Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	121665
Gene name Gene Name - the full gene name approved by the HGNC.	Signal peptide peptidase like 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPPL3
Synonyms (NCBI Gene) Gene synonyms aliases	IMP2, MDHV1887, PRO4332, PSH1, PSL4
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.31

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miRTarBase ID	miRNA	Experiments	Reference
MIRT698906	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT698905	hsa-miR-624-5p	HITS-CLIP	23313552
MIRT698904	hsa-miR-4682	HITS-CLIP	23313552
MIRT698903	hsa-miR-1911-5p	HITS-CLIP	23313552
MIRT698902	hsa-miR-4303	HITS-CLIP	23313552
MIRT698901	hsa-miR-4762-3p	HITS-CLIP	23313552
MIRT671960	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT671959	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT671958	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT671957	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT671956	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT671955	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671954	hsa-miR-6131	HITS-CLIP	23824327
MIRT671953	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT671952	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT671951	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT671950	hsa-miR-548s	HITS-CLIP	23824327
MIRT671949	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671948	hsa-miR-588	HITS-CLIP	23824327
MIRT671947	hsa-miR-4435	HITS-CLIP	23824327
MIRT671946	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671945	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671944	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT671943	hsa-miR-5096	HITS-CLIP	23824327
MIRT671942	hsa-miR-1303	HITS-CLIP	23824327
MIRT653177	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT653176	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT653175	hsa-miR-4255	HITS-CLIP	23824327
MIRT653174	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT653172	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT653173	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT653171	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653170	hsa-miR-4775	HITS-CLIP	23824327
MIRT653169	hsa-miR-4639-5p	HITS-CLIP	23824327
MIRT653167	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT653168	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT551034	hsa-miR-548ac	PAR-CLIP	21572407
MIRT551033	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT551032	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT551031	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT551030	hsa-miR-548z	PAR-CLIP	21572407
MIRT551029	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT551028	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT551027	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT551026	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT551025	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT551024	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT551023	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT551022	hsa-miR-548at-3p	PAR-CLIP	21572407
MIRT551021	hsa-miR-548ay-3p	PAR-CLIP	21572407
MIRT551020	hsa-miR-1537-3p	PAR-CLIP	21572407
MIRT551019	hsa-miR-3163	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551018	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT495407	hsa-miR-938	PAR-CLIP	21572407
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	21572407
