Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1234
Gene name Gene Name - the full gene name approved by the HGNC.	C-C motif chemokine receptor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CCR5
Synonyms (NCBI Gene) Gene synonyms aliases	CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-recep

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miRTarBase ID	miRNA	Experiments	Reference
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620770	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620770	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873225	hsa-miR-345	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873229	hsa-miR-451b	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873232	hsa-miR-4696	CLIP-seq
MIRT873233	hsa-miR-4714-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873236	hsa-miR-1279	CLIP-seq
MIRT873237	hsa-miR-2113	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873238	hsa-miR-3929	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873239	hsa-miR-4251	CLIP-seq
MIRT873240	hsa-miR-4257	CLIP-seq
MIRT873241	hsa-miR-4265	CLIP-seq
MIRT873242	hsa-miR-4296	CLIP-seq
MIRT873243	hsa-miR-4322	CLIP-seq
MIRT873244	hsa-miR-4419b	CLIP-seq
MIRT873245	hsa-miR-4478	CLIP-seq
MIRT873246	hsa-miR-4490	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873248	hsa-miR-539	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873249	hsa-miR-629	CLIP-seq
MIRT1959090	hsa-miR-1321	CLIP-seq
MIRT1959091	hsa-miR-185	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT1959092	hsa-miR-4306	CLIP-seq
MIRT1959093	hsa-miR-4419a	CLIP-seq
MIRT1959094	hsa-miR-4510	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT1959095	hsa-miR-4644	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT1959096	hsa-miR-4728-5p	CLIP-seq
MIRT1959097	hsa-miR-4739	CLIP-seq
MIRT1959098	hsa-miR-4756-5p	CLIP-seq
MIRT1959099	hsa-miR-511	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT1959100	hsa-miR-579	CLIP-seq
MIRT1959101	hsa-miR-607	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT1959102	hsa-miR-664	CLIP-seq
MIRT2196029	hsa-miR-150	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873225	hsa-miR-345	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT2196030	hsa-miR-376a	CLIP-seq
MIRT2196031	hsa-miR-376b	CLIP-seq
MIRT873238	hsa-miR-3929	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873239	hsa-miR-4251	CLIP-seq
MIRT2196032	hsa-miR-4277	CLIP-seq
MIRT873244	hsa-miR-4419b	CLIP-seq
MIRT873245	hsa-miR-4478	CLIP-seq
MIRT2196033	hsa-miR-4522	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT2196034	hsa-miR-498	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873248	hsa-miR-539	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT2385724	hsa-miR-3921	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT2385725	hsa-miR-4653-5p	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
KLF2	Activation	22988032
NFKB1	Unknown	12745546;19469019;9840284
NR3C2	Activation	11751947
RELA	Unknown	12745546;19469019;9840284
YY1	Repression	12571248;15737629

Show/Hide all(64)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEP	12032188
GO:0001618	Function	Virus receptor activity	IEA
GO:0001618	Function	Virus receptor activity	TAS	10228019
GO:0002407	Process	Dendritic cell chemotaxis	TAS	16621978
GO:0003779	Function	Actin binding	IDA	12421915
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS	8663314
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	10201901
GO:0005515	Function	Protein binding	IPI	10816381, 12421915, 15001559, 15660419, 18230715, 18632580, 23235831, 23480650, 23597562, 24405750, 28381538, 30542158, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	TAS	10415069
GO:0005768	Component	Endosome	IDA	10679098
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10201901, 10393923
GO:0006816	Process	Calcium ion transport	IDA	8699119
GO:0006915	Process	Apoptotic process	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	10741397
GO:0006952	Process	Defense response	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	8639485
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	TAS	8639485
GO:0006968	Process	Cellular defense response	TAS	10201901
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	8639485
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IMP	19523456
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10393923
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	TAS	10201901
GO:0007267	Process	Cell-cell signaling	IDA	10679098
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IDA	10383387, 10679098, 11278962, 19523456
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IDA	29739880
GO:0009986	Component	Cell surface	IDA	10521508
GO:0009986	Component	Cell surface	IEA
GO:0014808	Process	Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	19523456
GO:0015026	Function	Coreceptor activity	TAS	10469138
GO:0016020	Component	Membrane	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA
GO:0016493	Function	C-C chemokine receptor activity	IDA	8639485, 10383387, 11278962
GO:0016493	Function	C-C chemokine receptor activity	IEA
GO:0016493	Function	C-C chemokine receptor activity	NAS	8639485
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019722	Process	Calcium-mediated signaling	IDA	10679098, 19523456
GO:0019957	Function	C-C chemokine binding	IEA
GO:0019957	Function	C-C chemokine binding	IPI	8699119, 10383387, 10679098
GO:0023052	Process	Signaling	IEP	12032188
GO:0042802	Function	Identical protein binding	IPI	18230715, 18632580, 23121557
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0060326	Process	Cell chemotaxis	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0070723	Process	Response to cholesterol	IMP	19523456
GO:0071222	Process	Cellular response to lipopolysaccharide	IEP	10679098
GO:0071345	Process	Cellular response to cytokine stimulus	IEA
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IBA
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IPI	8699119
GO:2000110	Process	Negative regulation of macrophage apoptotic process	IEA

MIM	HGNC	e!Ensembl
601373	1606	ENSG00000160791

Protein

UniProt ID

P51681

Protein name

C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)

Protein function

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lin

PDB

2L87 , 2MZX , 2RLL , 2RRS , 4MBS , 5UIW , 5YD3 , 5YD4 , 5YD5 , 5YY4 , 6FGP , 6MEO , 6MET , 7F1Q , 7F1R , 7F1S , 7NJZ , 7NW3 , 7O7F , 8AS2 , 8AS3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	47 → 297	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.

Sequence

MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Sequence length

352

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Endocytosis Toxoplasmosis Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Viral carcinogenesis		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling

CCR5 (C-C motif chemokine receptor 5)