Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1230
Gene name Gene Name - the full gene name approved by the HGNC.	C-C motif chemokine receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CCR1
Synonyms (NCBI Gene) Gene synonyms aliases	CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), re

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005956	hsa-miR-21-5p	Luciferase reporter assay	21131358
MIRT733201	hsa-miR-191-5p	ELISA, qRT-PCR, Western blotting	33420627
MIRT873169	hsa-miR-1207-5p	CLIP-seq
MIRT873170	hsa-miR-1208	CLIP-seq
MIRT873171	hsa-miR-1254	CLIP-seq
MIRT873172	hsa-miR-1289	CLIP-seq
MIRT873173	hsa-miR-135a	CLIP-seq
MIRT873174	hsa-miR-135b	CLIP-seq
MIRT873175	hsa-miR-197	CLIP-seq
MIRT873176	hsa-miR-3065-5p	CLIP-seq
MIRT873177	hsa-miR-3116	CLIP-seq
MIRT873178	hsa-miR-3190	CLIP-seq
MIRT873179	hsa-miR-3198	CLIP-seq
MIRT873180	hsa-miR-34b	CLIP-seq
MIRT873181	hsa-miR-34c-3p	CLIP-seq
MIRT873182	hsa-miR-3653	CLIP-seq
MIRT873183	hsa-miR-3658	CLIP-seq
MIRT873184	hsa-miR-3940-5p	CLIP-seq
MIRT873185	hsa-miR-4294	CLIP-seq
MIRT873186	hsa-miR-4302	CLIP-seq
MIRT873187	hsa-miR-4309	CLIP-seq
MIRT873188	hsa-miR-4318	CLIP-seq
MIRT873189	hsa-miR-4507	CLIP-seq
MIRT873190	hsa-miR-4704-3p	CLIP-seq
MIRT873191	hsa-miR-4736	CLIP-seq
MIRT873192	hsa-miR-4757-5p	CLIP-seq
MIRT873193	hsa-miR-4763-3p	CLIP-seq
MIRT873194	hsa-miR-4790-3p	CLIP-seq
MIRT873195	hsa-miR-487a	CLIP-seq
MIRT873196	hsa-miR-501-3p	CLIP-seq
MIRT873197	hsa-miR-502-3p	CLIP-seq
MIRT873198	hsa-miR-550a	CLIP-seq
MIRT873199	hsa-miR-648	CLIP-seq
MIRT873200	hsa-miR-661	CLIP-seq
MIRT873201	hsa-miR-759	CLIP-seq
MIRT1959076	hsa-miR-3170	CLIP-seq
MIRT1959077	hsa-miR-4323	CLIP-seq
MIRT2196016	hsa-miR-134	CLIP-seq
MIRT2196017	hsa-miR-223	CLIP-seq
MIRT2196018	hsa-miR-3118	CLIP-seq
MIRT2196019	hsa-miR-3164	CLIP-seq
MIRT873186	hsa-miR-4302	CLIP-seq
MIRT2196020	hsa-miR-4687-3p	CLIP-seq
MIRT2196021	hsa-miR-4697-3p	CLIP-seq
MIRT2677602	hsa-miR-1227	CLIP-seq
MIRT2196016	hsa-miR-134	CLIP-seq
MIRT2677603	hsa-miR-3064-5p	CLIP-seq
MIRT2196018	hsa-miR-3118	CLIP-seq
MIRT2196019	hsa-miR-3164	CLIP-seq
MIRT2677604	hsa-miR-3652	CLIP-seq
MIRT1959077	hsa-miR-4323	CLIP-seq
MIRT2677605	hsa-miR-4430	CLIP-seq
MIRT2677606	hsa-miR-4480	CLIP-seq
MIRT2677607	hsa-miR-4505	CLIP-seq
MIRT2677608	hsa-miR-4786-3p	CLIP-seq
MIRT2677609	hsa-miR-490-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
STAT1	Activation	16628196

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002407	Process	Dendritic cell chemotaxis	TAS	16621978
GO:0002548	Process	Monocyte chemotaxis	IDA	29930254
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA	10734056
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	IDA	10660125
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	10770925
GO:0005515	Function	Protein binding	IPI	8699119, 15001559, 15474493, 28381538, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	IDA	10660125, 15474493, 18587271
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	15001559
GO:0005886	Component	Plasma membrane	TAS	7505609
GO:0006816	Process	Calcium ion transport	IDA	10734056
GO:0006874	Process	Intracellular calcium ion homeostasis	IDA	10734056
GO:0006887	Process	Exocytosis	IDA	10734056
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	NAS	15474493
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	IDA	10443688, 10748004
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	7683036
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IDA	10734056
GO:0006955	Process	Immune response	IEA
GO:0007155	Process	Cell adhesion	TAS	10910894
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10770925
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7505609
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	10734056
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	1406630, 9346484, 10882101, 25038658, 34721373
GO:0007267	Process	Cell-cell signaling	IDA	10734056
GO:0009611	Process	Response to wounding	TAS	7505609
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IDA	10706735
GO:0010629	Process	Negative regulation of gene expression	IMP	21403648
GO:0016020	Component	Membrane	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA
GO:0016493	Function	C-C chemokine receptor activity	IDA	10734056
GO:0016493	Function	C-C chemokine receptor activity	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	NAS	15474493
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019957	Function	C-C chemokine binding	IPI	7545673, 8699119, 10660125, 15764707
GO:0023019	Process	Signal transduction involved in regulation of gene expression	IDA	1406630, 9346484, 25038658, 34721373
GO:0030335	Process	Positive regulation of cell migration	IMP	24056371
GO:0030502	Process	Negative regulation of bone mineralization	IMP	21403648
GO:0035717	Function	Chemokine (C-C motif) ligand 7 binding	IBA
GO:0035717	Function	Chemokine (C-C motif) ligand 7 binding	IPI	7545673, 10660125
GO:0045672	Process	Positive regulation of osteoclast differentiation	IMP	21403648
GO:0050729	Process	Positive regulation of inflammatory response	IDA	23125416
GO:0050729	Process	Positive regulation of inflammatory response	IDA	23125416, 38417634
GO:0050729	Process	Positive regulation of inflammatory response	TAS	23125416
GO:0051928	Process	Positive regulation of calcium ion transport	IDA	15764707
GO:0060326	Process	Cell chemotaxis	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IDA	21403648, 23276697
GO:0070098	Process	Chemokine-mediated signaling pathway	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	21403648
GO:0071345	Process	Cellular response to cytokine stimulus	IEA
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IBA
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IPI	7545673, 8699119, 10660125, 10734056
GO:0090026	Process	Positive regulation of monocyte chemotaxis	IDA	18587271
GO:0090026	Process	Positive regulation of monocyte chemotaxis	IEA
GO:0150078	Process	Positive regulation of neuroinflammatory response	IDA	24854121
GO:0150078	Process	Positive regulation of neuroinflammatory response	ISS
GO:0150078	Process	Positive regulation of neuroinflammatory response	ISS
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	16968406

MIM	HGNC	e!Ensembl
601159	1602	ENSG00000163823

Protein

UniProt ID

P32246

Protein name

C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)

Protein function

Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells,

PDB

7VL8 , 7VL9 , 7VLA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	51 → 301	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in different hematopoietic cells.

Sequence

METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF

Sequence length

355

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling

CCR1 (C-C motif chemokine receptor 1)