NTAN1 (N-terminal asparagine amidase)

Gene

• Entrez ID: 123803
• Gene name: N-terminal asparagine amidase
• Gene symbol: NTAN1
• Synonyms (NCBI Gene): PNAA, PNAD
• Chromosome: 16
• Chromosome location: 16p13.11
• Summary: The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048539	hsa-miR-100-5p	CLASH	23622248
MIRT1196034	hsa-miR-1202	CLIP-seq
MIRT1196035	hsa-miR-18a	CLIP-seq
MIRT1196036	hsa-miR-18b	CLIP-seq
MIRT1196037	hsa-miR-1972	CLIP-seq
MIRT1196038	hsa-miR-3160-5p	CLIP-seq
MIRT1196039	hsa-miR-3194-5p	CLIP-seq
MIRT1196040	hsa-miR-3667-5p	CLIP-seq
MIRT1196041	hsa-miR-3972	CLIP-seq
MIRT1196042	hsa-miR-4320	CLIP-seq
MIRT1196043	hsa-miR-4323	CLIP-seq
MIRT1196044	hsa-miR-4527	CLIP-seq
MIRT1196045	hsa-miR-4650-5p	CLIP-seq
MIRT1196046	hsa-miR-4661-3p	CLIP-seq
MIRT1196047	hsa-miR-4735-3p	CLIP-seq
MIRT1196048	hsa-miR-4758-3p	CLIP-seq
MIRT1196049	hsa-miR-4782-5p	CLIP-seq
MIRT1196050	hsa-miR-517a	CLIP-seq
MIRT1196051	hsa-miR-517c	CLIP-seq
MIRT1196038	hsa-miR-3160-5p	CLIP-seq
MIRT1196034	hsa-miR-1202	CLIP-seq
MIRT2583416	hsa-miR-3150b-3p	CLIP-seq
MIRT2583417	hsa-miR-3173-3p	CLIP-seq
MIRT1196039	hsa-miR-3194-5p	CLIP-seq
MIRT1196040	hsa-miR-3667-5p	CLIP-seq
MIRT1196041	hsa-miR-3972	CLIP-seq
MIRT1196042	hsa-miR-4320	CLIP-seq
MIRT1196043	hsa-miR-4323	CLIP-seq
MIRT1196044	hsa-miR-4527	CLIP-seq
MIRT2583418	hsa-miR-4533	CLIP-seq
MIRT1196046	hsa-miR-4661-3p	CLIP-seq
MIRT2583419	hsa-miR-4689	CLIP-seq
MIRT2583420	hsa-miR-4695-5p	CLIP-seq
MIRT2583421	hsa-miR-4747-5p	CLIP-seq
MIRT1196048	hsa-miR-4758-3p	CLIP-seq
MIRT2583422	hsa-miR-4779	CLIP-seq
MIRT1196049	hsa-miR-4782-5p	CLIP-seq
MIRT2583423	hsa-miR-4784	CLIP-seq
MIRT1196050	hsa-miR-517a	CLIP-seq
MIRT1196051	hsa-miR-517c	CLIP-seq
MIRT2583416	hsa-miR-3150b-3p	CLIP-seq
MIRT2583417	hsa-miR-3173-3p	CLIP-seq
MIRT1196040	hsa-miR-3667-5p	CLIP-seq
MIRT1196042	hsa-miR-4320	CLIP-seq
MIRT2583418	hsa-miR-4533	CLIP-seq
MIRT1196046	hsa-miR-4661-3p	CLIP-seq
MIRT2583419	hsa-miR-4689	CLIP-seq
MIRT2583420	hsa-miR-4695-5p	CLIP-seq
MIRT2583421	hsa-miR-4747-5p	CLIP-seq
MIRT2583422	hsa-miR-4779	CLIP-seq
MIRT1196049	hsa-miR-4782-5p	CLIP-seq
MIRT2583423	hsa-miR-4784	CLIP-seq
MIRT1196050	hsa-miR-517a	CLIP-seq
MIRT1196051	hsa-miR-517c	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	21375249
GO:0007613	Process	Memory	IEA
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0008418	Function	Protein-N-terminal asparagine amidohydrolase activity	IBA
GO:0008418	Function	Protein-N-terminal asparagine amidohydrolase activity	IDA	21375249
GO:0008418	Function	Protein-N-terminal asparagine amidohydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA

Other IDs

• MIM: 615367
• HGNC: 29909
• e!Ensembl: ENSG00000157045

Protein

• UniProt ID: Q96AB6
• Protein name: Protein N-terminal asparagine amidohydrolase (EC 3.5.1.121) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein N-terminal asparagine amidase) (Protein NTN-am
• Protein function: N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the re
• PDB: 6A0E, 6A0F, 6A0H, 6A0I
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14736	N_Asn_amidohyd	36 → 304	Protein N-terminal asparagine amidohydrolase	Family

• Sequence:

  MPLLVEGRRVRLPQSAGDLVRAHPPLEERARLLRGQSVQQVGPQGLLYVQQRELAVTSPK
  DGSISILGSDDATTCHIVVLRHTGNGATCLTHCDGTDTKAEVPLIMNSIKSFSDHAQCGR
  LEVHLVGGFSDDRQLSQKLTHQLLSEFDRQEDDIHLVTLCVTELNDREENENHFPVIYGI
  AVNIKTAEIYRASFQDRGPEEQLRAARTLAGGPMISIYDAETEQLRIGPYSWTPFPHVDF
  WLHQDDKQILENLSTSPLAEPPHFVEHIRSTLMFLKKHPSPAHTLFSGNKALLYKKNEDG
  LWEKISSPGS

• Sequence length: 310