SLC25A29 (solute carrier family 25 member 29)

Gene

• Entrez ID: 123096
• Gene name: Solute carrier family 25 member 29
• Gene symbol: SLC25A29
• Synonyms (NCBI Gene): C14orf69, CACL, ORNT3
• Chromosome: 14
• Chromosome location: 14q32.2
• Summary: This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT726545	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726544	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726543	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726542	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT1356118	hsa-miR-122	CLIP-seq
MIRT1356119	hsa-miR-1254	CLIP-seq
MIRT1356120	hsa-miR-1282	CLIP-seq
MIRT1356121	hsa-miR-1307	CLIP-seq
MIRT1356122	hsa-miR-1323	CLIP-seq
MIRT1356123	hsa-miR-141	CLIP-seq
MIRT1356124	hsa-miR-146a	CLIP-seq
MIRT1356125	hsa-miR-146b-5p	CLIP-seq
MIRT1356126	hsa-miR-1827	CLIP-seq
MIRT1356127	hsa-miR-200a	CLIP-seq
MIRT1356128	hsa-miR-3116	CLIP-seq
MIRT1356129	hsa-miR-3135b	CLIP-seq
MIRT1356130	hsa-miR-3136-3p	CLIP-seq
MIRT1356131	hsa-miR-3192	CLIP-seq
MIRT1356132	hsa-miR-320e	CLIP-seq
MIRT1356133	hsa-miR-346	CLIP-seq
MIRT1356134	hsa-miR-3612	CLIP-seq
MIRT1356135	hsa-miR-3622b-5p	CLIP-seq
MIRT1356136	hsa-miR-3652	CLIP-seq
MIRT1356137	hsa-miR-3689a-3p	CLIP-seq
MIRT1356138	hsa-miR-3689c	CLIP-seq
MIRT1356139	hsa-miR-3689d	CLIP-seq
MIRT1356140	hsa-miR-376a	CLIP-seq
MIRT1356141	hsa-miR-376b	CLIP-seq
MIRT1356142	hsa-miR-3926	CLIP-seq
MIRT1356143	hsa-miR-4277	CLIP-seq
MIRT1356144	hsa-miR-4288	CLIP-seq
MIRT1356145	hsa-miR-4328	CLIP-seq
MIRT1356146	hsa-miR-4430	CLIP-seq
MIRT1356147	hsa-miR-4434	CLIP-seq
MIRT1356148	hsa-miR-4474-3p	CLIP-seq
MIRT1356149	hsa-miR-4491	CLIP-seq
MIRT1356150	hsa-miR-4492	CLIP-seq
MIRT1356151	hsa-miR-4498	CLIP-seq
MIRT1356152	hsa-miR-4505	CLIP-seq
MIRT1356153	hsa-miR-4516	CLIP-seq
MIRT1356154	hsa-miR-4531	CLIP-seq
MIRT1356155	hsa-miR-4638-5p	CLIP-seq
MIRT1356156	hsa-miR-4649-3p	CLIP-seq
MIRT1356157	hsa-miR-4651	CLIP-seq
MIRT1356158	hsa-miR-4657	CLIP-seq
MIRT1356159	hsa-miR-4728-5p	CLIP-seq
MIRT1356160	hsa-miR-4731-5p	CLIP-seq
MIRT1356161	hsa-miR-519a	CLIP-seq
MIRT1356162	hsa-miR-519b-3p	CLIP-seq
MIRT1356163	hsa-miR-519c-3p	CLIP-seq
MIRT1356164	hsa-miR-548o	CLIP-seq
MIRT1356165	hsa-miR-589	CLIP-seq
MIRT1356166	hsa-miR-608	CLIP-seq
MIRT1356167	hsa-miR-632	CLIP-seq
MIRT1356168	hsa-miR-650	CLIP-seq
MIRT1356169	hsa-miR-661	CLIP-seq
MIRT1356170	hsa-miR-663b	CLIP-seq
MIRT1356171	hsa-miR-762	CLIP-seq
