ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide)

Gene

• Entrez ID: 125
• Gene name: Alcohol dehydrogenase 1B (class I), beta polypeptide
• Gene symbol: ADH1B
• Synonyms (NCBI Gene): ADH2, HEL-S-117
• Chromosome: 4
• Chromosome location: 4q23
• Summary: The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT551507	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551506	hsa-miR-567	HITS-CLIP	21572407
MIRT551505	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551504	hsa-miR-3924	HITS-CLIP	21572407
MIRT551503	hsa-miR-568	HITS-CLIP	21572407
MIRT551502	hsa-miR-297	HITS-CLIP	21572407
MIRT551501	hsa-miR-3149	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	21572407
MIRT518107	hsa-miR-381-3p	HITS-CLIP	21572407
MIRT504589	hsa-miR-4280	HITS-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	HITS-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	HITS-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	HITS-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518103	hsa-miR-4705	HITS-CLIP	21572407
MIRT518102	hsa-let-7a-3p	HITS-CLIP	21572407
MIRT518101	hsa-let-7b-3p	HITS-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	21572407
MIRT518099	hsa-miR-98-3p	HITS-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	23313552
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23313552
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT551507	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551506	hsa-miR-567	PAR-CLIP	21572407
MIRT551505	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551504	hsa-miR-3924	PAR-CLIP	21572407
MIRT551503	hsa-miR-568	PAR-CLIP	21572407
MIRT551502	hsa-miR-297	PAR-CLIP	21572407
MIRT551501	hsa-miR-3149	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	21572407
MIRT518107	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT504589	hsa-miR-4280	PAR-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	21572407
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518103	hsa-miR-4705	PAR-CLIP	21572407
MIRT518102	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT518101	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT518099	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	23446348
MIRT518107	hsa-miR-381-3p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	23446348
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518103	hsa-miR-4705	PAR-CLIP	23446348
MIRT518102	hsa-let-7a-3p	PAR-CLIP	23446348
MIRT518101	hsa-let-7b-3p	PAR-CLIP	23446348
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	23446348
MIRT518099	hsa-miR-98-3p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT551507	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551506	hsa-miR-567	HITS-CLIP	21572407
MIRT551505	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551504	hsa-miR-3924	HITS-CLIP	21572407
MIRT551503	hsa-miR-568	HITS-CLIP	21572407
MIRT551502	hsa-miR-297	HITS-CLIP	21572407
MIRT551501	hsa-miR-3149	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	21572407
MIRT518107	hsa-miR-381-3p	HITS-CLIP	21572407
MIRT504589	hsa-miR-4280	HITS-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	HITS-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	HITS-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	HITS-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518103	hsa-miR-4705	HITS-CLIP	21572407
MIRT518102	hsa-let-7a-3p	HITS-CLIP	21572407
MIRT518101	hsa-let-7b-3p	HITS-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	21572407
MIRT518099	hsa-miR-98-3p	HITS-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	23313552
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23313552
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT551507	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551506	hsa-miR-567	PAR-CLIP	21572407
MIRT551505	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551504	hsa-miR-3924	PAR-CLIP	21572407
MIRT551503	hsa-miR-568	PAR-CLIP	21572407
MIRT551502	hsa-miR-297	PAR-CLIP	21572407
