Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	124995
Gene name	Mitochondrial ribosomal protein L10
Gene symbol	MRPL10
Synonyms (NCBI Gene)	L10MTMRP-L10MRP-L8MRPL8RPML8uL10m
Chromosome	17
Chromosome location	17q21.32
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025750	hsa-miR-7-5p	Microarray	19073608
MIRT031632	hsa-miR-16-5p	Proteomics	18668040
MIRT041125	hsa-miR-503-5p	CLASH	23622248
MIRT035957	hsa-miR-1301-3p	CLASH	23622248
MIRT693793	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT693792	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT693791	hsa-miR-1180-5p	HITS-CLIP	23313552
MIRT693790	hsa-miR-7114-3p	HITS-CLIP	23313552
MIRT693789	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT693788	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT693787	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT693786	hsa-miR-711	HITS-CLIP	23313552
MIRT693785	hsa-miR-1193	HITS-CLIP	23313552
MIRT693784	hsa-miR-3649	HITS-CLIP	23313552
MIRT693783	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT693782	hsa-miR-6745	HITS-CLIP	23313552
MIRT693781	hsa-miR-8071	HITS-CLIP	23313552
MIRT693780	hsa-miR-6880-5p	HITS-CLIP	23313552
MIRT693779	hsa-miR-3165	HITS-CLIP	23313552
MIRT693778	hsa-miR-3691-5p	HITS-CLIP	23313552
MIRT693777	hsa-miR-432-3p	HITS-CLIP	23313552
MIRT693793	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT693792	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT693791	hsa-miR-1180-5p	HITS-CLIP	23313552
MIRT693790	hsa-miR-7114-3p	HITS-CLIP	23313552
MIRT693789	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT693788	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT693787	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT693786	hsa-miR-711	HITS-CLIP	23313552
MIRT693785	hsa-miR-1193	HITS-CLIP	23313552
MIRT693784	hsa-miR-3649	HITS-CLIP	23313552
MIRT693783	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT693782	hsa-miR-6745	HITS-CLIP	23313552
MIRT693781	hsa-miR-8071	HITS-CLIP	23313552
MIRT693780	hsa-miR-6880-5p	HITS-CLIP	23313552
MIRT693779	hsa-miR-3165	HITS-CLIP	23313552
MIRT693778	hsa-miR-3691-5p	HITS-CLIP	23313552
MIRT693777	hsa-miR-432-3p	HITS-CLIP	23313552
MIRT1158380	hsa-miR-1291	CLIP-seq
MIRT1158381	hsa-miR-203	CLIP-seq
MIRT1158382	hsa-miR-214	CLIP-seq
MIRT1158383	hsa-miR-217	CLIP-seq
MIRT1158384	hsa-miR-2278	CLIP-seq
MIRT1158385	hsa-miR-2467-3p	CLIP-seq
MIRT1158386	hsa-miR-3065-3p	CLIP-seq
