PLIN2 (perilipin 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
123
Gene name Gene Name - the full gene name approved by the HGNC.
Perilipin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLIN2
Synonyms (NCBI Gene) Gene synonyms aliases
ADFP, ADRP
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p22.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1242782 hsa-miR-1305 CLIP-seq
MIRT1242783 hsa-miR-3135 CLIP-seq
MIRT1242784 hsa-miR-3942-3p CLIP-seq
MIRT1242785 hsa-miR-421 CLIP-seq
MIRT1242786 hsa-miR-4272 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
PPARA Repression 17150915
PPARG Activation 11420178;16403437
PPARG Unknown 17322100;19571381
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005576 Component Extracellular region TAS 9003395
GO:0005634 Component Nucleus IEA
GO:0005783 Component Endoplasmic reticulum TAS 9003395
GO:0005811 Component Lipid droplet IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
103195 248 ENSG00000147872
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q99541
Protein name Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP)
Protein function Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03036 Perilipin 5 → 409 Perilipin family Family
Tissue specificity TISSUE SPECIFICITY: Milk lipid globules. {ECO:0000269|PubMed:9003395}.
Sequence
Sequence length 437
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  PPAR signaling pathway   PPARA activates gene expression
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 16367923
Show/Hide Text Mining Associations (74)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Follicular Associate 36521425
Adenoma Associate 20118912
Alzheimer Disease Stimulate 34312912
Atherosclerosis Associate 10580108, 18827892, 31251843
Atherosclerosis Inhibit 30402637
Breast Neoplasms Associate 26928812, 35545051
Burkitt Lymphoma Associate 22952953
Carcinogenesis Associate 12387890, 20081801
Carcinoma Hepatocellular Associate 20081801, 36031387
Carcinoma Non Small Cell Lung Associate 32072637