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	21572407
MIRT495402	hsa-miR-4420	PAR-CLIP	21572407
MIRT495401	hsa-miR-653-3p	PAR-CLIP	21572407
MIRT551017	hsa-miR-5007-3p	PAR-CLIP	21572407
MIRT335505	hsa-miR-568	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT534087	hsa-miR-605-5p	PAR-CLIP	22012620
MIRT534086	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT534085	hsa-miR-6809-5p	PAR-CLIP	22012620
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	23708386
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	23708386
MIRT495406	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT495407	hsa-miR-938	PAR-CLIP	23708386
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	23708386
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	23708386
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	23708386
MIRT495402	hsa-miR-4420	PAR-CLIP	23708386
MIRT495401	hsa-miR-653-3p	PAR-CLIP	23708386
MIRT439550	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT439550	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT698906	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT698905	hsa-miR-624-5p	HITS-CLIP	23313552
MIRT698904	hsa-miR-4682	HITS-CLIP	23313552
MIRT698903	hsa-miR-1911-5p	HITS-CLIP	23313552
MIRT698902	hsa-miR-4303	HITS-CLIP	23313552
MIRT698901	hsa-miR-4762-3p	HITS-CLIP	23313552
MIRT671960	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT671959	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT671958	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT671957	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT671956	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT671955	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671954	hsa-miR-6131	HITS-CLIP	23824327
MIRT671953	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT671952	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT671951	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT671950	hsa-miR-548s	HITS-CLIP	23824327
MIRT671949	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671948	hsa-miR-588	HITS-CLIP	23824327
MIRT671947	hsa-miR-4435	HITS-CLIP	23824327
MIRT671946	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671945	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671944	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT671943	hsa-miR-5096	HITS-CLIP	23824327
MIRT671942	hsa-miR-1303	HITS-CLIP	23824327
MIRT653177	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT653176	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT653175	hsa-miR-4255	HITS-CLIP	23824327
MIRT653174	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT653172	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT653173	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT653171	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653170	hsa-miR-4775	HITS-CLIP	23824327
MIRT653169	hsa-miR-4639-5p	HITS-CLIP	23824327
MIRT653167	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT653168	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT551034	hsa-miR-548ac	PAR-CLIP	21572407
MIRT551033	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT551032	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT551031	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT551030	hsa-miR-548z	PAR-CLIP	21572407