MIRT1158387	hsa-miR-3144-3p	CLIP-seq
MIRT1158388	hsa-miR-3158-3p	CLIP-seq
MIRT1158389	hsa-miR-328	CLIP-seq
MIRT1158390	hsa-miR-3619-5p	CLIP-seq
MIRT1158391	hsa-miR-3677-5p	CLIP-seq
MIRT1158392	hsa-miR-3691-3p	CLIP-seq
MIRT1158393	hsa-miR-3913-3p	CLIP-seq
MIRT1158394	hsa-miR-3915	CLIP-seq
MIRT1158395	hsa-miR-3928	CLIP-seq
MIRT1158396	hsa-miR-4252	CLIP-seq
MIRT1158397	hsa-miR-4314	CLIP-seq
MIRT1158398	hsa-miR-4436a	CLIP-seq
MIRT1158399	hsa-miR-4468	CLIP-seq
MIRT1158400	hsa-miR-4502	CLIP-seq
MIRT1158401	hsa-miR-4637	CLIP-seq
MIRT1158402	hsa-miR-4694-3p	CLIP-seq
MIRT1158403	hsa-miR-4721	CLIP-seq
MIRT1158404	hsa-miR-4766-5p	CLIP-seq
MIRT1158405	hsa-miR-489	CLIP-seq
MIRT1158406	hsa-miR-490-3p	CLIP-seq
MIRT1158407	hsa-miR-515-5p	CLIP-seq
MIRT1158408	hsa-miR-555	CLIP-seq
MIRT1158409	hsa-miR-619	CLIP-seq
MIRT1158410	hsa-miR-649	CLIP-seq
MIRT1158411	hsa-miR-659	CLIP-seq
MIRT1158412	hsa-miR-663b	CLIP-seq
MIRT1158413	hsa-miR-761	CLIP-seq
MIRT1158414	hsa-miR-875-5p	CLIP-seq
MIRT2045353	hsa-miR-1224-5p	CLIP-seq
MIRT1158381	hsa-miR-203	CLIP-seq
MIRT2045354	hsa-miR-3150b-3p	CLIP-seq
MIRT1158391	hsa-miR-3677-5p	CLIP-seq
MIRT1158392	hsa-miR-3691-3p	CLIP-seq
MIRT2045355	hsa-miR-3692	CLIP-seq
MIRT1158393	hsa-miR-3913-3p	CLIP-seq
MIRT1158394	hsa-miR-3915	CLIP-seq
MIRT2045356	hsa-miR-4689	CLIP-seq
MIRT1158402	hsa-miR-4694-3p	CLIP-seq
MIRT1158404	hsa-miR-4766-5p	CLIP-seq
MIRT2045357	hsa-miR-4784	CLIP-seq
MIRT1158405	hsa-miR-489	CLIP-seq
MIRT1158407	hsa-miR-515-5p	CLIP-seq
MIRT2045358	hsa-miR-603	CLIP-seq
MIRT1158387	hsa-miR-3144-3p	CLIP-seq
MIRT1158414	hsa-miR-875-5p	CLIP-seq
MIRT2573215	hsa-miR-103a	CLIP-seq
MIRT2573216	hsa-miR-107	CLIP-seq
MIRT2573217	hsa-miR-1207-5p	CLIP-seq
MIRT2045353	hsa-miR-1224-5p	CLIP-seq
MIRT2573218	hsa-miR-1225-5p	CLIP-seq
MIRT2573219	hsa-miR-1226	CLIP-seq
MIRT2573220	hsa-miR-1229	CLIP-seq
MIRT2573221	hsa-miR-1237	CLIP-seq
MIRT2573222	hsa-miR-1248	CLIP-seq
MIRT1158380	hsa-miR-1291	CLIP-seq
MIRT2573223	hsa-miR-1827	CLIP-seq
MIRT2573224	hsa-miR-1973	CLIP-seq
MIRT1158381	hsa-miR-203	CLIP-seq
MIRT1158382	hsa-miR-214	CLIP-seq
MIRT1158383	hsa-miR-217	CLIP-seq
MIRT2573225	hsa-miR-24	CLIP-seq
MIRT2573226	hsa-miR-2682	CLIP-seq
MIRT1158386	hsa-miR-3065-3p	CLIP-seq
MIRT1158387	hsa-miR-3144-3p	CLIP-seq
MIRT2045354	hsa-miR-3150b-3p	CLIP-seq
MIRT2573227	hsa-miR-3155	CLIP-seq
MIRT2573228	hsa-miR-3155b	CLIP-seq
MIRT2573229	hsa-miR-3189-5p	CLIP-seq
