Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	1235
Gene name	C-C motif chemokine receptor 6
Gene symbol	CCR6
Synonyms (NCBI Gene)	BN-1C-C CKR-6CC-CKR-6CCR-6CD196CKR-L3CKRL3CMKBR6DCR2DRY6GPR29GPRCY4STRL22
Chromosome	6
Chromosome location	6q27
Summary	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligan

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029835	hsa-miR-26b-5p	Microarray	19088304
MIRT054540	hsa-miR-518a-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCR	24559209
MIRT054540	hsa-miR-518a-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCR	24559209
MIRT054540	hsa-miR-518a-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCR	24559209
MIRT054540	hsa-miR-518a-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCR	24559209
MIRT438120	hsa-miR-150-5p	ELISAImmunohistochemistryLuciferase reporter assayNorthern blotqRT-PCRWestern blot	24385540
MIRT438120	hsa-miR-150-5p	ELISAImmunohistochemistryLuciferase reporter assayNorthern blotqRT-PCRWestern blot	24385540
MIRT438120	hsa-miR-150-5p	ELISAImmunohistochemistryLuciferase reporter assayNorthern blotqRT-PCRWestern blot	24385540
MIRT438120	hsa-miR-150-5p	ELISAImmunohistochemistryLuciferase reporter assayNorthern blotqRT-PCRWestern blot	24385540
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT675084	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT675083	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT675082	hsa-miR-4770	HITS-CLIP	23824327
MIRT675081	hsa-miR-6088	HITS-CLIP	23824327
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT675079	hsa-miR-1273f	HITS-CLIP	23824327
MIRT675078	hsa-miR-4534	HITS-CLIP	23824327
MIRT675077	hsa-miR-8082	HITS-CLIP	23824327
MIRT675076	hsa-miR-1289	HITS-CLIP	23824327
MIRT675075	hsa-miR-4294	HITS-CLIP	23824327
MIRT675074	hsa-miR-3198	HITS-CLIP	23824327
MIRT675073	hsa-miR-4309	HITS-CLIP	23824327
MIRT675072	hsa-miR-8055	HITS-CLIP	23824327
MIRT675071	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT663559	hsa-miR-1245a	HITS-CLIP	23824327
MIRT663560	hsa-miR-8079	HITS-CLIP	23824327
MIRT663558	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT663557	hsa-miR-640	HITS-CLIP	23824327
MIRT663556	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT663555	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT663554	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT663552	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT663553	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT663551	hsa-miR-3666	HITS-CLIP	23824327
MIRT663550	hsa-miR-4295	HITS-CLIP	23824327
MIRT663549	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT663548	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT663547	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT663546	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT663545	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT663544	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663543	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663542	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663541	hsa-miR-564	HITS-CLIP	23824327
MIRT663540	hsa-miR-3652	HITS-CLIP	23824327
MIRT663539	hsa-miR-4430	HITS-CLIP	23824327
MIRT663538	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT663537	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT497572	hsa-miR-4539	PAR-CLIP	22291592
MIRT497571	hsa-miR-4635	PAR-CLIP	22291592
MIRT497570	hsa-miR-3928-5p	PAR-CLIP	22291592
MIRT497569	hsa-miR-6806-3p	PAR-CLIP	22291592
MIRT497568	hsa-miR-4749-3p	PAR-CLIP	22291592
MIRT497567	hsa-miR-7843-3p	PAR-CLIP	22291592
MIRT497566	hsa-miR-127-5p	PAR-CLIP	22291592
MIRT731937	hsa-miR-150-3p	Western blot	27935859
MIRT731937	hsa-miR-150-3p	Western blot	27935859
MIRT675079	hsa-miR-1273f	HITS-CLIP	27418678
MIRT675079	hsa-miR-1273f	HITS-CLIP	27418678
MIRT675076	hsa-miR-1289	HITS-CLIP	27418678
MIRT675076	hsa-miR-1289	HITS-CLIP	27418678
MIRT675071	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT675071	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT675083	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT675083	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT675074	hsa-miR-3198	HITS-CLIP	27418678
MIRT675074	hsa-miR-3198	HITS-CLIP	27418678
MIRT675075	hsa-miR-4294	HITS-CLIP	27418678
MIRT675075	hsa-miR-4294	HITS-CLIP	27418678
MIRT675073	hsa-miR-4309	HITS-CLIP	27418678
MIRT675073	hsa-miR-4309	HITS-CLIP	27418678
MIRT675078	hsa-miR-4534	HITS-CLIP	27418678
MIRT675078	hsa-miR-4534	HITS-CLIP	27418678
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT675082	hsa-miR-4770	HITS-CLIP	27418678
MIRT675082	hsa-miR-4770	HITS-CLIP	27418678
MIRT675081	hsa-miR-6088	HITS-CLIP	27418678
MIRT675081	hsa-miR-6088	HITS-CLIP	27418678
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	27418678
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	27418678
