Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1234
Gene name Gene Name - the full gene name approved by the HGNC.	C-C motif chemokine receptor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CCR5
Synonyms (NCBI Gene) Gene synonyms aliases	CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-recep

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miRTarBase ID	miRNA	Experiments	Reference
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620770	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620770	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873225	hsa-miR-345	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873229	hsa-miR-451b	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873232	hsa-miR-4696	CLIP-seq
MIRT873233	hsa-miR-4714-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873236	hsa-miR-1279	CLIP-seq
MIRT873237	hsa-miR-2113	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873238	hsa-miR-3929	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873239	hsa-miR-4251	CLIP-seq
MIRT873240	hsa-miR-4257	CLIP-seq
MIRT873241	hsa-miR-4265	CLIP-seq
MIRT873242	hsa-miR-4296	CLIP-seq
MIRT873243	hsa-miR-4322	CLIP-seq
MIRT873244	hsa-miR-4419b	CLIP-seq
MIRT873245	hsa-miR-4478	CLIP-seq
MIRT873246	hsa-miR-4490	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873248	hsa-miR-539	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873249	hsa-miR-629	CLIP-seq
MIRT1959090	hsa-miR-1321	CLIP-seq
MIRT1959091	hsa-miR-185	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT1959092	hsa-miR-4306	CLIP-seq
MIRT1959093	hsa-miR-4419a	CLIP-seq
MIRT1959094	hsa-miR-4510	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT1959095	hsa-miR-4644	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT1959096	hsa-miR-4728-5p	CLIP-seq
MIRT1959097	hsa-miR-4739	CLIP-seq
MIRT1959098	hsa-miR-4756-5p	CLIP-seq
MIRT1959099	hsa-miR-511	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT1959100	hsa-miR-579	CLIP-seq
MIRT1959101	hsa-miR-607	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT1959102	hsa-miR-664	CLIP-seq
MIRT2196029	hsa-miR-150	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873225	hsa-miR-345	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT2196030	hsa-miR-376a	CLIP-seq
MIRT2196031	hsa-miR-376b	CLIP-seq
MIRT873238	hsa-miR-3929	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873239	hsa-miR-4251	CLIP-seq
MIRT2196032	hsa-miR-4277	CLIP-seq
MIRT873244	hsa-miR-4419b	CLIP-seq
MIRT873245	hsa-miR-4478	CLIP-seq
MIRT2196033	hsa-miR-4522	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT2196034	hsa-miR-498	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873248	hsa-miR-539	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT2385724	hsa-miR-3921	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT2385725	hsa-miR-4653-5p	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
KLF2	Activation	22988032
NFKB1	Unknown	12745546;19469019;9840284
NR3C2	Activation	11751947
RELA	Unknown	12745546;19469019;9840284
YY1	Repression	12571248;15737629

Show/Hide all(43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEP	12032188
GO:0001618	Function	Virus receptor activity	IEA
GO:0002407	Process	Dendritic cell chemotaxis	TAS	16621978
GO:0003779	Function	Actin binding	IDA	12421915
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	TAS	8663314
GO:0004950	Function	Chemokine receptor activity	TAS	10201901
GO:0005515	Function	Protein binding	IPI	10816381, 12421915, 15001559, 15660419, 18230715, 18632580, 23235831, 23480650, 23597562, 24405750, 28381538, 30542158, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005768	Component	Endosome	IDA	10679098
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	10393923
GO:0006816	Process	Calcium ion transport	IDA	8699119
GO:0006935	Process	Chemotaxis	TAS	10741397
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006955	Process	Immune response	IBA	21873635
GO:0006968	Process	Cellular defense response	TAS	10201901
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	8639485
GO:0007186	Process	G protein-coupled receptor signaling pathway	IMP	19523456
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007267	Process	Cell-cell signaling	IDA	10679098
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009897	Component	External side of plasma membrane	IDA	10383387, 10679098, 11278962, 19523456
GO:0009986	Component	Cell surface	IDA	10521508
GO:0014808	Process	Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	19523456
GO:0015026	Function	Coreceptor activity	TAS	10469138
GO:0016493	Function	C-C chemokine receptor activity	IBA	21873635
GO:0016493	Function	C-C chemokine receptor activity	IDA	10383387, 11278962
GO:0016493	Function	C-C chemokine receptor activity	NAS	8639485
GO:0019064	Process	Fusion of virus membrane with host plasma membrane	TAS
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019722	Process	Calcium-mediated signaling	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IDA	10679098, 19523456
GO:0019957	Function	C-C chemokine binding	IBA	21873635
GO:0019957	Function	C-C chemokine binding	IPI	8699119, 10383387, 10679098
GO:0023052	Process	Signaling	IEP	12032188
GO:0042802	Function	Identical protein binding	IPI	18230715, 18632580, 23121557
GO:0060326	Process	Cell chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0070723	Process	Response to cholesterol	IMP	19523456
GO:0071222	Process	Cellular response to lipopolysaccharide	IEP	10679098
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IBA	21873635
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IPI	8699119

