Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	121665
Gene name Gene Name - the full gene name approved by the HGNC.	Signal peptide peptidase like 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPPL3
Synonyms (NCBI Gene) Gene synonyms aliases	IMP2, MDHV1887, PRO4332, PSH1, PSL4
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.31

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miRTarBase ID	miRNA	Experiments	Reference
MIRT698906	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT698905	hsa-miR-624-5p	HITS-CLIP	23313552
MIRT698904	hsa-miR-4682	HITS-CLIP	23313552
MIRT698903	hsa-miR-1911-5p	HITS-CLIP	23313552
MIRT698902	hsa-miR-4303	HITS-CLIP	23313552
MIRT698901	hsa-miR-4762-3p	HITS-CLIP	23313552
MIRT671960	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT671959	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT671958	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT671957	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT671956	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT671955	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671954	hsa-miR-6131	HITS-CLIP	23824327
MIRT671953	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT671952	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT671951	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT671950	hsa-miR-548s	HITS-CLIP	23824327
MIRT671949	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671948	hsa-miR-588	HITS-CLIP	23824327
MIRT671947	hsa-miR-4435	HITS-CLIP	23824327
MIRT671946	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671945	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671944	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT671943	hsa-miR-5096	HITS-CLIP	23824327
MIRT671942	hsa-miR-1303	HITS-CLIP	23824327
MIRT653177	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT653176	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT653175	hsa-miR-4255	HITS-CLIP	23824327
MIRT653174	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT653172	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT653173	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT653171	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653170	hsa-miR-4775	HITS-CLIP	23824327
MIRT653169	hsa-miR-4639-5p	HITS-CLIP	23824327
MIRT653167	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT653168	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT551034	hsa-miR-548ac	PAR-CLIP	21572407
MIRT551033	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT551032	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT551031	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT551030	hsa-miR-548z	PAR-CLIP	21572407
MIRT551029	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT551028	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT551027	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT551026	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT551025	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT551024	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT551023	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT551022	hsa-miR-548at-3p	PAR-CLIP	21572407
MIRT551021	hsa-miR-548ay-3p	PAR-CLIP	21572407
MIRT551020	hsa-miR-1537-3p	PAR-CLIP	21572407
MIRT551019	hsa-miR-3163	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551018	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT495407	hsa-miR-938	PAR-CLIP	21572407
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	21572407
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	21572407
MIRT495402	hsa-miR-4420	PAR-CLIP	21572407
