Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	125058
Gene name	TBC1 domain family member 16
Gene symbol	TBC1D16
Synonyms (NCBI Gene)	-
Chromosome	17
Chromosome location	17q25.3

121

Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050161	hsa-miR-26a-5p	CLASH	23622248
MIRT714418	hsa-miR-553	HITS-CLIP	19536157
MIRT714417	hsa-miR-1226-3p	HITS-CLIP	19536157
MIRT714416	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT714415	hsa-miR-302b-5p	HITS-CLIP	19536157
MIRT714414	hsa-miR-302d-5p	HITS-CLIP	19536157
MIRT714413	hsa-miR-505-5p	HITS-CLIP	19536157
MIRT665949	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT665948	hsa-miR-933	HITS-CLIP	23824327
MIRT665946	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT665947	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT639860	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT639859	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639858	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT639857	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT639855	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT639856	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT665949	hsa-miR-1250-3p	HITS-CLIP	27418678
MIRT665949	hsa-miR-1250-3p	HITS-CLIP	27418678
MIRT665949	hsa-miR-1250-3p	HITS-CLIP	27418678
MIRT665947	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT665947	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT665947	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT665946	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT665946	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT665946	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT665948	hsa-miR-933	HITS-CLIP	27418678
MIRT665948	hsa-miR-933	HITS-CLIP	27418678
MIRT665948	hsa-miR-933	HITS-CLIP	27418678
MIRT665948	hsa-miR-933	HITS-CLIP	27418678
MIRT714418	hsa-miR-553	HITS-CLIP	19536157
MIRT714417	hsa-miR-1226-3p	HITS-CLIP	19536157
MIRT714416	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT714415	hsa-miR-302b-5p	HITS-CLIP	19536157
MIRT714414	hsa-miR-302d-5p	HITS-CLIP	19536157
MIRT714413	hsa-miR-505-5p	HITS-CLIP	19536157
MIRT665949	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT665948	hsa-miR-933	HITS-CLIP	23824327
MIRT665946	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT665947	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT639860	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT639859	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639858	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT639857	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT639855	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT639856	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT1412488	hsa-miR-1207-3p	CLIP-seq
MIRT1412489	hsa-miR-1277	CLIP-seq
MIRT1412490	hsa-miR-192	CLIP-seq
MIRT1412491	hsa-miR-215	CLIP-seq
MIRT1412492	hsa-miR-219-1-3p	CLIP-seq
MIRT1412493	hsa-miR-3165	CLIP-seq
MIRT1412494	hsa-miR-3914	CLIP-seq
MIRT1412495	hsa-miR-4422	CLIP-seq
MIRT1412496	hsa-miR-4464	CLIP-seq
MIRT1412497	hsa-miR-4653-3p	CLIP-seq
MIRT1412498	hsa-miR-4718	CLIP-seq
MIRT1412499	hsa-miR-4742-3p	CLIP-seq
MIRT1412500	hsa-miR-4748	CLIP-seq
MIRT1554472	hsa-miR-4517	CLIP-seq
MIRT1554473	hsa-miR-4735-5p	CLIP-seq
MIRT1554474	hsa-miR-4775	CLIP-seq
MIRT1554475	hsa-miR-590-3p	CLIP-seq
MIRT1554476	hsa-miR-616	CLIP-seq
MIRT1554477	hsa-miR-889	CLIP-seq
MIRT2123839	hsa-miR-1238	CLIP-seq
MIRT2123840	hsa-miR-1245b-5p	CLIP-seq