MIRT663538	hsa-miR-6879-3p	HITS-CLIP	27418678
MIRT675072	hsa-miR-8055	HITS-CLIP	27418678
MIRT675072	hsa-miR-8055	HITS-CLIP	27418678
MIRT675077	hsa-miR-8082	HITS-CLIP	27418678
MIRT675077	hsa-miR-8082	HITS-CLIP	27418678
MIRT735791	hsa-miR-518a-5p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCRFlow cytometry	32600091
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT675084	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT675083	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT675082	hsa-miR-4770	HITS-CLIP	23824327
MIRT675081	hsa-miR-6088	HITS-CLIP	23824327
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT675079	hsa-miR-1273f	HITS-CLIP	23824327
MIRT675078	hsa-miR-4534	HITS-CLIP	23824327
MIRT675077	hsa-miR-8082	HITS-CLIP	23824327
MIRT675076	hsa-miR-1289	HITS-CLIP	23824327
MIRT675075	hsa-miR-4294	HITS-CLIP	23824327
MIRT675074	hsa-miR-3198	HITS-CLIP	23824327
MIRT675073	hsa-miR-4309	HITS-CLIP	23824327
MIRT675072	hsa-miR-8055	HITS-CLIP	23824327
MIRT675071	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT663559	hsa-miR-1245a	HITS-CLIP	23824327
MIRT663560	hsa-miR-8079	HITS-CLIP	23824327
MIRT663558	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT663557	hsa-miR-640	HITS-CLIP	23824327
MIRT663556	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT663555	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT663554	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT663552	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT663553	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT663551	hsa-miR-3666	HITS-CLIP	23824327
MIRT663550	hsa-miR-4295	HITS-CLIP	23824327
MIRT663549	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT663548	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT663547	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT663546	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT663545	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT663544	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663543	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663542	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663541	hsa-miR-564	HITS-CLIP	23824327
MIRT663540	hsa-miR-3652	HITS-CLIP	23824327
MIRT663539	hsa-miR-4430	HITS-CLIP	23824327
MIRT663538	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT663537	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT497572	hsa-miR-4539	PAR-CLIP	22291592
MIRT497571	hsa-miR-4635	PAR-CLIP	22291592
MIRT497570	hsa-miR-3928-5p	PAR-CLIP	22291592
MIRT497569	hsa-miR-6806-3p	PAR-CLIP	22291592
MIRT497568	hsa-miR-4749-3p	PAR-CLIP	22291592
MIRT497567	hsa-miR-7843-3p	PAR-CLIP	22291592
MIRT497566	hsa-miR-127-5p	PAR-CLIP	22291592
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873251	hsa-miR-1245	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT873258	hsa-miR-3149	CLIP-seq
MIRT873259	hsa-miR-371-5p	CLIP-seq
MIRT873260	hsa-miR-371b-5p	CLIP-seq
MIRT873261	hsa-miR-411	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT873263	hsa-miR-4729	CLIP-seq
MIRT873264	hsa-miR-548l	CLIP-seq
MIRT873265	hsa-miR-548n	CLIP-seq
MIRT873266	hsa-miR-720	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT873267	hsa-miR-150	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT873268	hsa-miR-3128	CLIP-seq
MIRT873269	hsa-miR-4258	CLIP-seq
MIRT873270	hsa-miR-4269	CLIP-seq
MIRT873271	hsa-miR-4438	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT873272	hsa-miR-5095	CLIP-seq
MIRT873273	hsa-miR-562	CLIP-seq
MIRT1959103	hsa-miR-3187-3p	CLIP-seq
MIRT1959104	hsa-miR-4435	CLIP-seq
MIRT1959105	hsa-miR-4701-5p	CLIP-seq
MIRT1959106	hsa-miR-4755-3p	CLIP-seq
MIRT1959107	hsa-miR-548s	CLIP-seq
MIRT1959108	hsa-miR-588	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873267	hsa-miR-150	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT2196035	hsa-miR-3152-5p	CLIP-seq
MIRT2196036	hsa-miR-377	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT2196037	hsa-miR-4641	CLIP-seq
MIRT2196038	hsa-miR-4690-3p	CLIP-seq
MIRT2196039	hsa-miR-4709-3p	CLIP-seq
MIRT2196040	hsa-miR-4731-5p	CLIP-seq
MIRT2196041	hsa-miR-4753-3p	CLIP-seq
MIRT2196042	hsa-miR-4772-3p	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT2446537	hsa-miR-143	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT873266	hsa-miR-720	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT2196035	hsa-miR-3152-5p	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT2196041	hsa-miR-4753-3p	CLIP-seq
MIRT2196042	hsa-miR-4772-3p	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873267	hsa-miR-150	CLIP-seq
MIRT2196035	hsa-miR-3152-5p	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873271	hsa-miR-4438	CLIP-seq
MIRT2196041	hsa-miR-4753-3p	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873272	hsa-miR-5095	CLIP-seq
MIRT873273	hsa-miR-562	CLIP-seq