MIRT495401	hsa-miR-653-3p	PAR-CLIP	21572407
MIRT551017	hsa-miR-5007-3p	PAR-CLIP	21572407
MIRT335505	hsa-miR-568	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT534087	hsa-miR-605-5p	PAR-CLIP	22012620
MIRT534086	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT534085	hsa-miR-6809-5p	PAR-CLIP	22012620
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	23708386
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	23708386
MIRT495406	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT495407	hsa-miR-938	PAR-CLIP	23708386
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	23708386
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	23708386
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	23708386
MIRT495402	hsa-miR-4420	PAR-CLIP	23708386
MIRT495401	hsa-miR-653-3p	PAR-CLIP	23708386
MIRT439550	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT439550	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT698906	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT698905	hsa-miR-624-5p	HITS-CLIP	23313552
MIRT698904	hsa-miR-4682	HITS-CLIP	23313552
MIRT698903	hsa-miR-1911-5p	HITS-CLIP	23313552
MIRT698902	hsa-miR-4303	HITS-CLIP	23313552
MIRT698901	hsa-miR-4762-3p	HITS-CLIP	23313552
MIRT671960	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT671959	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT671958	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT671957	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT671956	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT671955	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671954	hsa-miR-6131	HITS-CLIP	23824327
MIRT671953	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT671952	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT671951	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT671950	hsa-miR-548s	HITS-CLIP	23824327
MIRT671949	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671948	hsa-miR-588	HITS-CLIP	23824327
MIRT671947	hsa-miR-4435	HITS-CLIP	23824327
MIRT671946	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671945	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671944	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT671943	hsa-miR-5096	HITS-CLIP	23824327
MIRT671942	hsa-miR-1303	HITS-CLIP	23824327
MIRT653177	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT653176	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT653175	hsa-miR-4255	HITS-CLIP	23824327
MIRT653174	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT653172	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT653173	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT653171	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT653170	hsa-miR-4775	HITS-CLIP	23824327
MIRT653169	hsa-miR-4639-5p	HITS-CLIP	23824327
MIRT653167	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT653168	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT551034	hsa-miR-548ac	PAR-CLIP	21572407
MIRT551033	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT551032	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT551031	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT551030	hsa-miR-548z	PAR-CLIP	21572407
MIRT551029	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT551028	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT551027	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT551026	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT551025	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT551024	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT551023	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT551022	hsa-miR-548at-3p	PAR-CLIP	21572407
