Gene Gene information from NCBI Gene database.
Entrez ID 121274
Gene name Zinc finger protein 641
Gene symbol ZNF641
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12q13.11
miRNA miRNA information provided by mirtarbase database.
332
miRTarBase ID miRNA Experiments Reference
MIRT016736 hsa-miR-335-5p Microarray 18185580
MIRT026107 hsa-miR-192-5p Microarray 19074876
MIRT016736 hsa-miR-335-5p HITS-CLIP 23313552
MIRT697342 hsa-miR-4761-5p HITS-CLIP 23313552
MIRT697341 hsa-miR-7106-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613906 31834 ENSG00000167528
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96N77
Protein name Zinc finger protein 641
Protein function Transcriptional activator. Activates transcriptional activities of SRE and AP-1.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 108 149 KRAB box Family
PF00096 zf-C2H2 292 314 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 371 394 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 400 422 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in skeletal muscle, moderate expression in heart, liver, and pancreas, lower expression in placenta, no expression seen in brain, lung, and kidney. {ECO:0000269|PubMed:16343441}.
Sequence
MQAEDRSQFGSAAEMLSEQTAALGTGWESMNVQLDGAEPQVERGSQEERPWRTVPGPLEH
LCCDLEEEPQSLQEKAQSAPWVPAIPQEGNTGDWEMAAALLAAGSQGLVTIKDVSLCFSQ
EEWRSLDPSQTDFYGEYVMQENCGIVVSL
RFPIPKLDMLSQLEGGEEQWVPDPQDLEERD
ILRVTYTGDGSEHEGDTPELEAEPPRMLSSVSEDTVLWNPEHDESWDSMPSSSRGMLLGP
PFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKT
FGRRHHLIRHQKTH
LHDKTSRCSECGKNFRCNSHLASHQRVHAEGKSCKGQEVGESPGTR
KRQRAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCEKSFGRKHHLDRHLL
TH
QGQSPRNSWDRGTSVF
Sequence length 438
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 35709760
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Associate 35709760
★☆☆☆☆
Found in Text Mining only