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Transcription factor	Regulation	Reference
NR3C2	Activation	11751947

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002407	Process	Dendritic cell chemotaxis	TAS	16621978
GO:0002523	Process	Leukocyte migration involved in inflammatory response	IEA
GO:0002523	Process	Leukocyte migration involved in inflammatory response	ISS
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	11001880
GO:0005515	Function	Protein binding	IPI	20068036, 25122636
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9186513
GO:0006935	Process	Chemotaxis	IDA	20068036
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	IMP	12081481
GO:0006935	Process	Chemotaxis	TAS	11001880
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	TAS	9223454
GO:0006959	Process	Humoral immune response	TAS	11001880
GO:0006968	Process	Cellular defense response	TAS	10521347
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	9186513
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	TAS	9223454
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IDA	12081481
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA
GO:0016493	Function	C-C chemokine receptor activity	IDA	20068036
GO:0016493	Function	C-C chemokine receptor activity	IEA
GO:0016493	Function	C-C chemokine receptor activity	IMP	12081481
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019722	Process	Calcium-mediated signaling	IMP	12081481
GO:0019957	Function	C-C chemokine binding	IBA
GO:0019957	Function	C-C chemokine binding	IDA	20068036
GO:0019957	Function	C-C chemokine binding	IEA
GO:0019957	Function	C-C chemokine binding	IMP	12081481
GO:0036126	Component	Sperm flagellum	IDA	23765988
GO:0036126	Component	Sperm flagellum	IEA
GO:0038023	Function	Signaling receptor activity	TAS	9186513
GO:0048290	Process	Isotype switching to IgA isotypes	IEA
GO:0048290	Process	Isotype switching to IgA isotypes	ISS
GO:0060326	Process	Cell chemotaxis	IBA
GO:0060326	Process	Cell chemotaxis	IDA	23765988
GO:0060474	Process	Positive regulation of flagellated sperm motility involved in capacitation	IDA	23765988
GO:0060474	Process	Positive regulation of flagellated sperm motility involved in capacitation	IEA
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0072676	Process	Lymphocyte migration	IEA
GO:0072676	Process	Lymphocyte migration	ISS
GO:0072678	Process	T cell migration	IEA
GO:0072678	Process	T cell migration	ISS
GO:0072679	Process	Thymocyte migration	IBA
GO:0072679	Process	Thymocyte migration	IEA
GO:0072679	Process	Thymocyte migration	ISS
GO:0097225	Component	Sperm midpiece	IDA	23765988
GO:0097228	Component	Sperm principal piece	IDA	23765988
GO:0097228	Component	Sperm principal piece	IEA
GO:0097524	Component	Sperm plasma membrane	IDA	23765988
GO:0097524	Component	Sperm plasma membrane	IEA
GO:1904155	Process	DN2 thymocyte differentiation	IEA
GO:1904155	Process	DN2 thymocyte differentiation	ISS
GO:1904156	Process	DN3 thymocyte differentiation	IEA
GO:1904156	Process	DN3 thymocyte differentiation	ISS
GO:2000404	Process	Regulation of T cell migration	IEA
GO:2000404	Process	Regulation of T cell migration	ISS
GO:2000510	Process	Positive regulation of dendritic cell chemotaxis	IBA

MIM	HGNC	e!Ensembl
601835	1607	ENSG00000112486

P51684

Protein name

C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196)

Protein function

Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a recepto

PDB

6WWZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	63 → 316	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia p

Sequence

MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFG
LLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKL
LKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISS
STFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKT
LVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTV
TEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQT
SETADNDNASSFTM

Sequence length

374

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events

CCR6 (C-C motif chemokine receptor 6)