MIRT1158389	hsa-miR-328	CLIP-seq
MIRT2573230	hsa-miR-338-5p	CLIP-seq
MIRT2573231	hsa-miR-34a	CLIP-seq
MIRT2573232	hsa-miR-34c-5p	CLIP-seq
MIRT2573233	hsa-miR-3606	CLIP-seq
MIRT1158390	hsa-miR-3619-5p	CLIP-seq
MIRT2573234	hsa-miR-3664-3p	CLIP-seq
MIRT1158391	hsa-miR-3677-5p	CLIP-seq
MIRT2573235	hsa-miR-3688-5p	CLIP-seq
MIRT1158392	hsa-miR-3691-3p	CLIP-seq
MIRT2045355	hsa-miR-3692	CLIP-seq
MIRT2573236	hsa-miR-3912	CLIP-seq
MIRT1158393	hsa-miR-3913-3p	CLIP-seq
MIRT1158394	hsa-miR-3915	CLIP-seq
MIRT2573237	hsa-miR-3923	CLIP-seq
MIRT2573238	hsa-miR-3944-5p	CLIP-seq
MIRT1158396	hsa-miR-4252	CLIP-seq
MIRT2573239	hsa-miR-4268	CLIP-seq
MIRT2573240	hsa-miR-4291	CLIP-seq
MIRT2573241	hsa-miR-4318	CLIP-seq
MIRT2573242	hsa-miR-4417	CLIP-seq
MIRT2573243	hsa-miR-4433	CLIP-seq
MIRT2573244	hsa-miR-4437	CLIP-seq
MIRT2573245	hsa-miR-4446-3p	CLIP-seq
MIRT2573246	hsa-miR-4448	CLIP-seq
MIRT2573247	hsa-miR-4459	CLIP-seq
MIRT2573248	hsa-miR-4492	CLIP-seq
MIRT2573249	hsa-miR-4498	CLIP-seq
MIRT2573250	hsa-miR-449a	CLIP-seq
MIRT2573251	hsa-miR-449b	CLIP-seq
MIRT2573252	hsa-miR-449c	CLIP-seq
MIRT2573253	hsa-miR-4504	CLIP-seq
MIRT2573254	hsa-miR-4506	CLIP-seq
MIRT2573255	hsa-miR-451b	CLIP-seq
MIRT1158401	hsa-miR-4637	CLIP-seq
MIRT2573256	hsa-miR-4651	CLIP-seq
MIRT2573257	hsa-miR-4674	CLIP-seq
MIRT2573258	hsa-miR-4677-3p	CLIP-seq
MIRT2573259	hsa-miR-4679	CLIP-seq
MIRT2045356	hsa-miR-4689	CLIP-seq
MIRT2573260	hsa-miR-4690-5p	CLIP-seq
MIRT2573261	hsa-miR-4693-5p	CLIP-seq
MIRT1158402	hsa-miR-4694-3p	CLIP-seq
MIRT2573262	hsa-miR-4733-3p	CLIP-seq
MIRT2573263	hsa-miR-4736	CLIP-seq
MIRT2573264	hsa-miR-4758-3p	CLIP-seq
MIRT2573265	hsa-miR-4763-3p	CLIP-seq
MIRT1158404	hsa-miR-4766-5p	CLIP-seq
MIRT2573266	hsa-miR-4768-3p	CLIP-seq
MIRT2573267	hsa-miR-4768-5p	CLIP-seq
MIRT2573268	hsa-miR-4775	CLIP-seq
MIRT2045357	hsa-miR-4784	CLIP-seq
MIRT2573269	hsa-miR-4787-3p	CLIP-seq
MIRT2573270	hsa-miR-4794	CLIP-seq
MIRT2573271	hsa-miR-484	CLIP-seq
MIRT1158405	hsa-miR-489	CLIP-seq
MIRT2573272	hsa-miR-491-3p	CLIP-seq
MIRT1158407	hsa-miR-515-5p	CLIP-seq
MIRT2573273	hsa-miR-541	CLIP-seq
MIRT2573274	hsa-miR-548aa	CLIP-seq
MIRT2573275	hsa-miR-563	CLIP-seq
MIRT2573276	hsa-miR-570	CLIP-seq
MIRT2045358	hsa-miR-603	CLIP-seq
MIRT2573277	hsa-miR-608	CLIP-seq
MIRT2573278	hsa-miR-610	CLIP-seq
MIRT2573279	hsa-miR-654-5p	CLIP-seq
MIRT2573280	hsa-miR-657	CLIP-seq
MIRT1158412	hsa-miR-663b	CLIP-seq
