ANO4 (anoctamin 4)

Gene

• Entrez ID: 121601
• Gene name: Anoctamin 4
• Gene symbol: ANO4
• Synonyms (NCBI Gene): TMEM16D
• Chromosome: 12
• Chromosome location: 12q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052833	hsa-miR-378c	CLASH	23622248
MIRT785702	hsa-miR-1182	CLIP-seq
MIRT785703	hsa-miR-134	CLIP-seq
MIRT785704	hsa-miR-1910	CLIP-seq
MIRT785705	hsa-miR-193a-5p	CLIP-seq
MIRT785706	hsa-miR-30a	CLIP-seq
MIRT785707	hsa-miR-30b	CLIP-seq
MIRT785708	hsa-miR-30c	CLIP-seq
MIRT785709	hsa-miR-30d	CLIP-seq
MIRT785710	hsa-miR-30e	CLIP-seq
MIRT785711	hsa-miR-3118	CLIP-seq
MIRT785712	hsa-miR-3145-5p	CLIP-seq
MIRT785713	hsa-miR-3164	CLIP-seq
MIRT785714	hsa-miR-3655	CLIP-seq
MIRT785715	hsa-miR-382	CLIP-seq
MIRT785716	hsa-miR-3909	CLIP-seq
MIRT785717	hsa-miR-4302	CLIP-seq
MIRT1931793	hsa-miR-33a	CLIP-seq
MIRT1931794	hsa-miR-33b	CLIP-seq
MIRT785703	hsa-miR-134	CLIP-seq
MIRT785704	hsa-miR-1910	CLIP-seq
MIRT785711	hsa-miR-3118	CLIP-seq
MIRT785712	hsa-miR-3145-5p	CLIP-seq
MIRT785713	hsa-miR-3164	CLIP-seq
MIRT785716	hsa-miR-3909	CLIP-seq
MIRT785717	hsa-miR-4302	CLIP-seq
MIRT2384241	hsa-miR-23a	CLIP-seq
MIRT2384242	hsa-miR-23b	CLIP-seq
MIRT2384243	hsa-miR-23c	CLIP-seq
MIRT785702	hsa-miR-1182	CLIP-seq
MIRT785705	hsa-miR-193a-5p	CLIP-seq
MIRT785706	hsa-miR-30a	CLIP-seq
MIRT785707	hsa-miR-30b	CLIP-seq
MIRT785708	hsa-miR-30c	CLIP-seq
MIRT785709	hsa-miR-30d	CLIP-seq
MIRT785710	hsa-miR-30e	CLIP-seq
MIRT785714	hsa-miR-3655	CLIP-seq
MIRT785715	hsa-miR-382	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IBA
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IDA	22946059
GO:0005254	Function	Chloride channel activity	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22946059
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0017128	Function	Phospholipid scramblase activity	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0046983	Function	Protein dimerization activity	IEA
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0061589	Process	Calcium activated phosphatidylserine scrambling	IEA
GO:0061590	Process	Calcium activated phosphatidylcholine scrambling	IEA
GO:0061591	Process	Calcium activated galactosylceramide scrambling	IEA
GO:1902476	Process	Chloride transmembrane transport	IBA
GO:1902476	Process	Chloride transmembrane transport	IDA	22946059

Other IDs

• MIM: 610111
• HGNC: 23837
• e!Ensembl: ENSG00000151572

Protein

• UniProt ID: Q32M45
• Protein name: Anoctamin-4 (Transmembrane protein 16D)
• Protein function: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). {ECO:0000250|U
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16178	Anoct_dimer	111 → 336	Dimerisation domain of Ca+-activated chloride-channel, anoctamin	Family
  PF04547	Anoctamin	339 → 920	Calcium-activated chloride channel	Family

• Sequence:

  MEASSSGITNGKTKVFHPEGGVDLQGYQLDMQILPDGPKSDVDFSEILNAIQEMAKDVNI
  LFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEAGGETVPERNKSNGLYFRDGKCRID
  YILVYRKSNPQTEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMN
  VRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQ
  QRIHHFIIHNKETFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEG
  SYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGM
  LFPAAFIGLFVFLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTH
  LFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKE
  RMNPISGKPEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWA
  LIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQ
  FVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTW
  NNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQF
  GFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGIL
  SVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE
  PESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKH
  LISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKNGKAHHNEWP

• Sequence length: 955

Pathways

KEGG:

Efferocytosis

Reactome:

Stimuli-sensing channels

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Developmental and epileptic encephalopathy	Pathogenic	rs2049522225, rs2541493503, rs2049521857, rs2541533331, rs1224091418	RCV003991524 RCV003991525 RCV003991526 RCV003991527 RCV003991528
Generalized epilepsy with febrile seizures plus	Pathogenic	rs2541492742	RCV003991529
Temporal lobe epilepsy	Likely pathogenic	rs200708403	RCV003993695

Associations from Text Mining
Disease Name	Relationship Type	References
Herpes Zoster	Associate	31564164
Prostatic Neoplasms	Associate	32027096