Gene Gene information from NCBI Gene database.
Entrez ID 124491
Gene name Transmembrane protein 170A
Gene symbol TMEM170A
Synonyms (NCBI Gene)
TMEM170
Chromosome 16
Chromosome location 16q23.1
miRNA miRNA information provided by mirtarbase database.
418
miRTarBase ID miRNA Experiments Reference
MIRT019829 hsa-miR-375 Microarray 20215506
MIRT707826 hsa-miR-6732-3p HITS-CLIP 21572407
MIRT707825 hsa-miR-10a-5p HITS-CLIP 21572407
MIRT707824 hsa-miR-10b-5p HITS-CLIP 21572407
MIRT707823 hsa-miR-339-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 26906412
GO:0005634 Component Nucleus IEA
GO:0005635 Component Nuclear envelope IDA 26906412
GO:0005635 Component Nuclear envelope IEA
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620630 29577 ENSG00000166822
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WVE7
Protein name Transmembrane protein 170A
Protein function Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex f
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10190 Tmemb_170 39 144 Putative transmembrane protein 170 Family
Sequence
Sequence length 144
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AORTIC STENOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AORTIC VALVE CALCIFICATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Pancreatic Neoplasms Associate 31917448
★☆☆☆☆
Found in Text Mining only
Pulmonary Disease Chronic Obstructive Associate 35308900
★☆☆☆☆
Found in Text Mining only