MIRT551021	hsa-miR-548ay-3p	PAR-CLIP	21572407
MIRT551020	hsa-miR-1537-3p	PAR-CLIP	21572407
MIRT551019	hsa-miR-3163	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551018	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT495407	hsa-miR-938	PAR-CLIP	21572407
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	21572407
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	21572407
MIRT495402	hsa-miR-4420	PAR-CLIP	21572407
MIRT495401	hsa-miR-653-3p	PAR-CLIP	21572407
MIRT551017	hsa-miR-5007-3p	PAR-CLIP	21572407
MIRT335505	hsa-miR-568	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT112596	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544533	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544534	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT112592	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544532	hsa-miR-3924	PAR-CLIP	21572407
MIRT544530	hsa-miR-6083	PAR-CLIP	21572407
MIRT544531	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT544529	hsa-miR-4455	PAR-CLIP	21572407
MIRT534087	hsa-miR-605-5p	PAR-CLIP	22012620
MIRT534086	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT534085	hsa-miR-6809-5p	PAR-CLIP	22012620
MIRT495409	hsa-miR-6890-3p	PAR-CLIP	23708386
MIRT495408	hsa-miR-6780b-3p	PAR-CLIP	23708386
MIRT495406	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT495407	hsa-miR-938	PAR-CLIP	23708386
MIRT495405	hsa-miR-6886-3p	PAR-CLIP	23708386
MIRT495404	hsa-miR-181b-2-3p	PAR-CLIP	23708386
MIRT495403	hsa-miR-181b-3p	PAR-CLIP	23708386
MIRT495402	hsa-miR-4420	PAR-CLIP	23708386
MIRT495401	hsa-miR-653-3p	PAR-CLIP	23708386
MIRT1385493	hsa-miR-105	CLIP-seq
MIRT1385494	hsa-miR-1207-5p	CLIP-seq
MIRT1385495	hsa-miR-1253	CLIP-seq
MIRT1385496	hsa-miR-1272	CLIP-seq
MIRT1385497	hsa-miR-128	CLIP-seq
MIRT1385498	hsa-miR-132	CLIP-seq
MIRT1385499	hsa-miR-1322	CLIP-seq
MIRT1385500	hsa-miR-1323	CLIP-seq
MIRT1385501	hsa-miR-136	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT1385503	hsa-miR-1909	CLIP-seq
MIRT1385504	hsa-miR-194	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT1385507	hsa-miR-212	CLIP-seq
MIRT1385508	hsa-miR-223	CLIP-seq
MIRT1385509	hsa-miR-3065-3p	CLIP-seq
MIRT1385510	hsa-miR-3121-3p	CLIP-seq
MIRT1385511	hsa-miR-3140-5p	CLIP-seq
MIRT1385512	hsa-miR-3150a-3p	CLIP-seq
MIRT1385513	hsa-miR-3164	CLIP-seq
MIRT1385514	hsa-miR-3167	CLIP-seq
MIRT1385515	hsa-miR-3175	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT1385517	hsa-miR-331-5p	CLIP-seq
MIRT1385518	hsa-miR-339-5p	CLIP-seq
MIRT1385519	hsa-miR-33a	CLIP-seq
MIRT1385520	hsa-miR-33b	CLIP-seq
MIRT1385521	hsa-miR-3611	CLIP-seq
MIRT1385522	hsa-miR-361-3p	CLIP-seq
MIRT1385523	hsa-miR-3620	CLIP-seq
MIRT1385524	hsa-miR-370	CLIP-seq
MIRT1385525	hsa-miR-3923	CLIP-seq
MIRT1385526	hsa-miR-3925-3p	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT1385528	hsa-miR-4269	CLIP-seq
MIRT1385529	hsa-miR-4281	CLIP-seq
MIRT1385530	hsa-miR-4299	CLIP-seq
MIRT1385531	hsa-miR-4419a	CLIP-seq
MIRT1385532	hsa-miR-4434	CLIP-seq
MIRT1385533	hsa-miR-4456	CLIP-seq
MIRT1385534	hsa-miR-4477a	CLIP-seq
MIRT1385535	hsa-miR-4496	CLIP-seq
MIRT1385536	hsa-miR-4510	CLIP-seq
MIRT1385537	hsa-miR-4514	CLIP-seq
MIRT1385538	hsa-miR-4516	CLIP-seq
MIRT1385539	hsa-miR-4524	CLIP-seq
MIRT1385540	hsa-miR-4667-5p	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT1385542	hsa-miR-4690-5p	CLIP-seq
MIRT1385543	hsa-miR-4692	CLIP-seq
MIRT1385544	hsa-miR-4699-3p	CLIP-seq
MIRT1385545	hsa-miR-4700-5p	CLIP-seq
MIRT1385546	hsa-miR-4706	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385548	hsa-miR-4719	CLIP-seq
