KLHDC1 (kelch domain containing 1)

Gene

• Entrez ID: 122773
• Gene name: Kelch domain containing 1
• Gene symbol: KLHDC1
• Synonyms (NCBI Gene): MST025
• Chromosome: 14
• Chromosome location: 14q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017967	hsa-miR-335-5p	Microarray	18185580
MIRT1097109	hsa-miR-101	CLIP-seq
MIRT1097110	hsa-miR-122	CLIP-seq
MIRT1097111	hsa-miR-1283	CLIP-seq
MIRT1097112	hsa-miR-144	CLIP-seq
MIRT1097113	hsa-miR-3122	CLIP-seq
MIRT1097114	hsa-miR-3617	CLIP-seq
MIRT1097115	hsa-miR-3675-3p	CLIP-seq
MIRT1097116	hsa-miR-3689a-3p	CLIP-seq
MIRT1097117	hsa-miR-3689c	CLIP-seq
MIRT1097118	hsa-miR-3913-5p	CLIP-seq
MIRT1097119	hsa-miR-4282	CLIP-seq
MIRT1097120	hsa-miR-4434	CLIP-seq
MIRT1097121	hsa-miR-4516	CLIP-seq
MIRT1097122	hsa-miR-4531	CLIP-seq
MIRT1097123	hsa-miR-4670-3p	CLIP-seq
MIRT1097124	hsa-miR-4693-3p	CLIP-seq
MIRT1097125	hsa-miR-4729	CLIP-seq
MIRT1097126	hsa-miR-4752	CLIP-seq
MIRT1097127	hsa-miR-4762-3p	CLIP-seq
MIRT1097128	hsa-miR-4775	CLIP-seq
MIRT1097129	hsa-miR-526b	CLIP-seq
MIRT1097130	hsa-miR-549	CLIP-seq
MIRT1097131	hsa-miR-590-3p	CLIP-seq
MIRT1097132	hsa-miR-606	CLIP-seq
MIRT1097133	hsa-miR-641	CLIP-seq
MIRT2257411	hsa-miR-3120-5p	CLIP-seq
MIRT2257412	hsa-miR-431	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IDA	16964437
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	32200094
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0031461	Component	Cullin-RING ubiquitin ligase complex	IEA
GO:0031466	Component	Cul5-RING ubiquitin ligase complex	IDA	32200094
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA	32200094
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	32200094
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA

Other IDs

• MIM: 611281
• HGNC: 19836
• e!Ensembl: ENSG00000197776

Protein

• UniProt ID: Q8N7A1
• Protein name: Kelch domain-containing protein 1
• Protein function: Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13854	Kelch_5	11 → 54		Repeat
  PF13964	Kelch_6	67 → 124		Repeat
  PF13418	Kelch_4	196 → 246		Repeat
  PF13418	Kelch_4	247 → 295		Repeat

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with high levels in skeletal muscle, pancreas and liver. Undetectable in peripheral blood leukocytes. {ECO:0000269|PubMed:16964437}.
• Sequence:

  MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHL
  MEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQP
  PTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKT
  QTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITI
  NGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRL
  WHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLES
  QISLLPPKLLQQVLKKITFWAAANHREEQRVQKEETENKYQWISSN

• Sequence length: 406

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