Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
123720
Gene name Gene Name - the full gene name approved by the HGNC.
WASP homolog associated with actin, golgi membranes and microtubules
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WHAMM
Synonyms (NCBI Gene) Gene synonyms aliases
WHAMM1, WHDC1
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q25.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiat
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT048656 hsa-miR-99a-5p CLASH 23622248
MIRT639649 hsa-miR-3124-3p HITS-CLIP 23824327
MIRT639648 hsa-miR-6883-3p HITS-CLIP 23824327
MIRT639647 hsa-miR-4755-5p HITS-CLIP 23824327
MIRT639646 hsa-miR-5006-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 18614018
GO:0003779 Function Actin binding IEA
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol IDA
GO:0005874 Component Microtubule IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612393 30493 ENSG00000156232
Protein
UniProt ID Q8TF30
Protein name WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)
Protein function Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Pro
PDB 5X1G
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15920 WHAMM-JMY_N 5 54 N-terminal of Junction-mediating and WASP homolog-associated Family
PF15871 JMY 78 442 Junction-mediating and -regulatory protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, lung, heart, colon and kidney (at protein level).
Sequence
MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR
LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW
GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE
SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ
YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV
NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH
KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR
LIKEKQDEVVYYDPCENPEELK
VIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA
SLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQ
RLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSE
AGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLR
ALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHG
RAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERS
IKAALQRIKRVSADSEEDSDEQDPGQWDG
Sequence length 809
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Tight junction  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Chronic Periodontitis Associate 25056994, 30760334, 36360171
Galloway Mowat syndrome Associate 28720660
Periodontitis Associate 25056994