CCR8 (C-C motif chemokine receptor 8)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1237
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine receptor 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCR8
Synonyms (NCBI Gene) Gene synonyms aliases
CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT1959112 hsa-miR-421 CLIP-seq
MIRT2677610 hsa-miR-129-5p CLIP-seq
MIRT2677611 hsa-miR-205 CLIP-seq
MIRT2677612 hsa-miR-3978 CLIP-seq
MIRT2677613 hsa-miR-4539 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0004950 Function Chemokine receptor activity TAS 9417093
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 8816377
GO:0006935 Process Chemotaxis TAS 10910894
GO:0006955 Process Immune response IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601834 1609 ENSG00000179934
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P51685
Protein name C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198)
Protein function Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:9207005, ECO:0000269|PubMed:94694
PDB 8KFX , 8KFY , 8KFZ , 8TLM , 8U1U , 8XML
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 52 → 300 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 355
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Viral carcinogenesis 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Hypothyroidism Hypothyroidism GWAS
Show/Hide Text Mining Associations (42)
Associations from Text Mining
Disease Name Relationship Type References
Asthma Stimulate 20455898
Breast Neoplasms Associate 27851913, 39273290
Carcinoma Hepatocellular Associate 26813566, 36938723
Carcinoma Non Small Cell Lung Associate 32884223
Carcinoma Renal Cell Stimulate 23363815
Carcinoma Renal Cell Associate 26716905
Central Nervous System Diseases Associate 12547701
Cholangiocarcinoma Associate 33045415
Colorectal Neoplasms Associate 32884223, 33034614
Demyelinating Diseases Associate 12547701