MIM	HGNC	e!Ensembl
601373	1606	ENSG00000160791

Protein

UniProt ID

P51681

Protein name

C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)

Protein function

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lin

PDB

2L87 , 2MZX , 2RLL , 2RRS , 4MBS , 5UIW , 5YD3 , 5YD4 , 5YD5 , 5YY4 , 6FGP , 6MEO , 6MET , 7F1Q , 7F1R , 7F1S , 7NJZ , 7NW3 , 7O7F , 8AS2 , 8AS3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	47 → 297	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.

Sequence

MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Sequence length

352

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Endocytosis Toxoplasmosis Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Viral carcinogenesis		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Dermatitis	Dermatitis, Atopic	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	18249437
Diabetes mellitus	DIABETES MELLITUS, INSULIN-DEPENDENT, 22 (disorder)	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	16513874

Show/Hide Text Mining Associations (306)

Disease Name	Relationship Type	References
Associations from Text Mining
Achalasia Addisonianism Alacrimia syndrome	Associate	15557916
Acquired Immunodeficiency Syndrome	Associate	10068655, 10575146, 11091193, 11604406, 11752157, 12010355, 14499246, 15916792, 16100775, 17239419, 17461848, 17786209, 18371209, 18391751, 18510766 View all (27 more)
Acute Kidney Injury	Associate	14742268
Adenocarcinoma	Associate	32509861
Adenocarcinoma of Lung	Associate	17653092, 32549766
AIDS Associated Nephropathy	Associate	21592988, 22102307, 29376550, 37418541
AIDS Dementia Complex	Associate	10575135, 11162807, 22347417
Air crescent sign	Associate	10469367
Alzheimer Disease	Associate	15743889, 9665462
Anal Gland Neoplasms	Associate	19679608
Anemia Sickle Cell	Associate	25548430, 28671257, 32267841
Anodontia	Associate	36675305
Aortic Aneurysm Abdominal	Associate	15557916
Arterial Occlusive Diseases	Associate	15557916, 19874552
Arthritis	Associate	10323454, 16107514, 29880013
Arthritis Juvenile	Associate	10765921, 16775617, 17374135, 21739422
Arthritis Rheumatoid	Associate	10323455, 11352233, 11762935, 12699431, 15140775, 15331395, 16775617, 16838043, 19538721, 19740335, 19804625, 22479344, 22665517, 28866647, 30091955, 36311761 View all (1 more)
Arthritis Rheumatoid	Stimulate	15361394
Ascites	Associate	17926037
Asthma	Associate	12612298, 19223978, 19520154, 20220260, 23760409, 35751199
Ataxia Telangiectasia	Associate	30554073
Atherosclerosis	Associate	18511806, 19874552, 27177313, 30778913
Atrophy	Inhibit	14704722
Autoimmune Diseases	Associate	18511806, 25180533, 28086002, 29182645
Behcet Syndrome	Associate	15196263, 15654837, 22966075, 24984193
Belonephobia	Associate	10928621
Berylliosis	Associate	20075058
beta Thalassemia	Associate	27526959
Biliary Tract Diseases	Associate	15004773
Bipolar Disorder	Associate	25487697
Blood Platelet Disorders	Stimulate	30029921
Brain Diseases	Associate	12244149
Brain Ischemia	Associate	15004773
Breast Neoplasms	Associate	14597737, 16518599, 22380870, 23078970, 23543442, 25171476, 33245226, 33671956, 34907035, 35120331, 35606863, 37222841, 40395152
Burns	Associate	36522768
Calcinosis Cutis	Associate	17909797, 30411783, 33893084
Carcinogenesis	Associate	31011147, 39549571
