PLD4 (phospholipase D family member 4)

Gene

• Entrez ID: 122618
• Gene name: Phospholipase D family member 4
• Gene symbol: PLD4
• Synonyms (NCBI Gene): C14orf175
• Chromosome: 14
• Chromosome location: 14q32.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016764	hsa-miR-335-5p	Microarray	18185580
MIRT1240306	hsa-miR-1343	CLIP-seq
MIRT1240307	hsa-miR-3179	CLIP-seq
MIRT1240308	hsa-miR-3202	CLIP-seq
MIRT1240309	hsa-miR-3690	CLIP-seq
MIRT1240310	hsa-miR-4254	CLIP-seq
MIRT1240311	hsa-miR-4292	CLIP-seq
MIRT1240312	hsa-miR-4308	CLIP-seq
MIRT1240313	hsa-miR-4721	CLIP-seq
MIRT1240314	hsa-miR-516a-3p	CLIP-seq
MIRT2070665	hsa-miR-1266	CLIP-seq
MIRT2070666	hsa-miR-24	CLIP-seq
MIRT2070667	hsa-miR-3151	CLIP-seq
MIRT1240310	hsa-miR-4254	CLIP-seq
MIRT2070668	hsa-miR-4283	CLIP-seq
MIRT1240311	hsa-miR-4292	CLIP-seq
MIRT1240312	hsa-miR-4308	CLIP-seq
MIRT2070669	hsa-miR-4437	CLIP-seq
MIRT2070670	hsa-miR-4489	CLIP-seq
MIRT2070671	hsa-miR-4518	CLIP-seq
MIRT1240306	hsa-miR-1343	CLIP-seq
MIRT2070667	hsa-miR-3151	CLIP-seq
MIRT2297822	hsa-miR-3689d	CLIP-seq
MIRT1240309	hsa-miR-3690	CLIP-seq
MIRT2297823	hsa-miR-378	CLIP-seq
MIRT2297824	hsa-miR-378b	CLIP-seq
MIRT2297825	hsa-miR-378c	CLIP-seq
MIRT2297826	hsa-miR-378d	CLIP-seq
MIRT2297827	hsa-miR-378e	CLIP-seq
MIRT2297828	hsa-miR-378f	CLIP-seq
MIRT2297829	hsa-miR-378h	CLIP-seq
MIRT2297830	hsa-miR-378i	CLIP-seq
MIRT2297831	hsa-miR-422a	CLIP-seq
MIRT1240310	hsa-miR-4254	CLIP-seq
MIRT2070668	hsa-miR-4283	CLIP-seq
MIRT1240311	hsa-miR-4292	CLIP-seq
MIRT1240312	hsa-miR-4308	CLIP-seq
MIRT2070670	hsa-miR-4489	CLIP-seq
MIRT1240313	hsa-miR-4721	CLIP-seq
MIRT1240314	hsa-miR-516a-3p	CLIP-seq
MIRT2297832	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0004630	Function	Phospholipase D activity	ISS
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005764	Component	Lysosome	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005769	Component	Early endosome	ISS
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006259	Process	DNA metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006909	Process	Phagocytosis	IBA
GO:0006909	Process	Phagocytosis	IEA
GO:0006909	Process	Phagocytosis	ISS
GO:0006954	Process	Inflammatory response	IEA
GO:0012505	Component	Endomembrane system	IBA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032588	Component	Trans-Golgi network membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	ISS
GO:0045087	Process	Innate immune response	IEA
GO:0045145	Function	Single-stranded DNA 5'-3' DNA exonuclease activity	IEA
GO:0045145	Function	Single-stranded DNA 5'-3' DNA exonuclease activity	ISS
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045335	Component	Phagocytic vesicle	ISS
GO:0051649	Process	Establishment of localization in cell	IEA
GO:1900015	Process	Regulation of cytokine production involved in inflammatory response	IEA
GO:1900015	Process	Regulation of cytokine production involved in inflammatory response	ISS

Other IDs

• MIM: 618488
• HGNC: 23792
• e!Ensembl: ENSG00000166428

Protein

• UniProt ID: Q96BZ4
• Protein name: 5'-3' exonuclease PLD4 (EC 3.1.16.1) ((S,S)-bis(monoacylglycero)phosphate synthase PLD4) (EC 3.1.4.-) (Phospholipase D family member 4) (Phospholipase D4)
• Protein function: 5'->3' exonuclease that hydrolyzes the phosphodiester bond of single-stranded DNA (ssDNA) and RNA molecules to form nucleoside 3'-monophosphates and 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments (PubMed:30111894, PubMed:34620855
• PDB: 8V08
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13918	PLDc_3	239 → 416	PLD-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in plasmacytoid dendritic cells and monocytes (at protein level). {ECO:0000269|PubMed:38697119}.
• Sequence:

  MLKPLWKAAVAPTWPCSMPPRRPWDREAGTLQVLGALAVLWLGSVALICLLWQVPRPPTW
  GQVQPKDVPRSWEHGSSPAWEPLEAEARQQRDSCQLVLVESIPQDLPSAAGSPSAQPLGQ
  AWLQLLDTAQESVHVASYYWSLTGPDIGVNDSSSQLGEALLQKLQQLLGRNISLAVATSS
  PTLARTSTDLQVLAARGAHVRQVPMGRLTRGVLHSKFWVVDGRHIYMGSANMDWRSLTQV
  KELGAVIYNCSHLAQDLEKTFQTYWVLGVPKAVLPKTWPQNFSSHFNRFQPFHGLFDGVP
  TTAYFSASPPALCPQGRTRDLEALLAVMGSAQEFIYASVMEYFPTTRFSHPPRYWPVLDN
  ALRAAAFGKGVRVRLLVGCGLNTDPTMFPYLRSLQALSNPAANVSVDVKVFIVPVGNHSN
  IPFSRVNHSKFMVTEKAAYIGTSNWSEDYFSSTAGVGLVVTQSPGAQPAGATVQEQLRQL
  FERDWSSRYAVGLDGQAPGQDCVWQG

• Sequence length: 506

Pathways

KEGG:

Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways

Reactome:

Synthesis of IP3 and IP4 in the cytosol
Role of phospholipids in phagocytosis