Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	124535
Gene name	Heat shock transcription factor 5
Gene symbol	HSF5
Synonyms (NCBI Gene)	HSF 5HSTF 5
Chromosome	17
Chromosome location	17q22

137

Show/Hide all (137)

miRTarBase ID	miRNA	Experiments	Reference
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT504479	hsa-miR-4330	PAR-CLIP	20371350
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT504479	hsa-miR-4330	PAR-CLIP	20371350
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	22012620
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	22012620
MIRT504479	hsa-miR-4330	PAR-CLIP	22012620
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	22012620
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	23446348
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	23446348
MIRT504479	hsa-miR-4330	PAR-CLIP	23446348
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	23446348
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	23446348
MIRT504479	hsa-miR-4330	PAR-CLIP	23446348
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504479	hsa-miR-4330	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	26701625
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT504479	hsa-miR-4330	PAR-CLIP	20371350
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT504479	hsa-miR-4330	PAR-CLIP	20371350
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	20371350
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	20371350
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	20371350
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	22012620
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	22012620
MIRT504479	hsa-miR-4330	PAR-CLIP	22012620
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	22012620
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	23446348
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	23446348
MIRT504479	hsa-miR-4330	PAR-CLIP	23446348
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT504481	hsa-miR-5571-5p	PAR-CLIP	23446348
MIRT504480	hsa-miR-4733-5p	PAR-CLIP	23446348
MIRT504479	hsa-miR-4330	PAR-CLIP	23446348
MIRT504478	hsa-miR-6873-3p	PAR-CLIP	23446348
MIRT504477	hsa-miR-4768-5p	PAR-CLIP	23446348
MIRT504476	hsa-miR-6833-3p	PAR-CLIP	23446348
MIRT1055735	hsa-miR-1183	CLIP-seq
MIRT1055736	hsa-miR-296-3p	CLIP-seq
MIRT1055737	hsa-miR-3545-3p	CLIP-seq
MIRT1055738	hsa-miR-3913-3p	CLIP-seq
MIRT1055739	hsa-miR-4539	CLIP-seq
MIRT1055740	hsa-miR-4724-5p	CLIP-seq
MIRT1055741	hsa-miR-4747-5p	CLIP-seq
MIRT1055742	hsa-miR-489	CLIP-seq
MIRT1055743	hsa-miR-514	CLIP-seq
MIRT1055744	hsa-miR-514b-3p	CLIP-seq
MIRT2012791	hsa-miR-193a-5p	CLIP-seq
MIRT2012792	hsa-miR-3065-3p	CLIP-seq
MIRT2245125	hsa-miR-1243	CLIP-seq
MIRT2245126	hsa-miR-1261	CLIP-seq
MIRT2245127	hsa-miR-1273e	CLIP-seq
MIRT2245128	hsa-miR-3074-5p	CLIP-seq
MIRT2245129	hsa-miR-370	CLIP-seq
MIRT2245130	hsa-miR-3919	CLIP-seq
MIRT2245131	hsa-miR-421	CLIP-seq
MIRT2245132	hsa-miR-4480	CLIP-seq
MIRT2245133	hsa-miR-4668-5p	CLIP-seq
MIRT1055742	hsa-miR-489	CLIP-seq
MIRT2245134	hsa-miR-626	CLIP-seq
MIRT2245135	hsa-miR-668	CLIP-seq
MIRT2245128	hsa-miR-3074-5p	CLIP-seq
MIRT2451428	hsa-miR-4328	CLIP-seq
MIRT2451429	hsa-miR-4446-5p	CLIP-seq
MIRT2451430	hsa-miR-507	CLIP-seq
MIRT2451431	hsa-miR-557	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001216	Function	DNA-binding transcription activator activity	IEA
GO:0001217	Function	DNA-binding transcription repressor activity	IEA
GO:0001741	Component	XY body	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007140	Process	Male meiotic nuclear division	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
620843	26862	ENSG00000176160

Q4G112

Protein name

Heat shock factor protein 5 (HSF 5) (Heat shock transcription factor 5) (HSTF 5)

Protein function

DNA-binding transcription factor that is essential for male fertility, spermatogenesis and meiotic prophase progression in spermatocytes under non-stress conditions. Positvely and negatively regulates gene expression to ensure progression of mei

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00447	HSF_DNA-bind	14 → 130	HSF-type DNA-binding	Domain

Sequence

MEALLSTPINPNNFPAKLWRLVNSPRYRSIRWDGRGEGLLIDQPLFEAELLSPPGPGGGG
GTAGAGAEPELFKTTSFTSFIRQLNLYGFRKVVLGGPGGGKPAGNGPLHHFHNPHFRRDQ
PQLLVHLKRLTSANKAKLAAGLEVPCRPPNRFQRLLITSASAATAPLQHQQPPPPAGPRP
EPHGPVAVGQFHRSFRRDSLSPYSCVSTPSHDHSTYPLKGLDRTPVPHRIWQNSLGMHPG
QVETSPTFSDKGVPFPVLQRFPTEVTYTLQPSTTSVHVQQGPQTMVSSSQKYSNYTPSAQ
YSQAYYPTAVLQCCSPTHMDALSSCVTPNASSYAHCNYFQNPSMQSSYPVEFLPSNWPCS
TTDENTKTEVNLEAVFQIVDELHSSPKLEMVKVEPVENQCPTSPSYRGQHILANSNNSNP
CSASQASQLEPLTPVGSDIMSFVVGTEQAVACSLPQSPEYIYTIHTAQPVENSTIQESAA
IQQAHVKLKEHLNHNPSPSSVVFVQEGPPFSTHQVDANIKCQTSSRENILPSEQMGFLIS
EMGPASKPSEDTGLATPARYREHRSNSQQGKSPDLHLLVDVACKQERFPKEEELKE

Sequence length

596

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Inhibit	33390814	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	33390814	★★★★★ ★☆☆☆☆ Found in Text Mining only

HSF5 (heat shock transcription factor 5)