MIRT551029	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT551028	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT551027	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT551026	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT551025	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT551024	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT551023	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT551022	hsa-miR-548at-3p	PAR-CLIP	21572407
MIRT551021	hsa-miR-548ay-3p	PAR-CLIP	21572407
MIRT551020	hsa-miR-1537-3p	PAR-CLIP	21572407
MIRT551019	hsa-miR-3163	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551018	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT495407	hsa-miR-938	PAR-CLIP	21572407
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	21572407
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	21572407
MIRT495402	hsa-miR-4420	PAR-CLIP	21572407
MIRT495401	hsa-miR-653-3p	PAR-CLIP	21572407
MIRT551017	hsa-miR-5007-3p	PAR-CLIP	21572407
MIRT335505	hsa-miR-568	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT534087	hsa-miR-605-5p	PAR-CLIP	22012620
MIRT534086	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT534085	hsa-miR-6809-5p	PAR-CLIP	22012620
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	23708386
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	23708386
MIRT495406	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT495407	hsa-miR-938	PAR-CLIP	23708386
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	23708386
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	23708386
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	23708386
MIRT495402	hsa-miR-4420	PAR-CLIP	23708386
MIRT495401	hsa-miR-653-3p	PAR-CLIP	23708386
MIRT1385493	hsa-miR-105	CLIP-seq
MIRT1385494	hsa-miR-1207-5p	CLIP-seq
MIRT1385495	hsa-miR-1253	CLIP-seq
MIRT1385496	hsa-miR-1272	CLIP-seq
MIRT1385497	hsa-miR-128	CLIP-seq
MIRT1385498	hsa-miR-132	CLIP-seq
MIRT1385499	hsa-miR-1322	CLIP-seq
MIRT1385500	hsa-miR-1323	CLIP-seq
MIRT1385501	hsa-miR-136	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT1385503	hsa-miR-1909	CLIP-seq
MIRT1385504	hsa-miR-194	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT1385507	hsa-miR-212	CLIP-seq
MIRT1385508	hsa-miR-223	CLIP-seq
MIRT1385509	hsa-miR-3065-3p	CLIP-seq
MIRT1385510	hsa-miR-3121-3p	CLIP-seq
MIRT1385511	hsa-miR-3140-5p	CLIP-seq
MIRT1385512	hsa-miR-3150a-3p	CLIP-seq
MIRT1385513	hsa-miR-3164	CLIP-seq
MIRT1385514	hsa-miR-3167	CLIP-seq
MIRT1385515	hsa-miR-3175	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT1385517	hsa-miR-331-5p	CLIP-seq
MIRT1385518	hsa-miR-339-5p	CLIP-seq
MIRT1385519	hsa-miR-33a	CLIP-seq
MIRT1385520	hsa-miR-33b	CLIP-seq
MIRT1385521	hsa-miR-3611	CLIP-seq
MIRT1385522	hsa-miR-361-3p	CLIP-seq
MIRT1385523	hsa-miR-3620	CLIP-seq
MIRT1385524	hsa-miR-370	CLIP-seq
MIRT1385525	hsa-miR-3923	CLIP-seq
MIRT1385526	hsa-miR-3925-3p	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT1385528	hsa-miR-4269	CLIP-seq
MIRT1385529	hsa-miR-4281	CLIP-seq
MIRT1385530	hsa-miR-4299	CLIP-seq
MIRT1385531	hsa-miR-4419a	CLIP-seq
MIRT1385532	hsa-miR-4434	CLIP-seq
MIRT1385533	hsa-miR-4456	CLIP-seq
MIRT1385534	hsa-miR-4477a	CLIP-seq
MIRT1385535	hsa-miR-4496	CLIP-seq
MIRT1385536	hsa-miR-4510	CLIP-seq
MIRT1385537	hsa-miR-4514	CLIP-seq
MIRT1385538	hsa-miR-4516	CLIP-seq
MIRT1385539	hsa-miR-4524	CLIP-seq
MIRT1385540	hsa-miR-4667-5p	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT1385542	hsa-miR-4690-5p	CLIP-seq
MIRT1385543	hsa-miR-4692	CLIP-seq
MIRT1385544	hsa-miR-4699-3p	CLIP-seq
MIRT1385545	hsa-miR-4700-5p	CLIP-seq
MIRT1385546	hsa-miR-4706	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385548	hsa-miR-4719	CLIP-seq
MIRT1385549	hsa-miR-4722-3p	CLIP-seq