MIRT1385549	hsa-miR-4722-3p	CLIP-seq
MIRT1385550	hsa-miR-4729	CLIP-seq
MIRT1385551	hsa-miR-4731-5p	CLIP-seq
MIRT1385552	hsa-miR-4734	CLIP-seq
MIRT1385553	hsa-miR-4737	CLIP-seq
MIRT1385554	hsa-miR-4738-3p	CLIP-seq
MIRT1385555	hsa-miR-4742-5p	CLIP-seq
MIRT1385556	hsa-miR-4749-5p	CLIP-seq
MIRT1385557	hsa-miR-4762-5p	CLIP-seq
MIRT1385558	hsa-miR-4763-3p	CLIP-seq
MIRT1385559	hsa-miR-4763-5p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT1385561	hsa-miR-515-5p	CLIP-seq
MIRT1385562	hsa-miR-539	CLIP-seq
MIRT1385563	hsa-miR-548aa	CLIP-seq
MIRT1385564	hsa-miR-548ae	CLIP-seq
MIRT1385565	hsa-miR-548ag	CLIP-seq
MIRT1385566	hsa-miR-548ai	CLIP-seq
MIRT1385567	hsa-miR-548aj	CLIP-seq
MIRT1385568	hsa-miR-548am	CLIP-seq
MIRT1385569	hsa-miR-548m	CLIP-seq
MIRT1385570	hsa-miR-548o	CLIP-seq
MIRT1385571	hsa-miR-548q	CLIP-seq
MIRT1385572	hsa-miR-548x	CLIP-seq
MIRT1385573	hsa-miR-566	CLIP-seq
MIRT1385574	hsa-miR-579	CLIP-seq
MIRT1385575	hsa-miR-582-3p	CLIP-seq
MIRT1385576	hsa-miR-586	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT1385578	hsa-miR-605	CLIP-seq
MIRT1385579	hsa-miR-617	CLIP-seq
MIRT1385580	hsa-miR-622	CLIP-seq
MIRT1385581	hsa-miR-744	CLIP-seq
MIRT1385582	hsa-miR-766	CLIP-seq
MIRT1385583	hsa-miR-876-5p	CLIP-seq
MIRT1385584	hsa-miR-939	CLIP-seq
MIRT1385585	hsa-miR-940	CLIP-seq
MIRT1385493	hsa-miR-105	CLIP-seq
MIRT1385494	hsa-miR-1207-5p	CLIP-seq
MIRT2115330	hsa-miR-1224-3p	CLIP-seq
MIRT2115331	hsa-miR-1263	CLIP-seq
MIRT1385496	hsa-miR-1272	CLIP-seq
MIRT2115332	hsa-miR-1273f	CLIP-seq
MIRT2115333	hsa-miR-1289	CLIP-seq
MIRT2115334	hsa-miR-1290	CLIP-seq
MIRT2115335	hsa-miR-129-5p	CLIP-seq
MIRT1385498	hsa-miR-132	CLIP-seq
MIRT2115336	hsa-miR-1321	CLIP-seq
MIRT1385499	hsa-miR-1322	CLIP-seq
MIRT2115337	hsa-miR-140-3p	CLIP-seq
MIRT2115338	hsa-miR-143	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT2115339	hsa-miR-1827	CLIP-seq
MIRT1385503	hsa-miR-1909	CLIP-seq
MIRT2115340	hsa-miR-1911	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT2115341	hsa-miR-1972	CLIP-seq
MIRT1385507	hsa-miR-212	CLIP-seq
MIRT2115342	hsa-miR-224	CLIP-seq
MIRT2115343	hsa-miR-296-5p	CLIP-seq
MIRT2115344	hsa-miR-299-3p	CLIP-seq
MIRT1385509	hsa-miR-3065-3p	CLIP-seq
MIRT2115345	hsa-miR-3125	CLIP-seq
MIRT1385512	hsa-miR-3150a-3p	CLIP-seq
MIRT2115346	hsa-miR-3150b-3p	CLIP-seq
MIRT2115347	hsa-miR-3152-5p	CLIP-seq
MIRT1385514	hsa-miR-3167	CLIP-seq
MIRT1385515	hsa-miR-3175	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT2115349	hsa-miR-3198	CLIP-seq
MIRT2115350	hsa-miR-3202	CLIP-seq
MIRT1385519	hsa-miR-33a	CLIP-seq
MIRT1385520	hsa-miR-33b	CLIP-seq
MIRT2115351	hsa-miR-3613-5p	CLIP-seq
MIRT2115352	hsa-miR-3652	CLIP-seq
MIRT2115353	hsa-miR-3653	CLIP-seq
MIRT2115354	hsa-miR-3691-5p	CLIP-seq
MIRT2115355	hsa-miR-369-3p	CLIP-seq
MIRT1385524	hsa-miR-370	CLIP-seq
MIRT2115356	hsa-miR-374a	CLIP-seq
MIRT2115357	hsa-miR-374b	CLIP-seq
MIRT2115358	hsa-miR-374c	CLIP-seq
MIRT2115359	hsa-miR-3916	CLIP-seq
MIRT1385525	hsa-miR-3923	CLIP-seq
MIRT2115360	hsa-miR-3941	CLIP-seq
MIRT2115361	hsa-miR-4261	CLIP-seq
MIRT2115362	hsa-miR-4267	CLIP-seq
MIRT2115363	hsa-miR-4294	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115365	hsa-miR-4309	CLIP-seq
MIRT2115366	hsa-miR-432	CLIP-seq
MIRT2115367	hsa-miR-4328	CLIP-seq
MIRT2115368	hsa-miR-4430	CLIP-seq
MIRT2115369	hsa-miR-4491	CLIP-seq
MIRT1385535	hsa-miR-4496	CLIP-seq
MIRT1385537	hsa-miR-4514	CLIP-seq
MIRT1385539	hsa-miR-4524	CLIP-seq
MIRT2115370	hsa-miR-4533	CLIP-seq
MIRT2115371	hsa-miR-4534	CLIP-seq
MIRT2115372	hsa-miR-4539	CLIP-seq
MIRT2115373	hsa-miR-4657	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2115376	hsa-miR-466	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT2115377	hsa-miR-4680-5p	CLIP-seq