Carcinoma Adenoid Cystic	Associate	29549020
Carcinoma Hepatocellular	Inhibit	15180734
Carcinoma Hepatocellular	Associate	32170378, 32730361, 38552222
Carcinoma Ovarian Epithelial	Associate	17926037
Carcinoma Pancreatic Ductal	Associate	31432181, 40269781
Carcinoma Renal Cell	Associate	16863511
Cardiomyopathies	Associate	30180856
Cardiovascular Diseases	Associate	19389855, 21846359, 36035865
Carotid Stenosis	Associate	15557916, 18060801
Cartilage Diseases	Stimulate	11465714
CD59 Deficiency	Associate	26028088, 31522438
Central Nervous System Diseases	Associate	15194768
Cerebral Infarction	Associate	22769019
Cerebrovascular Disorders	Associate	19874552
Chagas Cardiomyopathy	Associate	23150742, 29160519, 30650073
Chagas Disease	Associate	26599761, 30650073
Chlamydia Infections	Associate	29287991
Cholangiocarcinoma	Associate	33045415
Chondrosarcoma	Associate	24047437
Chronic Kidney Diseases of Uncertain Etiology	Associate	19265171
Ciliary Motility Disorders	Associate	29116124
Coinfection	Associate	36443691
Colitis Ulcerative	Associate	31356607
Colorectal Neoplasms	Associate	25671296, 29606345, 30411783, 30554073, 33893084, 38212126
Common Variable Immunodeficiency	Associate	26684629, 29083052
Communicable Diseases	Associate	17177831, 29221851
Congenital thrombotic disease due to Protein C deficiency	Associate	18989363
Conjunctivitis Allergic	Associate	11673306
Coronary Artery Disease	Associate	12742282, 20628649, 39512689, 39600283
Coronary Artery Disease	Inhibit	24118494
Coronary Disease	Associate	27013693
COVID 19	Associate	32497778, 33728925, 34065289, 34116286, 34262570, 34322810, 34530915, 34913355, 35371005, 36506032, 36702907
Crohn Disease	Inhibit	12699425
Crohn Disease	Associate	19679608, 28273887
Cryptosporidiosis	Associate	12010355
Cytomegalovirus Infections	Associate	14645006, 24312168, 28501927
Death	Associate	11398114, 17461848, 17653092, 21091093, 21739027, 21789236, 30180856, 34913355, 37231494
Dementia	Associate	9971818
Demyelinating Autoimmune Diseases CNS	Associate	10079101
Demyelinating Diseases	Associate	11696431
Depressive Disorder	Associate	34291627
Depressive Disorder Major	Associate	32917850
Dermatitis Atopic 3	Associate	23454776
Diabetes Mellitus	Inhibit	18803760, 30184318
Diabetes Mellitus	Associate	28454543, 37773841
Diabetes Mellitus Type 1	Associate	12688247, 35638288
Diabetes Mellitus Type 1	Inhibit	32880687
Diabetes Mellitus Type 2	Associate	17428349, 30884193, 35936218, 36674502, 39600283
Diabetic Nephropathies	Associate	19357773
Diabetic Nephropathies	Stimulate	24786705
Down Syndrome	Associate	25222269
Drug Related Side Effects and Adverse Reactions	Associate	27965453, 37075611
Dry Eye Syndromes	Associate	36522768
Embolic Stroke	Associate	19874552
Encephalitis Tick Borne	Associate	25226020, 26906062
Encephalomyelitis	Associate	38457490
Endometrial Neoplasms	Associate	36675305
Endotoxemia	Associate	11023494
Enterovirus Infections	Associate	30180856
Epilepsies Partial	Associate	26599761
Erdheim Chester Disease	Associate	17133532
Esophageal Squamous Cell Carcinoma	Associate	32457351
Eye Burns	Associate	36522768
Familial Primary Pulmonary Hypertension	Associate	32159364
Fibrosis	Associate	20548789, 34696504
Fibrous Dysplasia Polyostotic	Associate	34440736
Flavivirus Infections	Associate	26906062
Focal Cortical Dysplasia	Stimulate	29162878