MIRT1385550	hsa-miR-4729	CLIP-seq
MIRT1385551	hsa-miR-4731-5p	CLIP-seq
MIRT1385552	hsa-miR-4734	CLIP-seq
MIRT1385553	hsa-miR-4737	CLIP-seq
MIRT1385554	hsa-miR-4738-3p	CLIP-seq
MIRT1385555	hsa-miR-4742-5p	CLIP-seq
MIRT1385556	hsa-miR-4749-5p	CLIP-seq
MIRT1385557	hsa-miR-4762-5p	CLIP-seq
MIRT1385558	hsa-miR-4763-3p	CLIP-seq
MIRT1385559	hsa-miR-4763-5p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT1385561	hsa-miR-515-5p	CLIP-seq
MIRT1385562	hsa-miR-539	CLIP-seq
MIRT1385563	hsa-miR-548aa	CLIP-seq
MIRT1385564	hsa-miR-548ae	CLIP-seq
MIRT1385565	hsa-miR-548ag	CLIP-seq
MIRT1385566	hsa-miR-548ai	CLIP-seq
MIRT1385567	hsa-miR-548aj	CLIP-seq
MIRT1385568	hsa-miR-548am	CLIP-seq
MIRT1385569	hsa-miR-548m	CLIP-seq
MIRT1385570	hsa-miR-548o	CLIP-seq
MIRT1385571	hsa-miR-548q	CLIP-seq
MIRT1385572	hsa-miR-548x	CLIP-seq
MIRT1385573	hsa-miR-566	CLIP-seq
MIRT1385574	hsa-miR-579	CLIP-seq
MIRT1385575	hsa-miR-582-3p	CLIP-seq
MIRT1385576	hsa-miR-586	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT1385578	hsa-miR-605	CLIP-seq
MIRT1385579	hsa-miR-617	CLIP-seq
MIRT1385580	hsa-miR-622	CLIP-seq
MIRT1385581	hsa-miR-744	CLIP-seq
MIRT1385582	hsa-miR-766	CLIP-seq
MIRT1385583	hsa-miR-876-5p	CLIP-seq
MIRT1385584	hsa-miR-939	CLIP-seq
MIRT1385585	hsa-miR-940	CLIP-seq
MIRT1385493	hsa-miR-105	CLIP-seq
MIRT1385494	hsa-miR-1207-5p	CLIP-seq
MIRT2115330	hsa-miR-1224-3p	CLIP-seq
MIRT2115331	hsa-miR-1263	CLIP-seq
MIRT1385496	hsa-miR-1272	CLIP-seq
MIRT2115332	hsa-miR-1273f	CLIP-seq
MIRT2115333	hsa-miR-1289	CLIP-seq
MIRT2115334	hsa-miR-1290	CLIP-seq
MIRT2115335	hsa-miR-129-5p	CLIP-seq
MIRT1385498	hsa-miR-132	CLIP-seq
MIRT2115336	hsa-miR-1321	CLIP-seq
MIRT1385499	hsa-miR-1322	CLIP-seq
MIRT2115337	hsa-miR-140-3p	CLIP-seq
MIRT2115338	hsa-miR-143	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT2115339	hsa-miR-1827	CLIP-seq
MIRT1385503	hsa-miR-1909	CLIP-seq
MIRT2115340	hsa-miR-1911	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT2115341	hsa-miR-1972	CLIP-seq
MIRT1385507	hsa-miR-212	CLIP-seq
MIRT2115342	hsa-miR-224	CLIP-seq
MIRT2115343	hsa-miR-296-5p	CLIP-seq
MIRT2115344	hsa-miR-299-3p	CLIP-seq
MIRT1385509	hsa-miR-3065-3p	CLIP-seq
MIRT2115345	hsa-miR-3125	CLIP-seq
MIRT1385512	hsa-miR-3150a-3p	CLIP-seq
MIRT2115346	hsa-miR-3150b-3p	CLIP-seq
MIRT2115347	hsa-miR-3152-5p	CLIP-seq
MIRT1385514	hsa-miR-3167	CLIP-seq
MIRT1385515	hsa-miR-3175	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT2115349	hsa-miR-3198	CLIP-seq
MIRT2115350	hsa-miR-3202	CLIP-seq
MIRT1385519	hsa-miR-33a	CLIP-seq
MIRT1385520	hsa-miR-33b	CLIP-seq
MIRT2115351	hsa-miR-3613-5p	CLIP-seq
MIRT2115352	hsa-miR-3652	CLIP-seq
MIRT2115353	hsa-miR-3653	CLIP-seq
MIRT2115354	hsa-miR-3691-5p	CLIP-seq
MIRT2115355	hsa-miR-369-3p	CLIP-seq
MIRT1385524	hsa-miR-370	CLIP-seq
MIRT2115356	hsa-miR-374a	CLIP-seq
MIRT2115357	hsa-miR-374b	CLIP-seq
MIRT2115358	hsa-miR-374c	CLIP-seq
MIRT2115359	hsa-miR-3916	CLIP-seq
MIRT1385525	hsa-miR-3923	CLIP-seq
MIRT2115360	hsa-miR-3941	CLIP-seq
MIRT2115361	hsa-miR-4261	CLIP-seq
MIRT2115362	hsa-miR-4267	CLIP-seq
MIRT2115363	hsa-miR-4294	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115365	hsa-miR-4309	CLIP-seq
MIRT2115366	hsa-miR-432	CLIP-seq
MIRT2115367	hsa-miR-4328	CLIP-seq
MIRT2115368	hsa-miR-4430	CLIP-seq
MIRT2115369	hsa-miR-4491	CLIP-seq
MIRT1385535	hsa-miR-4496	CLIP-seq
MIRT1385537	hsa-miR-4514	CLIP-seq
MIRT1385539	hsa-miR-4524	CLIP-seq
MIRT2115370	hsa-miR-4533	CLIP-seq
MIRT2115371	hsa-miR-4534	CLIP-seq
MIRT2115372	hsa-miR-4539	CLIP-seq