MIRT2573281	hsa-miR-759	CLIP-seq
MIRT1158413	hsa-miR-761	CLIP-seq
MIRT2573282	hsa-miR-762	CLIP-seq
MIRT2573283	hsa-miR-764	CLIP-seq
MIRT2573284	hsa-miR-767-3p	CLIP-seq
MIRT1158414	hsa-miR-875-5p	CLIP-seq
MIRT2573285	hsa-miR-892a	CLIP-seq
MIRT2573286	hsa-miR-922	CLIP-seq
MIRT2573287	hsa-miR-942	CLIP-seq
MIRT2573217	hsa-miR-1207-5p	CLIP-seq
MIRT2045353	hsa-miR-1224-5p	CLIP-seq
MIRT2573218	hsa-miR-1225-5p	CLIP-seq
MIRT2573219	hsa-miR-1226	CLIP-seq
MIRT2573220	hsa-miR-1229	CLIP-seq
MIRT2573221	hsa-miR-1237	CLIP-seq
MIRT2573222	hsa-miR-1248	CLIP-seq
MIRT1158380	hsa-miR-1291	CLIP-seq
MIRT1158381	hsa-miR-203	CLIP-seq
MIRT1158382	hsa-miR-214	CLIP-seq
MIRT1158383	hsa-miR-217	CLIP-seq
MIRT2573225	hsa-miR-24	CLIP-seq
MIRT1158386	hsa-miR-3065-3p	CLIP-seq
MIRT1158387	hsa-miR-3144-3p	CLIP-seq
MIRT2045354	hsa-miR-3150b-3p	CLIP-seq
MIRT2573227	hsa-miR-3155	CLIP-seq
MIRT2573228	hsa-miR-3155b	CLIP-seq
MIRT2573229	hsa-miR-3189-5p	CLIP-seq
MIRT1158389	hsa-miR-328	CLIP-seq
MIRT2573230	hsa-miR-338-5p	CLIP-seq
MIRT2573231	hsa-miR-34a	CLIP-seq
MIRT2573232	hsa-miR-34c-5p	CLIP-seq
MIRT2573233	hsa-miR-3606	CLIP-seq
MIRT1158390	hsa-miR-3619-5p	CLIP-seq
MIRT2573234	hsa-miR-3664-3p	CLIP-seq
MIRT1158391	hsa-miR-3677-5p	CLIP-seq
MIRT2573235	hsa-miR-3688-5p	CLIP-seq
MIRT1158392	hsa-miR-3691-3p	CLIP-seq
MIRT2045355	hsa-miR-3692	CLIP-seq
MIRT2573236	hsa-miR-3912	CLIP-seq
MIRT1158393	hsa-miR-3913-3p	CLIP-seq
MIRT1158394	hsa-miR-3915	CLIP-seq
MIRT2573237	hsa-miR-3923	CLIP-seq
MIRT1158396	hsa-miR-4252	CLIP-seq
MIRT2573239	hsa-miR-4268	CLIP-seq
MIRT2573240	hsa-miR-4291	CLIP-seq
MIRT2573241	hsa-miR-4318	CLIP-seq
MIRT2573242	hsa-miR-4417	CLIP-seq
MIRT2573243	hsa-miR-4433	CLIP-seq
MIRT2573244	hsa-miR-4437	CLIP-seq
MIRT2573245	hsa-miR-4446-3p	CLIP-seq
MIRT2573246	hsa-miR-4448	CLIP-seq
MIRT2573247	hsa-miR-4459	CLIP-seq
MIRT2573248	hsa-miR-4492	CLIP-seq
MIRT2573249	hsa-miR-4498	CLIP-seq
MIRT2573250	hsa-miR-449a	CLIP-seq
MIRT2573251	hsa-miR-449b	CLIP-seq
MIRT2573254	hsa-miR-4506	CLIP-seq
MIRT1158401	hsa-miR-4637	CLIP-seq
MIRT2573256	hsa-miR-4651	CLIP-seq
MIRT2573257	hsa-miR-4674	CLIP-seq
MIRT2573258	hsa-miR-4677-3p	CLIP-seq
MIRT2573259	hsa-miR-4679	CLIP-seq
MIRT2045356	hsa-miR-4689	CLIP-seq
MIRT2573260	hsa-miR-4690-5p	CLIP-seq
MIRT2573261	hsa-miR-4693-5p	CLIP-seq
MIRT1158402	hsa-miR-4694-3p	CLIP-seq
MIRT2573262	hsa-miR-4733-3p	CLIP-seq
MIRT2573263	hsa-miR-4736	CLIP-seq
MIRT2573264	hsa-miR-4758-3p	CLIP-seq