Gait Ataxia	Associate	36380716
Gallbladder Neoplasms	Associate	18405329
Gallstones	Associate	18405329
Geographic Atrophy	Associate	32324857, 38165703
Glioblastoma	Associate	32545571, 35464424
Glioma	Associate	17066899, 17849315, 31649684
Glomerulonephritis	Associate	10469367, 11012889
Glomerulonephritis IGA	Associate	15610230
Graft vs Host Disease	Stimulate	15812393
Graft vs Host Disease	Associate	18814951, 20025985, 29061535, 31442594, 38457490
Granuloma	Associate	26684629
Granulomatosis with Polyangiitis	Stimulate	12716450
Granulomatosis with Polyangiitis	Associate	22490506, 27624647
Graves Disease	Associate	11966764
Hand Foot Syndrome	Associate	29606345
Hashimoto Disease	Associate	27872865, 35720300
Head and Neck Neoplasms	Associate	18386165
Heart Failure	Associate	32159364
Hemorrhagic Fever with Renal Syndrome	Associate	31340562
Hepatic Encephalopathy	Associate	34938356
Hepatitis B	Associate	17079285
Hepatitis C	Associate	20710056, 28387899
Hepatitis C Chronic	Associate	22577869
Herpes Zoster	Associate	34322810
Hippocampal Sclerosis	Associate	29162878
HIV Infections	Associate	10540164, 10803406, 10820198, 10928621, 11023494, 11032864, 11091193, 11309482, 11320252, 11398114, 11604406, 11672507, 12097565, 12426633, 12434015 View all (172 more)
HIV Infections	Stimulate	17474134, 23147374, 29789655
HIV Infections	Inhibit	21667221
HIV Seropositivity	Associate	10733746, 22665517
Hodgkin Disease	Associate	11238088
HTLV I Infections	Associate	10559343, 10575146, 10713092, 11413305, 11507184, 11861874, 12599073, 12719578, 14517097, 14715575, 15479822, 15919952, 15994814, 16015368, 16251315 View all (13 more)
HTLV I Infections	Inhibit	27126912
HTLV II Infections	Associate	17035326, 21902586
Hyperandrogenism	Associate	34119324
Hypersensitivity Delayed	Associate	21288827
Hypertension	Associate	22769019
Hypotension	Associate	25487697, 29927949
Hypoxia	Stimulate	22380870, 30778913
Hypoxia Brain	Associate	31424111
Idiopathic Pulmonary Fibrosis	Inhibit	15802346
Idiopathic Pulmonary Fibrosis	Associate	37544465
IgA Vasculitis	Associate	10323455, 11762935, 12699431, 15331395, 15661933
Immune Reconstitution Inflammatory Syndrome	Stimulate	23908492
Immune Reconstitution Inflammatory Syndrome	Associate	26609048
Immune System Diseases	Associate	19479371, 31522438, 31730458
Immuno hemolytic anemia	Associate	17177831
Immunologic Deficiency Syndromes	Associate	20710056
Infections	Inhibit	10516042, 18941536
Infections	Associate	10575135, 10803406, 10888639, 11112502, 11150506, 11274418, 11312658, 11698309, 11739668, 12518064, 12599073, 12610152, 12805416, 12815099, 12946321 View all (52 more)
Infections	Stimulate	11023494, 37404829, 9770527
Inflammation	Associate	10323454, 12612298, 12621126, 12688247, 12716450, 15557916, 15610230, 15661933, 15743472, 16395252, 19389855, 19538721, 19874552, 20025985, 20220260 View all (26 more)
Inflammation	Stimulate	30759186
Inflammatory Bowel Diseases	Associate	15306587, 16909434
Influenza Human	Associate	35371005
Insulin Resistance	Associate	34119324, 39600283
Intellectual Disability	Associate	21288827
Intestinal Diseases	Inhibit	14704722
Intestinal Diseases	Associate	15654837
Kallmann Syndrome	Associate	22102307
Keratoconus	Associate	37001853
Kidney Diseases	Associate	14742268
Kidney Diseases	Stimulate	19357773
