Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	123803
Gene name Gene Name - the full gene name approved by the HGNC.	N-terminal asparagine amidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NTAN1
Synonyms (NCBI Gene) Gene synonyms aliases	PNAA, PNAD
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p13.11
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp

Show/Hide all(54)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048539	hsa-miR-100-5p	CLASH	23622248
MIRT1196034	hsa-miR-1202	CLIP-seq
MIRT1196035	hsa-miR-18a	CLIP-seq
MIRT1196036	hsa-miR-18b	CLIP-seq
MIRT1196037	hsa-miR-1972	CLIP-seq
MIRT1196038	hsa-miR-3160-5p	CLIP-seq
MIRT1196039	hsa-miR-3194-5p	CLIP-seq
MIRT1196040	hsa-miR-3667-5p	CLIP-seq
MIRT1196041	hsa-miR-3972	CLIP-seq
MIRT1196042	hsa-miR-4320	CLIP-seq
MIRT1196043	hsa-miR-4323	CLIP-seq
MIRT1196044	hsa-miR-4527	CLIP-seq
MIRT1196045	hsa-miR-4650-5p	CLIP-seq
MIRT1196046	hsa-miR-4661-3p	CLIP-seq
MIRT1196047	hsa-miR-4735-3p	CLIP-seq
MIRT1196048	hsa-miR-4758-3p	CLIP-seq
MIRT1196049	hsa-miR-4782-5p	CLIP-seq
MIRT1196050	hsa-miR-517a	CLIP-seq
MIRT1196051	hsa-miR-517c	CLIP-seq
MIRT1196038	hsa-miR-3160-5p	CLIP-seq
MIRT1196034	hsa-miR-1202	CLIP-seq
MIRT2583416	hsa-miR-3150b-3p	CLIP-seq
MIRT2583417	hsa-miR-3173-3p	CLIP-seq
MIRT1196039	hsa-miR-3194-5p	CLIP-seq
MIRT1196040	hsa-miR-3667-5p	CLIP-seq
MIRT1196041	hsa-miR-3972	CLIP-seq
MIRT1196042	hsa-miR-4320	CLIP-seq
MIRT1196043	hsa-miR-4323	CLIP-seq
MIRT1196044	hsa-miR-4527	CLIP-seq
MIRT2583418	hsa-miR-4533	CLIP-seq
MIRT1196046	hsa-miR-4661-3p	CLIP-seq
MIRT2583419	hsa-miR-4689	CLIP-seq
MIRT2583420	hsa-miR-4695-5p	CLIP-seq
MIRT2583421	hsa-miR-4747-5p	CLIP-seq
MIRT1196048	hsa-miR-4758-3p	CLIP-seq
MIRT2583422	hsa-miR-4779	CLIP-seq
MIRT1196049	hsa-miR-4782-5p	CLIP-seq
MIRT2583423	hsa-miR-4784	CLIP-seq
MIRT1196050	hsa-miR-517a	CLIP-seq
MIRT1196051	hsa-miR-517c	CLIP-seq
MIRT2583416	hsa-miR-3150b-3p	CLIP-seq
MIRT2583417	hsa-miR-3173-3p	CLIP-seq
MIRT1196040	hsa-miR-3667-5p	CLIP-seq
MIRT1196042	hsa-miR-4320	CLIP-seq
MIRT2583418	hsa-miR-4533	CLIP-seq
MIRT1196046	hsa-miR-4661-3p	CLIP-seq
MIRT2583419	hsa-miR-4689	CLIP-seq
MIRT2583420	hsa-miR-4695-5p	CLIP-seq
MIRT2583421	hsa-miR-4747-5p	CLIP-seq
MIRT2583422	hsa-miR-4779	CLIP-seq
MIRT1196049	hsa-miR-4782-5p	CLIP-seq
MIRT2583423	hsa-miR-4784	CLIP-seq
MIRT1196050	hsa-miR-517a	CLIP-seq
MIRT1196051	hsa-miR-517c	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	21375249
GO:0007613	Process	Memory	IEA
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0008418	Function	Protein-N-terminal asparagine amidohydrolase activity	IBA
GO:0008418	Function	Protein-N-terminal asparagine amidohydrolase activity	IDA	21375249
GO:0008418	Function	Protein-N-terminal asparagine amidohydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA

MIM	HGNC	e!Ensembl
615367	29909	ENSG00000157045

Protein

UniProt ID

Q96AB6

Protein name

Protein N-terminal asparagine amidohydrolase (EC 3.5.1.121) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein N-terminal asparagine amidase) (Protein NTN-am

Protein function

N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the re

PDB

6A0E , 6A0F , 6A0H , 6A0I

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14736	N_Asn_amidohyd	36 → 304	Protein N-terminal asparagine amidohydrolase	Family

Sequence

MPLLVEGRRVRLPQSAGDLVRAHPPLEERARLLRGQSVQQVGPQGLLYVQQRELAVTSPK
DGSISILGSDDATTCHIVVLRHTGNGATCLTHCDGTDTKAEVPLIMNSIKSFSDHAQCGR
LEVHLVGGFSDDRQLSQKLTHQLLSEFDRQEDDIHLVTLCVTELNDREENENHFPVIYGI
AVNIKTAEIYRASFQDRGPEEQLRAARTLAGGPMISIYDAETEQLRIGPYSWTPFPHVDF
WLHQDDKQILENLSTSPLAEPPHFVEHIRSTLMFLKKHPSPAHTLFSGNKALLYKKNEDG
LWEKISSPGS

Sequence length

310

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Insomnia	Insomnia	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Dyslexia	Associate	19786961
Inflammatory Bowel Diseases	Associate	8119529
Neoplasms	Associate	32577795
von Willebrand Disease Type 2	Associate	32577795

NTAN1 (N-terminal asparagine amidase)