MIRT1385542	hsa-miR-4690-5p	CLIP-seq
MIRT1385543	hsa-miR-4692	CLIP-seq
MIRT2115378	hsa-miR-4705	CLIP-seq
MIRT2115379	hsa-miR-4708-5p	CLIP-seq
MIRT1385548	hsa-miR-4719	CLIP-seq
MIRT2115380	hsa-miR-4727-5p	CLIP-seq
MIRT2115381	hsa-miR-4739	CLIP-seq
MIRT2115382	hsa-miR-4752	CLIP-seq
MIRT2115383	hsa-miR-4753-3p	CLIP-seq
MIRT2115384	hsa-miR-4756-5p	CLIP-seq
MIRT2115385	hsa-miR-4758-3p	CLIP-seq
MIRT1385558	hsa-miR-4763-3p	CLIP-seq
MIRT2115386	hsa-miR-4764-5p	CLIP-seq
MIRT2115387	hsa-miR-4770	CLIP-seq
MIRT2115388	hsa-miR-4774-3p	CLIP-seq
MIRT2115389	hsa-miR-4784	CLIP-seq
MIRT2115390	hsa-miR-495	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT1385574	hsa-miR-579	CLIP-seq
MIRT1385576	hsa-miR-586	CLIP-seq
MIRT1385580	hsa-miR-622	CLIP-seq
MIRT2115391	hsa-miR-654-3p	CLIP-seq
MIRT2115392	hsa-miR-655	CLIP-seq
MIRT2115393	hsa-miR-664	CLIP-seq
MIRT2115394	hsa-miR-668	CLIP-seq
MIRT2115395	hsa-miR-765	CLIP-seq
MIRT1385582	hsa-miR-766	CLIP-seq
MIRT1385583	hsa-miR-876-5p	CLIP-seq
MIRT1385584	hsa-miR-939	CLIP-seq
MIRT1385585	hsa-miR-940	CLIP-seq
MIRT2115396	hsa-miR-942	CLIP-seq
MIRT1385493	hsa-miR-105	CLIP-seq
MIRT2338064	hsa-miR-1252	CLIP-seq
MIRT1385495	hsa-miR-1253	CLIP-seq
MIRT1385496	hsa-miR-1272	CLIP-seq
MIRT2338065	hsa-miR-1293	CLIP-seq
MIRT1385498	hsa-miR-132	CLIP-seq
MIRT1385499	hsa-miR-1322	CLIP-seq
MIRT1385500	hsa-miR-1323	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT1385504	hsa-miR-194	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT2338066	hsa-miR-21	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT1385507	hsa-miR-212	CLIP-seq
MIRT2338067	hsa-miR-216b	CLIP-seq
MIRT1385508	hsa-miR-223	CLIP-seq
MIRT2338068	hsa-miR-300	CLIP-seq
MIRT1385509	hsa-miR-3065-3p	CLIP-seq
MIRT2338069	hsa-miR-3120-3p	CLIP-seq
MIRT2338070	hsa-miR-3138	CLIP-seq
MIRT2338071	hsa-miR-3148	CLIP-seq
MIRT2115347	hsa-miR-3152-5p	CLIP-seq
MIRT1385514	hsa-miR-3167	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT1385519	hsa-miR-33a	CLIP-seq
MIRT1385520	hsa-miR-33b	CLIP-seq
MIRT1385521	hsa-miR-3611	CLIP-seq
MIRT1385522	hsa-miR-361-3p	CLIP-seq
MIRT1385523	hsa-miR-3620	CLIP-seq
MIRT2338072	hsa-miR-3622b-5p	CLIP-seq
MIRT2338073	hsa-miR-3688-3p	CLIP-seq
MIRT2115354	hsa-miR-3691-5p	CLIP-seq
MIRT2115355	hsa-miR-369-3p	CLIP-seq
MIRT1385524	hsa-miR-370	CLIP-seq
MIRT2338074	hsa-miR-371b-5p	CLIP-seq
MIRT2115356	hsa-miR-374a	CLIP-seq
MIRT2115357	hsa-miR-374b	CLIP-seq
MIRT2115358	hsa-miR-374c	CLIP-seq
MIRT2338075	hsa-miR-381	CLIP-seq
MIRT1385525	hsa-miR-3923	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2338076	hsa-miR-4253	CLIP-seq
MIRT1385528	hsa-miR-4269	CLIP-seq
MIRT2338077	hsa-miR-4271	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT1385530	hsa-miR-4299	CLIP-seq
MIRT2338078	hsa-miR-4438	CLIP-seq
MIRT1385533	hsa-miR-4456	CLIP-seq
MIRT2338079	hsa-miR-4483	CLIP-seq
MIRT1385537	hsa-miR-4514	CLIP-seq
MIRT1385539	hsa-miR-4524	CLIP-seq
MIRT2115370	hsa-miR-4533	CLIP-seq
MIRT2115372	hsa-miR-4539	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2338080	hsa-miR-4666-3p	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT2115377	hsa-miR-4680-5p	CLIP-seq
MIRT1385542	hsa-miR-4690-5p	CLIP-seq
MIRT1385543	hsa-miR-4692	CLIP-seq
MIRT2338081	hsa-miR-4704-3p	CLIP-seq
MIRT2115378	hsa-miR-4705	CLIP-seq
MIRT1385546	hsa-miR-4706	CLIP-seq
MIRT1385548	hsa-miR-4719	CLIP-seq
MIRT2338082	hsa-miR-4721	CLIP-seq
MIRT2338083	hsa-miR-4725-3p	CLIP-seq
MIRT1385552	hsa-miR-4734	CLIP-seq
MIRT1385553	hsa-miR-4737	CLIP-seq
MIRT1385555	hsa-miR-4742-5p	CLIP-seq
MIRT2338084	hsa-miR-4747-5p	CLIP-seq