MIRT2105397	hsa-miR-1207-3p	CLIP-seq
MIRT2105398	hsa-miR-1233	CLIP-seq
MIRT1356119	hsa-miR-1254	CLIP-seq
MIRT2105399	hsa-miR-1275	CLIP-seq
MIRT1356120	hsa-miR-1282	CLIP-seq
MIRT2105400	hsa-miR-135a	CLIP-seq
MIRT2105401	hsa-miR-135b	CLIP-seq
MIRT2105402	hsa-miR-139-5p	CLIP-seq
MIRT2105403	hsa-miR-145	CLIP-seq
MIRT2105404	hsa-miR-1909	CLIP-seq
MIRT2105405	hsa-miR-1972	CLIP-seq
MIRT2105406	hsa-miR-2117	CLIP-seq
MIRT2105407	hsa-miR-216a	CLIP-seq
MIRT2105408	hsa-miR-216b	CLIP-seq
MIRT2105409	hsa-miR-2355-5p	CLIP-seq
MIRT2105410	hsa-miR-2467-3p	CLIP-seq
MIRT2105411	hsa-miR-3064-5p	CLIP-seq
MIRT1356128	hsa-miR-3116	CLIP-seq
MIRT2105412	hsa-miR-3126-5p	CLIP-seq
MIRT2105413	hsa-miR-3130-3p	CLIP-seq
MIRT2105414	hsa-miR-3150a-3p	CLIP-seq
MIRT2105415	hsa-miR-3157-5p	CLIP-seq
MIRT2105416	hsa-miR-3175	CLIP-seq
MIRT1356131	hsa-miR-3192	CLIP-seq
MIRT2105417	hsa-miR-3199	CLIP-seq
MIRT1356132	hsa-miR-320e	CLIP-seq
MIRT2105418	hsa-miR-338-3p	CLIP-seq
MIRT1356134	hsa-miR-3612	CLIP-seq
MIRT2105419	hsa-miR-3620	CLIP-seq
MIRT1356135	hsa-miR-3622b-5p	CLIP-seq
MIRT1356136	hsa-miR-3652	CLIP-seq
MIRT2105420	hsa-miR-3678-3p	CLIP-seq
MIRT1356137	hsa-miR-3689a-3p	CLIP-seq
MIRT1356138	hsa-miR-3689c	CLIP-seq
MIRT2105421	hsa-miR-3945	CLIP-seq
MIRT2105422	hsa-miR-4251	CLIP-seq
MIRT2105423	hsa-miR-4253	CLIP-seq
MIRT2105424	hsa-miR-4260	CLIP-seq
MIRT2105425	hsa-miR-4265	CLIP-seq
MIRT2105426	hsa-miR-4273	CLIP-seq
MIRT1356143	hsa-miR-4277	CLIP-seq
MIRT2105427	hsa-miR-4296	CLIP-seq
MIRT2105428	hsa-miR-4302	CLIP-seq
MIRT2105429	hsa-miR-4322	CLIP-seq
MIRT2105430	hsa-miR-4417	CLIP-seq
MIRT1356146	hsa-miR-4430	CLIP-seq
MIRT2105431	hsa-miR-4433	CLIP-seq
MIRT1356147	hsa-miR-4434	CLIP-seq
MIRT2105432	hsa-miR-4468	CLIP-seq
MIRT1356149	hsa-miR-4491	CLIP-seq
MIRT2105433	hsa-miR-4504	CLIP-seq
MIRT1356152	hsa-miR-4505	CLIP-seq
MIRT1356153	hsa-miR-4516	CLIP-seq
MIRT2105434	hsa-miR-452	CLIP-seq
MIRT2105435	hsa-miR-4522	CLIP-seq
MIRT2105436	hsa-miR-4525	CLIP-seq
MIRT2105437	hsa-miR-4530	CLIP-seq
MIRT1356154	hsa-miR-4531	CLIP-seq
MIRT2105438	hsa-miR-4536	CLIP-seq
MIRT2105439	hsa-miR-4646-5p	CLIP-seq
MIRT1356158	hsa-miR-4657	CLIP-seq
MIRT2105440	hsa-miR-4665-5p	CLIP-seq
MIRT2105441	hsa-miR-4667-5p	CLIP-seq
MIRT2105442	hsa-miR-4676-3p	CLIP-seq
MIRT2105443	hsa-miR-4677-3p	CLIP-seq
MIRT2105444	hsa-miR-4679	CLIP-seq
MIRT2105445	hsa-miR-4687-5p	CLIP-seq
MIRT2105446	hsa-miR-4691-3p	CLIP-seq
MIRT2105447	hsa-miR-4700-5p	CLIP-seq
MIRT2105448	hsa-miR-4713-3p	CLIP-seq
MIRT2105449	hsa-miR-4723-5p	CLIP-seq
MIRT1356159	hsa-miR-4728-5p	CLIP-seq
MIRT1356160	hsa-miR-4731-5p	CLIP-seq
MIRT2105450	hsa-miR-4743	CLIP-seq
MIRT2105451	hsa-miR-4755-3p	CLIP-seq
MIRT2105452	hsa-miR-4757-5p	CLIP-seq
MIRT2105453	hsa-miR-4793-3p	CLIP-seq
MIRT1356161	hsa-miR-519a	CLIP-seq
MIRT1356162	hsa-miR-519b-3p	CLIP-seq
MIRT1356163	hsa-miR-519c-3p	CLIP-seq
MIRT2105454	hsa-miR-541	CLIP-seq
MIRT2105455	hsa-miR-542-3p	CLIP-seq
MIRT2105456	hsa-miR-580	CLIP-seq
MIRT2105457	hsa-miR-604	CLIP-seq
MIRT2105458	hsa-miR-615-5p	CLIP-seq
MIRT2105459	hsa-miR-625	CLIP-seq
MIRT2105460	hsa-miR-646	CLIP-seq
MIRT2105461	hsa-miR-647	CLIP-seq
MIRT1356168	hsa-miR-650	CLIP-seq
MIRT2105462	hsa-miR-654-5p	CLIP-seq
MIRT1356169	hsa-miR-661	CLIP-seq
MIRT2105463	hsa-miR-764	CLIP-seq
MIRT2105464	hsa-miR-766	CLIP-seq
MIRT2105465	hsa-miR-885-3p	CLIP-seq
MIRT2105466	hsa-miR-939	CLIP-seq
MIRT2329968	hsa-miR-103a	CLIP-seq
MIRT2329969	hsa-miR-107	CLIP-seq
MIRT2105397	hsa-miR-1207-3p	CLIP-seq
MIRT2329970	hsa-miR-1266	CLIP-seq
MIRT1356121	hsa-miR-1307	CLIP-seq
MIRT1356122	hsa-miR-1323	CLIP-seq
MIRT2105403	hsa-miR-145	CLIP-seq
MIRT2105404	hsa-miR-1909	CLIP-seq
MIRT2329971	hsa-miR-1912	CLIP-seq
MIRT2329972	hsa-miR-198	CLIP-seq
MIRT2329973	hsa-miR-19a	CLIP-seq
MIRT2329974	hsa-miR-19b	CLIP-seq
MIRT2329975	hsa-miR-214	CLIP-seq
MIRT2105409	hsa-miR-2355-5p	CLIP-seq
MIRT2329976	hsa-miR-3130-5p	CLIP-seq
MIRT2105415	hsa-miR-3157-5p	CLIP-seq
MIRT2329977	hsa-miR-3180-5p	CLIP-seq
MIRT2329978	hsa-miR-3187-3p	CLIP-seq
MIRT2329979	hsa-miR-324-5p	CLIP-seq
MIRT2105418	hsa-miR-338-3p	CLIP-seq
MIRT2329980	hsa-miR-3619-5p	CLIP-seq
MIRT1356135	hsa-miR-3622b-5p	CLIP-seq
MIRT1356136	hsa-miR-3652	CLIP-seq
MIRT2329981	hsa-miR-3686	CLIP-seq
MIRT2329982	hsa-miR-383	CLIP-seq
MIRT1356142	hsa-miR-3926	CLIP-seq
MIRT2329983	hsa-miR-4274	CLIP-seq
MIRT1356143	hsa-miR-4277	CLIP-seq
MIRT1356145	hsa-miR-4328	CLIP-seq
MIRT1356146	hsa-miR-4430	CLIP-seq
MIRT2329984	hsa-miR-4431	CLIP-seq
MIRT2105431	hsa-miR-4433	CLIP-seq
MIRT2329985	hsa-miR-4482	CLIP-seq
MIRT1356149	hsa-miR-4491	CLIP-seq
MIRT1356150	hsa-miR-4492	CLIP-seq
MIRT1356151	hsa-miR-4498	CLIP-seq
MIRT2329986	hsa-miR-4518	CLIP-seq
MIRT2329987	hsa-miR-4519	CLIP-seq
MIRT2329988	hsa-miR-4529-5p	CLIP-seq
MIRT2105437	hsa-miR-4530	CLIP-seq
MIRT1356155	hsa-miR-4638-5p	CLIP-seq
MIRT2329989	hsa-miR-4652-3p	CLIP-seq
MIRT1356158	hsa-miR-4657	CLIP-seq
MIRT2329990	hsa-miR-4661-3p	CLIP-seq
MIRT2329991	hsa-miR-4690-3p	CLIP-seq
MIRT2329992	hsa-miR-4722-5p	CLIP-seq
MIRT1356160	hsa-miR-4731-5p	CLIP-seq
MIRT2329993	hsa-miR-4733-3p	CLIP-seq
MIRT2105450	hsa-miR-4743	CLIP-seq
MIRT2329994	hsa-miR-4772-5p	CLIP-seq
MIRT2329995	hsa-miR-510	CLIP-seq
MIRT2329996	hsa-miR-518a-5p	CLIP-seq
MIRT2329997	hsa-miR-527	CLIP-seq
MIRT2329998	hsa-miR-545	CLIP-seq
MIRT1356164	hsa-miR-548o	CLIP-seq
MIRT2329999	hsa-miR-548p	CLIP-seq
MIRT2105460	hsa-miR-646	CLIP-seq
MIRT2330000	hsa-miR-662	CLIP-seq
MIRT2330001	hsa-miR-665	CLIP-seq
MIRT2330002	hsa-miR-761	CLIP-seq
MIRT1356171	hsa-miR-762	CLIP-seq
MIRT2105464	hsa-miR-766	CLIP-seq
MIRT2105465	hsa-miR-885-3p	CLIP-seq
MIRT2105399	hsa-miR-1275	CLIP-seq
MIRT2394663	hsa-miR-3663-3p	CLIP-seq
MIRT2394664	hsa-miR-412	CLIP-seq
MIRT2105424	hsa-miR-4260	CLIP-seq
MIRT2394665	hsa-miR-4420	CLIP-seq
MIRT2105436	hsa-miR-4525	CLIP-seq
MIRT2105440	hsa-miR-4665-5p	CLIP-seq
MIRT2105449	hsa-miR-4723-5p	CLIP-seq
MIRT2105459	hsa-miR-625	CLIP-seq
MIRT2329975	hsa-miR-214	CLIP-seq
MIRT2105409	hsa-miR-2355-5p	CLIP-seq
MIRT2459600	hsa-miR-3184	CLIP-seq
MIRT2105418	hsa-miR-338-3p	CLIP-seq
MIRT2329980	hsa-miR-3619-5p	CLIP-seq
MIRT2105419	hsa-miR-3620	CLIP-seq
MIRT2459601	hsa-miR-423-5p	CLIP-seq
MIRT2459602	hsa-miR-4299	CLIP-seq
MIRT2105431	hsa-miR-4433	CLIP-seq
MIRT2105437	hsa-miR-4530	CLIP-seq
MIRT2459603	hsa-miR-4645-5p	CLIP-seq
MIRT2459604	hsa-miR-4650-5p	CLIP-seq
MIRT2459605	hsa-miR-4673	CLIP-seq
MIRT2459606	hsa-miR-4710	CLIP-seq
MIRT2329992	hsa-miR-4722-5p	CLIP-seq
MIRT2459607	hsa-miR-4792	CLIP-seq
MIRT2105458	hsa-miR-615-5p	CLIP-seq
MIRT2330002	hsa-miR-761	CLIP-seq
MIRT2105464	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005289	Function	High-affinity L-arginine transmembrane transporter activity	IBA
GO:0005289	Function	High-affinity L-arginine transmembrane transporter activity	IDA	24652292
GO:0005292	Function	High-affinity lysine transmembrane transporter activity	IBA
GO:0005292	Function	High-affinity lysine transmembrane transporter activity	IDA	24652292
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	19287344
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006865	Process	Amino acid transport	IEA
GO:0006865	Process	Amino acid transport	TAS
GO:0015101	Function	Organic cation transmembrane transporter activity	IEA
GO:0015174	Function	Basic amino acid transmembrane transporter activity	IEA
GO:0015174	Function	Basic amino acid transmembrane transporter activity	IMP	19287344
GO:0015174	Function	Basic amino acid transmembrane transporter activity	TAS
GO:0015227	Function	O-acyl-L-carnitine transmembrane transporter activity	IDA	24652292
GO:0015822	Process	Ornithine transport	IDA	24652292
GO:0015879	Process	Carnitine transport	IDA	24652292
GO:0016020	Component	Membrane	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0089709	Process	L-histidine transmembrane transport	IDA	24652292
GO:1902616	Process	O-acyl-L-carnitine transmembrane transport	IDA	24652292
GO:1903401	Process	L-lysine transmembrane transport	IDA	24652292
GO:1903826	Process	L-arginine transmembrane transport	IDA	24652292
GO:1990575	Process	Mitochondrial L-ornithine transmembrane transport	IBA
GO:1990575	Process	Mitochondrial L-ornithine transmembrane transport	IEA
GO:1990575	Process	Mitochondrial L-ornithine transmembrane transport	IMP	19287344

Other IDs

• MIM: 615064
• HGNC: 20116
• e!Ensembl: ENSG00000197119

Protein

• UniProt ID: Q8N8R3
• Protein name: Mitochondrial basic amino acids transporter (Carnitine/acylcarnitine translocase-like) (CACT-like) (Mitochondrial carnitine/acylcarnitine carrier protein CACL) (Mitochondrial ornithine transporter 3) (Solute carrier family 25 member 29)
• Protein function: Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:19287344, PubMed:24652292). Does not transport carnitine nor acylcarnitines (PubMed:24652292). Functions by
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00153	Mito_carr	1 → 91	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	88 → 182	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	185 → 279	Mitochondrial carrier protein	Family

• Sequence:

  MALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYK
  GLGSPLMGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRL
  QLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALG
  CEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYR
  AEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTYARGEEAGPEGEAVPAAPAGPALAQP
  SSL

• Sequence length: 303

Pathways

KEGG:

Thermogenesis

Reactome:

Amino acid transport across the plasma membrane

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Neoplasm Metastasis	Inhibit	36514121	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	36514121	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	36514121	★☆☆☆☆ Found in Text Mining only