MIRT2573265	hsa-miR-4763-3p	CLIP-seq
MIRT1158404	hsa-miR-4766-5p	CLIP-seq
MIRT2573266	hsa-miR-4768-3p	CLIP-seq
MIRT2573267	hsa-miR-4768-5p	CLIP-seq
MIRT2573268	hsa-miR-4775	CLIP-seq
MIRT2045357	hsa-miR-4784	CLIP-seq
MIRT2573269	hsa-miR-4787-3p	CLIP-seq
MIRT2573270	hsa-miR-4794	CLIP-seq
MIRT2573271	hsa-miR-484	CLIP-seq
MIRT1158405	hsa-miR-489	CLIP-seq
MIRT2573272	hsa-miR-491-3p	CLIP-seq
MIRT1158407	hsa-miR-515-5p	CLIP-seq
MIRT2573273	hsa-miR-541	CLIP-seq
MIRT2573274	hsa-miR-548aa	CLIP-seq
MIRT2573275	hsa-miR-563	CLIP-seq
MIRT2573276	hsa-miR-570	CLIP-seq
MIRT2045358	hsa-miR-603	CLIP-seq
MIRT2573277	hsa-miR-608	CLIP-seq
MIRT2573278	hsa-miR-610	CLIP-seq
MIRT2573279	hsa-miR-654-5p	CLIP-seq
MIRT2573280	hsa-miR-657	CLIP-seq
MIRT1158412	hsa-miR-663b	CLIP-seq
MIRT2573281	hsa-miR-759	CLIP-seq
MIRT1158413	hsa-miR-761	CLIP-seq
MIRT2573282	hsa-miR-762	CLIP-seq
MIRT2573283	hsa-miR-764	CLIP-seq
MIRT2573284	hsa-miR-767-3p	CLIP-seq
MIRT1158414	hsa-miR-875-5p	CLIP-seq
MIRT2573285	hsa-miR-892a	CLIP-seq
MIRT2573286	hsa-miR-922	CLIP-seq
MIRT2573287	hsa-miR-942	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 25910212
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IBA
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	IEA
GO:0005762	Component	Mitochondrial large ribosomal subunit	ISS
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	ISS
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990904	Component	Ribonucleoprotein complex	ISS

MIM	HGNC	e!Ensembl
611825	14055	ENSG00000159111

Q7Z7H8

Protein name

Large ribosomal subunit protein uL10m (39S ribosomal protein L10, mitochondrial) (L10mt) (MRP-L10) (39S ribosomal protein L8, mitochondrial) (L8mt) (MRP-L8)

PDB

3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00466	Ribosomal_L10	81 → 170	Ribosomal protein L10	Family

Sequence

MAAAVAGMLRGGLLPQAGRLPTLQTVRYGSKAVTRHRRVMHFQRQKLMAVTEYIPPKPAI
HPSCLPSPPSPPQEEIGLIRLLRREIAAVFQDNRMIAVCQNVALSAEDKLLMRHQLRKHK
ILMKVFPNQVLKPFLEDSKYQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGC
IDDTILSRQGFINYSKLPSLPLVQGELVGGLTCLTAQTHSLLQHQPLQLTTLLDQYIREQ
REKDSVMSANGKPDPDTVPDS

Sequence length

261

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MRPL10-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Ovarian Neoplasms	Associate	33934540	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPL10 (mitochondrial ribosomal protein L10)