MIRT1385556	hsa-miR-4749-5p	CLIP-seq
MIRT2115382	hsa-miR-4752	CLIP-seq
MIRT2115383	hsa-miR-4753-3p	CLIP-seq
MIRT2115388	hsa-miR-4774-3p	CLIP-seq
MIRT2338085	hsa-miR-4786-3p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT2338086	hsa-miR-5095	CLIP-seq
MIRT1385562	hsa-miR-539	CLIP-seq
MIRT2338087	hsa-miR-548ad	CLIP-seq
MIRT1385564	hsa-miR-548ae	CLIP-seq
MIRT1385565	hsa-miR-548ag	CLIP-seq
MIRT1385566	hsa-miR-548ai	CLIP-seq
MIRT1385567	hsa-miR-548aj	CLIP-seq
MIRT1385568	hsa-miR-548am	CLIP-seq
MIRT2338088	hsa-miR-548g	CLIP-seq
MIRT1385570	hsa-miR-548o	CLIP-seq
MIRT1385571	hsa-miR-548q	CLIP-seq
MIRT1385572	hsa-miR-548x	CLIP-seq
MIRT2338089	hsa-miR-570	CLIP-seq
MIRT1385574	hsa-miR-579	CLIP-seq
MIRT1385576	hsa-miR-586	CLIP-seq
MIRT2338090	hsa-miR-590-5p	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT1385580	hsa-miR-622	CLIP-seq
MIRT2338091	hsa-miR-624	CLIP-seq
MIRT2338092	hsa-miR-646	CLIP-seq
MIRT2115392	hsa-miR-655	CLIP-seq
MIRT2338093	hsa-miR-671-5p	CLIP-seq
MIRT1385581	hsa-miR-744	CLIP-seq
MIRT1385583	hsa-miR-876-5p	CLIP-seq
MIRT2115396	hsa-miR-942	CLIP-seq
MIRT1385495	hsa-miR-1253	CLIP-seq
MIRT2115337	hsa-miR-140-3p	CLIP-seq
MIRT2338066	hsa-miR-21	CLIP-seq
MIRT2338068	hsa-miR-300	CLIP-seq
MIRT1385516	hsa-miR-3179	CLIP-seq
MIRT1385521	hsa-miR-3611	CLIP-seq
MIRT2338075	hsa-miR-381	CLIP-seq
MIRT2338077	hsa-miR-4271	CLIP-seq
MIRT2115370	hsa-miR-4533	CLIP-seq
MIRT2338083	hsa-miR-4725-3p	CLIP-seq
MIRT2338084	hsa-miR-4747-5p	CLIP-seq
MIRT2338085	hsa-miR-4786-3p	CLIP-seq
MIRT2338090	hsa-miR-590-5p	CLIP-seq
MIRT2338091	hsa-miR-624	CLIP-seq
MIRT2338092	hsa-miR-646	CLIP-seq
MIRT2338093	hsa-miR-671-5p	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT2460474	hsa-miR-3657	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2460475	hsa-miR-4669	CLIP-seq
MIRT2460476	hsa-miR-4688	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT2460477	hsa-miR-489	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT2460478	hsa-miR-514	CLIP-seq
MIRT2460479	hsa-miR-514b-3p	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT2631621	hsa-miR-106a	CLIP-seq
MIRT2631622	hsa-miR-106b	CLIP-seq
MIRT2631623	hsa-miR-1234	CLIP-seq
MIRT1385502	hsa-miR-150	CLIP-seq
MIRT2631624	hsa-miR-17	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT2631625	hsa-miR-20a	CLIP-seq
MIRT2631626	hsa-miR-20b	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT2631627	hsa-miR-302a	CLIP-seq
MIRT2631628	hsa-miR-302b	CLIP-seq
MIRT2631629	hsa-miR-302c	CLIP-seq
MIRT2631630	hsa-miR-302d	CLIP-seq
MIRT2631631	hsa-miR-302e	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT2631632	hsa-miR-372	CLIP-seq
MIRT2631633	hsa-miR-373	CLIP-seq
MIRT2115360	hsa-miR-3941	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT2115376	hsa-miR-466	CLIP-seq
MIRT1385541	hsa-miR-4672	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385549	hsa-miR-4722-3p	CLIP-seq
MIRT2115380	hsa-miR-4727-5p	CLIP-seq
MIRT2631634	hsa-miR-4760-3p	CLIP-seq
MIRT1385559	hsa-miR-4763-5p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT2631635	hsa-miR-519d	CLIP-seq
MIRT2631636	hsa-miR-520a-3p	CLIP-seq
MIRT2631637	hsa-miR-520b	CLIP-seq
MIRT2631638	hsa-miR-520c-3p	CLIP-seq
MIRT2631639	hsa-miR-520d-3p	CLIP-seq
MIRT2631640	hsa-miR-520e	CLIP-seq
MIRT2631641	hsa-miR-520g	CLIP-seq
MIRT2631642	hsa-miR-520h	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq
MIRT2631643	hsa-miR-640	CLIP-seq
MIRT2631644	hsa-miR-642b	CLIP-seq
MIRT2115393	hsa-miR-664	CLIP-seq
MIRT2631645	hsa-miR-93	CLIP-seq
MIRT1385505	hsa-miR-197	CLIP-seq
MIRT1385506	hsa-miR-2113	CLIP-seq
MIRT2115348	hsa-miR-3182	CLIP-seq
