002221450	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL ADENOMA	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GONADAL DYSGENESIS, 46,XX	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	CTD, Orphanet CTD, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 1	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR AZOOSPERMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Amenorrhea	Associate	35218660	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arrest of spermatogenesis	Associate	34402903	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy Absence	Associate	35218660	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Associate	31673075	★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Ovarian Insufficiency	Associate	34402903, 35218660, 37953503	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Associate	29394082	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZSWIM7 (zinc finger SWIM-type containing 7)