ANO4 (anoctamin 4)

Gene

• Entrez ID: 121601
• Gene name: Anoctamin 4
• Gene symbol: ANO4
• Synonyms (NCBI Gene): TMEM16D
• Chromosome: 12
• Chromosome location: 12q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052833	hsa-miR-378c	CLASH	23622248
MIRT785702	hsa-miR-1182	CLIP-seq
MIRT785703	hsa-miR-134	CLIP-seq
MIRT785704	hsa-miR-1910	CLIP-seq
MIRT785705	hsa-miR-193a-5p	CLIP-seq
MIRT785706	hsa-miR-30a	CLIP-seq
MIRT785707	hsa-miR-30b	CLIP-seq
MIRT785708	hsa-miR-30c	CLIP-seq
MIRT785709	hsa-miR-30d	CLIP-seq
MIRT785710	hsa-miR-30e	CLIP-seq
MIRT785711	hsa-miR-3118	CLIP-seq
MIRT785712	hsa-miR-3145-5p	CLIP-seq
MIRT785713	hsa-miR-3164	CLIP-seq
MIRT785714	hsa-miR-3655	CLIP-seq
MIRT785715	hsa-miR-382	CLIP-seq
MIRT785716	hsa-miR-3909	CLIP-seq
MIRT785717	hsa-miR-4302	CLIP-seq
MIRT1931793	hsa-miR-33a	CLIP-seq
MIRT1931794	hsa-miR-33b	CLIP-seq
MIRT785703	hsa-miR-134	CLIP-seq
MIRT785704	hsa-miR-1910	CLIP-seq
MIRT785711	hsa-miR-3118	CLIP-seq
MIRT785712	hsa-miR-3145-5p	CLIP-seq
MIRT785713	hsa-miR-3164	CLIP-seq
MIRT785716	hsa-miR-3909	CLIP-seq
MIRT785717	hsa-miR-4302	CLIP-seq
MIRT2384241	hsa-miR-23a	CLIP-seq
MIRT2384242	hsa-miR-23b	CLIP-seq
MIRT2384243	hsa-miR-23c	CLIP-seq
MIRT785702	hsa-miR-1182	CLIP-seq
MIRT785705	hsa-miR-193a-5p	CLIP-seq
MIRT785706	hsa-miR-30a	CLIP-seq
MIRT785707	hsa-miR-30b	CLIP-seq
MIRT785708	hsa-miR-30c	CLIP-seq
MIRT785709	hsa-miR-30d	CLIP-seq
MIRT785710	hsa-miR-30e	CLIP-seq
MIRT785714	hsa-miR-3655	CLIP-seq
MIRT785715	hsa-miR-382	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellular calcium activated chloride channel activity	IBA	21873635
GO:0005229	Function	Intracellular calcium activated chloride channel activity	IDA	22946059
GO:0005254	Function	Chloride channel activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	22946059
GO:0005886	Component	Plasma membrane	TAS
GO:0006821	Process	Chloride transport	IDA	22946059
GO:0016021	Component	Integral component of membrane	IEA
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0046983	Function	Protein dimerization activity	IEA
GO:0055085	Process	Transmembrane transport	IBA	21873635
GO:0061588	Process	Calcium activated phospholipid scrambling	IEA
GO:1902476	Process	Chloride transmembrane transport	IBA	21873635

Other IDs

• MIM: 610111
• HGNC: 23837
• e!Ensembl: ENSG00000151572

Protein

• UniProt ID: Q32M45
• Protein name: Anoctamin-4 (Transmembrane protein 16D)
• Protein function: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). {ECO:0000250|U
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16178	Anoct_dimer	111 → 336	Dimerisation domain of Ca+-activated chloride-channel, anoctamin	Family
  PF04547	Anoctamin	339 → 920	Calcium-activated chloride channel	Family

• Sequence:

  MEASSSGITNGKTKVFHPEGGVDLQGYQLDMQILPDGPKSDVDFSEILNAIQEMAKDVNI
  LFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEAGGETVPERNKSNGLYFRDGKCRID
  YILVYRKSNPQTEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMN
  VRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQ
  QRIHHFIIHNKETFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEG
  SYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGM
  LFPAAFIGLFVFLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTH
  LFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKE
  RMNPISGKPEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWA
  LIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQ
  FVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTW
  NNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQF
  GFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGIL
  SVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE
  PESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKH
  LISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKNGKAHHNEWP

• Sequence length: 955

Pathways

KEGG:

Efferocytosis

Reactome:

Stimuli-sensing channels

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	23535033
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	27846195

Unknown
Disease term	Disease name	Evidence	References	Source
Endometriosis	Endometriosis		20864642	ClinVar
Neurodevelopmental Disorders	complex neurodevelopmental disorder			GenCC
Diabetes	Diabetes			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Herpes Zoster	Associate	31564164
Prostatic Neoplasms	Associate	32027096