MIRT551501	hsa-miR-3149	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	21572407
MIRT518107	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT504589	hsa-miR-4280	PAR-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	21572407
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518103	hsa-miR-4705	PAR-CLIP	21572407
MIRT518102	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT518101	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT518099	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	23446348
MIRT518107	hsa-miR-381-3p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	23446348
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518103	hsa-miR-4705	PAR-CLIP	23446348
MIRT518102	hsa-let-7a-3p	PAR-CLIP	23446348
MIRT518101	hsa-let-7b-3p	PAR-CLIP	23446348
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	23446348
MIRT518099	hsa-miR-98-3p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT768618	hsa-miR-4686	CLIP-seq
MIRT768619	hsa-miR-4795-3p	CLIP-seq
MIRT768620	hsa-miR-4797-5p	CLIP-seq
MIRT768621	hsa-miR-548c-3p	CLIP-seq
MIRT1926688	hsa-miR-1303	CLIP-seq
MIRT1926689	hsa-miR-23a	CLIP-seq
MIRT1926690	hsa-miR-23b	CLIP-seq
MIRT1926691	hsa-miR-23c	CLIP-seq
MIRT1926692	hsa-miR-4422	CLIP-seq
MIRT1926693	hsa-miR-4699-5p	CLIP-seq
MIRT1926692	hsa-miR-4422	CLIP-seq
MIRT2167642	hsa-miR-4699-3p	CLIP-seq
MIRT2470328	hsa-miR-2355-5p	CLIP-seq
MIRT2674553	hsa-miR-1183	CLIP-seq
MIRT2674554	hsa-miR-1200	CLIP-seq
MIRT2674555	hsa-miR-1229	CLIP-seq
MIRT2674556	hsa-miR-1252	CLIP-seq
MIRT2674557	hsa-miR-224	CLIP-seq
MIRT2470328	hsa-miR-2355-5p	CLIP-seq
MIRT2674558	hsa-miR-299-3p	CLIP-seq
MIRT2674559	hsa-miR-3074-5p	CLIP-seq
MIRT2674560	hsa-miR-3127-5p	CLIP-seq
MIRT2674561	hsa-miR-3136-3p	CLIP-seq
MIRT2674562	hsa-miR-3140-5p	CLIP-seq
MIRT2674563	hsa-miR-3151	CLIP-seq
MIRT2674564	hsa-miR-338-3p	CLIP-seq
MIRT2674565	hsa-miR-3614-5p	CLIP-seq
MIRT2674566	hsa-miR-3653	CLIP-seq
MIRT2674567	hsa-miR-3658	CLIP-seq
MIRT2674568	hsa-miR-3662	CLIP-seq
MIRT2674569	hsa-miR-3682-5p	CLIP-seq
MIRT2674570	hsa-miR-3918	CLIP-seq
MIRT2674571	hsa-miR-3978	CLIP-seq
MIRT2674572	hsa-miR-421	CLIP-seq
MIRT2674573	hsa-miR-432	CLIP-seq
MIRT2674574	hsa-miR-4447	CLIP-seq
MIRT2674575	hsa-miR-4452	CLIP-seq
MIRT2674576	hsa-miR-4464	CLIP-seq
MIRT2674577	hsa-miR-4472	CLIP-seq
MIRT2674578	hsa-miR-4476	CLIP-seq
MIRT2674579	hsa-miR-4535	CLIP-seq
MIRT2674580	hsa-miR-4680-5p	CLIP-seq
MIRT2674581	hsa-miR-4693-5p	CLIP-seq
MIRT2674582	hsa-miR-4696	CLIP-seq
MIRT2167642	hsa-miR-4699-3p	CLIP-seq
MIRT1926693	hsa-miR-4699-5p	CLIP-seq
MIRT2674583	hsa-miR-4742-3p	CLIP-seq
MIRT2674584	hsa-miR-4744	CLIP-seq
MIRT2674585	hsa-miR-4748	CLIP-seq
MIRT2674586	hsa-miR-4776-5p	CLIP-seq
MIRT2674587	hsa-miR-4790-3p	CLIP-seq
MIRT768620	hsa-miR-4797-5p	CLIP-seq
MIRT2674588	hsa-miR-486-3p	CLIP-seq
MIRT2674589	hsa-miR-486-5p	CLIP-seq
MIRT2674590	hsa-miR-491-5p	CLIP-seq
MIRT2674591	hsa-miR-492	CLIP-seq
MIRT2674592	hsa-miR-513a-3p	CLIP-seq
MIRT2674593	hsa-miR-513a-5p	CLIP-seq
MIRT2674594	hsa-miR-587	CLIP-seq
MIRT2674595	hsa-miR-590-3p	CLIP-seq
MIRT2674596	hsa-miR-642b	CLIP-seq
MIRT2674597	hsa-miR-9	CLIP-seq
MIRT2674598	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	15369820, 16787387
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IDA	9982, 2398055
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IEA
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IBA
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IDA	15369820
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005929	Component	Cilium	IDA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	9982
GO:0008270	Function	Zinc ion binding	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0036064	Component	Ciliary basal body	IDA
GO:0042572	Process	Retinol metabolic process	IBA
GO:0042573	Process	Retinoic acid metabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 103720
• HGNC: 250
• e!Ensembl: ENSG00000196616