MIRT2115373	hsa-miR-4657	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2115376	hsa-miR-466	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT2115377	hsa-miR-4680-5p	CLIP-seq
MIRT1385542	hsa-miR-4690-5p	CLIP-seq
MIRT1385543	hsa-miR-4692	CLIP-seq
MIRT2115378	hsa-miR-4705	CLIP-seq
MIRT2115379	hsa-miR-4708-5p	CLIP-seq
MIRT1385548	hsa-miR-4719	CLIP-seq
MIRT2115380	hsa-miR-4727-5p	CLIP-seq
MIRT2115381	hsa-miR-4739	CLIP-seq
MIRT2115382	hsa-miR-4752	CLIP-seq
MIRT2115383	hsa-miR-4753-3p	CLIP-seq
MIRT2115384	hsa-miR-4756-5p	CLIP-seq
MIRT2115385	hsa-miR-4758-3p	CLIP-seq
MIRT1385558	hsa-miR-4763-3p	CLIP-seq
MIRT2115386	hsa-miR-4764-5p	CLIP-seq
MIRT2115387	hsa-miR-4770	CLIP-seq
MIRT2115388	hsa-miR-4774-3p	CLIP-seq
MIRT2115389	hsa-miR-4784	CLIP-seq
MIRT2115390	hsa-miR-495	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT1385574	hsa-miR-579	CLIP-seq
MIRT1385576	hsa-miR-586	CLIP-seq
MIRT1385580	hsa-miR-622	CLIP-seq
MIRT2115391	hsa-miR-654-3p	CLIP-seq
MIRT2115392	hsa-miR-655	CLIP-seq
MIRT2115393	hsa-miR-664	CLIP-seq
MIRT2115394	hsa-miR-668	CLIP-seq
MIRT2115395	hsa-miR-765	CLIP-seq
MIRT1385582	hsa-miR-766	CLIP-seq
MIRT1385583	hsa-miR-876-5p	CLIP-seq
MIRT1385584	hsa-miR-939	CLIP-seq
MIRT1385585	hsa-miR-940	CLIP-seq
MIRT2115396	hsa-miR-942	CLIP-seq
MIRT1385493	hsa-miR-105	CLIP-seq
MIRT2338064	hsa-miR-1252	CLIP-seq
MIRT1385495	hsa-miR-1253	CLIP-seq
MIRT1385496	hsa-miR-1272	CLIP-seq
MIRT2338065	hsa-miR-1293	CLIP-seq
MIRT1385498	hsa-miR-132	CLIP-seq
MIRT1385499	hsa-miR-1322	CLIP-seq
MIRT1385500	hsa-miR-1323	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT1385504	hsa-miR-194	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT2338066	hsa-miR-21	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT1385507	hsa-miR-212	CLIP-seq
MIRT2338067	hsa-miR-216b	CLIP-seq
MIRT1385508	hsa-miR-223	CLIP-seq
MIRT2338068	hsa-miR-300	CLIP-seq
MIRT1385509	hsa-miR-3065-3p	CLIP-seq
MIRT2338069	hsa-miR-3120-3p	CLIP-seq
MIRT2338070	hsa-miR-3138	CLIP-seq
MIRT2338071	hsa-miR-3148	CLIP-seq
MIRT2115347	hsa-miR-3152-5p	CLIP-seq
MIRT1385514	hsa-miR-3167	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT1385519	hsa-miR-33a	CLIP-seq
MIRT1385520	hsa-miR-33b	CLIP-seq
MIRT1385521	hsa-miR-3611	CLIP-seq
MIRT1385522	hsa-miR-361-3p	CLIP-seq
MIRT1385523	hsa-miR-3620	CLIP-seq
MIRT2338072	hsa-miR-3622b-5p	CLIP-seq
MIRT2338073	hsa-miR-3688-3p	CLIP-seq
MIRT2115354	hsa-miR-3691-5p	CLIP-seq
MIRT2115355	hsa-miR-369-3p	CLIP-seq
MIRT1385524	hsa-miR-370	CLIP-seq
MIRT2338074	hsa-miR-371b-5p	CLIP-seq
MIRT2115356	hsa-miR-374a	CLIP-seq
MIRT2115357	hsa-miR-374b	CLIP-seq
MIRT2115358	hsa-miR-374c	CLIP-seq
MIRT2338075	hsa-miR-381	CLIP-seq
MIRT1385525	hsa-miR-3923	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2338076	hsa-miR-4253	CLIP-seq
MIRT1385528	hsa-miR-4269	CLIP-seq
MIRT2338077	hsa-miR-4271	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT1385530	hsa-miR-4299	CLIP-seq
MIRT2338078	hsa-miR-4438	CLIP-seq
MIRT1385533	hsa-miR-4456	CLIP-seq
MIRT2338079	hsa-miR-4483	CLIP-seq
MIRT1385537	hsa-miR-4514	CLIP-seq
MIRT1385539	hsa-miR-4524	CLIP-seq
MIRT2115370	hsa-miR-4533	CLIP-seq
MIRT2115372	hsa-miR-4539	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2338080	hsa-miR-4666-3p	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT2115377	hsa-miR-4680-5p	CLIP-seq
MIRT1385542	hsa-miR-4690-5p	CLIP-seq
MIRT1385543	hsa-miR-4692	CLIP-seq
MIRT2338081	hsa-miR-4704-3p	CLIP-seq
MIRT2115378	hsa-miR-4705	CLIP-seq
MIRT1385546	hsa-miR-4706	CLIP-seq
MIRT1385548	hsa-miR-4719	CLIP-seq
