Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	1233
Gene name	C-C motif chemokine receptor 4
Gene symbol	CCR4
Synonyms (NCBI Gene)	CC-CKR-4CD194CKR4CMKBR4ChemR13HGCN:14099K5-5
Chromosome	3
Chromosome location	3p22.3
Summary	The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell traff

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018019	hsa-miR-335-5p	Microarray	18185580
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT571162	hsa-miR-4459	PAR-CLIP	20371350
MIRT571160	hsa-miR-665	PAR-CLIP	20371350
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT571158	hsa-miR-6087	PAR-CLIP	20371350
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT571156	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT571154	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	27292025
MIRT571156	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT571162	hsa-miR-4459	PAR-CLIP	27292025
MIRT571154	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	27292025
MIRT571158	hsa-miR-6087	PAR-CLIP	27292025
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT571160	hsa-miR-665	PAR-CLIP	27292025
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT735368	hsa-miR-6089	Luciferase reporter assayWestern blottingqRT-PCR	32552050
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT571162	hsa-miR-4459	PAR-CLIP	20371350
MIRT571160	hsa-miR-665	PAR-CLIP	20371350
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT571158	hsa-miR-6087	PAR-CLIP	20371350
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT571156	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT571154	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	20371350
MIRT873216	hsa-miR-1205	CLIP-seq
MIRT873217	hsa-miR-345	CLIP-seq
MIRT873218	hsa-miR-4690-3p	CLIP-seq
MIRT873219	hsa-miR-4726-3p	CLIP-seq
MIRT873220	hsa-miR-4742-5p	CLIP-seq
MIRT873221	hsa-miR-4763-5p	CLIP-seq
MIRT1959082	hsa-miR-3124-3p	CLIP-seq
MIRT1959083	hsa-miR-3692	CLIP-seq
MIRT1959084	hsa-miR-4318	CLIP-seq
MIRT1959085	hsa-miR-4436b-5p	CLIP-seq
MIRT1959086	hsa-miR-4455	CLIP-seq
MIRT1959087	hsa-miR-511	CLIP-seq
MIRT1959088	hsa-miR-609	CLIP-seq
MIRT1959089	hsa-miR-626	CLIP-seq
MIRT873216	hsa-miR-1205	CLIP-seq
MIRT873221	hsa-miR-4763-5p	CLIP-seq

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Transcription factor	Regulation	Reference
FOSL2	Activation	22493372
FOXP3	Activation	21036387
JUND	Activation	22493372
TBX21	Repression	14500650

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IEA
GO:0002507	Process	Tolerance induction	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	7642634
GO:0005515	Function	Protein binding	IPI	28381538, 32296183
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7642634
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	7642634
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	7642634
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	TAS	7642634
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	TAS	7642634
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA
GO:0016493	Function	C-C chemokine receptor activity	IEA
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019957	Function	C-C chemokine binding	IBA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0060326	Process	Cell chemotaxis	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0071345	Process	Cellular response to cytokine stimulus	IEA
GO:1904936	Process	Interneuron migration	IEA

MIM	HGNC	e!Ensembl
604836	1605	ENSG00000183813

P51679

Protein name

C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)

Protein function

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	56 → 304	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected a

Sequence

MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL

Sequence length

360

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Kaposi sarcoma-associated herpesvirus infection Viral carcinogenesis		Chemokine receptors bind chemokines G alpha (i) signalling events

CCR4 (C-C motif chemokine receptor 4)