Protein

• UniProt ID: P00325
• Protein name: All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)
• Protein function: Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyze the NADH-dependent reduct
• PDB: 1DEH, 1HDX, 1HDY, 1HDZ, 1HSZ, 1HTB, 1U3U, 1U3V, 3HUD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08240	ADH_N	34 → 161	Alcohol dehydrogenase GroES-like domain	Domain
  PF00107	ADH_zinc_N	203 → 339	Zinc-binding dehydrogenase	Family

• Sequence:

  MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT
  PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNP
  RGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG
  YGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATE
  CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ
  NLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGF
  DLLHSGKSIRTVLTF

• Sequence length: 375

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Fatty acid degradation
Tyrosine metabolism
Pyruvate metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Alcoholic liver disease

Reactome:

Ethanol oxidation

<

Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Gout	Gout	N/A	N/A	GWAS
Hypertension	Hypertension, Hypertension (PheCode 401), Essential hypertension (PheCode 401.1)	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	29808834
Adenocarcinoma of Lung	Inhibit	37848457, 37985446
Adenoma	Inhibit	24599561, 36482184
Adenomatous Polyposis Coli	Associate	36923554
Alcohol Related Disorders	Associate	35670037
Alcoholism	Associate	15679538, 18322963, 22048268, 23134043, 23134050, 24553426, 26284938, 26644136, 28158658, 30482948, 30629674, 35633389, 36028843, 37378938
Alzheimer Disease	Associate	27808372
Anemia Macrocytic	Associate	28158658
Asthma	Associate	23148572, 30209858
Atrial Fibrillation	Associate	27927211
Binge Drinking	Associate	33893496, 36028843
Breast Neoplasms	Associate	17295732, 22331481, 32300124
Breast Neoplasms	Inhibit	31292488
Carcinogenesis	Associate	24282520, 28824723
Carcinoma Hepatocellular	Associate	18439068, 2167445, 2295648, 29600553, 30720105, 33287761
Carcinoma Non Small Cell Lung	Associate	29808834
Carcinoma Pancreatic Ductal	Associate	32439797
Carcinoma Squamous Cell	Associate	18322963, 27038040
Carcinoma Squamous Cell	Inhibit	37985446
Cerebral Hemorrhage	Associate	32107439
Colonic Neoplasms	Associate	34564978
Colonic Neoplasms	Inhibit	36482184
Colorectal Neoplasms	Associate	17517051, 18763293, 24282520, 27706775, 28962550, 31137244, 36482184
Colorectal Neoplasms	Inhibit	24599561
Congenital Hypothyroidism	Associate	30629674
Coronary Artery Disease	Associate	25047496, 40026415
Crohn Disease	Associate	35872023
Depressive Disorder	Associate	30482948
Digestive System Neoplasms	Associate	21437268
Drug Hypersensitivity	Associate	30209858
Endometrial Neoplasms	Stimulate	36702668
Endometriosis	Associate	36702668
Esophageal Neoplasms	Associate	16127737, 16235983, 17963305, 19452585, 22292652, 22703580, 22930414, 23134043, 28158658, 33132654, 35048370, 35670037, 40156023
Esophageal Squamous Cell Carcinoma	Associate	16127737, 18322963, 19826048, 21926110, 22292652, 24722735, 26873401, 27038040, 30639619
Esophageal Squamous Cell Carcinoma	Inhibit	19826048
Fetal Alcohol Spectrum Disorders	Stimulate	37510297
Fowler Christmas Chapple syndrome	Associate	27038040
Gout	Associate	28566767
Hashimoto Disease	Associate	37324256
Head and Neck Neoplasms	Associate	25770642, 35048370, 36028843
Heart Diseases	Associate	29016726, 35633389
Hemolytic Uremic Syndrome	Associate	24358217
Hemorrhagic Stroke	Associate	34051793
Hypertension	Associate	23615284
Hypopharyngeal Neoplasms	Associate	36261585
Idiopathic Noncirrhotic Portal Hypertension	Associate	29695616
Insulin Resistance	Associate	25830378, 33479282
Keratoacanthoma	Associate	25676557
Laryngeal Neoplasms	Associate	27689323, 35670037
Leukopenia	Associate	28158658
Liver Cirrhosis Alcoholic	Associate	37378938
Liver Diseases	Associate	22048268
Liver Diseases Alcoholic	Associate	26937962
Lung Neoplasms	Associate	28236470, 30177858
Lymphatic Metastasis	Associate	34155937
Malignant mesenchymal tumor	Inhibit	36482184
Mesothelioma Malignant	Associate	36523602
Multiple Myeloma	Associate	35053305
Nemaline myopathy 5	Inhibit	36482184
Neoplasm Metastasis	Associate	37985446
Neoplasms	Inhibit	18500343, 33807717, 37848457
Neoplasms	Associate	18500343, 21940907, 25770642, 26992901, 32880385, 35048370, 35280985, 35670037, 36261585, 36482184, 37985446
Neoplasms Second Primary	Associate	25770642
Non alcoholic Fatty Liver Disease	Associate	29718361, 32454036
Obesity	Associate	25830378, 31046077
Obesity	Inhibit	33479282
Ovarian Diseases	Associate	32880385
Ovarian Neoplasms	Associate	24756370, 31689861
Pancreatic Neoplasms	Associate	19068087, 35670037
Pancreatitis	Associate	34267279
Pulmonary Disease Chronic Obstructive	Associate	24188068
Renal Insufficiency Chronic	Associate	24358217
Schizophrenia	Associate	30482948
Squamous Cell Carcinoma of Head and Neck	Associate	17489985, 21940907, 22052802, 25874489, 34546328
Stomach Neoplasms	Associate	28002588, 28586067, 29166882, 34155937, 34686626
Stroke	Associate	22155604, 30955975
Substance Related Disorders	Associate	37796845
Thyroid Cancer Papillary	Associate	37324256
Triple Negative Breast Neoplasms	Associate	39529035
Tuberculosis	Associate	24690209
Urinary Bladder Neoplasms	Associate	26992901
Ventricular Remodeling	Associate	29016726