MIRT1385527	hsa-miR-411	CLIP-seq
MIRT2115364	hsa-miR-4297	CLIP-seq
MIRT2115374	hsa-miR-4659a-3p	CLIP-seq
MIRT2115375	hsa-miR-4659b-3p	CLIP-seq
MIRT1385547	hsa-miR-4715-3p	CLIP-seq
MIRT1385560	hsa-miR-498	CLIP-seq
MIRT1385577	hsa-miR-599	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	2313285
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IDA	15998642
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0006465	Process	Signal peptide processing	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006509	Process	Membrane protein ectodomain proteolysis	IMP	16829952, 17965014
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	ISS
GO:0008233	Function	Peptidase activity	IEA
GO:0016020	Component	Membrane	IDA	2313285
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030660	Component	Golgi-associated vesicle membrane	IBA
GO:0030660	Component	Golgi-associated vesicle membrane	IDA	16829952
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	IEA
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	ISS
GO:0033619	Process	Membrane protein proteolysis	IBA
GO:0033619	Process	Membrane protein proteolysis	IDA	2313285
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IBA
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IDA	2313285
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IEA
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IMP	16873890
GO:0042803	Function	Protein homodimerization activity	IDA	15385547, 15998642, 16873890
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050852	Process	T cell receptor signaling pathway	IMP	25384971
GO:0050852	Process	T cell receptor signaling pathway	ISS
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IEA
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IMP	25384971
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IBA
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IDA	15385547
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IEA
GO:0098554	Component	Cytoplasmic side of endoplasmic reticulum membrane	IBA
GO:0098554	Component	Cytoplasmic side of endoplasmic reticulum membrane	IDA	15385547
GO:0098554	Component	Cytoplasmic side of endoplasmic reticulum membrane	IEA

MIM	HGNC	e!Ensembl
608240	30424	ENSG00000157837

Protein

UniProt ID

Q8TCT6

Protein name

Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)

Protein function

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediatin

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04258	Peptidase_A22B	60 → 374	Signal peptide peptidase	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed (PubMed:15385547). Expressed in the brain (PubMed:11978763). {ECO:0000269|PubMed:11978763, ECO:0000269|PubMed:15385547}.

Sequence

MAEQTYSWAYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSNSSSGSFNGNS
TNNSIQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQY
LTRPCSPQNKISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAF
VRLPSLKVSCLLLSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPN
VGRDVPRLSLPGKLVFPSSTGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAP
GPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYL
KGDLRRMWSEPFHSKSSSSRFLEV

Sequence length

384

Interactions

View interactions

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma (childhood onset), Asthma	N/A	N/A	GWAS
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Diabetes	Type 2 diabetes, Type 2 diabetes mellitus or coronary artery disease (pleiotropy)	N/A	N/A	GWAS
Eczema	Eczema	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Glioma	Associate	33271119

SPPL3 (signal peptide peptidase like 3)