CCR3 (C-C motif chemokine receptor 3)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1232
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCR3
Synonyms (NCBI Gene) Gene synonyms aliases
C C CKR3, CC-CKR-3, CD193, CKR 3, CKR3, CMKBR3
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT873213 hsa-miR-3163 CLIP-seq
MIRT873214 hsa-miR-3622a-5p CLIP-seq
MIRT873215 hsa-miR-4423-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
GATA1 Unknown 22217447
NFKB1 Activation 16604092
RELA Activation 16604092
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004950 Function Chemokine receptor activity IEA
GO:0004950 Function Chemokine receptor activity TAS 10415069
GO:0005515 Function Protein binding IPI 23597562
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601268 1604 ENSG00000183625
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P51677
Protein name C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Protein function Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intr
PDB 7X9Y
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 51 → 301 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: In eosinophils as well as trace amounts in neutrophils and monocytes. {ECO:0000269|PubMed:8676064}.
Sequence
Sequence length 355
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Viral carcinogenesis 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Astrocytoma Astrocytoma N/A N/A GWAS
Celiac disease Celiac disease N/A N/A GWAS
Dementia Dementia N/A N/A GWAS
Myocardial Infarction Myocardial infarction N/A N/A GWAS
Show/Hide Text Mining Associations (86)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alveolitis Extrinsic Allergic Associate 19842835
Alzheimer Disease Associate 17188679, 9665462
Arthritis Psoriatic Associate 35095831
Arthritis Rheumatoid Associate 11352233, 15140775, 33846499
Asthma Associate 11160184, 11286622, 11307756, 12871220, 19223978, 19735481, 20214667, 20220260
Asthma Stimulate 40534099
Autoimmune Diseases Associate 29182645
Behcet Syndrome Associate 15654837, 33393726
Brain Diseases Associate 12244149
Breast Neoplasms Associate 27086913, 33671956, 35754051