Kidney Failure Chronic	Associate	15610230, 16395252, 19389855, 19679608
Kidney Failure Chronic	Inhibit	28651949
Leukemia	Associate	18842429
Leukemia Hairy Cell	Associate	15001469
Leukemia Large Granular Lymphocytic	Associate	15902300
Leukemia Lymphocytic Chronic B Cell	Associate	19383907
Leukemia Myeloid Acute	Associate	19213682, 31740623
Lichen Planus Oral	Associate	12819030, 33107682
Light Fixation Seizure Syndrome	Associate	11023494, 11672507
Liver Cirrhosis	Associate	20548789, 30239650
Liver Diseases	Associate	20548789
Liver Failure Acute	Stimulate	22837127
Lung Diseases	Associate	14514472, 20075058
Lung Diseases Interstitial	Inhibit	18383361, 35216350
Lung Neoplasms	Associate	19309748, 32549766
Lupus Erythematosus Systemic	Associate	17971457, 23298254, 32214033
Lupus Nephritis	Associate	17971457
Lymphatic Metastasis	Associate	22380870
Lymphocytosis	Associate	18842429
Lymphohistiocytosis Hemophagocytic	Associate	32356861
Lymphoma	Associate	18842429
Lymphoma B Cell Marginal Zone	Associate	22936065, 27233960
Lymphoma Follicular	Stimulate	35887224
Lymphoma Large B Cell Diffuse	Associate	20038229, 34516642, 35887224, 39376717
Lymphoma Large B Cell Diffuse	Stimulate	22936065
Lymphoma Mantle Cell	Associate	15001469
Lymphoma Non Hodgkin	Associate	10068655, 20038229
Lymphoma T Cell Peripheral	Associate	12958063
Lymphoproliferative Disorders	Associate	34119324
Macular Degeneration	Associate	30894217
Macular Degeneration	Inhibit	35352887
Melanoma	Associate	17909797, 24129241
Melanoma	Stimulate	32002296
Melanoma Cutaneous Malignant	Associate	31983065
Metabolic Syndrome	Associate	27013693
Metrorrhagia	Associate	37716915
Mucocutaneous Lymph Node Syndrome	Associate	15962231, 17672867, 20628649
Multiple Myeloma	Associate	15730850, 16542368
Multiple Sclerosis	Stimulate	10359806, 11966770
Multiple Sclerosis	Associate	11696431, 17257590, 18511806, 19479371, 19666086, 22479344, 23202893, 27346865, 30759186, 34596589
Multiple Sclerosis Relapsing Remitting	Associate	36810163
Muscular Disorders Atrophic	Associate	32324857
Myositis Inclusion Body	Associate	28086002, 32259312
Nasopharyngeal Carcinoma	Associate	22226739
Neointima	Associate	12716450
Neoplasm Metastasis	Associate	22380870, 31011147, 31151412, 33245226, 35045088, 36597144
Neoplasm Metastasis	Stimulate	29549020
Neoplasms	Associate	15588486, 16863511, 17686053, 17909797, 18215331, 18842429, 19223978, 20622890, 21091093, 22226739, 22380870, 22735807, 24129241, 25227814, 26028088 View all (22 more)
Nervous System Diseases	Associate	23916293
Neuroblastoma	Associate	10820198, 16001969
Neurocognitive Disorders	Associate	37418541
Neurodegenerative Diseases	Associate	31972607
Neurologic Manifestations	Associate	33571163
Neuromyelitis Optica	Associate	23202893
Neurotoxicity Syndromes	Associate	12768009
Non alcoholic Fatty Liver Disease	Associate	31136997
Non Muscle Invasive Bladder Neoplasms	Associate	32923162
Obesity	Associate	23760409, 28454543, 28903065, 28963085, 32188105
Obesity	Stimulate	24895488, 27677832
Oliguria	Associate	31340562
Opportunistic Infections	Associate	12010355, 9770527
Optic Neuritis	Stimulate	11966770
Osteoarthritis	Associate	11352237, 39236430
Osteogenesis imperfecta type 1A	Associate	35711453
Osteoporosis	Associate	37361541
Osteosarcoma	Associate	22506069