MIRT2338082	hsa-miR-4721	CLIP-seq
MIRT2338083	hsa-miR-4725-3p	CLIP-seq
MIRT1385552	hsa-miR-4734	CLIP-seq
MIRT1385553	hsa-miR-4737	CLIP-seq
MIRT1385555	hsa-miR-4742-5p	CLIP-seq
MIRT2338084	hsa-miR-4747-5p	CLIP-seq
MIRT1385556	hsa-miR-4749-5p	CLIP-seq
MIRT2115382	hsa-miR-4752	CLIP-seq
MIRT2115383	hsa-miR-4753-3p	CLIP-seq
MIRT2115388	hsa-miR-4774-3p	CLIP-seq
MIRT2338085	hsa-miR-4786-3p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT2338086	hsa-miR-5095	CLIP-seq
MIRT1385562	hsa-miR-539	CLIP-seq
MIRT2338087	hsa-miR-548ad	CLIP-seq
MIRT1385564	hsa-miR-548ae	CLIP-seq
MIRT1385565	hsa-miR-548ag	CLIP-seq
MIRT1385566	hsa-miR-548ai	CLIP-seq
MIRT1385567	hsa-miR-548aj	CLIP-seq
MIRT1385568	hsa-miR-548am	CLIP-seq
MIRT2338088	hsa-miR-548g	CLIP-seq
MIRT1385570	hsa-miR-548o	CLIP-seq
MIRT1385571	hsa-miR-548q	CLIP-seq
MIRT1385572	hsa-miR-548x	CLIP-seq
MIRT2338089	hsa-miR-570	CLIP-seq
MIRT1385574	hsa-miR-579	CLIP-seq
MIRT1385576	hsa-miR-586	CLIP-seq
MIRT2338090	hsa-miR-590-5p	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT1385580	hsa-miR-622	CLIP-seq
MIRT2338091	hsa-miR-624	CLIP-seq
MIRT2338092	hsa-miR-646	CLIP-seq
MIRT2115392	hsa-miR-655	CLIP-seq
MIRT2338093	hsa-miR-671-5p	CLIP-seq
MIRT1385581	hsa-miR-744	CLIP-seq
MIRT1385583	hsa-miR-876-5p	CLIP-seq
MIRT2115396	hsa-miR-942	CLIP-seq
MIRT1385495	hsa-miR-1253	CLIP-seq
MIRT2115337	hsa-miR-140-3p	CLIP-seq
MIRT2338066	hsa-miR-21	CLIP-seq
MIRT2338068	hsa-miR-300	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT1385521	hsa-miR-3611	CLIP-seq
MIRT2338075	hsa-miR-381	CLIP-seq
MIRT2338077	hsa-miR-4271	CLIP-seq
MIRT2115370	hsa-miR-4533	CLIP-seq
MIRT2338083	hsa-miR-4725-3p	CLIP-seq
MIRT2338084	hsa-miR-4747-5p	CLIP-seq
MIRT2338085	hsa-miR-4786-3p	CLIP-seq
MIRT2338090	hsa-miR-590-5p	CLIP-seq
MIRT2338091	hsa-miR-624	CLIP-seq
MIRT2338092	hsa-miR-646	CLIP-seq
MIRT2338093	hsa-miR-671-5p	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT2460474	hsa-miR-3657	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2460475	hsa-miR-4669	CLIP-seq
MIRT2460476	hsa-miR-4688	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT2460477	hsa-miR-489	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT2460478	hsa-miR-514	CLIP-seq
MIRT2460479	hsa-miR-514b-3p	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT2631621	hsa-miR-106a	CLIP-seq
MIRT2631622	hsa-miR-106b	CLIP-seq
MIRT2631623	hsa-miR-1234	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT2631624	hsa-miR-17	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT2631625	hsa-miR-20a	CLIP-seq
MIRT2631626	hsa-miR-20b	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT2631627	hsa-miR-302a	CLIP-seq
MIRT2631628	hsa-miR-302b	CLIP-seq
MIRT2631629	hsa-miR-302c	CLIP-seq
MIRT2631630	hsa-miR-302d	CLIP-seq
MIRT2631631	hsa-miR-302e	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT2631632	hsa-miR-372	CLIP-seq
MIRT2631633	hsa-miR-373	CLIP-seq
MIRT2115360	hsa-miR-3941	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2115376	hsa-miR-466	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385549	hsa-miR-4722-3p	CLIP-seq
MIRT2115380	hsa-miR-4727-5p	CLIP-seq
MIRT2631634	hsa-miR-4760-3p	CLIP-seq
MIRT1385559	hsa-miR-4763-5p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT2631635	hsa-miR-519d	CLIP-seq
MIRT2631636	hsa-miR-520a-3p	CLIP-seq
MIRT2631637	hsa-miR-520b	CLIP-seq
MIRT2631638	hsa-miR-520c-3p	CLIP-seq
MIRT2631639	hsa-miR-520d-3p	CLIP-seq
MIRT2631640	hsa-miR-520e	CLIP-seq
MIRT2631641	hsa-miR-520g	CLIP-seq
