CCR4 (C-C motif chemokine receptor 4)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1233
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine receptor 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCR4
Synonyms (NCBI Gene) Gene synonyms aliases
CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell traff
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(161)
miRTarBase ID miRNA Experiments Reference
MIRT018019 hsa-miR-335-5p Microarray 18185580
MIRT635508 hsa-miR-6813-3p HITS-CLIP 23824327
MIRT677124 hsa-miR-128-3p HITS-CLIP 23824327
MIRT677123 hsa-miR-216a-3p HITS-CLIP 23824327
MIRT677122 hsa-miR-3681-3p HITS-CLIP 23824327
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
FOSL2 Activation 22493372
FOXP3 Activation 21036387
JUND Activation 22493372
TBX21 Repression 14500650
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(35)
GO ID Ontology Definition Evidence Reference
GO:0001764 Process Neuron migration IEA
GO:0002507 Process Tolerance induction IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004950 Function Chemokine receptor activity IEA
GO:0004950 Function Chemokine receptor activity TAS 7642634
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604836 1605 ENSG00000183813
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P51679
Protein name C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
Protein function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 56 → 304 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected a
Sequence
Sequence length 360
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Viral carcinogenesis 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Celiac disease Celiac disease N/A N/A GWAS
Multiple Sclerosis Multiple sclerosis N/A N/A GWAS
Show/Hide Text Mining Associations (141)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
3 Hydroxy 3 Methylglutaryl CoA Lyase Deficiency Associate 18362907
Adenocarcinoma Associate 28640357
Adenocarcinoma of Lung Associate 33318300
Arthritis Associate 28619088, 29880013
Arthritis Juvenile Associate 21739422
Arthritis Psoriatic Associate 11310827, 33452865, 34681660
Arthritis Rheumatoid Associate 11352233, 11762935, 15498047, 26177310, 27250804, 30619268, 32365786
Arthritis Rheumatoid Stimulate 15361394
Asthma Associate 15788997, 30087444, 31222115, 32914944
Asthma Stimulate 24641287