MIRT2123841	hsa-miR-1254	CLIP-seq
MIRT2123842	hsa-miR-1262	CLIP-seq
MIRT2123843	hsa-miR-1976	CLIP-seq
MIRT2123844	hsa-miR-2964a-5p	CLIP-seq
MIRT2123845	hsa-miR-3116	CLIP-seq
MIRT2123846	hsa-miR-3124-3p	CLIP-seq
MIRT2123847	hsa-miR-3142	CLIP-seq
MIRT2123848	hsa-miR-3160-5p	CLIP-seq
MIRT2123849	hsa-miR-3183	CLIP-seq
MIRT2123850	hsa-miR-3667-3p	CLIP-seq
MIRT2123851	hsa-miR-4297	CLIP-seq
MIRT2123852	hsa-miR-4316	CLIP-seq
MIRT2123853	hsa-miR-4317	CLIP-seq
MIRT2123854	hsa-miR-4421	CLIP-seq
MIRT2123855	hsa-miR-4701-3p	CLIP-seq
MIRT2123856	hsa-miR-4723-3p	CLIP-seq
MIRT1554473	hsa-miR-4735-5p	CLIP-seq
MIRT2123857	hsa-miR-4765	CLIP-seq
MIRT1554474	hsa-miR-4775	CLIP-seq
MIRT1554475	hsa-miR-590-3p	CLIP-seq
MIRT2123858	hsa-miR-593	CLIP-seq
MIRT1554476	hsa-miR-616	CLIP-seq
MIRT2345887	hsa-miR-1231	CLIP-seq
MIRT2123839	hsa-miR-1238	CLIP-seq
MIRT2345888	hsa-miR-149	CLIP-seq
MIRT2345889	hsa-miR-203	CLIP-seq
MIRT2345890	hsa-miR-214	CLIP-seq
MIRT2345891	hsa-miR-28-5p	CLIP-seq
MIRT2345892	hsa-miR-3064-5p	CLIP-seq
MIRT2123846	hsa-miR-3124-3p	CLIP-seq
MIRT2345893	hsa-miR-3139	CLIP-seq
MIRT2345894	hsa-miR-3160-3p	CLIP-seq
MIRT2345895	hsa-miR-3619-5p	CLIP-seq
MIRT2345896	hsa-miR-4436b-3p	CLIP-seq
MIRT2345897	hsa-miR-4530	CLIP-seq
MIRT2345898	hsa-miR-4685-5p	CLIP-seq
MIRT2345899	hsa-miR-4722-5p	CLIP-seq
MIRT2345900	hsa-miR-4768-3p	CLIP-seq
MIRT2345901	hsa-miR-4794	CLIP-seq
MIRT2345902	hsa-miR-604	CLIP-seq
MIRT2345903	hsa-miR-647	CLIP-seq
MIRT2345904	hsa-miR-708	CLIP-seq
MIRT2345905	hsa-miR-761	CLIP-seq
MIRT2395539	hsa-miR-1184	CLIP-seq
MIRT2345891	hsa-miR-28-5p	CLIP-seq
MIRT2345893	hsa-miR-3139	CLIP-seq
MIRT2395540	hsa-miR-4418	CLIP-seq
MIRT2395541	hsa-miR-4433	CLIP-seq
MIRT2395542	hsa-miR-4436b-5p	CLIP-seq
MIRT2395543	hsa-miR-4459	CLIP-seq
MIRT2345900	hsa-miR-4768-3p	CLIP-seq
MIRT2395544	hsa-miR-509-3-5p	CLIP-seq
MIRT2395545	hsa-miR-509-5p	CLIP-seq
MIRT2345904	hsa-miR-708	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001919	Process	Regulation of receptor recycling	IDA	23019362
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	23019362
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	22354992
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	IDA	23019362
GO:0005829	Component	Cytosol	IDA	23019362
GO:1902017	Process	Regulation of cilium assembly	IMP	17646400

MIM	HGNC	e!Ensembl
616637	28356	ENSG00000167291

Q8TBP0

Protein name

TBC1 domain family member 16

Protein function

May act as a GTPase-activating protein for Rab family protein(s).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00566	RabGAP-TBC	428 → 657	Rab-GTPase-TBC domain	Family

Sequence

MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR

Sequence length

767

Interactions

View interactions

	Reactome
			TBC/RABGAPs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	31383000	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	29962380	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Associate	29962380	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	21129771, 28578692, 31383000	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Stimulate	23019362	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	29962380, 31383000	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	21129771, 28578692, 29962380, 31383000	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pyruvate Carboxylase Deficiency Disease	Associate	23360921	★★★★★ ★☆☆☆☆ Found in Text Mining only

TBC1D16 (TBC1 domain family member 16)