MIRT2631642	hsa-miR-520h	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT2631643	hsa-miR-640	CLIP-seq
MIRT2631644	hsa-miR-642b	CLIP-seq
MIRT2115393	hsa-miR-664	CLIP-seq
MIRT2631645	hsa-miR-93	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	2313285
GO:0005791	Component	Rough endoplasmic reticulum	IDA	15998642
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0006465	Process	Signal peptide processing	IBA	21873635
GO:0006509	Process	Membrane protein ectodomain proteolysis	IMP	16829952, 17965014
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	ISS
GO:0016020	Component	Membrane	IDA	2313285
GO:0030660	Component	Golgi-associated vesicle membrane	IBA	21873635
GO:0030660	Component	Golgi-associated vesicle membrane	IDA	16829952
GO:0032092	Process	Positive regulation of protein binding	ISS
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	ISS
GO:0033619	Process	Membrane protein proteolysis	IBA	21873635
GO:0033619	Process	Membrane protein proteolysis	IDA	2313285
GO:0035307	Process	Positive regulation of protein dephosphorylation	IMP	25384971
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IBA	21873635
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IDA	2313285
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IMP	16873890
GO:0042803	Function	Protein homodimerization activity	IDA	15385547, 15998642, 16873890
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0050852	Process	T cell receptor signaling pathway	IMP	25384971
GO:0050852	Process	T cell receptor signaling pathway	ISS
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IMP	25384971
GO:0071458	Component	Integral component of cytoplasmic side of endoplasmic reticulum membrane	IBA	21873635
GO:0071458	Component	Integral component of cytoplasmic side of endoplasmic reticulum membrane	IDA	15385547
GO:0071556	Component	Integral component of lumenal side of endoplasmic reticulum membrane	IBA	21873635
GO:0071556	Component	Integral component of lumenal side of endoplasmic reticulum membrane	IDA	15385547

MIM	HGNC	e!Ensembl
608240	30424	ENSG00000157837

Protein

UniProt ID

Q8TCT6

Protein name

Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)

Protein function

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediatin

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04258	Peptidase_A22B	60 → 374	Signal peptide peptidase	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed (PubMed:15385547). Expressed in the brain (PubMed:11978763). {ECO:0000269|PubMed:11978763, ECO:0000269|PubMed:15385547}.

Sequence

MAEQTYSWAYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSNSSSGSFNGNS
TNNSIQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQY
LTRPCSPQNKISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAF
VRLPSLKVSCLLLSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPN
VGRDVPRLSLPGKLVFPSSTGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAP
GPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYL
KGDLRRMWSEPFHSKSSSSRFLEV

Sequence length

384

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	30718926

Show/Hide Unknown Diseases (8)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		30718901, 29942085, 27479909	ClinVar
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Eczema	Eczema			GWAS
Diabetes	Diabetes			GWAS
Asthma	Asthma			GWAS
Mental Depression	Mental Depression			GWAS
Schizophrenia	Schizophrenia			GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Glioma	Associate	33271119

SPPL3 (signal peptide peptidase like 3)