Gene Gene information from NCBI Gene database.
Entrez ID 123879
Gene name Defective in cullin neddylation 1 domain containing 3
Gene symbol DCUN1D3
Synonyms (NCBI Gene)
44M2.4DCNL3SCCRO3
Chromosome 16
Chromosome location 16p12.3
miRNA miRNA information provided by mirtarbase database.
723
miRTarBase ID miRNA Experiments Reference
MIRT031328 hsa-miR-18a-5p Sequencing 20371350
MIRT567836 hsa-miR-152-3p PAR-CLIP 20371350
MIRT567835 hsa-miR-148b-3p PAR-CLIP 20371350
MIRT567834 hsa-miR-148a-3p PAR-CLIP 20371350
MIRT567833 hsa-miR-3666 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IBA
GO:0005515 Function Protein binding IPI 19617556, 23201271, 26906416, 27542266
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus IMP 26906416
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616167 28734 ENSG00000188215
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IWE4
Protein name DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
Protein function Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the
PDB 4GBA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03556 Cullin_binding 162 276 Cullin binding Family
Tissue specificity TISSUE SPECIFICITY: Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416
Sequence
MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAE
AATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCV
DPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFK
DLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISR
DTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEW
EMERRKREGEGRGALSSGPEGLCP
EEQT
Sequence length 304
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation