Gene Gene information from NCBI Gene database.
Entrez ID 123036
Gene name Tandem C2 domains, nuclear
Gene symbol TC2N
Synonyms (NCBI Gene)
C14orf47C2CD1MTAC2D1TAC2NTac2-N
Chromosome 14
Chromosome location 14q32.12
miRNA miRNA information provided by mirtarbase database.
333
miRTarBase ID miRNA Experiments Reference
MIRT021482 hsa-miR-9-5p Sequencing 20371350
MIRT1415372 hsa-miR-106a CLIP-seq
MIRT1415373 hsa-miR-106b CLIP-seq
MIRT1415374 hsa-miR-1263 CLIP-seq
MIRT1415375 hsa-miR-1264 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619305 19859 ENSG00000165929
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N9U0
Protein name Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00168 C2 238 342 C2 domain Domain
PF00168 C2 366 473 C2 domain Domain
Sequence
MATEFIKSCCGGCFYGETEKHNFSVERDFKAAVPNSQNATISVPPLTSVSVKPQLGCTED
YLLSKLPSDGKEVPFVVPKFKLSYIQPRTQETPSHLEELEGSARASFGDRKVELSSSSQH
GPSYDVYNPFYMYQHISPDLSRRFPPRSEVKRLYGSVCDLRTNKLPGSPGLSKSMFDLTN
SSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDFGRLNVKLFYNSSVEQI
WITVLQCRDLSWPSSYGDTPTVSIKGILTLPKPVHFKSSAKEGSNAIEFMETFVFAIKLQ
NLQTVRLVFKIQTQTPRKKTIGECSMSLRTLSTQEMDYSLDI
TPPSKISVCHAELELGTC
FQAVNSRIQLQILEARYLPSSSTPLTLSFFVKVGMFSSGELIYKKKTRLLKASNGRVKWG
ETMIFPLIQSEKEIVFLIKLYSRSSVRRKHFVGQIWISEDSNNIEAVNQWKET
VINPEKV
VIRWHKLNPS
Sequence length 490
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Stimulate 33247676
★☆☆☆☆
Found in Text Mining only
Brain Diseases Associate 33247676
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Inhibit 33247676
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 30254375, 33247676
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 37839635
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 33247676
★☆☆☆☆
Found in Text Mining only
Carcinosarcoma Inhibit 33247676
★☆☆☆☆
Found in Text Mining only
Cholangiocarcinoma Stimulate 33247676
★☆☆☆☆
Found in Text Mining only
Glioma Associate 33247676
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Stimulate 30254375, 33247676
★☆☆☆☆
Found in Text Mining only