Ovarian Neoplasms	Associate	19351767, 24762504, 28868628, 36597144, 37800814
Overweight	Associate	28963085
Pancreatic Neoplasms	Associate	29358632
Pemphigus Benign Familial	Associate	21592988
Peripheral Arterial Occlusive Disease 1	Associate	15557916
Plague	Associate	14645720
Plaque Amyloid	Associate	15743889, 9665462
Plaque Atherosclerotic	Associate	39512689
Pleural Effusion Malignant	Associate	18515987
Pneumoconiosis	Associate	16524739
Pneumonia Pneumocystis	Associate	12010355
Polycystic Ovary Syndrome	Stimulate	34119324
Post Acute COVID 19 Syndrome	Associate	34262570
Precancerous Conditions	Associate	39549571
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	30836379
Primary Myelofibrosis	Associate	32923146
Prostatic Neoplasms	Stimulate	28903065
Prostatic Neoplasms	Associate	28903065
Pulmonary Disease Chronic Obstructive	Stimulate	18727632, 19229703, 25775429, 29907106
Pulmonary Disease Chronic Obstructive	Inhibit	24742278, 28053515
Pulmonary Disease Chronic Obstructive	Associate	26965295, 28494757, 28963085, 37200921
Renal Insufficiency	Associate	17428349, 18376407, 18820725, 19075055
Renal Insufficiency Chronic	Associate	17428349
Reperfusion Injury	Associate	40705804
Rhinitis Allergic	Associate	17982926
Sarcoidosis	Inhibit	15802346
Sarcoidosis	Associate	20075058, 34440736
Sarcoidosis Pulmonary	Associate	19679608
Schizophrenia	Associate	25487697
Scleroderma Systemic	Inhibit	18383361, 35216350
Sepsis	Associate	34925370
Sexually Transmitted Diseases	Stimulate	31619762, 9708808
Sjogren's Syndrome	Associate	34386009
Sleep Apnea Obstructive	Stimulate	30778913
Smallpox	Associate	14645720
Smoldering Multiple Myeloma	Inhibit	26668134
Soft Tissue Injuries	Associate	27677832
Squamous Cell Carcinoma of Head and Neck	Associate	20622890, 31011147, 32079256, 36167571
Stomach Neoplasms	Associate	21091093
Stroke	Associate	22769019, 34291627, 36380716, 38457490
Stroke	Stimulate	22769019
Substance Related Disorders	Stimulate	29944719
Substance Related Disorders	Associate	34093554
Sutton disease 2	Associate	22727097
Tarlov Cysts	Stimulate	29549020
Thymus Neoplasms	Associate	12072494
Thyroid Nodule	Associate	27872865
Thyroiditis	Associate	11966764
Tooth Erosion	Associate	19538721
Toxoplasmosis	Associate	12010355
Toxoplasmosis Ocular	Associate	29221851
Trigeminal Neuralgia	Associate	34067581
Triple Negative Breast Neoplasms	Associate	34717291
Tuberculosis	Stimulate	15459144
Tuberculosis	Associate	21592988, 30029921, 30231065, 33679683
Tuberculosis Extrapulmonary	Associate	19538721
Tuberculosis Pulmonary	Associate	15459144, 33679683
Tuberculosis Pulmonary	Stimulate	16232220
Uterine Cervical Dysplasia	Associate	31151412
Uterine Cervical Neoplasms	Associate	17094383, 31151412
Uterine Cervical Neoplasms	Stimulate	31151412
Uveitis	Associate	15196263
Uveitis Anterior	Stimulate	15043537
Uveitis Posterior	Associate	17417600
Vascular Diseases	Associate	19874552
Vasculitis	Associate	12716450, 39186910
Venous Thromboembolism	Stimulate	19263529
Ventricular Dysfunction	Associate	23150742
Vestibular Neuronitis	Associate	11966770
Viremia	Associate	12719595, 17474134, 24597865, 33571163
Virus Diseases	Associate	14645006, 16109172, 23185351, 26636929, 31837381, 34913355, 36012436, 37042759
Vitiligo	Associate	34516831
Zika Virus Infection	Associate	33525328

CCR5 (C-C motif chemokine receptor 5)